Abstract:
:Background: The association of genetically elevated levels of circulating C-reactive protein (CRP) with cancer risk has been extensively investigated in European populations; however, there are conflicting conclusions. The tri-allelic rs3091244 is a functionally validated genetic variant, and its allelic frequencies differ significantly between European and Asian populations. Here, we examined the association of rs3091244 with cancer risk in a Chinese population. Methods: rs3091244 was genotyped by Sanger sequencing in 4,971 cancer cases and 2,485 controls. The rs1205 and rs2794521 gene variants were also genotyped using TaqMan assays in subgroups. Results: No association was detected between the genotyped CRP variants and cancer risk, with or without distinguishing cancer types, suggesting that circulating CRP is not causally involved in tumorigenesis in Chinese populations.
journal_name
Front Immunoljournal_title
Frontiers in immunologyauthors
Wang MY,Zhou HH,Zhang CM,Su HX,Li SL,Ji SR,Liu E,Wu Ydoi
10.3389/fimmu.2020.00926subject
Has Abstractpub_date
2020-05-14 00:00:00pages
926issn
1664-3224journal_volume
11pub_type
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journal_title:Frontiers in immunology
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journal_title:Frontiers in immunology
pub_type: 杂志文章,评审
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pub_type: 杂志文章
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