Presence of Infected Gr-1intCD11bhiCD11cint Monocytic Myeloid Derived Suppressor Cells Subverts T Cell Response and Is Associated With Impaired Dendritic Cell Function in Mycobacterium avium-Infected Mice.

abstract：:Early detection of Primary Immunodeficiencies Disorders (PIDDs) is of paramount importance for effective treatment and disease management. Many PIDDs would be strong candidates for newborn screening (NBS) if robust screening methods could identify patients from dried blood spots (DBS) during the neonatal period. As ma...

journal_title：Frontiers in immunology

authors： Collins CJ,Yi F,Dayuha R,Whiteaker JR,Ochs HD,Freeman A,Su HC,Paulovich AG,Segundo GRS,Torgerson T,Hahn SH

更新日期：2020-04-01 00:00:00

abstract：:The glycans on the plasma membrane of cells manifest as the glycocalyx, which serves as an information-rich frontier that is directly in contact with its immediate milieu. The glycoconjugates (GCs) that adorn most of the mammalian cells are also abundant in gametes, especially the spermatozoa where they perform unique...

journal_title：Frontiers in immunology

authors： Batra V,Dagar K,Nayak S,Kumaresan A,Kumar R,Datta TK

更新日期：2020-08-28 00:00:00

abstract：:Multiple myeloma (MM) is a plasma cell malignancy and the second most common hematological neoplasm in adults, comprising 1.8% of all cancers. With an annual incidence of ~30,770 cases in the United States, MM has a high mortality rate, leading to 12,770 deaths per year. MM is a genetically complex, highly heterogeneo...

journal_title：Frontiers in immunology

authors： Caraccio C,Krishna S,Phillips DJ,Schürch CM

更新日期：2020-04-24 00:00:00

abstract：:[This corrects the article on p. 125 in vol. 6, PMID: 25852693.]. ...

journal_title：Frontiers in immunology

authors： Dalai SK,Yadav N,Patidar M,Patel H,Singh AP

更新日期：2015-06-22 00:00:00

abstract：:Objectives: This study, developed within the Innovative Medicines Initiative Joint Undertaking project PRECISESADS framework, aimed at functionally characterize the monocyte subsets in RA patients, and analyze their involvement in the increased CV risk associated with RA. Methods: The frequencies of monocyte subpopula...

journal_title：Frontiers in immunology

authors： Ruiz-Limon P,Ortega-Castro R,Barbarroja N,Perez-Sanchez C,Jamin C,Patiño-Trives AM,Luque-Tevar M,Ibáñez-Costa A,Perez-Sanchez L,de la Rosa IA,Abalos-Aguilera M,Jimenez-Gomez Y,Calvo-Gutierrez J,Font P,Escudero-Contreras A,A

更新日期：2019-05-21 00:00:00

abstract：:Studies to develop cell-based therapies for cancer and other diseases have consistently shown that purified human natural killer (NK) cells secrete cytokines and kill target cells after in vitro culture with high concentrations of cytokines. However, these assays poorly reflect the conditions that are likely to prevai...

journal_title：Frontiers in immunology

authors： Nielsen CM,Wolf AS,Goodier MR,Riley EM

更新日期：2016-03-22 00:00:00

abstract：:The cyclic AMP/protein kinase A (cAMP/PKA) pathway is one of the most common and versatile signal pathways in eukaryotic cells. A-kinase anchoring proteins (AKAPs) target PKA to specific substrates and distinct subcellular compartments providing spatial and temporal specificity for mediation of biological effects chan...

journal_title：Frontiers in immunology

authors： Wehbi VL,Taskén K

更新日期：2016-06-08 00:00:00

abstract：:TonEBP is a key transcriptional activator in macrophages with an M1 phenotype. High expression of TonEBP is associated with many inflammatory diseases. Heme oxygenase-1 (HO-1), a stress-inducible protein, is induced by various oxidative and inflammatory signals, and its expression is regarded as an adaptive cellular r...

