Cytokines in Pain: Harnessing Endogenous Anti-Inflammatory Signaling for Improved Pain Management.

abstract：:Dendritic cells (DCs) are uniquely potent antigen presenting cells that acquire microbial products and prime adaptive immune responses against pathogens. Furthermore, DCs also play a key role in induction and maintenance of tolerance. Although numerous studies have assessed the diverse functions of DCs, many unanswere...

journal_title：Frontiers in immunology

authors： Zelante T,Fric J,Wong AY,Ricciardi-Castagnoli P

更新日期：2012-06-18 00:00:00

abstract：:The T lymphocyte response initiates with the recognition of MHC/peptides on antigen presenting cells by the T cell receptor (TCR). After the TCR engagement, the proximal signaling pathways are activated for downstream cellular events. Among these pathways, the calcium-signaling flux is activated through the depletion ...

journal_title：Frontiers in immunology

authors： Jia W,He MX,McLeod IX,He YW

更新日期：2013-07-04 00:00:00

abstract：:Antibody-derived chimeric antigen receptor (CAR) T cell therapy has achieved gratifying breakthrough in hematologic malignancies but has shown limited success in solid tumor immunotherapy. Monoclonal antibody, TAB004, specifically recognizes the aberrantly glycosylated tumor form of MUC1 (tMUC1) in all subtypes of bre...

journal_title：Frontiers in immunology

authors： Zhou R,Yazdanifar M,Roy LD,Whilding LM,Gavrill A,Maher J,Mukherjee P

更新日期：2019-05-24 00:00:00

abstract：:Short-chain fatty acids (SCFAs), such as acetate, butyrate, and propionate, modulate immune responses in the gut. However, the effect of SCFAs on mucosal vaccine-induced immune cell migration is poorly understood. Here, we investigated whether SCFAs modulate chemokine expression induced by the killed whole-cell oral c...

journal_title：Frontiers in immunology

authors： Sim JR,Kang SS,Lee D,Yun CH,Han SH

更新日期：2018-01-29 00:00:00

abstract：:Newly generated bone marrow B cells are positively selected into the peripheral lymphoid tissue only when they express a B cell receptor (BCR) that is nonautoreactive or one that binds self-antigen with only minimal avidity. This positive selection process, moreover, is critically contingent on the ligand-independent ...

journal_title：Frontiers in immunology

authors： Greaves SA,Peterson JN,Torres RM,Pelanda R

更新日期：2018-04-09 00:00:00

abstract：:Innate immune dysfunction persists in HIV+ individuals despite effective combination antiretroviral therapy (cART). We recently demonstrated that an adaptive-like CD56dim NK cell population lacking the signal transducing protein FcRγ is expanded in HIV+ individuals. Here, we analyzed a cohort of HIV+ men who have sex ...

journal_title：Frontiers in immunology

authors： Hearps AC,Agius PA,Zhou J,Brunt S,Chachage M,Angelovich TA,Cameron PU,Giles M,Price P,Elliott J,Jaworowski A

更新日期：2017-06-30 00:00:00

abstract：:The Th17/T-regulatory (Treg) cell imbalance is involved in the occurrence and development of organ inflammation in systemic lupus erythematosus (SLE). Metabolic pathways can regulate T cell differentiation and function, thus contributing to SLE inflammation. Increasingly, data have shown metabolism influences and repr...

journal_title：Frontiers in immunology

authors： Shan J,Jin H,Xu Y

更新日期：2020-05-22 00:00:00

abstract：:Degeneration of central cholinergic neurons impairs memory, and enhancement of cholinergic synapses improves cognitive processes. Cholinergic signaling is also anti-inflammatory, and neuroinflammation is increasingly linked to adverse memory, especially in Alzheimer's disease. Much of the evidence surrounding choliner...

journal_title：Frontiers in immunology

authors： Maurer SV,Williams CL

更新日期：2017-11-08 00:00:00

abstract：:We have developed a therapeutic vaccine consisting of a mixture of lethally-irradiated allogeneic cutaneous melanoma cell lines with BCG and GM-CSF as adjuvants. The CSF-470 vaccine is currently being assayed in a Phase II-III trial against medium-dose IFN-α2b. All vaccinated patients immunized intradermally developed...

journal_title：Frontiers in immunology

authors： Aris M,Bravo AI,Barrio MM,Mordoh J

更新日期：2015-03-30 00:00:00

abstract：:Objective: Intestinal Behcet's disease (iBD) is an autoimmune disorder diagnosed by typical intestinal ulcers and systemic Behcet's disease (BD) manifestations. Haploinsufficiency of A20 (HA20) is a recently described autoinflammatory disease with a phenotype resembling BD, caused by heterozygous loss-of-function muta...

