Platelets and infection - an emerging role of platelets in viral infection.

abstract：:Understanding the mechanisms of human immunodeficiency virus type I (HIV-1) pathogenesis would facilitate the identification of new therapeutic targets to control the infection in face of current antiretroviral therapy limitations. CD74 membrane expression is upregulated in HIV-1-infected cells and the magnitude of it...

journal_title：Frontiers in immunology

authors： Trifone C,Salido J,Ruiz MJ,Leng L,Quiroga MF,Salomón H,Bucala R,Ghiglione Y,Turk G

更新日期：2018-06-27 00:00:00

abstract：:Fracture repair is initiated by a multitude of immune cells and induction of an inflammatory cascade. Alterations in the early healing response due to an aged adaptive immune system leads to impaired bone repair, delayed healing or even formation of non-union. However, immuno-senescence is not limited to the adaptive ...

journal_title：Frontiers in immunology

authors： Löffler J,Sass FA,Filter S,Rose A,Ellinghaus A,Duda GN,Dienelt A

更新日期：2019-10-18 00:00:00

abstract：:The Ebola virus (EBOV) epidemic indicated a great need for prophylactic and therapeutic strategies. The use of plants for the production of biopharmaceuticals is a concept being adopted by the pharmaceutical industry, with an enzyme for human use currently commercialized since 2012 and some plant-based vaccines close ...

journal_title：Frontiers in immunology

authors： Rosales-Mendoza S,Nieto-Gómez R,Angulo C

更新日期：2017-03-10 00:00:00

abstract：:The genome has the ability to respond in a precise and co-ordinated manner to cellular signals. It achieves this through the concerted actions of transcription factors and the chromatin platform, which are targets of the signaling pathways. Our understanding of the molecular mechanisms through which transcription fact...

journal_title：Frontiers in immunology

authors： Brettingham-Moore KH,Taberlay PC,Holloway AF

更新日期：2015-09-29 00:00:00

abstract：:Respiratory syncytial virus (RSV) is a leading cause of severe lower respiratory tract disease in young children and a substantial contributor to respiratory tract disease throughout life and as such a high priority for vaccine development. However, after nearly 60 years of research no vaccine is yet available. The ch...

journal_title：Frontiers in immunology

authors： Boyoglu-Barnum S,Chirkova T,Anderson LJ

更新日期：2019-07-25 00:00:00

abstract：:THE REGULATORY CYTOKINE TUMOR NECROSIS FACTOR (TNF) EXERTS ITS EFFECTS THROUGH TWO RECEPTORS: TNFR1 and TNFR2. Defects in TNFR2 signaling are evident in a variety of autoimmune diseases. One new treatment strategy for autoimmune disease is selective destruction of autoreactive T cells by administration of TNF, TNF ind...

journal_title：Frontiers in immunology

authors： Faustman DL,Davis M

更新日期：2013-12-23 00:00:00

abstract：:Keloids are disfiguring, fibroproliferative growths and their pathogenesis remains unclear, inhibiting therapeutic development. Available treatment options have limited efficacy and harbor safety concerns. Thus, there is a great need to clarify keloid pathomechanisms that may lead to novel treatments. In this study, w...

journal_title：Frontiers in immunology

authors： Wu J,Del Duca E,Espino M,Gontzes A,Cueto I,Zhang N,Estrada YD,Pavel AB,Krueger JG,Guttman-Yassky E

更新日期：2020-11-23 00:00:00

abstract：:Despite the availability of yearly vaccinations, influenza continues to cause seasonal, and pandemic rises in illness and death. An error prone replication mechanism results in antigenic drift and viral escape from immune pressure, and recombination results in antigenic shift that can rapidly move through populations ...

