Anatomy of a discovery: m1 and m2 macrophages.

abstract：:Tumors are composed of abnormally transformed cell types and tissues that differ from normal tissues in their genetic and epigenetic makeup, metabolism, and immunology. Molecular compounds that modulate the immune response against neoplasms offer promising new strategies to combat cancer. Inhibitors targeting the indo...

journal_title：Frontiers in immunology

authors： Hornyák L,Dobos N,Koncz G,Karányi Z,Páll D,Szabó Z,Halmos G,Székvölgyi L

更新日期：2018-01-31 00:00:00

abstract：:Tumor-mediated regulation of the host immune system involves an intricate signaling network that results in the tumor's inherent survival benefit. Myeloid cells are central in orchestrating the mechanisms by which tumors escape immune detection and continue their proliferative programming. Myeloid cell activation has ...

journal_title：Frontiers in immunology

authors： Davidov V,Jensen G,Mai S,Chen SH,Pan PY

更新日期：2020-09-02 00:00:00

abstract：:Fungal bioaerosols are ubiquitous in the environment and human exposure can result in a variety of health effects ranging from systemic, subcutaneous, and cutaneous infections to respiratory morbidity including allergy, asthma, and hypersensitivity pneumonitis. Recent research has focused on the role of microRNAs (miR...

journal_title：Frontiers in immunology

authors： Croston TL,Lemons AR,Beezhold DH,Green BJ

更新日期：2018-02-07 00:00:00

abstract：:Extracellular vesicles (EVs) are increasingly recognized as important mediators of intercellular communication. In this study, we aimed to further characterize the role of macrophage-derived EVs in immune responses against hepatitis C virus (HCV) and the potential of polyunsaturated fatty acids (PUFAs) to modulate thi...

journal_title：Frontiers in immunology

authors： Cai C,Koch B,Morikawa K,Suda G,Sakamoto N,Rueschenbaum S,Akhras S,Dietz J,Hildt E,Zeuzem S,Welsch C,Lange CM

更新日期：2018-04-12 00:00:00

abstract：:The role of γδ T cells in immunotherapy has gained specific importance in the recent years because of their prominent function involving directly or indirectly in the rehabilitation of the diseases. γδ T cells represent a minor population of T cells that express a distinct T cell receptor (TCR) composed of γδ chains i...

journal_title：Frontiers in immunology

authors： Latha TS,Reddy MC,Durbaka PV,Rachamallu A,Pallu R,Lomada D

更新日期：2014-11-10 00:00:00

abstract：:Inflammatory bowel disease (IBD) is a chronic and relapsing intestinal inflammatory condition with no effective treatment. Probiotics have gained wide attention because of their outstanding advantages in intestinal health issues. In previous studies, a novel soluble protein, HM0539, which is derived from Lactobacillus...

journal_title：Frontiers in immunology

authors： Li Y,Yang S,Lun J,Gao J,Gao X,Gong Z,Wan Y,He X,Cao H

更新日期：2020-10-05 00:00:00

abstract：:Many a disease associates with inflammation. Upon binding of antigen-antibody complexes to immunoglobulin-like receptors, mast cells release tumor necrosis factor-α and proteases, causing fibroblasts to release endogenous antigens that may be cross reactive with exogenous antigens. We made a predictive dynamic map of ...

journal_title：Frontiers in immunology

authors： Abudukelimu A,Barberis M,Redegeld FA,Sahin N,Westerhoff HV

更新日期：2018-08-07 00:00:00

abstract：:Polyunsaturated fatty acids (PUFAs) are important for immune function. Limited evidence indicates that immune cell activation involves endogenous PUFA synthesis, but this has not been characterised. To address this, we measured metabolism of 18:3n-3 in quiescent and activated peripheral blood mononuclear cells (PBMCs)...

journal_title：Frontiers in immunology

authors： Sibbons CM,Irvine NA,Pérez-Mojica JE,Calder PC,Lillycrop KA,Fielding BA,Burdge GC

更新日期：2018-03-05 00:00:00

abstract：:Dendritic cell (DC) vaccination has been investigated as a potential strategy to target hematologic malignancies, while generating sustained immunological responses to control potential future relapse. Nonetheless, few clinical trials have shown robust long-term efficacy. It has been suggested that a combination of su...

journal_title：Frontiers in immunology

authors： Cornel AM,van Til NP,Boelens JJ,Nierkens S

更新日期：2018-05-18 00:00:00

abstract：:COVID-19 is a global pandemic currently in an acute phase of rapid expansion. While public health measures remain the most effective protection strategy at this stage, when the peak passes, it will leave in its wake important health problems. Historically, very few viruses have ever been eradicated. Instead, the virus...