journal_title：Frontiers in immunology

authors： Chen Y,Huang H,He Y,Chen M,Seidler U,Tian D,Xiao F

更新日期：2020-07-03 00:00:00

abstract：:Secretion of extracellular vesicles (EVs) is a ubiquitous mechanism of intercellular communication based on the exchange of effector molecules, such as growth factors, cytokines, and nucleic acids. Recent studies identified tumor-derived EVs as central players in tumor progression and the establishment of the tumor mi...

journal_title：Frontiers in immunology

authors： Dörsam B,Bösl T,Reiners KS,Barnert S,Schubert R,Shatnyeva O,Zigrino P,Engert A,Hansen HP,von Strandmann EP

更新日期：2018-06-18 00:00:00

abstract：:Cooperation between the innate and adaptive immune responses is critical for enabling protective immunity against various invading microbes. Distinct types of effector T cells have different functions in adaptive immune responses. Th1 cells play important roles in the control of intracellular bacteria by producing IFN...

journal_title：Frontiers in immunology

authors： Koyasu S,Moro K

更新日期：2012-05-07 00:00:00

abstract：:Chemokines and their cognate receptors have been identified as major factors initiating and governing cell movement and interaction. These ligands and their receptors are expressed on a wide variety of cells and act during steady-state migration as well as inflammatory recruitment. CCR6 is a non-promiscuous chemokine ...

journal_title：Frontiers in immunology

authors： Lee AY,Eri R,Lyons AB,Grimm MC,Korner H

更新日期：2013-07-15 00:00:00

abstract：:Antibody evolution studies have been traditionally limited to either tracing a single clonal lineage (B cells derived from a single V-(D)-J recombination) over time or examining bulk functionality changes (e.g., tracing serum polyclonal antibody proteins). Studying a single B cell disregards the majority of the humora...

journal_title：Frontiers in immunology

authors： Yermanos AD,Dounas AK,Stadler T,Oxenius A,Reddy ST

更新日期：2018-10-02 00:00:00

abstract：:M2 macrophage (Mφ) promotes pathologic angiogenesis through a release of pro-angiogenic mediators or the direct cell-cell interaction with endothelium in the micromilieu of several chronic inflammatory diseases, including rheumatoid arthritis and cancer, where interleukin (IL)-18 also contributes to excessive angiogen...

journal_title：Frontiers in immunology

authors： Kobori T,Hamasaki S,Kitaura A,Yamazaki Y,Nishinaka T,Niwa A,Nakao S,Wake H,Mori S,Yoshino T,Nishibori M,Takahashi H

更新日期：2018-03-06 00:00:00

abstract：:Flow cytometry has emerged as a useful technology that has facilitated our understanding of the human immune system. Primary immune deficiency disorders (PIDDs) are a heterogeneous group of inherited disorders affecting the immune system. More than 350 genes causing various PIDDs have been identified. While the initia...

journal_title：Frontiers in immunology

authors： Rawat A,Arora K,Shandilya J,Vignesh P,Suri D,Kaur G,Rikhi R,Joshi V,Das J,Mathew B,Singh S

更新日期：2019-09-11 00:00:00

abstract：:Antiretroviral therapy (ART) for human immunodeficiency virus (HIV) infections has been designed to optimize CD4 T-cell survival and limit HIV replication. Cell types other than CD4 T cells such as monocytes/macrophage, dendritic cells, and granulocytes (collectively known as myeloid cells), are generally not consider...

journal_title：Frontiers in immunology

authors： Murray SM,Zhang Y,Douek DC,Sekaly RP

更新日期：2020-03-04 00:00:00

abstract：:The recently emerged SARS-CoV-2 causing the ongoing COVID-19 pandemic is particularly virulent in the elderly while children are largely spared. Here, we explored the potential role of cross-reactive immunity acquired from pediatric vaccinations and exposure to common human pathogens in the protection and pathology of...

journal_title：Frontiers in immunology

authors： Reche PA

更新日期：2020-10-16 00:00:00

abstract：:M1 and M2 macrophage-type responses kill or repair in vivo. The unique ability of macrophages to make these polar opposite type of responses provides primary host protection and maintains tissue homeostasis throughout the animal kingdom. In humans and other higher animals, M1 and M2-type macrophage responses also init...

journal_title：Frontiers in immunology

authors： Mills CD

更新日期：2015-05-05 00:00:00

abstract：:The intestinal barrier provides the host with a strong defense line against the external environment playing also a pivotal role in the crosstalk between the gut microbiota and the immune system. Notably, increasing lines of evidence concerning autoimmune disorders such as Multiple Sclerosis (MS) report an imbalance i...