journal_title：Frontiers in immunology

authors： Von Holle TA,Moody MA

更新日期：2019-06-25 00:00:00

abstract：:The suppressor of cytokine signaling (SOCS) family of intracellular checkpoint inhibitors has received little recognition compared to other checkpoint inhibitors. Two members of this family, SOCS1 and SOCS3, are indispensable, since SOCS1 knockout in mice results in neonatal death due to interferon gamma (IFNγ) induce...

journal_title：Frontiers in immunology

authors： Johnson HM,Lewin AS,Ahmed CM

更新日期：2020-10-23 00:00:00

abstract：Introduction:High-density lipoproteins (HDL) are responsible for the efflux and transport of cholesterol from peripheral tissues to the liver. In addition, HDL can modulate various immunological mechanisms, including the inflammatory response. Inflammasomes are multiprotein complexes that have been reported to be activ...

journal_title：Frontiers in immunology

authors： Marín-Palma D,Castro GA,Cardona-Arias JA,Urcuqui-Inchima S,Hernandez JC

更新日期：2018-06-14 00:00:00

abstract：:Most animals maintain mutually beneficial symbiotic relationships with their intestinal microbiota. Resident microbes in the gastrointestinal tract breakdown indigestible food, provide essential nutrients, and, act as a barrier against invading microbes, such as the enteric pathogen Vibrio cholerae. Over the last deca...

journal_title：Frontiers in immunology

authors： Davoodi S,Foley E

更新日期：2020-01-24 00:00:00

abstract：:The apparition of adaptive immunity in Gnathostomata correlates with the expansion of the E-protein family to encompass E2-2, HEB, and E2A. Within the family, E2-2 and HEB are more closely evolutionarily related but their concerted action in hematopoiesis remains to be explored. Here we show that the combined disrupti...

journal_title：Frontiers in immunology

authors： Bouderlique T,Peña-Pérez L,Kharazi S,Hils M,Li X,Krstic A,De Paepe A,Schachtrup C,Gustafsson C,Holmberg D,Schachtrup K,Månsson R

更新日期：2019-03-18 00:00:00

abstract：:NOD-like receptors (NLRs) are a class of cytoplasmic pattern-recognition receptors. Although most NLRs play some role in immunity, their functions range from regulating antigen presentation (NLRC5, CIITA) to pathogen/damage sensing (NLRP1, NLRP3, NLRC1/2, NLRC4) to suppression or modulation of inflammation (NLRC3, NLR...

journal_title：Frontiers in immunology

authors： Lupfer C,Kanneganti TD

更新日期：2013-09-17 00:00:00

abstract：:Silver nanoparticles (AgNPs) are promising new antimicrobial agents against a wide range of skin and mucosal pathogens. However, their interaction with the immune system is currently not fully understood. Dendritic cells (DCs) are crucial during development of T cell-specific responses against bacterial and viral path...

journal_title：Frontiers in immunology

authors： Orlowski P,Tomaszewska E,Ranoszek-Soliwoda K,Gniadek M,Labedz O,Malewski T,Nowakowska J,Chodaczek G,Celichowski G,Grobelny J,Krzyzowska M

更新日期：2018-05-22 00:00:00

abstract：:The potential of tolerogenic dendritic cells (tolDCs) to shape immune responses and restore tolerance has turn them into a promising therapeutic tool for cellular therapies directed toward immune regulation in autoimmunity. Although the cellular mechanisms by which these cells can exert their regulatory function are w...

journal_title：Frontiers in immunology

authors： García-González PA,Maggi J,Schinnerling K,Sepúlveda-Gutiérrez A,Soto L,Neira O,Mehdi AM,Nel HJ,Pesce B,Aravena O,Molina MC,Catalán D,Thomas R,Verdugo RA,Aguillón JC

更新日期：2019-05-28 00:00:00

abstract：:Dysregulation of macrophage has been demonstrated to contribute to aberrant immune responses and inflammatory diseases. CD11b, expressed on macrophages, plays a critical role in regulating pathogen recognition, phagocytosis, and cell survival. In the present study, we explored the effect of leukadherin-1 (LA1), an ago...

