CC Chemokine Ligand 20 and Its Cognate Receptor CCR6 in Mucosal T Cell Immunology and Inflammatory Bowel Disease: Odd Couple or Axis of Evil?

abstract：:Pertussis is an acute respiratory disease caused by Bordetella pertussis. Due to its frequency and severity, prevention of pertussis has been considered an important public health issue for many years. The development of the whole-cell pertussis vaccine (wPV) and its introduction into the pediatric immunization schedu...

journal_title：Frontiers in immunology

authors： Esposito S,Stefanelli P,Fry NK,Fedele G,He Q,Paterson P,Tan T,Knuf M,Rodrigo C,Weil Olivier C,Flanagan KL,Hung I,Lutsar I,Edwards K,O'Ryan M,Principi N,World Association of Infectious Diseases and Immunological Disorders

更新日期：2019-07-03 00:00:00

abstract：:The role of intestinal epithelial cells (IECs) in mucosal tolerance and immunity remains poorly understood. We present a method for inducing MHC class II (MHC-II) in human enteroids, "mini-guts" derived from small intestinal crypt stem cells, and show that the intracellular MHC-II peptide-pathway is intact and functio...

journal_title：Frontiers in immunology

authors： Wosen JE,Ilstad-Minnihan A,Co JY,Jiang W,Mukhopadhyay D,Fernandez-Becker NQ,Kuo CJ,Amieva MR,Mellins ED

更新日期：2019-08-20 00:00:00

abstract：:The clinical experience gathered throughout the years has raised awareness of primary immunodeficiency diseases (PIDD). T cell receptor excision circles (TREC) and kappa-deleting recombination excision circles (KREC) assays for thymic and bone marrow outputs measurement have been widely implemented in newborn screenin...

journal_title：Frontiers in immunology

authors： Kwok JSY,Cheung SKF,Ho JCY,Tang IWH,Chu PWK,Leung EYS,Lee PPW,Cheuk DKL,Lee V,Ip P,Lau YL

更新日期：2020-07-16 00:00:00

abstract：:Preclinical and early human clinical studies of broadly neutralizing antibodies (bNAbs) to prevent and treat HIV infection support the clinical utility and potential of bNAbs for prevention, postexposure prophylaxis, and treatment of acute and chronic infection. Observed and potential limitations of bNAbs from these r...

journal_title：Frontiers in immunology

authors： Hua CK,Ackerman ME

更新日期：2017-11-28 00:00:00

abstract：:Piscirickettsia salmonis, an aggressive intracellular pathogen, is the etiological agent of salmonid rickettsial septicemia (SRS). This is a chronic multisystemic disease that generates high mortalities and large losses in Chilean salmon farming, threatening the sustainability of the salmon industry. Previous reports ...

journal_title：Frontiers in immunology

authors： Pérez-Stuardo D,Espinoza A,Tapia S,Morales-Reyes J,Barrientos C,Vallejos-Vidal E,Sandino AM,Spencer E,Toro-Ascuy D,Rivas-Pardo JA,Reyes-López FE,Reyes-Cerpa S

更新日期：2020-11-12 00:00:00

abstract：:Thymic epithelial cells (TECs) provide the microenvironment required for the development of T cells in the thymus. A unique property of medullary thymic epithelial cells (mTECs) is their expression of a wide range of tissue-restricted self-antigens, critically regulated by the nuclear protein AIRE, which contributes t...

journal_title：Frontiers in immunology

authors： Akiyama T,Shinzawa M,Akiyama N

更新日期：2012-09-04 00:00:00

abstract：:Viral infections have a major impact on morbidity and mortality of immunosuppressed solid organ transplant (SOT) patients because of missing or failure of adequate pharmacologic antiviral treatment. Adoptive antiviral T-cell therapy (AVTT), regenerating disturbed endogenous T-cell immunity, emerged as an attractive al...

journal_title：Frontiers in immunology

authors： Amini L,Vollmer T,Wendering DJ,Jurisch A,Landwehr-Kenzel S,Otto NM,Jürchott K,Volk HD,Reinke P,Schmueck-Henneresse M

