Adjuvant Effect of Toll-Like Receptor 9 Activation on Cancer Immunotherapy Using Checkpoint Blockade.

abstract：:Polyunsaturated fatty acids (PUFAs) are important for immune function. Limited evidence indicates that immune cell activation involves endogenous PUFA synthesis, but this has not been characterised. To address this, we measured metabolism of 18:3n-3 in quiescent and activated peripheral blood mononuclear cells (PBMCs)...

journal_title：Frontiers in immunology

authors： Sibbons CM,Irvine NA,Pérez-Mojica JE,Calder PC,Lillycrop KA,Fielding BA,Burdge GC

更新日期：2018-03-05 00:00:00

abstract：:CD83 is a member of the immunoglobulin (Ig) superfamily and is expressed in membrane bound or soluble forms. Membrane CD83 (mCD83) can be detected on a variety of activated immune cells, although it is most highly and stably expressed by mature dendritic cells (DC). mCD83 regulates maturation, activation and homeostas...

journal_title：Frontiers in immunology

authors： Li Z,Ju X,Silveira PA,Abadir E,Hsu WH,Hart DNJ,Clark GJ

更新日期：2019-06-07 00:00:00

abstract：:Dendritic cells (DCs) are the guardians of the immune system since they are located in the majority of peripheral tissues. In addition, they are crucial for the induction of an effective immune response based on their unique capacity to stimulate naive T cells. During co-evolution, the human pathogen herpes simplex vi...

journal_title：Frontiers in immunology

authors： Birzer A,Krawczyk A,Draßner C,Kuhnt C,Mühl-Zürbes P,Heilingloh CS,Steinkasserer A,Popella L

更新日期：2020-08-26 00:00:00

abstract：:Malaria vaccine development has largely focused on Plasmodium falciparum; however, a reawakening to the importance of Plasmodium vivax has spurred efforts to develop vaccines against this difficult to treat and at times severe form of relapsing malaria, which constitutes a significant proportion of human malaria cases...

journal_title：Frontiers in immunology

authors： de Cassan SC,Shakri AR,Llewellyn D,Elias SC,Cho JS,Goodman AL,Jin J,Douglas AD,Suwanarusk R,Nosten FH,Rénia L,Russell B,Chitnis CE,Draper SJ

更新日期：2015-07-08 00:00:00

abstract：:Genital herpes is a common sexually transmitted infection caused by herpes simplex virus type 2 (HSV-2). Genital herpes significantly enhances the acquisition and transmission of HIV-1 by creating a microenvironment that supports HIV infection in the host. Dendritic cells (DCs) represent one of the first innate cell t...

journal_title：Frontiers in immunology

authors： Crisci E,Svanberg C,Ellegård R,Khalid M,Hellblom J,Okuyama K,Bhattacharya P,Nyström S,Shankar EM,Eriksson K,Larsson M

更新日期：2019-12-06 00:00:00

abstract：:Low vitamin D and insufficient sun exposure are additive independent risk factors for the development of multiple sclerosis (MS). The usual measure of vitamin D status, serum 25-hydroxy vitamin D [25(OH)D], is also a marker of recent exposure to the UVB rays of sunshine. The main evidence for a protective effect for M...

journal_title：Frontiers in immunology

authors： Hart PH,Lucas RM,Booth DR,Carroll WM,Nolan D,Cole JM,Jones AP,Kermode AG

更新日期：2017-01-24 00:00:00

abstract：:Monocytes are critical defense components that play an important role in the primary innate immune response. The heterogeneous nature of monocytes and their ability to differentiate into either monocyte-derived macrophages or monocyte-derived dendritic cells allows them to serve as a bridge between the innate and adap...

journal_title：Frontiers in immunology

authors： Sampath P,Moideen K,Ranganathan UD,Bethunaickan R

更新日期：2018-07-30 00:00:00

abstract：:The treatment of respiratory infections is associated with the dissemination of antibiotic resistance in the community and clinical settings. Development of new antibiotics is notoriously costly and slow; therefore, alternative strategies are needed. Antimicrobial peptides (AMPs), the central effector molecules of the...

journal_title：Frontiers in immunology

authors： Geitani R,Moubareck CA,Xu Z,Karam Sarkis D,Touqui L

更新日期：2020-06-30 00:00:00

abstract：:It was recently proposed that T lymphocytes, which closely interact with APCs, can extract surface molecules from the presenting cells when they dissociate. These observations question the classical view of discrete interactions between phenotypically defined cell populations. In this review, we summarize some reports...

journal_title：Frontiers in immunology

authors： Dhainaut M,Moser M

更新日期：2014-03-28 00:00:00

abstract：:The Autism Spectrum Disorder (ASD) is a heterogeneous group of neurodevelopmental disorders, only clinically diagnosed since the lack of reliable biomarkers. Autism etiology is probably attributable to the combination of genetic vulnerability and environmental factors, and recently, maternal immune activation has been...