journal_title：Frontiers in immunology

authors： Yao X,Dong G,Zhu Y,Yan F,Zhang H,Ma Q,Fu X,Li X,Zhang Q,Zhang J,Shi H,Ning Z,Dai J,Li Z,Li C,Wang B,Ming J,Yang Y,Hong F,Meng X,Xiong H,Si C

更新日期：2019-02-12 00:00:00

abstract：:Therapy with Tyrosine Kinase Inhibitors (TKI) aiming stable deep molecular response is the gold standard to treat Chronic Myeloid Leukemia (CML). NKT-like cells (CD3+CD56+) combine characteristics of T and NK cells. The physiopathological role of these cells remains unknown although the literature refers their associa...

journal_title：Frontiers in immunology

authors： Almeida JS,Couceiro P,López-Sejas N,Alves V,Růžičková L,Tarazona R,Solana R,Freitas-Tavares P,Santos-Rosa M,Rodrigues-Santos P

更新日期：2019-10-22 00:00:00

abstract：:Combination therapy with inhibitors of cytotoxic T lymphocyte-associated protein (CTLA)4 and programmed death (PD)-1 has demonstrated efficacy in cancer patients. However, there is little information on CTLA4 and PD-1 expression levels and their clinical significance across diverse cancers. In this study, we addressed...

journal_title：Frontiers in immunology

authors： Liu JN,Kong XS,Huang T,Wang R,Li W,Chen QF

更新日期：2020-09-10 00:00:00

abstract：:The role of macrophages during regeneration in zebrafish has been well-documented. Nevertheless, new evidence indicates that zebrafish macrophages are a heterogeneous population of cells, and that they can play different roles during immune responses and in tissue restoration after damage and infection. In this work, ...

journal_title：Frontiers in immunology

authors： Morales RA,Allende ML

更新日期：2019-02-15 00:00:00

abstract：:Phosphatidylinositol-3-kinase p110δ (PI3Kδ) inhibition by Idelalisib (CAL-101) in hematological malignancies directly induces apoptosis in cancer cells and disrupts immunological tolerance by depleting regulatory T cells. Yet, little is known about the direct impact of PI3Kδ blockade on effector T cells from CAL-101 t...

journal_title：Frontiers in immunology

authors： Bowers JS,Majchrzak K,Nelson MH,Aksoy BA,Wyatt MM,Smith AS,Bailey SR,Neal LR,Hammerbacher JE,Paulos CM

更新日期：2017-09-29 00:00:00

abstract：:The human bone marrow (BM) gives rise to all distinct blood cell lineages, including CD1c+ (cDC2) and CD141+ (cDC1) myeloid dendritic cells (DC) and monocytes. These cell subsets are also present in peripheral blood (PB) and lymphoid tissues. However, the difference between the BM and PB compartment in terms of differ...

journal_title：Frontiers in immunology

authors： van Leeuwen-Kerkhoff N,Lundberg K,Westers TM,Kordasti S,Bontkes HJ,Lindstedt M,de Gruijl TD,van de Loosdrecht AA

更新日期：2018-07-16 00:00:00

abstract：:Cyclic dinucleotides are bacterial signal transducers that bind to host intracellular protein, stimulator of interferon genes (STING) encoded by Tmem173. In this study, we demonstrate that STING triggers adaptive immune responses that control Th17 differentiation. Cyclic dinucleotides recognition enables classical den...

journal_title：Frontiers in immunology

authors： Liu S,Xia Q,Wu X,Sun F,Hu Q,Wu J,Wang M,Rao Q,Guan W

更新日期：2018-05-16 00:00:00

abstract：:Chimeric antigen receptor (CAR) therapy has been proved effective in a stream of clinical trials, especially in hematologic malignancies. However, current CAR therapy is highly personalized as cells used are derived from patients themselves, which can be costly, time-consuming, and sometimes fails to achieve optimal t...

