Exploitation of Neisseria meningitidis Group B OMV Vaccines Against N. gonorrhoeae to Inform the Development and Deployment of Effective Gonorrhea Vaccines.

abstract：:We consider the problem of self-tolerance in the frame of a minimalistic model of the idiotypic network. A node of this network represents a population of B-lymphocytes of the same idiotype, which is encoded by a bit string. The links of the network connect nodes with (nearly) complementary strings. The population of ...

journal_title：Frontiers in immunology

authors： Schulz R,Werner B,Behn U

更新日期：2014-03-10 00:00:00

abstract：:The development of stable and long-circulating liposomes provides protection of the drug cargo from degradation and increases tumor drug delivery, leading to the design of liposome formulations with great potential in cancer therapy. However, despite the sound pharmacologic basis, many liposomal as well as other nanop...

journal_title：Frontiers in immunology

authors： La-Beck NM,Gabizon AA

更新日期：2017-04-06 00:00:00

abstract：:KIR2DL5 (CD158f) is the most recently identified inhibitory member of human killer-cell Ig-like receptors (KIRs), which enable NK cells to sense self-HLA. Unlike KIR2DL1-3, recognizing HLA-C allotypes through Ig-like domains of the D1-D2 type, KIR2DL5 shares a D0-D2 configuration with KIR2DL4, and its ligands have not...

journal_title：Frontiers in immunology

authors： Cisneros E,Estefanía E,Vilches C

更新日期：2017-01-17 00:00:00

abstract：:Therapy with Tyrosine Kinase Inhibitors (TKI) aiming stable deep molecular response is the gold standard to treat Chronic Myeloid Leukemia (CML). NKT-like cells (CD3+CD56+) combine characteristics of T and NK cells. The physiopathological role of these cells remains unknown although the literature refers their associa...

journal_title：Frontiers in immunology

authors： Almeida JS,Couceiro P,López-Sejas N,Alves V,Růžičková L,Tarazona R,Solana R,Freitas-Tavares P,Santos-Rosa M,Rodrigues-Santos P

更新日期：2019-10-22 00:00:00

abstract：:The immune system evolved to respond to foreign invaders and prevent autoimmunity to self-antigens. Several types of regulatory T cells facilitate the latter process. These include a subset of Foxp3(-) CD4(+) T cells able to secrete IL-10 in an antigen-specific manner, type 1 regulatory (Tr1) T cells. Although their s...

journal_title：Frontiers in immunology

authors： White AM,Wraith DC

更新日期：2016-09-14 00:00:00

abstract：Objectives:Granulocyte monocyte colony-stimulating factor (GM-CSF) is currently considered a crucial inflammatory mediator and a novel therapeutic target in rheumatoid arthritis (RA), despite the fact that its precise cellular sources remain uncertain. We studied the expression of GM-CSF in peripheral lymphocytes from ...

journal_title：Frontiers in immunology

authors： Makris A,Adamidi S,Koutsianas C,Tsalapaki C,Hadziyannis E,Vassilopoulos D

更新日期：2018-01-10 00:00:00

abstract：:Immune aging is best known for its immune defects that increase susceptibility to infections and reduce adaptive immune responses to vaccination. In parallel, the aged immune system is prone to autoimmune responses and many autoimmune diseases increase in incidence with age or are even preferentially encountered in th...

journal_title：Frontiers in immunology

authors： Goronzy JJ,Li G,Yang Z,Weyand CM

更新日期：2013-06-04 00:00:00

abstract：:Coal is one of the most abundant and economic sources for global energy production. However, the burning of coal is widely recognized as a significant contributor to atmospheric particulate matter linked to deleterious respiratory impacts. Recently, we have discovered that burning coal generates large quantities of ot...

journal_title：Frontiers in immunology

authors： McDaniel DK,Ringel-Scaia VM,Morrison HA,Coutermarsh-Ott S,Council-Troche M,Angle JW,Perry JB,Davis G,Leng W,Minarchick V,Yang Y,Chen B,Reece SW,Brown DA,Cecere TE,Brown JM,Gowdy KM,Hochella MF Jr,Allen IC

更新日期：2019-11-28 00:00:00

abstract：:Aims: Heart failure is a clinical syndrome characterized by subclinical systemic inflammation and immune system activation associated with iron deficiency. No data exist on the various activations of immune-mediated mechanisms of inflammation in heart failure patients with reduced/preserved ejection fraction. We aimed...

journal_title：Frontiers in immunology

authors： Perticone M,Zito R,Miceli S,Pinto A,Suraci E,Greco M,Gigliotti S,Hribal ML,Corrao S,Sesti G,Perticone F

更新日期：2019-10-01 00:00:00

abstract：:The complement, as part of the innate immune system, represents the first line of defense against Gram-negative bacteria invading the bloodstream. The complement system is a zymogen cascade that ultimately assemble into the so-called membrane attack complex (MAC), which lyses Gram-negative bacteria upon insertion into...

