Long Non-coding RNAs Are Central Regulators of the IL-1β-Induced Inflammatory Response in Normal and Idiopathic Pulmonary Lung Fibroblasts.


:There is accumulating evidence to indicate that long non-coding RNAs (lncRNAs) are important regulators of the inflammatory response. In this report, we have employed next generation sequencing to identify 14 lncRNAs that are differentially expressed in human lung fibroblasts following the induction of inflammation using interleukin-1β (IL-1β). Knockdown of the two most highly expressed lncRNAs, IL7AS, and MIR3142HG, showed that IL7AS negatively regulated IL-6 release whilst MIR3142HG was a positive regulator of IL-8 and CCL2 release. Parallel studies in fibroblasts derived from patients with idiopathic pulmonary fibrosis showed similar increases in IL7AS levels, that also negatively regulate IL-6 release. In contrast, IL-1β-induced MIR3142HG expression, and its metabolism to miR-146a, was reduced by 4- and 9-fold in IPF fibroblasts, respectively. This correlated with a reduced expression of inflammatory mediators whilst MIR3142HG knockdown showed no effect upon IL-8 and CCL2 release. Pharmacological studies showed that IL-1β-induced IL7AS and MIR3142HG production and release of IL-6, IL-8, and CCL2 in both control and IPF fibroblasts were mediated via an NF-κB-mediated pathway. In summary, we have cataloged those lncRNAs that are differentially expressed following IL-1β-activation of human lung fibroblasts, shown that IL7AS and MIR3142HG regulate the inflammatory response and demonstrated that the reduced inflammatory response in IPF fibroblast is correlated with attenuated expression of MIR3142HG/miR-146a.


Front Immunol


Frontiers in immunology


Hadjicharalambous MR,Roux BT,Feghali-Bostwick CA,Murray LA,Clarke DL,Lindsay MA




Has Abstract


2018-12-11 00:00:00








  • Tissue Immune Cells Fuel Obesity-Associated Inflammation in Adipose Tissue and Beyond.

    abstract::Obesity-associated inflammation stems from a combination of cell-intrinsic changes of individual immune cell subsets and the dynamic crosstalk amongst a broad array of immune cells. Although much of the focus of immune cell contributions to metabolic disease has focused on adipose tissue-associated cells, these potent...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Liu R,Nikolajczyk BS

    更新日期:2019-07-17 00:00:00

  • Mesenchymal cell differentiation during lymph node organogenesis.

    abstract::Secondary lymphoid tissues such as lymph nodes are essential for the interactions between antigen presenting cells and lymphocytes that result in adaptive immune responses that protect the host against invading pathogens. The specialized architecture of these organs facilitates the cognate interactions between antigen...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Brendolan A,Caamaño JH

    更新日期:2012-12-14 00:00:00

  • Toll-like Interleukin 1 Receptor Regulator Is an Important Modulator of Inflammation Responsive Genes.

    abstract::TILRR (Toll-like interleukin-1 receptor regulator), a transcript variant of FREM1, is a novel regulatory component, which stimulates innate immune responses through binding to IL-1R1 (Interleukin-1 receptor, type 1) and TLR (Toll-like receptor) complex. However, it is not known whether TILRR expression influences othe...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Kashem MA,Li H,Toledo NP,Omange RW,Liang B,Liu LR,Li L,Yang X,Yuan XY,Kindrachuk J,Plummer FA,Luo M

    更新日期:2019-02-28 00:00:00

  • The role of placental tryptophan catabolism.

    abstract::This review discusses the mechanisms and consequences of degradation of tryptophan (Trp) in the placenta, focusing mainly on the role of indoleamine 2,3-dioxygenase-1 (IDO1), one of three enzymes catalyzing the first step of the kynurenine pathway of Trp degradation. IDO1 has been implicated in regulation of feto-mate...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Sedlmayr P,Blaschitz A,Stocker R

    更新日期:2014-05-19 00:00:00

  • Several Follicular Regulatory T Cell Subsets With Distinct Phenotype and Function Emerge During Germinal Center Reactions.

    abstract::An efficient B cell immunity requires a dynamic equilibrium between positive and negative signals. In germinal centers (GCs), T follicular helper cells are supposed to be the positive regulator while T follicular regulatory (Tfr) cells were assigned to be the negative regulators. Indeed, Tfr cells are considered as a ...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Fazilleau N,Aloulou M

    更新日期:2018-08-13 00:00:00

  • iRAGu: A Novel Inducible and Reversible Mouse Model for Ubiquitous Recombinase Activity.