journal_title：Frontiers in immunology

authors： Yoo EJ,Lee HH,Ye BJ,Lee JH,Lee CY,Kang HJ,Jeong GW,Park H,Lim SW,Lee-Kwon W,Kwon HM,Choi SY

更新日期：2019-04-18 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is a multi-system autoimmune disease including the cardiovascular system. Atherosclerosis is the most common cardiovascular complication of SLE and a significant risk factor for morbidity and mortality. Vascular damage/protection mechanism in SLE patients is out of balance, caused by...

journal_title：Frontiers in immunology

authors： Ding X,Xiang W,He X

更新日期：2020-11-11 00:00:00

abstract：:Immunity to influenza is unique among pathogens, in that immune memory is established both via intermittent lung localized infections with highly variable influenza virus strains and by intramuscular vaccinations with inactivated protein-based vaccines. Studies in the past decades have suggested that the B cell respon...

journal_title：Frontiers in immunology

authors： Nelson SA,Sant AJ

更新日期：2019-05-07 00:00:00

abstract：:In order to recognize and combat a diverse array of pathogens the immune system has a large repertoire of T cells having unique T cell receptors (TCRs) with only a few clones specific for any given antigen. We discuss how the number of different possible TCRs encoded in the genome (the potential repertoire) and the nu...

journal_title：Frontiers in immunology

authors： Zarnitsyna VI,Evavold BD,Schoettle LN,Blattman JN,Antia R

更新日期：2013-12-26 00:00:00

abstract：:Proteinase 3 (PR3) is the autoantigen in granulomatosis with polyangiitis, an autoimmune necrotizing vasculitis associated with anti-neutrophil cytoplasmic antibodies (ANCAs). Moreover, PR3 is a serine protease whose membrane expression can potentiate inflammatory diseases such as ANCA-associated vasculitis and rheuma...

journal_title：Frontiers in immunology

authors： Tacnet-Delorme P,Gabillet J,Chatfield S,Thieblemont N,Frachet P,Witko-Sarsat V

更新日期：2018-04-25 00:00:00

abstract：:Responsiveness of maturing natural killer (NK) cells to chemotactic molecules directly affect their retention and relocation in selected bone marrow (BM) microenvironment during development, as well as their localization at sites of immune response during inflammatory diseases. BM is the main site of NK cell generatio...

journal_title：Frontiers in immunology

authors： Bernardini G,Sciumè G,Santoni A

更新日期：2013-01-30 00:00:00

abstract：:The close association between cardiovascular pathology and renal dysfunction is well documented and significant. Patients with conventional risk factors for cardiovascular disease like diabetes and hypertension also suffer renal dysfunction. This is unsurprising if the kidney is simply regarded as a "modified blood ve...

journal_title：Frontiers in immunology

authors： Hewitson TD,Holt SG,Smith ER

更新日期：2015-09-17 00:00:00

abstract：:Soluble factors are an essential means of communication between cells and their environment. However, many molecules readily interact with extracellular matrix components, giving rise to multiple modes of diffusion. The molecular quantification of diffusion in situ is thus a challenging imaging frontier, requiring ver...

journal_title：Frontiers in immunology

authors： Miller H,Cosgrove J,Wollman AJM,Taylor E,Zhou Z,O'Toole PJ,Coles MC,Leake MC

更新日期：2018-05-22 00:00:00

abstract：Objective:To examine the utility of the peripheral blood neutrophil-to-lymphocyte ratio (NLR) and monocyte-to-lymphocyte ratio (MLR) as biomarkers of prognosis in seropositive autoimmune encephalitis (AE). Methods:In this multicenter study, we retrospectively analyzed 57 cases of seropositive AE with hospital admissio...

journal_title：Frontiers in immunology

authors： Broadley J,Wesselingh R,Seneviratne U,Kyndt C,Beech P,Buzzard K,Nesbitt C,D'Souza W,Brodtmann A,Kalincik T,Butzkueven H,O'Brien TJ,Monif M,Australian Autoimmune Encephalitis Consortium.

