What Is the Clinical Relevance of TNF Inhibitor Immunogenicity in the Management of Patients With Rheumatoid Arthritis?

abstract：:CD8+ T cells represent one of the most versatile immune cells critical for clearing away viral infections. Due to their important role, CD8+ T cell activation and memory formation during viral infection have been the focus of several studies recently. Although CD8+ T cell activation and memory formation have been asso...

journal_title：Frontiers in immunology

authors： Gupta SS,Wang J,Chen M

更新日期：2020-05-22 00:00:00

abstract：:IgA binding to FcαRI (CD89) is rapidly enhanced by cytokine induced inside-out signaling. Dephosphorylation of serine 263 in the intracellular tail of FcαRI by PP2A and PI3K activation are instrumental in this process. To further investigate these signaling pathways, we targeted downstream kinases of PI3K. Our experim...

journal_title：Frontiers in immunology

authors： Ten Broeke T,Honing H,Brandsma AM,Jacobino S,Bakema JE,Kanters D,van der Linden JAM,Bracke M,Koenderman L,Leusen JHW

更新日期：2019-01-31 00:00:00

abstract：:Viral defense at mucosal sites depends on interferons (IFN) and IFN stimulated genes (ISGs), either of which may be constitutively expressed to maintain an "antiviral state" (AVS). However, the mechanisms that govern the AVS are poorly defined. Using a BEAS-2B respiratory epithelial cell line deficient in IRF1, we dem...

journal_title：Frontiers in immunology

authors： Panda D,Gjinaj E,Bachu M,Squire E,Novatt H,Ozato K,Rabin RL

更新日期：2019-05-15 00:00:00

abstract：:Epidermal infiltration of neutrophils is a hallmark of psoriasis, where their activation leads to release of neutrophil extracellular traps (NETs). The contribution of NETs to psoriasis pathogenesis has been unclear, but here we demonstrate that NETs drive inflammatory responses in skin through activation of epidermal...

journal_title：Frontiers in immunology

authors： Shao S,Fang H,Dang E,Xue K,Zhang J,Li B,Qiao H,Cao T,Zhuang Y,Shen S,Zhang T,Qiao P,Li C,Gudjonsson JE,Wang G

更新日期：2019-04-05 00:00:00

abstract：:Chikungunya virus (CHIKV), a mosquito-borne Alphavirus, is endemic in different parts of the globe. The host macrophages are identified as the major cellular reservoirs of CHIKV during infection and this virus triggers robust TNF production in the host macrophages, which might be a key mediator of virus induced inflam...

journal_title：Frontiers in immunology

authors： Nayak TK,Mamidi P,Sahoo SS,Kumar PS,Mahish C,Chatterjee S,Subudhi BB,Chattopadhyay S,Chattopadhyay S

更新日期：2019-04-12 00:00:00

abstract：:A domain that is often neglected in the assessment of chimeric antigen receptor (CAR) functionality is the extracellular spacer module. However, several studies have elucidated that membrane proximal epitopes are best targeted through CARs comprising long spacers, while short spacer CARs exhibit highest activity on di...

journal_title：Frontiers in immunology

authors： Schäfer D,Henze J,Pfeifer R,Schleicher A,Brauner J,Mockel-Tenbrinck N,Barth C,Gudert D,Al Rawashdeh W,Johnston ICD,Hardt O

更新日期：2020-08-07 00:00:00

abstract：:Proximal tubular epithelial cells are particularly sensitive to damage. In search of a biomarker, this study evaluated the potential of different cell activation models (hypoxia/replenishment and protein overload) to lead to a release of trefoil factor 3 (TFF3). Surprisingly, we found disparity in the ability of the d...

journal_title：Frontiers in immunology

authors： Zwaini Z,Alammari D,Byrne S,Stover C

更新日期：2016-03-30 00:00:00

abstract：:The intestinal microbiota, composed of a large population of microorganisms, is often considered a "forgotten organ" in human health and diseases. Increasing evidence indicates that dysbiosis of the intestinal microbiota is closely related to colorectal cancer (CRC). The roles for intestinal microorganisms that initia...

journal_title：Frontiers in immunology

authors： Cheng Y,Ling Z,Li L

更新日期：2020-11-30 00:00:00

abstract：:Trauma represents a major socioeconomic burden worldwide. After a severe injury, hemorrhagic shock (HS) as a frequent concomitant aspect is a central driver of systemic inflammation and organ damage. The kidney is often strongly affected by traumatic-HS, and acute kidney injury (AKI) poses the patient at great risk fo...

journal_title：Frontiers in immunology

authors： Halbgebauer R,Karasu E,Braun CK,Palmer A,Braumüller S,Schultze A,Schäfer F,Bückle S,Eigner A,Wachter U,Radermacher P,Resuello RRG,Tuplano JV,Nilsson Ekdahl K,Nilsson B,Armacki M,Kleger A,Seufferlein T,Kalbitz M,Gebh