journal_title：Frontiers in immunology

authors： Mutti M,Ramoni K,Nagy G,Nagy E,Szijártó V

更新日期：2018-12-04 00:00:00

abstract：:Despite effective antiretroviral therapy (ART), HIV-infected individuals with apparently similar clinical and immunological characteristics can vary in responsiveness to vaccinations. However, molecular mechanisms responsible for such impairment, as well as biomarkers able to predict vaccine responsiveness in HIV-infe...

journal_title：Frontiers in immunology

authors： Cotugno N,De Armas L,Pallikkuth S,Rinaldi S,Issac B,Cagigi A,Rossi P,Palma P,Pahwa S

更新日期：2017-09-11 00:00:00

abstract：:Circular RNAs (circRNAs) are a class of endogenous noncoding RNA, which is different from linear RNA. CircRNA is an RNA molecule with a closed loop structure formed by reverse splicing. CircRNAs have been studied in several organisms, however, the circRNAs associated with the response to Salmonella enterica serovar En...

journal_title：Frontiers in immunology

authors： Zheng L,Liu L,Lin L,Tang H,Fan X,Lin H,Li X

更新日期：2019-05-31 00:00:00

abstract：:The immune system plays a significant role in controlling systemic metabolism. Innate-like T (ILT) cells in particular, such as mucosal-associated invariant T (MAIT) cells, invariant natural killer T (iNKT) cells and γδ T cell receptor expressing cells, have been reported to promote metabolic homeostasis. However, the...

journal_title：Frontiers in immunology

authors： Li Y,Woods K,Parry-Strong A,Anderson RJ,Capistrano C,Gestin A,Painter GF,Hermans IF,Krebs J,Gasser O

更新日期：2020-03-13 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fimmu.2019.00917.]. ...

journal_title：Frontiers in immunology

authors： Magcwebeba T,Dorhoi A,du Plessis N

更新日期：2019-07-02 00:00:00

abstract：:Exhaustion of CD8+ T cells and increased IL-10 production is well-known in chronic viral infections but mechanisms leading to loss of their cytotoxic capabilities and consequent exhaustion remain unclear. Exhausted CD8+T cells also called T suppressors are highly immune suppressive with altered T cell receptor signali...

journal_title：Frontiers in immunology

authors： Mohanty S,Barik P,Debata N,Nagarajan P,Devadas S

更新日期：2020-03-06 00:00:00

abstract：:Around four decades ago, it had been observed that there were cell lines as well as cells in the fetal liver that expressed antibody μ heavy (μH) chains in the apparent absence of bona fide light chains. It was thus possible that these cells expressed another molecule(s), that assembled with μH chains. The ensuing stu...

journal_title：Frontiers in immunology

authors： Winkler TH,Mårtensson IL

更新日期：2018-11-15 00:00:00

abstract：:Metabolic reprogramming is rapidly gaining appreciation in the etiology of immune cell dysfunction in a variety of diseases. Tuberculosis, schistosomiasis, and sarcoidosis represent an important class of diseases characterized by the formation of granulomas, where macrophages are causatively implicated in disease path...

journal_title：Frontiers in immunology

authors： Wilson JL,Mayr HK,Weichhart T

更新日期：2019-10-04 00:00:00

abstract：:Platelets are non-nucleated cells that play central roles in the processes of hemostasis, innate immunity, and inflammation; however, several reports show that these distinct functions are more closely linked than initially thought. Platelets express numerous receptors and contain hundreds of secretory products. These...

journal_title：Frontiers in immunology

authors： Cognasse F,Nguyen KA,Damien P,McNicol A,Pozzetto B,Hamzeh-Cognasse H,Garraud O

更新日期：2015-03-02 00:00:00

abstract：:Protein 4.1R, a member of the 4.1 family, functions as a bridge between cytoskeletal and plasma membrane proteins. It is expressed in T cells, where it binds to a linker for activation of T cell (LAT) family member 1 and inhibits its phosphorylation and downstream signaling events after T cell receptor triggering. The...

journal_title：Frontiers in immunology

authors： Draberova L,Draberova H,Potuckova L,Halova I,Bambouskova M,Mohandas N,Draber P

更新日期：2020-01-14 00:00:00

abstract：:Membranous nephropathy (MN) is an autoimmune disease caused by binding of circulating antibodies to podocyte antigens in the kidney. For decades and still today primary MN has been considered to have an unspecified IgG4-driven autoimmune genesis, while secondary MN has been associated with other diseases, most notably...

journal_title：Frontiers in immunology

authors： von Haxthausen F,Reinhard L,Pinnschmidt HO,Rink M,Soave A,Hoxha E,Stahl RAK