journal_title：Frontiers in immunology

authors： Antonini M,Lo Conte M,Sorini C,Falcone M

更新日期：2019-08-16 00:00:00

abstract：:Cancer neoantigens derived from random somatic mutations in tumor tissue represent an attractive type of targets for the cancer immunotherapies including cancer vaccine. Vaccination against the tumor-specific neoantigens minimizes the potential induction of central and peripheral tolerance as well as the risk of autoi...

journal_title：Frontiers in immunology

authors： Guo Y,Lei K,Tang L

更新日期：2018-07-02 00:00:00

abstract：:The spectrum of clinical forms observed in leprosy and its pathogenesis are dictated by the host's immune response against Mycobacterium leprae, the etiological agent of leprosy. Previous results, based on metabolomics studies, demonstrated a strong relationship between clinical manifestations of leprosy and alteratio...

journal_title：Frontiers in immunology

authors： Silva CAM,Belisle JT

更新日期：2018-02-02 00:00:00

abstract：:Treatment with the macrolide antibiotic azithromycin (AZM) is an important intervention for controlling infection of children with Bordetella pertussis and as a prophylaxis for preventing transmission to family members. However, antibiotics are known to have immunomodulatory effects independent of their antimicrobial ...

journal_title：Frontiers in immunology

authors： Borkner L,Misiak A,Wilk MM,Mills KHG

更新日期：2018-07-30 00:00:00

abstract：:Large-scale study of the properties of T-cell receptor (TCR) and B-cell receptor (BCR) repertoires through next-generation sequencing is providing excellent insights into the understanding of adaptive immune responses. Variable(Diversity)Joining [V(D)J] germline genes and alleles must be characterized in detail to fac...

journal_title：Frontiers in immunology

authors： Zhang W,Wang IM,Wang C,Lin L,Chai X,Wu J,Bett AJ,Dhanasekaran G,Casimiro DR,Liu X

更新日期：2016-11-04 00:00:00

abstract：:Background: The association of genetically elevated levels of circulating C-reactive protein (CRP) with cancer risk has been extensively investigated in European populations; however, there are conflicting conclusions. The tri-allelic rs3091244 is a functionally validated genetic variant, and its allelic frequencies d...

journal_title：Frontiers in immunology

authors： Wang MY,Zhou HH,Zhang CM,Su HX,Li SL,Ji SR,Liu E,Wu Y

更新日期：2020-05-14 00:00:00

abstract：:Platelets are anucleate cells produced by megakaryocytes. In recent years, a robust body of literature supports the evolving role of platelets as key sentinel and effector cells in infectious diseases, especially critical in bridging hemostatic, inflammatory, and immune continuums. Upon intravascular pathogen invasion...

journal_title：Frontiers in immunology

authors： Guo L,Rondina MT

更新日期：2019-09-13 00:00:00

abstract：:Visceral leishmaniasis is a severe form of the disease, caused by Leishmania infantum in the New World. Patients present an anergic immune response that favors parasite establishment and spreading through tissues like bone marrow and liver. On the other hand, Leishmania braziliensis causes localized cutaneous lesions,...

journal_title：Frontiers in immunology

authors： Falcão Sde A,Jaramillo TM,Ferreira LG,Bernardes DM,Santana JM,Favali CB

更新日期：2016-08-03 00:00:00

abstract：:Arginine methylation is a post-translational modification that regulates many biological processes. However, the role of arginine methylation in immune cells is not well studied. Here we report an essential role of protein arginine methyltransferase 5 (PRMT5) in T cell homeostasis and activation-induced expansion. Usi...

journal_title：Frontiers in immunology

authors： Tanaka Y,Nagai Y,Okumura M,Greene MI,Kambayashi T

更新日期：2020-04-09 00:00:00

abstract：:Pemphigus and systemic lupus erythematosus (SLE) are severe potentially life-threatening autoimmune diseases. They are classified as B-cell-mediated autoimmune diseases, both depending on autoreactive CD4+ T lymphocytes to modulate the autoimmune B-cell response. Despite the reported association of pemphigus and SLE, ...

journal_title：Frontiers in immunology

authors： Sezin T,Vorobyev A,Sadik CD,Zillikens D,Gupta Y,Ludwig RJ

更新日期：2018-01-17 00:00:00

abstract：:The COVID-19 pandemic demonstrates the ongoing threat of pandemics caused by novel, previously unrecognized, or mutated pathogens with high transmissibility. Currently, vaccine development is too slow for vaccines to be used in the control of emerging pandemics. RNA-based vaccines might be suitable to meet this challe...

journal_title：Frontiers in immunology

authors： Sandbrink JB,Shattock RJ

更新日期：2020-12-22 00:00:00