    abstract::Developing lymphocytes express the recombination activating genes (RAGs) 1 and 2 products that form a site specific recombinase complex (RAG), introducing double strand DNA breaks (DSBs) at recombination signal sequences (RSSs) flanking the V, D, and J gene segments in the antigen receptor loci. The subsequent steps i...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Bonnet M,Sarmento LM,Martins AC,Sobral D,Silva J,Demengeot J

    更新日期:2017-11-10 00:00:00

  • Dermatomyositis and Immune-Mediated Necrotizing Myopathies: A Window on Autoimmunity and Cancer.

    abstract::Autoimmune myopathies (myositides) are strongly associated with malignancy. The link between myositis and cancer, originally noticed by Bohan and Peter in their classification in 1975 (1), has been evidenced by large population-based cohort studies and a recent meta-analysis. The numerous reports of cases in which the...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Aussy A,Boyer O,Cordel N

    更新日期:2017-08-21 00:00:00

  • Further Advances in Cancer Immunotherapy: Going Beyond Checkpoint Blockade.

    abstract::Significant advances have been made to identify effective therapies that either restore or generate de novo a patient's immune response to cancer, so-called immunotherapy or immuno-oncology (IO) therapies. Some tumors overcome immune surveillance by promoting mechanisms to evade or suppress the immune system. This con...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Wilkinson RW,Leishman AJ

    更新日期:2018-06-01 00:00:00

  • Arid5a Regulation and the Roles of Arid5a in the Inflammatory Response and Disease.

    abstract::Abnormal gene expression patterns underlie many diseases that represent major public health concerns and robust therapeutic challenges. Posttranscriptional gene regulation by RNA-binding proteins (RBPs) is well-recognized, and the biological functions of RBPs have been implicated in many diseases, such as autoimmune d...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Nyati KK,Agarwal RG,Sharma P,Kishimoto T

    更新日期:2019-12-05 00:00:00

  • NKT-Like (CD3+CD56+) Cells in Chronic Myeloid Leukemia Patients Treated With Tyrosine Kinase Inhibitors.

    abstract::Therapy with Tyrosine Kinase Inhibitors (TKI) aiming stable deep molecular response is the gold standard to treat Chronic Myeloid Leukemia (CML). NKT-like cells (CD3+CD56+) combine characteristics of T and NK cells. The physiopathological role of these cells remains unknown although the literature refers their associa...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Almeida JS,Couceiro P,López-Sejas N,Alves V,Růžičková L,Tarazona R,Solana R,Freitas-Tavares P,Santos-Rosa M,Rodrigues-Santos P

    更新日期:2019-10-22 00:00:00

  • The Role of Natural Killer Cells in the Immune Response in Kidney Transplantation.

    abstract::Natural killer cells (NK) represent a population of lymphocytes involved in innate immune response. In addition to their role in anti-viral and anti-tumor defense, they also regulate several aspects of the allo-immune response in kidney transplant recipients. Growing evidence suggests a key role of NK cells in the pat...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Pontrelli P,Rascio F,Castellano G,Grandaliano G,Gesualdo L,Stallone G

    更新日期:2020-07-23 00:00:00

  • Immunoglobulin A Isotype of Antiphospholipid Antibodies Does Not Provide Added Value for the Diagnosis of Antiphospholipid Syndrome in a Chinese Population.

    abstract:Objective:Antiphospholipid syndrome (APS) is characterized by the presence of anti-phospholipid (aPL) antibodies. However, the relationship between the immunoglobulin (Ig) A isotype of aPL positivity and its clinical utility in APS diagnosis is controversial. Presently, we determine the clinical utility of IgA-aPL from...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Hu C,Li X,Zhao J,Wang Q,Li M,Tian X,Zeng X

    更新日期:2020-10-05 00:00:00

  • Azithromycin Clears Bordetella pertussis Infection in Mice but Also Modulates Innate and Adaptive Immune Responses and T Cell Memory.

    abstract::Treatment with the macrolide antibiotic azithromycin (AZM) is an important intervention for controlling infection of children with Bordetella pertussis and as a prophylaxis for preventing transmission to family members. However, antibiotics are known to have immunomodulatory effects independent of their antimicrobial ...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Borkner L,Misiak A,Wilk MM,Mills KHG

    更新日期:2018-07-30 00:00:00

  • Immune Checkpoint Molecules on Tumor-Infiltrating Lymphocytes and Their Association with Tertiary Lymphoid Structures in Human Breast Cancer.

    abstract::There is an exponentially growing interest in targeting immune checkpoint molecules in breast cancer (BC), particularly in the triple-negative subtype where unmet treatment needs remain. This study was designed to analyze the expression, localization, and prognostic role of PD-1, PD-L1, PD-L2, CTLA-4, LAG3, and TIM3 i...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Solinas C,Garaud S,De Silva P,Boisson A,Van den Eynden G,de Wind A,Risso P,Rodrigues Vitória J,Richard F,Migliori E,Noël G,Duvillier H,Craciun L,Veys I,Awada A,Detours V,Larsimont D,Piccart-Gebhart M,Willard-Gallo K