journal_title：Frontiers in immunology

authors： Balestrieri E,Cipriani C,Matteucci C,Benvenuto A,Coniglio A,Argaw-Denboba A,Toschi N,Bucci I,Miele MT,Grelli S,Curatolo P,Sinibaldi-Vallebona P

更新日期：2019-09-26 00:00:00

abstract：:Neutrophils releasing neutrophil extracellular traps (NETs) infiltrate the pancreas prior to type 1 diabetes (T1D) onset; however, the precise nature of their contribution to disease remains poorly defined. To examine how NETs affect immune functions in T1D, we investigated NET composition and their effect on dendriti...

journal_title：Frontiers in immunology

authors： Parackova Z,Zentsova I,Vrabcova P,Klocperk A,Sumnik Z,Pruhova S,Petruzelkova L,Hasler R,Sediva A

更新日期：2020-04-14 00:00:00

abstract：:High-throughput sequencing has the power to reveal the nature of adaptive immunity as represented by the full complexity of T-cell receptor (TCR) and antibody (IG) repertoires, but is at present severely compromised by the quantitative bias, bottlenecks, and accumulated errors that inevitably occur in the course of li...

journal_title：Frontiers in immunology

authors： Mamedov IZ,Britanova OV,Zvyagin IV,Turchaninova MA,Bolotin DA,Putintseva EV,Lebedev YB,Chudakov DM

更新日期：2013-12-23 00:00:00

abstract：:Innate lymphoid cells (ILCs) are the most recently identified family of the innate immune system and are hypothesized to modulate immune functions prior to the generation of adaptive immune responses. Subsets of ILCs reside in the mucosa and regulate immune responses to external pathogens; however, their role and the ...

journal_title：Frontiers in immunology

authors： Yin S,Yu J,Hu B,Lu C,Liu X,Gao X,Li W,Zhou L,Wang J,Wang D,Lu L,Wang L

更新日期：2018-09-12 00:00:00

abstract：:Disturbed homeostasis as a result of tissue stress can provoke leukocyte responses enabling recovery. Since mild hypothermia displays specific clinically relevant tissue-protective properties and interleukin (IL)-22 promotes healing at host/environment interfaces, effects of lowered ambient temperature on IL-22 were s...

journal_title：Frontiers in immunology

authors： Chichelnitskiy E,Himmelseher B,Bachmann M,Pfeilschifter J,Mühl H

更新日期：2017-06-29 00:00:00

abstract：:Single trauma injuries or isolated fractures are often manageable and generally heal without complications. In contrast, high-energy trauma results in multi/poly-trauma injury patterns presenting imbalanced pro- and anti- inflammatory responses often leading to immune dysfunction. These injuries often exhibit delayed ...

journal_title：Frontiers in immunology

authors： Muire PJ,Mangum LH,Wenke JC

更新日期：2020-06-04 00:00:00

abstract：:Diseases due to mycobacteria, including tuberculosis, leprosy, and Buruli ulcer, rank among the top causes of death and disability worldwide. Animal studies have revealed the importance of T cells in controlling these infections. However, the specific antigens recognized by T cells that confer protective immunity and ...

journal_title：Frontiers in immunology

authors： James CA,Seshadri C

更新日期：2020-02-11 00:00:00

abstract：:Pregnancy comprises a unique immunological condition, to allow fetal development and to protect the host from pathogenic infections. Viral infections during pregnancy can disrupt immunological tolerance and may generate deleterious effects on the fetus. Despite these possible links between pregnancy and infection-indu...

journal_title：Frontiers in immunology

authors： Alberca RW,Pereira NZ,Oliveira LMDS,Gozzi-Silva SC,Sato MN

更新日期：2020-07-07 00:00:00

abstract：:Compared to naive T cells, differentiated T cells are thought to be less dependent on CD28 costimulation for full activation. To revisit the role of CD28 costimulation in mouse T cell recall responses, we adoptively transferred in vitro generated OT-II T helper (Th) 1 cells into C57BL/6 mice (Thy1.2+) and then either ...

journal_title：Frontiers in immunology

authors： Langenhorst D,Haack S,Göb S,Uri A,Lühder F,Vanhove B,Hünig T,Beyersdorf N

更新日期：2018-05-16 00:00:00

abstract：:Epithelial damage and loss of intestinal barrier function are hallmark pathologies of the mucosal inflammation associated with conditions such as inflammatory bowel disease. In order to resolve inflammation and restore intestinal integrity the mucosa must rapidly and effectively repair the epithelial barrier. Epitheli...

journal_title：Frontiers in immunology

authors： Goggins BJ,Chaney C,Radford-Smith GL,Horvat JC,Keely S

更新日期：2013-09-11 00:00:00

abstract：:Transcriptome profiling approaches have been widely used to investigate the mechanisms underlying psoriasis pathogenesis. Most researchers have measured changes in transcript abundance in skin biopsies; relatively few have examined transcriptome changes in the blood. Although less relevant to the study of psoriasis pa...

