Abstract:
:The intestinal barrier provides the host with a strong defense line against the external environment playing also a pivotal role in the crosstalk between the gut microbiota and the immune system. Notably, increasing lines of evidence concerning autoimmune disorders such as Multiple Sclerosis (MS) report an imbalance in both intestinal microbiota composition and mucosal immunity activation, along with an alteration of gut barrier permeability, suggesting this complex network plays a crucial role in modulating the course of autoimmune responses occurring in tissues outside the gut such as the central nervous system (CNS). Here, we review current knowledge on how gut inflammation and breakage of gut barrier integrity modulates the interplay between the commensal gut microbiota and the immune system and its role in shaping brain immunity.
journal_name
Front Immunoljournal_title
Frontiers in immunologyauthors
Antonini M,Lo Conte M,Sorini C,Falcone Mdoi
10.3389/fimmu.2019.01937subject
Has Abstractpub_date
2019-08-16 00:00:00pages
1937issn
1664-3224journal_volume
10pub_type
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