journal_title：Frontiers in immunology

authors： Sviridov D,Miller YI,Ballout RA,Remaley AT,Bukrinsky M

更新日期：2020-09-29 00:00:00

abstract：:Regulatory T cells (Tregs) play an important role by controlling allergic inflammation of airways. Recently, it has been shown that statins have immunomodulatory properties, probably mediated by their effects on Tregs. Therefore, we evaluated the in vivo effect of atorvastatin (ATV) on Tregs and its association with t...

journal_title：Frontiers in immunology

authors： Blanquiceth Y,Rodríguez-Perea AL,Tabares Guevara JH,Correa LA,Sánchez MD,Ramírez-Pineda JR,Velilla PA

更新日期：2016-12-21 00:00:00

abstract：:Donor-specific blood transfusion (DST) can lead to significant prolongation of allograft survival in experimental animal models and sometimes human recipients of solid organs. The mechanisms responsible for the beneficial effect on graft survival have been a topic of research and debate for decades and are not yet ful...

journal_title：Frontiers in immunology

authors： Mohr Gregoriussen AM,Bohr HG

更新日期：2017-02-21 00:00:00

abstract：:The glycans on the plasma membrane of cells manifest as the glycocalyx, which serves as an information-rich frontier that is directly in contact with its immediate milieu. The glycoconjugates (GCs) that adorn most of the mammalian cells are also abundant in gametes, especially the spermatozoa where they perform unique...

journal_title：Frontiers in immunology

authors： Batra V,Dagar K,Nayak S,Kumaresan A,Kumar R,Datta TK

更新日期：2020-08-28 00:00:00

abstract：:The T lymphocyte response initiates with the recognition of MHC/peptides on antigen presenting cells by the T cell receptor (TCR). After the TCR engagement, the proximal signaling pathways are activated for downstream cellular events. Among these pathways, the calcium-signaling flux is activated through the depletion ...

journal_title：Frontiers in immunology

authors： Jia W,He MX,McLeod IX,He YW

更新日期：2013-07-04 00:00:00

abstract：:The intestinal microbiota, composed of a large population of microorganisms, is often considered a "forgotten organ" in human health and diseases. Increasing evidence indicates that dysbiosis of the intestinal microbiota is closely related to colorectal cancer (CRC). The roles for intestinal microorganisms that initia...

journal_title：Frontiers in immunology

authors： Cheng Y,Ling Z,Li L

更新日期：2020-11-30 00:00:00

abstract：:Tissue macrophages play a crucial role in the maintenance of tissue homeostasis and also contribute to inflammatory and reparatory responses during pathogenic infection and tissue injury. The high heterogeneity of these macrophages is consistent with their adaptation to distinct tissue environments and specialization ...

journal_title：Frontiers in immunology

authors： Cassado Ados A,D'Império Lima MR,Bortoluci KR

更新日期：2015-05-19 00:00:00

abstract：Purpose:In the elderly population, the influenza infection and its clinical complications are important causes of hospitalization and death, particularly, in longer-lived age. The objective of this study is to analyze the impact of influenza virus circulation on mortality in the elderly and adults, in years with differ...

journal_title：Frontiers in immunology

authors： Freitas ARR,Donalisio MR

更新日期：2018-01-08 00:00:00

abstract：:Cancer stem cells (CSCs) have been identified as the source of tumor growth and disease recurrence. Eradication of CSCs is thus essential to achieve durable responses, but CSCs are resistant to current anti-tumor therapies. Novel therapeutic approaches that specifically target CSCs will, therefore, be crucial to impro...

journal_title：Frontiers in immunology

authors： Wefers C,Schreibelt G,Massuger LFAG,de Vries IJM,Torensma R

更新日期：2018-06-19 00:00:00

abstract：:Epstein-Barr virus (EBV) is an oncogenic human herpes virus that was discovered in 1964. Viral non-coding RNAs, such as BamHI-A rightward fragment-derived microRNAs (BART miRNAs) or BamHI-H rightward fragment 1-derived miRNAs (BHRF1 miRNA) in EBV-infected cells have been recently reported. Host miRNAs are also upregul...

journal_title：Frontiers in immunology

authors： Iizasa H,Kim H,Kartika AV,Kanehiro Y,Yoshiyama H

更新日期：2020-03-03 00:00:00

abstract：:Development of semi-automated devices that can reduce the hands-on time and standardize the production of clinical-grade CAR T-cells, such as CliniMACS Prodigy from Miltenyi, is key to facilitate the development of CAR T-cell therapies, especially in academic institutions. However, the feasibility of manufacturing CAR...

journal_title：Frontiers in immunology

authors： Castella M,Caballero-Baños M,Ortiz-Maldonado V,González-Navarro EA,Suñé G,Antoñana-Vidósola A,Boronat A,Marzal B,Millán L,Martín-Antonio B,Cid J,Lozano M,García E,Tabera J,Trias E,Perpiña U,Canals JM,Baumann T,Benítez