更新日期：2019-05-28 00:00:00

abstract：:Background and Objectives: The live non-pathogenic Leishmania tarantolae has recently provided a promising approach as an effective vaccine candidate against experimental leishmaniasis (ILL). Here, we evaluated the immunoprotective potential of the live Iranian Lizard Leishmania mixed with CpG adjuvant against L. majo...

journal_title：Frontiers in immunology

authors： Keshavarzian N,Noroozbeygi M,Haji Molla Hoseini M,Yeganeh F

更新日期：2020-10-23 00:00:00

abstract：:Adjuvanted whole inactivated virus (WIV) influenza vaccines show promise as broadly protective influenza vaccine candidates. Using WIV as basis we assessed the relative efficacy of different adjuvants by carrying out a head-to-head comparison of the liposome-based adjuvants CAF01 and CAF09 and the protein-based adjuva...

journal_title：Frontiers in immunology

authors： Bhide Y,Dong W,Gribonika I,Voshart D,Meijerhof T,de Vries-Idema J,Norley S,Guilfoyle K,Skeldon S,Engelhardt OG,Boon L,Christensen D,Lycke N,Huckriede A

更新日期：2019-03-29 00:00:00

abstract：:Cholera toxin (CT) is one of most strong mucosal adjuvants, but it cannot be clinically used owing to its toxicity. The cytosolic A1 subunit of CT (CTA1) is the molecule responsible for its immunostimulatory activity, which increases the concentration of cyclic AMP and causes the induction of pro-inflammatory cytokine...

journal_title：Frontiers in immunology

authors： Kim MS,Yi EJ,Kim YI,Kim SH,Jung YS,Kim SR,Iwawaki T,Ko HJ,Chang SY

更新日期：2019-06-04 00:00:00

abstract：:Hematopoietic cell transplantation (HCT) is a therapy option for aggressive forms of hematopoietic malignancies that are resistant to standard antitumoral therapies. Hematoablative treatment preceding HCT, however, opens a "window of opportunity" for latent Cytomegalovirus (CMV) by releasing it from immune control wit...

journal_title：Frontiers in immunology

authors： Reddehase MJ

更新日期：2016-08-04 00:00:00

abstract：:Currently, inflammatory bowel disease (IBD) is a serious public health problem on the rise worldwide. In this work, we utilized the zebrafish to introduce a new model of intestinal inflammation triggered by food intake. Taking advantage of the translucency of the larvae and the availability of transgenic zebrafish lin...

journal_title：Frontiers in immunology

authors： Coronado M,Solis CJ,Hernandez PP,Feijóo CG

更新日期：2019-04-02 00:00:00

abstract：:For many years, disappointing results have been generated by many investigations, which have utilized a variety of immunologic strategies to enhance the ability of a patient's immune system to recognize and eliminate malignant cells. However, in recent years, immunotherapy has been used successfully for the treatment ...

journal_title：Frontiers in immunology

authors： Caratelli S,Sconocchia T,Arriga R,Coppola A,Lanzilli G,Lauro D,Venditti A,Del Principe MI,Buccisano F,Maurillo L,Ferrone S,Sconocchia G

更新日期：2017-04-27 00:00:00

abstract：:DiGeorge syndrome is an immunodeficiency characterized by thymic dysplasia resulting in T cell lymphopenia. Most patients suffer from increased susceptibility to infections and heightened prevalence of autoimmune disorders, such as autoimmune thrombocytopenia. B cells in DiGeorge syndrome show impaired maturation, wit...

journal_title：Frontiers in immunology

authors： Klocperk A,Paračková Z,Bloomfield M,Rataj M,Pokorný J,Unger S,Warnatz K,Šedivá A

更新日期：2018-07-23 00:00:00

abstract：:Despite the role of pigs as a source of new Influenza A Virus viruses (IAV) potentially capable of initiating human pandemics, immune responses to swine influenza virus (SwIV) in pigs are not fully understood. Several SwIV epitopes presented by swine MHC (SLA) class I have been identified using different approaches ei...

