A Sensitive Method for Detecting Peptide-specific CD4+ T Cell Responses in Peripheral Blood from Patients with Myasthenia Gravis.

abstract：:Re-directing T cells via chimeric antigen receptors (CARs) was first tested in HIV-infected individuals with limited success, but these pioneering studies laid the groundwork for the clinically successful CD19 CARs that were recently FDA approved. Now there is great interest in revisiting the concept of using CAR-expr...

journal_title：Frontiers in immunology

authors： Kim GB,Hege K,Riley JL

更新日期：2019-09-27 00:00:00

abstract：:Mast cells (MCs) are considered as key effector cells in the elicitation of allergic symptoms, and they are essential players in innate and adaptive immune responses. In mice, two main types of MCs have been described: connective tissue MCs (CTMCs) and mucosal MCs (MMCs). However, little is known about the biological ...

journal_title：Frontiers in immunology

authors： Luo Y,Meyer N,Jiao Q,Scheffel J,Zimmermann C,Metz M,Zenclussen A,Maurer M,Siebenhaar F

更新日期：2019-10-15 00:00:00

abstract：:Immune evasion is an important cancer hallmark and the understanding of its mechanisms has generated successful therapeutic approaches. Induction of immunogenic cell death (ICD) is expected to attract immune cell populations that promote innate and adaptive immune responses. Here, we present a critical advance for our...

journal_title：Frontiers in immunology

authors： Cerqueira OLD,Clavijo-Salomon MA,Cardoso EC,Citrangulo Tortelli Junior T,Mendonça SA,Barbuto JAM,Strauss BE

更新日期：2020-10-22 00:00:00

abstract：:Human autoantibodies targeting myelin oligodendrocyte glycoprotein (MOG Ab) have become a useful clinical biomarker for the diagnosis of a spectrum of inflammatory demyelinating disorders. Live cell-based assays that detect MOG Ab against conformational MOG are currently the gold standard. Flow cytometry, in which ser...

journal_title：Frontiers in immunology

authors： Tea F,Pilli D,Ramanathan S,Lopez JA,Merheb V,Lee FXZ,Zou A,Liyanage G,Bassett CB,Thomsen S,Reddel SW,Barnett MH,Brown DA,Dale RC,Brilot F,Australasian New Zealand MOG Study Group.

更新日期：2020-02-06 00:00:00

abstract：:For many years, disappointing results have been generated by many investigations, which have utilized a variety of immunologic strategies to enhance the ability of a patient's immune system to recognize and eliminate malignant cells. However, in recent years, immunotherapy has been used successfully for the treatment ...

journal_title：Frontiers in immunology

authors： Caratelli S,Sconocchia T,Arriga R,Coppola A,Lanzilli G,Lauro D,Venditti A,Del Principe MI,Buccisano F,Maurillo L,Ferrone S,Sconocchia G

更新日期：2017-04-27 00:00:00

abstract：:Pulmonary tuberculosis (TB) is a difficult-to-eliminate disease. Although the Bacille Calmette-Guérin (BCG) vaccine against Mycobacterium tuberculosis (MTB) has been available for decades, its efficacy is variable and has lessened over time. Furthermore, the BCG vaccine no longer protects against newly emerged Beijing...

journal_title：Frontiers in immunology

authors： Yang SJ,Chen YY,Hsu CH,Hsu CW,Chang CY,Chang JR,Dou HY

更新日期：2020-06-23 00:00:00

abstract：:A new paradigm of mucosal vaccination against human immunodeficiency virus (HIV) infection has been investigated in the macaque model. A vaccine consisting of inactivated simian immunodeficiency virus (SIV)mac239 particles together with a living bacterial adjuvant (either the Calmette and Guerin bacillus, Lactobacillu...

journal_title：Frontiers in immunology

authors： Andrieu JM,Chen S,Lai C,Guo W,Lu W

更新日期：2014-06-30 00:00:00

abstract：:Foxp3+ Treg cells are indispensable for maintaining self-tolerance in secondary lymphoid organs (SLOs). However, Treg cells are also recruited to non-lymphoid tissues (NLTs) during inflammation. Recent advances in the understanding of Treg cell biology provided us with molecular mechanisms-both transcriptional and epi...

journal_title：Frontiers in immunology

authors： Korn T,Muschaweckh A

更新日期：2019-11-14 00:00:00

abstract：:Transcriptome profiling approaches have been widely used to investigate the mechanisms underlying psoriasis pathogenesis. Most researchers have measured changes in transcript abundance in skin biopsies; relatively few have examined transcriptome changes in the blood. Although less relevant to the study of psoriasis pa...

journal_title：Frontiers in immunology

authors： Rawat A,Rinchai D,Toufiq M,Marr AK,Kino T,Garand M,Tatari-Calderone Z,Kabeer BSA,Krishnamoorthy N,Bedognetti D,Karim MY,Sastry KS,Chaussabel D