    更新日期:2017-10-30 00:00:00

  • Cervical Gene Delivery of the Antimicrobial Peptide, Human β-Defensin (HBD)-3, in a Mouse Model of Ascending Infection-Related Preterm Birth.

    abstract::Approximately 40% of preterm births are preceded by microbial invasion of the intrauterine space; ascent from the vagina being the most common pathway. Within the cervical canal, antimicrobial peptides and proteins (AMPs) are important components of the cervical barrier which help to prevent ascending vaginal infectio...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Suff N,Karda R,Diaz JA,Ng J,Baruteau J,Perocheau D,Taylor PW,Alber D,Buckley SMK,Bajaj-Elliott M,Waddington SN,Peebles D

    更新日期:2020-02-11 00:00:00

  • Intestinal epithelium and autophagy: partners in gut homeostasis.

    abstract::One of the most significant challenges of cell biology is to understand how each type of cell copes with its specific workload without suffering damage. Among the most intriguing questions concerns intestinal epithelial cells in mammals; these cells act as a barrier between the internally protected region and the exte...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Randall-Demllo S,Chieppa M,Eri R

    更新日期:2013-09-30 00:00:00

  • Diet-Induced Obesity Elicits Macrophage Infiltration and Reduction in Spine Density in the Hypothalami of Male but Not Female Mice.

    abstract::Increasing prevalence in obesity has become a significant public concern. C57BL/6J mice are prone to diet-induced obesity (DIO) when fed high-fat diet (HFD), and develop chronic inflammation and metabolic syndrome, making them a good model to analyze mechanisms whereby obesity elicits pathologies. DIO mice demonstrate...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Lainez NM,Jonak CR,Nair MG,Ethell IM,Wilson EH,Carson MJ,Coss D

    更新日期:2018-09-11 00:00:00

  • Corrigendum: Zoledronate Triggers Vδ2 T Cells to Destroy and Kill Spheroids of Colon Carcinoma: Quantitative Image Analysis of Three-Dimensional Cultures.

    abstract::[This corrects the article on p. 998 in vol. 9, PMID: 29867975.]. ...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,已发布勘误


    authors: Varesano S,Zocchi MR,Poggi A

    更新日期:2018-06-13 00:00:00

  • Early Resistance of Non-virulent Mycobacterial Infection in C57BL/6 Mice Is Associated With Rapid Up-Regulation of Antimicrobial Cathelicidin Camp.

    abstract::Early clearance of tuberculosis is the successful eradication of inhaled bacteria before the development of an adaptive immune response. We previously showed, by utilizing a non-virulent mycobacteria infection model, that C57BL/6 mice are more efficient than BALB/c in their control of bacterial growth in the lungs dur...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Adam L,López-González M,Björk A,Pålsson S,Poux C,Wahren-Herlenius M,Fernández C,Spetz AL

    更新日期:2018-09-03 00:00:00

  • The Heterogeneity, Origins, and Impact of Migratory iILC2 Cells in Anti-helminth Immunity.

    abstract::Soil-transmitted helminths represent a major global health burden with infections and infection-related comorbidities causing significant reductions in the quality of life for individuals living in endemic areas. Repeated infections and chronic colonization by these large extracellular worms in mammals led to the evol...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Miller MM,Reinhardt RL

    更新日期:2020-07-23 00:00:00

  • Cross Type Neutralizing Antibodies Detected in a Unique HIV-2 Infected Individual From India.

    abstract::Background: Infection with HIV-2, a retrovirus that is closely related to HIV-1, is characterized by slower disease progression and transmission, longer latency period and low or undetectable viremia. Host immunity, including production of potent neutralizing antibodies, may be one of the possible contributors to the ...

    journal_title:Frontiers in immunology

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Vidyavijayan KK,Cheedarala N,Babu H,Precilla LK,Sathyamurthi P,Chandrasekaran P,Murugavel KG,Swaminathan S,Tripathy SP,Hanna LE

    更新日期:2018-12-17 00:00:00

  • IL-19 Up-Regulates Mucin 5AC Production in Patients With Chronic Rhinosinusitis via STAT3 Pathway.

    abstract::The mucin gene, MUC5AC, is highly expressed both in chronic respiratory inflammatory diseases and inflammatory bowel disease where mucin secretion is regulated by members of the interleukin IL-20 subfamily. This study was conducted to determine the roles and mechanisms of IL-19, a member of the IL-20 subfamily, in reg...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Lai X,Li X,Chang L,Chen X,Huang Z,Bao H,Huang J,Yang L,Wu X,Wang Z,Bellanti JA,Zheng SG,Zhang G