journal_title：Frontiers in immunology

authors： Baratelli M,Morgan S,Hemmink JD,Reid E,Carr BV,Lefevre E,Montaner-Tarbes S,Charleston B,Fraile L,Tchilian E,Montoya M

更新日期：2020-09-16 00:00:00

abstract：:Glutathione (GSH), a major cellular antioxidant, is considered an inhibitor of the inflammatory response involving reactive oxygen species (ROS). However, evidence is largely based on experiments with exogenously added antioxidants/reducing agents or pro-oxidants. We show that depleting macrophages of 99% of GSH does ...

journal_title：Frontiers in immunology

authors： Diotallevi M,Checconi P,Palamara AT,Celestino I,Coppo L,Holmgren A,Abbas K,Peyrot F,Mengozzi M,Ghezzi P

更新日期：2017-09-29 00:00:00

abstract：:Cross-presentation of endocytosed antigen as peptide/class I major histocompatibility complex complexes plays a central role in the elicitation of CD8(+) T cell clones that mediate anti-viral and anti-tumor immune responses. While it has been clear that there are specific subsets of professional antigen presenting cel...

journal_title：Frontiers in immunology

authors： Compeer EB,Flinsenberg TW,van der Grein SG,Boes M

更新日期：2012-03-07 00:00:00

abstract：:Effective prophylactic strategy against the current epidemic of sexually transmitted HIV-1 infection requires understanding of the innate gatekeeping mechanisms at the genital mucosa. Surfactant protein D (SP-D), a member of the collectin family of proteins naturally present in the vaginal tract, is a potential HIV-1 ...

journal_title：Frontiers in immunology

authors： Pandit H,Kale K,Yamamoto H,Thakur G,Rokade S,Chakraborty P,Vasudevan M,Kishore U,Madan T,Fichorova RN

更新日期：2019-03-28 00:00:00

abstract：:Immunological aging remodels the immune system at several levels. This has been documented in particular for the T-cell receptor (TCR)αβ+ T-cell compartment, showing reduced naive T-cell outputs and an accumulation of terminally differentiated clonally expanding effector T-cells, leading to increased proneness to auto...

journal_title：Frontiers in immunology

authors： Kallemeijn MJ,Kavelaars FG,van der Klift MY,Wolvers-Tettero ILM,Valk PJM,van Dongen JJM,Langerak AW

更新日期：2018-03-06 00:00:00

abstract：:Disialoganglioside GD2 is an important target on several pediatric and adult cancer types including neuroblastoma, retinoblastoma, melanoma, small-cell lung cancer, brain tumors, sarcomas, and cancer stem cells. We have utilized structural and computational methods to refine the framework of humanized monoclonal antib...

journal_title：Frontiers in immunology

authors： Ahmed M,Hu J,Cheung NK

更新日期：2014-08-14 00:00:00

abstract：:Myeloid-derived suppressor cells (MDSC) are a heterogeneous group of immune cells from the myeloid lineage. MDSCs expand in pathological situations, such as chronic infection, cancer, autoimmunity, and allograft rejection. As chronic lung allograft dysfunction (CLAD) limits long-term survival after lung transplantatio...

journal_title：Frontiers in immunology

authors： Heigl T,Singh A,Saez-Gimenez B,Kaes J,Van Herck A,Sacreas A,Beeckmans H,Vanstapel A,Verleden SE,Van Raemdonck DE,Verleden G,Vanaudenaerde BM,Hartl D,Vos R

更新日期：2019-04-26 00:00:00

abstract：:Mesenchymal stromal cells (MSCs) exert immunosuppressive effects on immune cells including dendritic cells (DCs). However, many details of the bidirectional interaction of MSCs with DCs are still unsolved and information on key molecules by which DCs can modulate MSC functions is limited. Here, we report that osteopon...

journal_title：Frontiers in immunology

authors： Scutera S,Salvi V,Lorenzi L,Piersigilli G,Lonardi S,Alotto D,Casarin S,Castagnoli C,Dander E,D'Amico G,Sozzani S,Musso T