更新日期：2020-11-24 00:00:00

abstract：:Cytokines are known to shape the tumor microenvironment and although progress has been made in understanding their role in carcinogenesis, much remains to learn regarding their role in tumor growth and progression. We have identified granulocyte colony-stimulating factor (G-CSF) as one such cytokine, showing that G-CS...

journal_title：Frontiers in immunology

authors： Karagiannidis I,Jerman SJ,Jacenik D,Phinney BB,Yao R,Prossnitz ER,Beswick EJ

更新日期：2020-09-15 00:00:00

abstract：:Chronic hepatitis B virus (HBV) infection is a major global health burden affecting around 257 million people worldwide. The consequences of chronic HBV infection include progressive liver damage, liver cirrhosis, and hepatocellular carcinoma. Although current direct antiviral therapies successfully lead to suppressio...

journal_title：Frontiers in immunology

authors： Heim K,Neumann-Haefelin C,Thimme R,Hofmann M

更新日期：2019-09-20 00:00:00

abstract：:While rodent cancer models are essential for early proof-of-concept and mechanistic studies for immune therapies, these models have limitations with regards to predicting the ultimate effectiveness of new immunotherapies in humans. As a unique spontaneous, large animal model of cancer, the value of conducting studies ...

journal_title：Frontiers in immunology

authors： Dow S

更新日期：2020-01-17 00:00:00

abstract：:Macrophages, as professional phagocytes of the immune system, possess the ability to detect and clear invading pathogens and apoptotic cells through phagocytosis. Phagocytosis involves membrane reorganization and remodeling events on the cell surface, which play an essential role in innate immunity and tissue homeosta...

journal_title：Frontiers in immunology

authors： Rubio JM,Astudillo AM,Casas J,Balboa MA,Balsinde J

更新日期：2018-07-24 00:00:00

abstract：:The mucosal immune system is constantly exposed to antigen, whether it be food antigen, commensal bacteria, or harmful antigen. It is essential that the mucosal immune system can distinguish between harmful and non-harmful antigens, and initiate an active immune response to clear the harmful antigens, while initiating...

journal_title：Frontiers in immunology

authors： Lambert SE,Kinder JM,Then JE,Parliament KN,Bruns HA

更新日期：2012-07-18 00:00:00

abstract：:Malaria is caused by infection with Plasmodium parasites. Various studies with knockout mice have indicated that IFN-γ plays essential roles in protective immunity against blood-stage Plasmodium infection. However, after Plasmodium infection, increased IFN-γ production by various types of cells is involved not only in...

journal_title：Frontiers in immunology

authors： Inoue S,Niikura M,Mineo S,Kobayashi F

更新日期：2013-08-29 00:00:00

abstract：:The cytosolic adhesion and degranulation-promoting adapter protein ADAP is expressed in various hematopoietic cells including T cells, NK cells, myeloid cells, and platelets but absent in mature B cells. The role of ADAP in T cell activation, proliferation and integrin activation is well-accepted. We previously demons...

journal_title：Frontiers in immunology

authors： Rudolph J,Meinke C,Voss M,Guttek K,Kliche S,Reinhold D,Schraven B,Reinhold A

更新日期：2019-10-01 00:00:00

abstract：:Toll-like receptor 9 (TLR9) belongs to the group of endosomal receptors of the innate immune system with the ability to recognize hypomethylated CpG sequences from DNA. There is scarce information about TLR9 expression and its association with the circadian cycle (CC). Different patterns of TLR9 expression are regulat...

journal_title：Frontiers in immunology

authors： Martínez-García EA,Zavala-Cerna MG,Lujano-Benítez AV,Sánchez-Hernández PE,Martín-Márquez BT,Sandoval-García F,Vázquez-Del Mercado M

更新日期：2018-07-06 00:00:00

abstract：:Chronic hepatitis C virus (HCV) infection disrupts immune functions, including that of cytotoxic CD8+ T-cells which are important mediators of immune response. While HCV cure aims to eliminate long term sequelae of infection, whether direct-acting antiviral (DAA) treatment results in immune reconstitution remains uncl...

journal_title：Frontiers in immunology

authors： Vranjkovic A,Deonarine F,Kaka S,Angel JB,Cooper CL,Crawley AM

更新日期：2019-08-13 00:00:00

abstract：:Natural killer (NK) cells play an important role in the containment of HIV replication during primary infection, though their functions are impaired during chronic HIV infection. Infants experience more rapid HIV disease progression than adults, but contributions of infant NK cells to containing HIV infection are unkn...

journal_title：Frontiers in immunology

authors： Slyker JA,Lohman-Payne B,John-Stewart GC,Dong T,Mbori-Ngacha D,Tapia K,Atzberger A,Taylor S,Rowland-Jones SL,Blish CA

更新日期：2012-12-31 00:00:00

abstract：:CD28 is an important co-stimulatory receptor for T lymphocytes that, in humans, delivers TCR-independent signal leading to the up-regulation of pro-inflammatory cytokines. We have recently reported that CD28 autonomous signaling induces the expression of IL-17A in peripheral CD4+ T lymphocytes from healthy donors, mul...