更新日期：2021-01-14 00:00:00

abstract：:Asthma is a chronic airway disease often due to sensitization to aeroallergens, especially house dust mite allergens (HDMs). The Dermatophagoides pteronyssinus group 2 (Der p 2), is one of the most representative HDM allergens and is recognized by more than 90% of HDM-allergic patients. In mouse models, all asthma-rel...

journal_title：Frontiers in immunology

authors： Klein M,Colas L,Cheminant MA,Brosseau C,Sauzeau V,Magnan A,Bouchaud G

更新日期：2020-11-18 00:00:00

abstract：:Tumor-induced remodeling of the microenvironment in lymph nodes (LNs) includes the formation of blood vessels, which goes beyond the regulation of metabolism, and shaping a survival niche for tumor cells. In contrast to solid tumors, which primarily rely on neo-angiogenesis, hematopoietic malignancies usually grow wit...

journal_title：Frontiers in immunology

authors： Menzel L,Höpken UE,Rehm A

更新日期：2020-12-03 00:00:00

abstract：:Diet is a major factor determining gut microbiota composition and perturbances in this complex ecosystem are associated with the inflammatory bowel disease (IBD). Here, we used gnotobiotic approach to analyze, how interaction between diet rich in proteins and gut microbiota influences the sensitivity to intestinal inf...

journal_title：Frontiers in immunology

authors： Kostovcikova K,Coufal S,Galanova N,Fajstova A,Hudcovic T,Kostovcik M,Prochazkova P,Jiraskova Zakostelska Z,Cermakova M,Sediva B,Kuzma M,Tlaskalova-Hogenova H,Kverka M

更新日期：2019-04-26 00:00:00

abstract：:Cervical cancer remains a global health burden despite the introduction of highly effective vaccines for the prophylaxis of causative human papillomavirus infection (HPV). Current efforts to eradicate cervical cancer focus on the development of broadly protective, cost-effective approaches. HPV minor capsid protein L2...

journal_title：Frontiers in immunology

authors： Yang F,Mariz FC,Zhao X,Spagnoli G,Ottonello S,Müller M

更新日期：2020-12-04 00:00:00

abstract：:Large-scale study of the properties of T-cell receptor (TCR) and B-cell receptor (BCR) repertoires through next-generation sequencing is providing excellent insights into the understanding of adaptive immune responses. Variable(Diversity)Joining [V(D)J] germline genes and alleles must be characterized in detail to fac...

journal_title：Frontiers in immunology

authors： Zhang W,Wang IM,Wang C,Lin L,Chai X,Wu J,Bett AJ,Dhanasekaran G,Casimiro DR,Liu X

更新日期：2016-11-04 00:00:00

abstract：:Malaria infections remain a serious global health problem in the world, particularly among children and pregnant women in Sub-Saharan Africa. Moreover, malaria control and elimination is hampered by rapid development of resistance by the parasite and the vector to commonly used antimalarial drugs and insecticides, res...

journal_title：Frontiers in immunology

authors： Kengne-Ouafo JA,Sutherland CJ,Binka FN,Awandare GA,Urban BC,Dinko B

更新日期：2019-02-11 00:00:00

abstract：:Prenatal glucocorticoids are routinely administered to pregnant women at risk of preterm delivery in order to improve survival of the newborn. However, in half of the cases, birth occurs outside the beneficial period for lung development. Glucocorticoids are potent immune modulators and cause apoptotic death of immatu...

journal_title：Frontiers in immunology

authors： Gieras A,Gehbauer C,Perna-Barrull D,Engler JB,Diepenbruck I,Glau L,Joosse SA,Kersten N,Klinge S,Mittrücker HW,Friese MA,Vives-Pi M,Tolosa E