更新日期：2018-12-20 00:00:00

abstract：:Complement plays an essential role in the opsonophagocytic clearance of apoptotic/necrotic cells. Dysregulation of this process may lead to inflammatory and autoimmune diseases. Factor H (FH), a major soluble complement inhibitor, binds to dead cells and inhibits excessive complement activation on their surface, preve...

journal_title：Frontiers in immunology

authors： Kárpáti É,Papp A,Schneider AE,Hajnal D,Cserhalmi M,Csincsi ÁI,Uzonyi B,Józsi M

更新日期：2020-07-16 00:00:00

abstract：:Extracellular vesicle or EV is a term that encompasses all classes of secreted lipid membrane vesicles. Despite being scientific novelties, EVs are gaining importance as a mediator of important physiological and pathological intercellular activities possibly through the transfer of their cargo of protein and RNA betwe...

journal_title：Frontiers in immunology

authors： Zhang B,Yin Y,Lai RC,Lim SK

更新日期：2014-10-22 00:00:00

abstract：:γδ T cells, known to be an important source of innate IL-17 in mice, provide critical contributions to host immune responses. Development and function of γδ T cells are directed by networks of diverse transcription factors (TFs). Here, we examine the role of the zinc finger TFs, Kruppel-like factor 10 (KLF10), in the ...

journal_title：Frontiers in immunology

authors： Kim G,Gu MJ,Kim SJ,Ko KH,Kye YC,Kim CG,Cho JH,Lee WK,Song KD,Chu H,Park YM,Han SH,Yun CH

更新日期：2018-02-28 00:00:00

abstract：:Infectious diseases are still a significant cause of morbidity and mortality worldwide. Despite the progress in drug development, the occurrence of microbial resistance is still a significant concern. Alternative therapeutic strategies are required for non-responding or relapsing patients. Chimeric antigen receptor (C...

journal_title：Frontiers in immunology

authors： Seif M,Einsele H,Löffler J

更新日期：2019-11-21 00:00:00

abstract：:Preclinical and clinical studies have shown that prior receipt of radiotherapy enhances antitumor immune responses, a phenomenon we call the "radio-memory effect." However, all of the evidence regarding this effect to date comes from work with PD1/PDL1 inhibitors. Here we explored whether this effect also occurs with ...

journal_title：Frontiers in immunology

authors： Chen D,Song X,Wang H,Gao Z,Meng W,Chen S,Ma Y,Wang Y,Li K,Yu J,Yue J

更新日期：2018-12-11 00:00:00

abstract：:Delivery of high doses of radiation to thoracic region, particularly with non-small cell lung cancer patients, becomes difficult due to subsequent complications arising in the lungs of the patient. Radiation-induced pneumonitis is an early event evident in most radiation exposed patients observed within 2-4 months of ...

journal_title：Frontiers in immunology

authors： Kainthola A,Haritwal T,Tiwari M,Gupta N,Parvez S,Tiwari M,Prakash H,Agrawala PK

更新日期：2017-05-02 00:00:00

abstract：:Diabetic retinopathy is a vision-threatening disease affecting neurons and microvasculature of the retina. The development of this disease is associated with the action of inflammatory factors that are connected to the activation of microglial cells, the resident tissue macrophages of the CNS. In the quiescent state, ...

journal_title：Frontiers in immunology

authors： Kinuthia UM,Wolf A,Langmann T

更新日期：2020-11-06 00:00:00

abstract：:Effector CD8+ T cells generally produce type-1 cytokines and mediators of the perforin/granzyme cytolytic pathway, yet type-2-polarized CD8+ cells (Tc2) are detected in type-2 (T2) cytokine-driven diseases such as asthma. It is unclear whether T2 cytokine exposure during activation is sufficient to polarize human CD8+...

journal_title：Frontiers in immunology

authors： Fox A,Harland KL,Kedzierska K,Kelso A

更新日期：2018-05-28 00:00:00

abstract：:Specific antibody deficiency (SAD) is a primary immunodeficiency disease characterized by normal immunoglobulins (Igs), IgA, IgM, total IgG, and IgG subclass levels, but with recurrent infection and diminished antibody responses to polysaccharide antigens following vaccination. There is a lack of consensus regarding t...

journal_title：Frontiers in immunology

authors： Perez E,Bonilla FA,Orange JS,Ballow M

更新日期：2017-05-22 00:00:00

abstract：:Recent studies suggest that the cross-talk between the gut microbiota and human immune system during the first year of life is an important regulator of the later development of atopic diseases. We explored the changes in the gut microbiota, blood regulatory T cells, and atopic sensitization in a birth-cohort of Eston...

journal_title：Frontiers in immunology

authors： Ruohtula T,de Goffau MC,Nieminen JK,Honkanen J,Siljander H,Hämäläinen AM,Peet A,Tillmann V,Ilonen J,Niemelä O,Welling GW,Knip M,Harmsen HJ,Vaarala O

更新日期：2019-10-23 00:00:00