journal_title：Frontiers in immunology

authors： Kunkl M,Mastrogiovanni M,Porciello N,Caristi S,Monteleone E,Arcieri S,Tuosto L

更新日期：2019-04-24 00:00:00

abstract：:Cross-presentation of endocytosed antigen as peptide/class I major histocompatibility complex complexes plays a central role in the elicitation of CD8(+) T cell clones that mediate anti-viral and anti-tumor immune responses. While it has been clear that there are specific subsets of professional antigen presenting cel...

journal_title：Frontiers in immunology

authors： Compeer EB,Flinsenberg TW,van der Grein SG,Boes M

更新日期：2012-03-07 00:00:00

abstract：:Ruggero Ceppellini, who died at the age of 71 in 1988, was one of the most stimulating and original human geneticists of his generation (1). Ceppellini's outstanding contributions to the genetics of the human blood groups, immunoglobulin allotypes and the HLA system epitomize the study of immunogenetics. By using his ...

journal_title：Frontiers in immunology

authors： Bodmer W

更新日期：2019-06-05 00:00:00

abstract：:Platelets are anucleate blood cells that play a crucial role in the maintenance of hemostasis. While platelet activation and elevated platelet counts (thrombocytosis) are associated with increased risk of thrombotic complications, low platelet counts (thrombocytopenia) and several platelet function disorders increase ...

journal_title：Frontiers in immunology

authors： Assinger A

更新日期：2014-12-18 00:00:00

abstract：:In response to microenvironmental cues, macrophages undergo a profound phenotypic transformation acquiring distinct activation phenotypes ranging from pro-inflammatory (M1) to anti-inflammatory (M2). To study how activation phenotype influences phagocytosis and production of reactive oxygen species (ROS) mediated by r...

journal_title：Frontiers in immunology

authors： Mendoza-Coronel E,Ortega E

更新日期：2017-03-27 00:00:00

abstract：:Systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS) are two autoimmune diseases that can occur together or separately. Insights into the pathogenesis have revealed similarities, such as development of autoantibodies targeting subcellular antigens as well as a shared increased risk of cardiovascular ...

journal_title：Frontiers in immunology

authors： Wirestam L,Arve S,Linge P,Bengtsson AA

更新日期：2019-11-22 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fimmu.2019.00702.]. ...

journal_title：Frontiers in immunology

authors： Ryffel B,Huang F,Robinet P,Panek C,Couillin I,Erard F,Piotet J,Le Bert M,Mackowiak C,Torres Arias M,Dimier-Poisson I,Zheng SG

更新日期：2020-10-28 00:00:00

abstract：:The lymphatic vasculature plays a crucial role in regulating the inflammatory response by influencing drainage of extravasated fluid, inflammatory mediators, and leukocytes. Lymphatic vessels undergo pronounced enlargement in inflamed tissue and display increased leakiness, indicating reduced functionality. Interferin...

journal_title：Frontiers in immunology

authors： Schwager S,Detmar M

更新日期：2019-02-26 00:00:00

abstract：:During the course of Chagas disease, infectious forms of Trypanosoma cruzi are occasionally liberated from parasitized heart cells. Studies performed with tissue culture trypomastigotes (TCTs, Dm28c strain) demonstrated that these parasites evoke neutrophil/CXCR2-dependent microvascular leakage by activating innate se...

journal_title：Frontiers in immunology

authors： Nascimento CR,Andrade D,Carvalho-Pinto CE,Serra RR,Vellasco L,Brasil G,Ramos-Junior ES,da Mota JB,Almeida LN,Andrade MV,Correia Soeiro MN,Juliano L,Alvarenga PH,Oliveira AC,Sicuro FL,de Carvalho ACC,Svensjö E,Scharfstei

更新日期：2017-08-02 00:00:00

abstract：:Heavy chain-only antibodies (HCAbs) do not associate with light chains and their VH regions are functional as single domains, forming the smallest active antibody fragment. These VH regions are ideal building blocks for a variety of antibody-based biologics because they tolerate fusion to other molecules and may also ...

journal_title：Frontiers in immunology

authors： Clarke SC,Ma B,Trinklein ND,Schellenberger U,Osborn MJ,Ouisse LH,Boudreau A,Davison LM,Harris KE,Ugamraj HS,Balasubramani A,Dang KH,Jorgensen B,Ogana HAN,Pham DT,Pratap PP,Sankaran P,Anegon I,van Schooten WC,Brüggem

更新日期：2019-01-07 00:00:00

abstract：:Aerobic glycolysis is a recognized feature shared by tumors, leading to the accumulation of lactic acid in their local microenvironments. Like the tumors, the blastocysts, placenta, trophoblasts and decidual immune cells can also produce a large amount of lactic acid through aerobic glycolysis during the early pregnan...

journal_title：Frontiers in immunology

authors： Ma LN,Huang XB,Muyayalo KP,Mor G,Liao AH

更新日期：2020-02-27 00:00:00