更新日期：2020-03-20 00:00:00

abstract：:Pemphigus and systemic lupus erythematosus (SLE) are severe potentially life-threatening autoimmune diseases. They are classified as B-cell-mediated autoimmune diseases, both depending on autoreactive CD4+ T lymphocytes to modulate the autoimmune B-cell response. Despite the reported association of pemphigus and SLE, ...

journal_title：Frontiers in immunology

authors： Sezin T,Vorobyev A,Sadik CD,Zillikens D,Gupta Y,Ludwig RJ

更新日期：2018-01-17 00:00:00

abstract：:The remarkable clinical efficacy of anti-CD20 monoclonal antibodies (mAb) in relapsing-remitting multiple sclerosis points at the critical involvement of B cells in the disease. However, the exact pathogenic contribution of B cells is poorly understood. In this publication we review new data on the role of CD20+ B cel...

journal_title：Frontiers in immunology

authors： 't Hart BA,Jagessar SA,Haanstra K,Verschoor E,Laman JD,Kap YS

更新日期：2013-06-13 00:00:00

abstract：:The conceptualization of immunological self is amongst the most important theories of modern biology, representing a sort of theoretical guideline for experimental immunologists, in order to understand how host constituents are ignored by the immune system (IS). A consistent advancement in this field has been represen...

journal_title：Frontiers in immunology

authors： Grignolio A,Mishto M,Faria AM,Garagnani P,Franceschi C,Tieri P

更新日期：2014-04-09 00:00:00

abstract：:A systemic immune related response (SIME) of radiotherapy has been occasionally observed on metastatic tumors, but the clinical outcomes remain poor. Novel treatment approaches are therefore needed to improve SIME ratio. We used a combination of hypo-fractionated radiation therapy (H-RT) with low-dose total body irrad...

journal_title：Frontiers in immunology

authors： Liu J,Zhou J,Wu M,Hu C,Yang J,Li D,Wu P,Chen Y,Chen P,Lin S,Cui Y,Fu S,Wu J

更新日期：2019-02-27 00:00:00

abstract：:Cells communicate with other cells in their microenvironment by transferring lipids, peptides, RNA, and sugars in extracellular vesicles (EVs), thereby also influencing recipient cell functions. Several studies indicate that these vesicles are involved in a variety of critical cellular processes including immune, meta...

journal_title：Frontiers in immunology

authors： Karasu E,Eisenhardt SU,Harant J,Huber-Lang M

更新日期：2018-04-11 00:00:00

abstract：:Glioblastoma multiforme (GBM) is the most frequently occurring primary brain tumor and has a very poor prognosis, with only around 5% of patients surviving for a period of 5 years or more after diagnosis. Despite aggressive multimodal therapy, consisting mostly of a combination of surgery, radiotherapy, and temozolomi...

journal_title：Frontiers in immunology

authors： Pearson JRD,Cuzzubbo S,McArthur S,Durrant LG,Adhikaree J,Tinsley CJ,Pockley AG,McArdle SEB

更新日期：2020-10-15 00:00:00

abstract：:Defective complement action is a cause of several human glomerular diseases including atypical hemolytic uremic syndrome (aHUS), anti-neutrophil cytoplasmic antibody mediated vasculitis (ANCA), C3 glomerulopathy, IgA nephropathy, immune complex membranoproliferative glomerulonephritis, ischemic reperfusion injury, lup...

journal_title：Frontiers in immunology

authors： Zipfel PF,Wiech T,Rudnick R,Afonso S,Person F,Skerka C

更新日期：2019-09-27 00:00:00

abstract：:An important goal for personalized treatment is predicting response to a particular therapeutic. A drawback of biological treatment is immunogenicity and the development of antibodies directed against the drug [anti-drug antibodies (ADA)], which are associated with a poorer clinical outcome. Here we set out to identif...

journal_title：Frontiers in immunology

authors： Magill L,Adriani M,Berthou V,Chen K,Gleizes A,Hacein-Bey-Abina S,Hincelin-Mery A,Mariette X,Pallardy M,Spindeldreher S,Szely N,Isenberg DA,Manson JJ,Jury EC,Mauri C

更新日期：2018-12-05 00:00:00

abstract：:Paclitaxel is a chemotherapeutic drug commonly used to treat different types of cancer. In addition to its antitumor effect, paclitaxel is also known to promote Toll-like receptor (TLR) 4-dependent inflammatory responses, which may lower its chemotherapeutic efficacy. However, it remains unclear whether paclitaxel is ...

journal_title：Frontiers in immunology

authors： Son S,Shim DW,Hwang I,Park JH,Yu JW

更新日期：2019-05-16 00:00:00

abstract：:This article describes the work I did in Bill Paul's lab as a postdoctoral fellow between 1979 and 1983, and to a lesser extent puts that work in the context of other work on B cell activation and antibody responses that was going on in Bill's lab at that time and shortly beforehand, including the discovery of interle...

journal_title：Frontiers in immunology

authors： DeFranco AL

更新日期：2018-04-23 00:00:00