journal_title：Frontiers in immunology

authors： Rawat A,Rinchai D,Toufiq M,Marr AK,Kino T,Garand M,Tatari-Calderone Z,Kabeer BSA,Krishnamoorthy N,Bedognetti D,Karim MY,Sastry KS,Chaussabel D

更新日期：2020-11-24 00:00:00

abstract：:Health-related quality of life (HRQoL) in common variable immunodeficiency diseases (CVID) was evaluated by different tools, which were mainly used to compare different schedules of immunoglobulins administration in cross-sectional or short-term longitudinal studies. We assessed the HRQoL and psychological status of C...

journal_title：Frontiers in immunology

authors： Tabolli S,Giannantoni P,Pulvirenti F,La Marra F,Granata G,Milito C,Quinti I

更新日期：2014-11-26 00:00:00

abstract：:NK cells are capable of an array of functions that range widely from their classic anti-tumor and anti-viral cytotoxic effector functions, to their critical regulatory roles in controlling inflammatory immune responses and promoting tissue growth. However, the mechanisms that polarize NK cells to these distinct and op...

journal_title：Frontiers in immunology

authors： Poznanski SM,Ashkar AA

更新日期：2019-06-19 00:00:00

abstract：:Objective: Postoperative ileus (POI) is an inflammation-mediated complication of abdominal surgery, characterized by intestinal dysmotility and leukocyte infiltration into the muscularis externa (ME). Previous studies indicated that interleukin (IL)-10 is crucial for the resolution of a variety of inflammation-driven ...

journal_title：Frontiers in immunology

authors： Stein K,Lysson M,Schumak B,Vilz T,Specht S,Heesemann J,Roers A,Kalff JC,Wehner S

更新日期：2018-11-13 00:00:00

abstract：:Cells communicate with other cells in their microenvironment by transferring lipids, peptides, RNA, and sugars in extracellular vesicles (EVs), thereby also influencing recipient cell functions. Several studies indicate that these vesicles are involved in a variety of critical cellular processes including immune, meta...

journal_title：Frontiers in immunology

authors： Karasu E,Eisenhardt SU,Harant J,Huber-Lang M

更新日期：2018-04-11 00:00:00

abstract：:DiGeorge syndrome is an immunodeficiency characterized by thymic dysplasia resulting in T cell lymphopenia. Most patients suffer from increased susceptibility to infections and heightened prevalence of autoimmune disorders, such as autoimmune thrombocytopenia. B cells in DiGeorge syndrome show impaired maturation, wit...

journal_title：Frontiers in immunology

authors： Klocperk A,Paračková Z,Bloomfield M,Rataj M,Pokorný J,Unger S,Warnatz K,Šedivá A

更新日期：2018-07-23 00:00:00

abstract：:Every human possesses millions of distinct antibodies. It is now possible to analyze this diversity via next-generation sequencing of immunoglobulin genes (Ig-seq). This technique produces large volume sequence snapshots of B-cell receptors that are indicative of the antibody repertoire. In this paper, we enrich these...

journal_title：Frontiers in immunology

authors： Krawczyk K,Kelm S,Kovaltsuk A,Galson JD,Kelly D,Trück J,Regep C,Leem J,Wong WK,Nowak J,Snowden J,Wright M,Starkie L,Scott-Tucker A,Shi J,Deane CM

更新日期：2018-07-23 00:00:00

abstract：:Cancer stem cells (CSCs) have been identified as the source of tumor growth and disease recurrence. Eradication of CSCs is thus essential to achieve durable responses, but CSCs are resistant to current anti-tumor therapies. Novel therapeutic approaches that specifically target CSCs will, therefore, be crucial to impro...

journal_title：Frontiers in immunology

authors： Wefers C,Schreibelt G,Massuger LFAG,de Vries IJM,Torensma R

更新日期：2018-06-19 00:00:00

abstract：:The influence of CD4(+)CD25(+)Foxp3(+) regulatory T-cells (Tregs) on cancer progression has been demonstrated in a large number of preclinical models and confirmed in several types of malignancies. Neoplastic processes trigger an increase of Treg numbers in draining lymph nodes, spleen, blood, and tumors, leading to t...

journal_title：Frontiers in immunology

authors： Darrasse-Jèze G,Podsypanina K

更新日期：2013-09-26 00:00:00

abstract：:Mast cells are immune cells of the myeloid lineage and are present in connective tissues throughout the body. The activation and degranulation of mast cells significantly modulates many aspects of physiological and pathological conditions in various settings. With respect to normal physiological functions, mast cells ...

journal_title：Frontiers in immunology

authors： Krystel-Whittemore M,Dileepan KN,Wood JG

更新日期：2016-01-06 00:00:00

abstract：:CD1d-restricted invariant natural killer T (iNKT) cells are innate-like T cells that express an invariant T cell receptor (TCR) α-chain and recognize self and foreign glycolipid antigens. They can rapidly respond to agonist activation and stimulate an extensive array of immune responses. Thymic development and functio...

journal_title：Frontiers in immunology

authors： Yang G,Driver JP,Van Kaer L

更新日期：2018-11-14 00:00:00