Abstract:
:Interleukin-33 (IL-33) is a well-recognized immunomodulatory cytokine which plays critical roles in tissue function and immune-mediated diseases. The abundant expression of IL-33 in brain and spinal cord prompted many scientists to explore its unique role in the central nervous system (CNS) under physiological and pathological conditions. Indeed emerging evidence from over a decade's research suggests that IL-33 acts as one of the key molecular signaling cues coordinating the network between the immune and CNS systems, particularly during the development of neurological diseases. Here, we highlight the recent advances in our knowledge regarding the distribution and cellular localization of IL-33 and its receptor ST2 in specific CNS regions, and more importantly the key roles IL-33/ST2 signaling pathway play in CNS function under normal and diseased conditions.
journal_name
Front Immunoljournal_title
Frontiers in immunologyauthors
Fairlie-Clarke K,Barbour M,Wilson C,Hridi SU,Allan D,Jiang HRdoi
10.3389/fimmu.2018.02596subject
Has Abstractpub_date
2018-11-20 00:00:00pages
2596issn
1664-3224journal_volume
9pub_type
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abstract::[This corrects the article DOI: 10.3389/fimmu.2020.01529.]. ...
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,随机对照试验
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