    更新日期:2019-07-17 00:00:00

  • MAIT Cells at the Fetal-Maternal Interface During Pregnancy.

    abstract::One of the main functions of the human placenta is to provide a barrier between the fetal and maternal blood circulations, where gas exchange and transfer of nutrients to the developing fetus take place. Despite being a barrier, there is a multitude of crosstalk between maternal immune cells and fetally derived semi-a...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Kaipe H,Raffetseder J,Ernerudh J,Solders M,Tiblad E

    更新日期:2020-08-19 00:00:00

  • Gene Expression in Spontaneous Experimental Autoimmune Encephalomyelitis Is Linked to Human Multiple Sclerosis Risk Genes.

    abstract::Recent genome-wide association studies have identified over 230 genetic risk loci for multiple sclerosis. Current experimental autoimmune encephalomyelitis (EAE) models requiring active induction of disease may not be optimally suited for the characterization of the function of these genes. We have thus used gene expr...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Faber H,Kurtoic D,Krishnamoorthy G,Weber P,Pütz B,Müller-Myhsok B,Weber F,Andlauer TFM

    更新日期:2020-09-18 00:00:00

  • Interleukin-2 production by dendritic cells and its immuno-regulatory functions.

    abstract::Dendritic cells (DCs) are uniquely potent antigen presenting cells that acquire microbial products and prime adaptive immune responses against pathogens. Furthermore, DCs also play a key role in induction and maintenance of tolerance. Although numerous studies have assessed the diverse functions of DCs, many unanswere...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Zelante T,Fric J,Wong AY,Ricciardi-Castagnoli P

    更新日期:2012-06-18 00:00:00

  • Bullous Pemphigoid Triggered by Thermal Burn Under Medication With a Dipeptidyl Peptidase-IV Inhibitor: A Case Report and Review of the Literature.

    abstract::Bullous pemphigoid (BP) is a common autoimmune blistering disease in which autoantibodies mainly target the hemidesmosomal component BP180 (also known as type XVII collagen) in basal keratinocytes. Various triggering factors are known to induce BP onset, including radiotherapy, burns, ultraviolet exposure, surgery, an...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Mai Y,Nishie W,Sato K,Hotta M,Izumi K,Ito K,Hosokawa K,Shimizu H

    更新日期:2018-04-12 00:00:00

  • The critical role of the tumor microenvironment in shaping natural killer cell-mediated anti-tumor immunity.

    abstract::Considerable evidence has been gathered over the last 10 years showing that the tumor microenvironment (TME) is not simply a passive recipient of immune cells, but an active participant in the establishment of immunosuppressive conditions. It is now well documented that hypoxia, within the TME, affects the functions o...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Baginska J,Viry E,Paggetti J,Medves S,Berchem G,Moussay E,Janji B

    更新日期:2013-12-25 00:00:00

  • The Soluble Form of Toll-Like Receptor 2 Is Elevated in Serum of Multiple Sclerosis Patients: A Novel Potential Disease Biomarker.

    abstract::Multiple sclerosis (MS) is an immune-mediated inflammatory demyelinating disease of the central nervous system. It was previously shown that toll-like receptor (TLR)-2 signaling plays a key role in the murine experimental autoimmune encephalomyelitis (EAE) model of MS, and that TLR2-stimulation of regulatory T cells (...

    journal_title:Frontiers in immunology

    pub_type: 临床试验,杂志文章


    authors: Hossain MJ,Morandi E,Tanasescu R,Frakich N,Caldano M,Onion D,Faraj TA,Erridge C,Gran B

    更新日期:2018-03-14 00:00:00

  • Surfing on Membrane Waves: Microvilli, Curved Membranes, and Immune Signaling.

    abstract::Microvilli are finger-like membrane protrusions, supported by the actin cytoskeleton, and found on almost all cell types. A growing body of evidence suggests that the dynamic lymphocyte microvilli, with their highly curved membranes, play an important role in signal transduction leading to immune responses. Neverthele...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Orbach R,Su X

    更新日期:2020-09-11 00:00:00

  • Volcanic Ash Activates the NLRP3 Inflammasome in Murine and Human Macrophages.

    abstract::Volcanic ash is a heterogeneous mineral dust that is typically composed of a mixture of amorphous (glass) and crystalline (mineral) fragments. It commonly contains an abundance of the crystalline silica (SiO2) polymorph cristobalite. Inhalation of crystalline silica can induce inflammation by stimulating the NLRP3 inf...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Damby DE,Horwell CJ,Baxter PJ,Kueppers U,Schnurr M,Dingwell DB,Duewell P

    更新日期:2018-01-22 00:00:00