更新日期：2018-06-01 00:00:00

abstract：:Strategies targeting T cells are the cornerstone of immunosuppression after solid organ transplantation. The transcription factor NF-κB is a key regulator of downstream T-cell activation and induction of inflammatory mediators; its full activation via antigen receptor engagement requires both the scaffold and the prot...

journal_title：Frontiers in immunology

authors： Govender L,Mikulic J,Wyss JC,Gaide O,Thome M,Golshayan D

更新日期：2020-09-11 00:00:00

abstract：:Salmonella infections remain a big problem worldwide, causing enteric fever by Salmonella Typhi (or Paratyphi) or self-limiting gastroenteritis by non-typhoidal Salmonella (NTS) in healthy individuals. NTS may become invasive and cause septicemia in elderly or immuno-compromised individuals, leading to high mortality ...

journal_title：Frontiers in immunology

authors： Li P,Liu Q,Luo H,Liang K,Yi J,Luo Y,Hu Y,Han Y,Kong Q

更新日期：2017-12-04 00:00:00

abstract：:Systemic Sclerosis (SSc) is a complex auto-immune connective tissue disease combining inflammatory, vasculopathic and fibrotic manifestations. Skin effectively recapitulates the main pathogenic processes and therefore is a good organ to decipher the disease pathophysiology, which remains unclear. However, culturing pr...

journal_title：Frontiers in immunology

authors： Henrot P,Laurent P,Levionnois E,Leleu D,Pain C,Truchetet ME,Cario M

更新日期：2020-10-07 00:00:00

abstract：:Hemolysis-associated anemia is characteristic of diseases such as atherosclerosis, lupus, malaria, and leishmaniasis; the toxic effects of free hemoglobin (Hb) have been extensively described. This study was based on the premise that release of this sequestered, inflammatory molecule can result in deleterious immunolo...

journal_title：Frontiers in immunology

authors： Jain S,Bose A,Bastia B,Sharma H,Sachdeva R,Jain AK,Pal R

更新日期：2017-06-26 00:00:00

abstract：:How B cells contribute to protective immunity against parasitic nematodes remains unclear, with their importance as accessory cells underexplored. In this study, anti-CD20 monoclonal antibody (α-CD20 mAb)-mediated depletion of B cells from C57BL/6 mice revealed an important role for B cells in supporting Th2 immune re...

journal_title：Frontiers in immunology

authors： Sahputra R,Ruckerl D,Couper KN,Muller W,Else KJ

更新日期：2019-12-10 00:00:00

abstract：:Mesenchymal stem cells (MSC) are under investigation as a therapy for a variety of disorders. Although animal models show long term regenerative and immunomodulatory effects of MSC, the fate of MSC after infusion remains to be elucidated. In the present study the localization and viability of MSC was examined by isola...

journal_title：Frontiers in immunology

authors： Eggenhofer E,Benseler V,Kroemer A,Popp FC,Geissler EK,Schlitt HJ,Baan CC,Dahlke MH,Hoogduijn MJ

更新日期：2012-09-26 00:00:00

abstract：:To improve the efficacy of immunotherapy for cancer and autoimmune diseases, recent ongoing and completed clinical trials have focused on specific targets to redirect the immune network toward eradicating a variety of tumors and ameliorating the self-destructive process. In a previous review, both systemic immunomodul...

journal_title：Frontiers in immunology

authors： Kong YC,Flynn JC

更新日期：2014-05-16 00:00:00

abstract：:The omentum is enriched with pro-inflammatory effector memory CD8+ T cells in patients with the obesity-associated malignancy, esophagogastric adenocarcinoma (EAC) and we have identified the chemokine macrophage inflammatory protein-1alpha as a key player in their active migration to this inflamed tissue. More recentl...

journal_title：Frontiers in immunology

authors： Conroy MJ,Maher SG,Melo AM,Doyle SL,Foley E,Reynolds JV,Long A,Lysaght J

更新日期：2018-08-13 00:00:00