更新日期：2017-11-13 00:00:00

abstract：:The effects of calcium (Ca) or strontium (Sr) on host osteogenesis and immune responses have been investigated separately. In clinical practice, these two elements may both be present around an orthopedic device, but their potential synergistic effects on osteogenesis and the immune response have not been explored to ...

journal_title：Frontiers in immunology

authors： Yuan X,Cao H,Wang J,Tang K,Li B,Zhao Y,Cheng M,Qin H,Liu X,Zhang X

更新日期：2017-09-29 00:00:00

abstract：:Neuronal apoptosis inhibitory protein (NAIP)/NOD-like receptor (NLR) containing a caspase activating and recruitment domain (CARD) 4 (NLRC4) inflammasome complexes are activated in response to proteins from virulent bacteria that reach the cell cytosol. Specific NAIP proteins bind to the agonists and then physically a...

journal_title：Frontiers in immunology

authors： Lage SL,Longo C,Branco LM,da Costa TB,Buzzo Cde L,Bortoluci KR

更新日期：2014-07-02 00:00:00

abstract：:Hemagglutinin glycoprotein (HA) is a principle influenza vaccine antigen. Recombinant HA-based vaccines become a potential alternative for traditional approach. Complexity and variation of HA N-glycosylation are considered as the important factors for the vaccine design. The number and location of glycan moieties in t...

journal_title：Frontiers in immunology

authors： Macioła AK,Pietrzak MA,Kosson P,Czarnocki-Cieciura M,Śmietanka K,Minta Z,Kopera E

更新日期：2017-04-20 00:00:00

abstract：:Leishmania parasites infect macrophages, causing a wide spectrum of human diseases, from cutaneous to visceral forms. In search of novel therapeutic targets, we performed comprehensive in vitro and ex vivo mapping of the signaling pathways upstream and downstream of antioxidant transcription factor [nuclear factor ery...

journal_title：Frontiers in immunology

authors： Vivarini ÁC,Calegari-Silva TC,Saliba AM,Boaventura VS,França-Costa J,Khouri R,Dierckx T,Dias-Teixeira KL,Fasel N,Barral AMP,Borges VM,Van Weyenbergh J,Lopes UG

更新日期：2017-09-15 00:00:00

abstract：:The caspase recruitment domain family member 11 (CARD11 or CARMA1)-B cell CLL/lymphoma 10 (BCL10)-MALT1 paracaspase (MALT1) [CBM] signalosome complex serves as a molecular bridge between cell surface antigen receptor signaling and the activation of the NF-κB, JNK, and mTORC1 signaling axes. This positions the CBM comp...

journal_title：Frontiers in immunology

authors： Lu HY,Bauman BM,Arjunaraja S,Dorjbal B,Milner JD,Snow AL,Turvey SE

更新日期：2018-09-19 00:00:00

abstract：:Rationale: Caspase-1 is a zymogen whose activation predominantly depends upon the assembly of ASC monomers into insoluble prion-like polymers (specks). ASC polymers support caspase-1 dimer formation inducing a proximity mediated auto-activation of caspase-1. Therefore, the amount and nature of ASC monomers and polymer...

journal_title：Frontiers in immunology

authors： Gavrilin MA,McAndrew CC,Prather ER,Tsai M,Spitzer CR,Song MA,Mitra S,Sarkar A,Shields PG,Diaz PT,Wewers MD

更新日期：2020-03-19 00:00:00

abstract：:HLA-E is a member of the non-classical HLA molecules and by interaction with activating or inhibitory receptors of NK and T cells, HLA-E can lead to immune activation or suppression context-dependently. Recently, the non-classical HLA molecules gain more attention in the setting of allogeneic hematopoietic stem cell t...

journal_title：Frontiers in immunology

authors： Kordelas L,Schwich E,Lindemann M,Heinemann FM,Buttkereit U,Horn PA,Beelen DW,Rebmann V

更新日期：2020-01-10 00:00:00