更新日期：2020-08-26 00:00:00

abstract：:For successful bone marrow transplantation (BMT), a preconditioning regime involving chemo and radiotherapy is used that results in DNA damage to both hematopoietic and stromal elements. Following radiation exposure, it is well recognized that a single wave of host-derived thymocytes reconstitutes the irradiated thymu...

journal_title：Frontiers in immunology

authors： Calvo-Asensio I,Sugrue T,Bosco N,Rolink A,Ceredig R

更新日期：2018-06-11 00:00:00

abstract：:Innate immune dysfunction persists in HIV+ individuals despite effective combination antiretroviral therapy (cART). We recently demonstrated that an adaptive-like CD56dim NK cell population lacking the signal transducing protein FcRγ is expanded in HIV+ individuals. Here, we analyzed a cohort of HIV+ men who have sex ...

journal_title：Frontiers in immunology

authors： Hearps AC,Agius PA,Zhou J,Brunt S,Chachage M,Angelovich TA,Cameron PU,Giles M,Price P,Elliott J,Jaworowski A

更新日期：2017-06-30 00:00:00

abstract：:TonEBP is a key transcriptional activator in macrophages with an M1 phenotype. High expression of TonEBP is associated with many inflammatory diseases. Heme oxygenase-1 (HO-1), a stress-inducible protein, is induced by various oxidative and inflammatory signals, and its expression is regarded as an adaptive cellular r...

journal_title：Frontiers in immunology

authors： Yoo EJ,Lee HH,Ye BJ,Lee JH,Lee CY,Kang HJ,Jeong GW,Park H,Lim SW,Lee-Kwon W,Kwon HM,Choi SY

更新日期：2019-04-18 00:00:00

abstract：:Construction of an optimal vaccine against tumors relies on the availability of appropriate tumor-specific antigens capable to stimulate CD4+ T helper cells (TH) and CD8+ cytolytic T cells (CTL). CTL are considered the major effectors of the anti-tumor adaptive immune response as they recognize antigens presented on M...

journal_title：Frontiers in immunology

authors： Accolla RS,Ramia E,Tedeschi A,Forlani G

更新日期：2019-07-30 00:00:00

abstract：:Background: Vascular microthrombotic lesions in lupus nephritis with or without antiphospholipid antibodies may relate to worse renal outcomes. Whether microthrombotic lesions are a consequence of renal inflammation or independently contribute to renal damage is unclear. Our aim was to investigate the relationship bet...

journal_title：Frontiers in immunology

authors： Gonzalo-Gil E,García-Herrero C,Toldos O,Usategui A,Criado G,Pérez-Yagüe S,Barber DF,Pablos JL,Galindo M

更新日期：2018-08-28 00:00:00

abstract：:The induction of donor-specific transplant tolerance is one of the main goals of modern immunology. Establishment of a mixed chimerism state in the transplant recipient has proven to be a suitable strategy for the induction of long-term allograft tolerance; however, current experimental recipient preconditioning proto...

journal_title：Frontiers in immunology

authors： Ruiz P,Maldonado P,Hidalgo Y,Sauma D,Rosemblatt M,Bono MR

更新日期：2015-11-23 00:00:00

abstract：:Dendritic cells (DC), master antigen-presenting cells that orchestrate interactions between the adaptive and innate immune arms, are increasingly utilized in cancer immunotherapy. Despite remarkable progress in our understanding of DC immunobiology, as well as several encouraging clinical applications - such as DC-bas...

journal_title：Frontiers in immunology

authors： Datta J,Berk E,Cintolo JA,Xu S,Roses RE,Czerniecki BJ

更新日期：2015-06-02 00:00:00

abstract：:In primary infection with Salmonella, it has been reported-without consideration of Salmonella's functions-that humoral immunity plays no role in the clearance of bacteria. In fact, Salmonella targets and suppresses several aspects of humoral immunity, including B cell lymphopoiesis, B cell activation, and IgG product...

journal_title：Frontiers in immunology

authors： Takaya A,Yamamoto T,Tokoyoda K

更新日期：2020-01-21 00:00:00

abstract：:Significant advances have been made to identify effective therapies that either restore or generate de novo a patient's immune response to cancer, so-called immunotherapy or immuno-oncology (IO) therapies. Some tumors overcome immune surveillance by promoting mechanisms to evade or suppress the immune system. This con...

journal_title：Frontiers in immunology

authors： Wilkinson RW,Leishman AJ

更新日期：2018-06-01 00:00:00

abstract：:Autophagy is a lysosomal degradation process that contributes to host immunity by eliminating invasive pathogens and the modulating inflammatory response. Several infectious and immune disorders are associated with autophagy defects, suggesting that stimulation of autophagy in these diseases should be beneficial. Here...

journal_title：Frontiers in immunology

authors： Al Azzaz J,Rieu A,Aires V,Delmas D,Chluba J,Winckler P,Bringer MA,Lamarche J,Vervandier-Fasseur D,Dalle F,Lapaquette P,Guzzo J

更新日期：2019-01-14 00:00:00

abstract：:The pathogenicity of group A Streptococcus (GAS) is mediated by direct bacterial invasivity and toxin-associated damage. Among the extracellular products, the exotoxin streptolysin O (SLO) is produced by almost all GAS strains. SLO is a pore forming toxin (PFT) hemolitically active and extremely toxic in vivo. Recent ...