journal_title：Frontiers in immunology

authors： Zhang Y,Li P,Fang H,Wang G,Zeng X

更新日期：2020-12-10 00:00:00

abstract：:Human coronavirus (HCoV) is one of the most common causes of respiratory tract infections throughout the world. Two phenomena observed so far in the development of the SARS-CoV-2 pandemic deserve further attention. First, the relative absence of clinical signs of infections in children, second, the early appearance of...

journal_title：Frontiers in immunology

authors： Fierz W,Walz B

更新日期：2020-06-05 00:00:00

abstract：:Dendritic cells are considered as the main coordinators of both mucosal and systemic immune responses, thus playing a determining role in shaping the outcome of effector cell responses. However, it is still uncovered how primary human monocyte-derived DC (moDC) populations drive the polarization of helper T (Th) cells...

journal_title：Frontiers in immunology

authors： Bene K,Varga Z,Petrov VO,Boyko N,Rajnavolgyi E

更新日期：2017-04-18 00:00:00

abstract：:Enamel matrix derivatives (EMDs)-based periodontal tissue regenerative therapy is known to promote healing with minimal inflammatory response after periodontal surgery, i. e., it promotes wound healing with reduced pain and swelling. It has also been reported that macrophages stimulated with amelogenin, a major compon...

journal_title：Frontiers in immunology

authors： Yotsumoto K,Sanui T,Tanaka U,Yamato H,Alshargabi R,Shinjo T,Nakao Y,Watanabe Y,Hayashi C,Taketomi T,Fukuda T,Nishimura F

更新日期：2020-04-21 00:00:00

abstract：:Influenza virus NS2 is well known for its role in viral ribonucleoprotein nuclear export; however, its function has not been fully understood. A recent study showed that NS2 might interact with HIST1H1C (H1C, H1.2). Histones have been found to affect influenza virus replication, such as the H2A, H2B, H3, and H4, but H...

journal_title：Frontiers in immunology

authors： Liu X,Yang C,Hu Y,Lei E,Lin X,Zhao L,Zou Z,Zhang A,Zhou H,Chen H,Qian P,Jin M

更新日期：2017-03-24 00:00:00

abstract：:Sepsis is life-threatening organ dysfunction due to dysregulated response to infection. Patients with sepsis exhibit wide heterogeneity stemming from genetic, molecular, and clinical factors as well as differences in pathogens, creating challenges for the development of effective treatments. Several gaps in knowledge ...

journal_title：Frontiers in immunology

authors： Talisa VB,Yende S,Seymour CW,Angus DC

更新日期：2018-06-28 00:00:00

abstract：:This study aimed to investigate the adipokine and cytokine profiles of adipocytes from epicardial and subcutaneous adipose tissues in interconnection with the visceral adipose tissue area and the biochemical and clinical characteristics of patients with coronary artery disease. We assessed 84 patients with coronary ar...

journal_title：Frontiers in immunology

authors： Gruzdeva O,Uchasova E,Dyleva Y,Borodkina D,Akbasheva O,Antonova L,Matveeva V,Belik E,Ivanov S,Sotnikov A,Kozyrin K,Brel N,Sinitsky M,Karetnikova V,Kokov A,Bychkova E,Pecherina T,Barbarash O

更新日期：2019-09-19 00:00:00

abstract：:Primary immunodeficiency diseases (PID) area heterogeneous group of disorders caused by genetic defects of the immune system, which manifest clinically as recurrent infections, autoimmune diseases or malignancies. Early detection of PID remains a challenge, particularly in older children with milder and less specific ...

journal_title：Frontiers in immunology

authors： Korsunskiy I,Blyuss O,Gordukova M,Davydova N,Zaikin A,Zinovieva N,Zimin S,Molchanov R,Salpagarova A,Eremeeva A,Filipenko M,Prodeus A,Korsunskiy A,Hsu P,Munblit D

更新日期：2020-03-03 00:00:00