journal_title：Frontiers in immunology

authors： Vita GM,De Simone G,Leboffe L,Montagnani F,Mariotti D,Di Bella S,Luzzati R,Gori A,Ascenzi P,di Masi A

更新日期：2020-12-08 00:00:00

abstract：:Recent studies have demonstrated that combination of modulatory immune strategies may potentiate tumor cell elimination. Most strategies rely on the use of monoclonal antibodies that can block cell surface receptors to overcome tumor-induced immunosuppression or acting as costimulatory ligands to boost activation of T...

journal_title：Frontiers in immunology

authors： Manrique-Rincón AJ,Beraldo CM,Toscaro JM,Bajgelman MC

更新日期：2017-09-19 00:00:00

abstract：:Mycobacteria propelled modulation of host responses is of considerable interest in the face of emerging drug resistance. Although it is known that Abl tyrosine kinases affect entry and persistence of mycobacteria, mechanisms that couple c-Abl to proximal signaling pathways during immunity are poorly understood. Loss-o...

journal_title：Frontiers in immunology

authors： Mahadik K,Prakhar P,Rajmani RS,Singh A,Balaji KN

更新日期：2018-02-01 00:00:00

abstract：:The intestinal microbiome maintains a close relationship with the host immunity. This connection fosters a health state by direct and indirect mechanisms. Direct influences occur mainly through the production of short-chain fatty acids (SCFAs), gastrointestinal hormones and precursors of bioactive molecules. Indirect ...

journal_title：Frontiers in immunology

authors： Elias-Oliveira J,Leite JA,Pereira ÍS,Guimarães JB,Manso GMDC,Silva JS,Tostes RC,Carlos D

更新日期：2020-08-11 00:00:00

abstract：:An essential role of the intestine is to build and maintain a barrier preventing the luminal gut microbiota from invading the host. This involves two coordinated physical and immunological barriers formed by single layers of intestinal epithelial and endothelial cells, which avoid the activation of local immune respon...

journal_title：Frontiers in immunology

authors： López-Posadas R,Stürzl M,Atreya I,Neurath MF,Britzen-Laurent N

更新日期：2017-10-05 00:00:00

abstract：:Hemagglutinin glycoprotein (HA) is a principle influenza vaccine antigen. Recombinant HA-based vaccines become a potential alternative for traditional approach. Complexity and variation of HA N-glycosylation are considered as the important factors for the vaccine design. The number and location of glycan moieties in t...

journal_title：Frontiers in immunology

authors： Macioła AK,Pietrzak MA,Kosson P,Czarnocki-Cieciura M,Śmietanka K,Minta Z,Kopera E

更新日期：2017-04-20 00:00:00

abstract：:Dendritic cell (DC)-based immunotherapies are being explored for over 20 years and found to be very safe. Most often, granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-4 (IL-4)-induced monocyte-derived DCs (moDCs) are being used, which have demonstrated some life-prolonging benefit to patients ...

journal_title：Frontiers in immunology

authors： Zeng Q,Zhou Y,Schwarz H

更新日期：2019-10-02 00:00:00

abstract：:The size and composition of the T lymphocyte compartment is subject to strict homeostatic regulation and is remarkably stable throughout life in spite of variable dynamics in cell production and death during T cell development and immune responses. Homeostasis is achieved by careful orchestration of lymphocyte surviva...

journal_title：Frontiers in immunology

authors： Hapuarachchi T,Lewis J,Callard RE

更新日期：2013-11-11 00:00:00

abstract：:Impairment or stimulation of the immune system by ionizing radiation (IR) impacts on immune surveillance of tumor cells and non-malignant cells and can either foster therapy response or side effects/toxicities of radiation therapy. For a better understanding of the mechanisms by which IR modulates T-cell activation an...

journal_title：Frontiers in immunology

authors： Voos P,Fuck S,Weipert F,Babel L,Tandl D,Meckel T,Hehlgans S,Fournier C,Moroni A,Rödel F,Thiel G

更新日期：2018-04-30 00:00:00

abstract：:Continued discoveries of negative regulators of inflammatory signaling provide detailed molecular insights into peripheral tolerance and anti-tumor immunity. Accumulating evidence indicates that peripheral tolerance is maintained at multiple levels of immune responses by negative regulators of proinflammatory signalin...

journal_title：Frontiers in immunology

authors： Guram K,Kim SS,Wu V,Sanders PD,Patel S,Schoenberger SP,Cohen EEW,Chen SY,Sharabi AB

更新日期：2019-03-18 00:00:00

abstract：:Inflammation is a common characteristic of chronic liver disease (CLD). Inflammasomes are multiprotein complexes that can sense and recognize various exogenous and endogenous danger signals, eventually activating interleukin (IL)-1β and IL-18. The sensor component of the inflammasome system is a nucleotide-binding oli...

journal_title：Frontiers in immunology

authors： Wu X,Dong L,Lin X,Li J

更新日期：2017-12-12 00:00:00