Inflammation and Lymphatic Function.


:The lymphatic vasculature plays a crucial role in regulating the inflammatory response by influencing drainage of extravasated fluid, inflammatory mediators, and leukocytes. Lymphatic vessels undergo pronounced enlargement in inflamed tissue and display increased leakiness, indicating reduced functionality. Interfering with lymphatic expansion by blocking the vascular endothelial growth factor C (VEGF-C)/vascular endothelial growth factor receptor 3 (VEGFR-3) signaling axis exacerbates inflammation in a variety of disease models, including inflammatory bowel disease (IBD), rheumatoid arthritis and skin inflammation. In contrast, stimulation of the lymphatic vasculature, e.g., by transgenic or viral overexpression as well as local injections of VEGF-C, has been shown to reduce inflammation severity in models of rheumatoid arthritis, skin inflammation, and IBD. Strikingly, the induced expansion of the lymphatic vasculature improves lymphatic function as assessed by the drainage of dyes, fluorescent tracers or inflammatory cells and labeled antigens. The drainage performance of lymphatic vessels is influenced by vascular permeability and pumping activity, which are influenced by VEGF-C/VEGFR-3 signaling as well as several inflammatory mediators, including TNF-α, IL-1β, and nitric oxide. Considering the beneficial effects of lymphatic activation in inflammation, administration of pro-lymphangiogenic factors like VEGF-C, preferably in a targeted, inflammation site-specific fashion, represents a promising therapeutic approach in the setting of inflammatory pathologies.


Front Immunol


Frontiers in immunology


Schwager S,Detmar M




Has Abstract


2019-02-26 00:00:00








  • Halted Lymphocyte Egress via Efferent Lymph Contributes to Lymph Node Hypertrophy During Hypercholesterolemia.

    abstract::Dyslipidemia is a central component of atherosclerosis and metabolic syndrome linked to chronic inflammation and immune dysfunction. Previously, we showed that hypercholesterolemic apolipoprotein E knock out (apoE-/-) mice exhibit systemic effects including skin inflammation and hypertrophic lymph nodes (LNs). However...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Tay MHD,Lim SYJ,Leong YFI,Thiam CH,Tan KW,Torta FT,Narayanaswamy P,Wenk M,Angeli V

    更新日期:2019-03-27 00:00:00

  • The Role of Mucosal Immunity in Pertussis.

    abstract::Pertussis or whooping cough, mainly caused by Bordetella pertussis, is a severe respiratory disease that can affect all age groups but is most severe and can be life-threatening in young children. Vaccines against this disease are widely available since the 1950s. Despite high global vaccination coverage, the disease ...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Solans L,Locht C

    更新日期:2019-01-14 00:00:00

  • White Spot Syndrome Virus-Induced Shrimp miR-315 Attenuates Prophenoloxidase Activation via PPAE3 Gene Suppression.

    abstract::MicroRNAs (miRNAs), the small non-coding RNAs, play a pivotal role in post-transcriptional gene regulation in various cellular processes. However, the miRNA function in shrimp antiviral response is not clearly understood. This research aims to uncover the function of pmo-miR-315, a white spot syndrome virus (WSSV)-res...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Jaree P,Wongdontri C,Somboonwiwat K

    更新日期:2018-09-25 00:00:00

  • Stability and Maintenance of Foxp3+ Treg Cells in Non-lymphoid Microenvironments.

    abstract::Foxp3+ Treg cells are indispensable for maintaining self-tolerance in secondary lymphoid organs (SLOs). However, Treg cells are also recruited to non-lymphoid tissues (NLTs) during inflammation. Recent advances in the understanding of Treg cell biology provided us with molecular mechanisms-both transcriptional and epi...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Korn T,Muschaweckh A

    更新日期:2019-11-14 00:00:00

  • Immune Status Against Hepatitis B in Patients After Allogeneic Hematopoietic Cell Transplantation-Factors Affecting Early and Long-Lasting Maintenance of Protective Anti-HBs Titers.

    abstract::The immunization of allogeneic hematopoietic cell transplantation (HCT) recipients against vaccine-preventable diseases is a part of posttransplantation guidelines. We conducted a prospective study to assess clinical and immunological parameters that would determine the response and long-term maintenance of protective...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Piekarska A,Wisniewski P,Lewandowski K,Gil L,Trzonkowski P,Bieniaszewska M,Zaucha JM

    更新日期:2020-11-24 00:00:00

  • Role of T Cells in Chikungunya Virus Infection and Utilizing Their Potential in Anti-Viral Immunity.

    abstract::Chikungunya virus (CHIKV) is an arthropod-borne alphavirus that causes hallmark debilitating polyarthralgia, fever, and rash in patients. T cell-mediated immunity, especially CD4+ T cells, are known to participate in the pathogenic role of CHIKV immunopathology. The other T cell subsets, notably CD8+, NKT, and gamma-d...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Poh CM,Chan YH,Ng LFP

    更新日期:2020-02-21 00:00:00

  • Interaction Between Macrophage Migration Inhibitory Factor and CD74 in Human Immunodeficiency Virus Type I Infected Primary Monocyte-Derived Macrophages Triggers the Production of Proinflammatory Mediators and Enhances Infection of Unactivated CD4+ T Cell

    abstract::Understanding the mechanisms of human immunodeficiency virus type I (HIV-1) pathogenesis would facilitate the identification of new therapeutic targets to control the infection in face of current antiretroviral therapy limitations. CD74 membrane expression is upregulated in HIV-1-infected cells and the magnitude of it...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Trifone C,Salido J,Ruiz MJ,Leng L,Quiroga MF,Salomón H,Bucala R,Ghiglione Y,Turk G

    更新日期:2018-06-27 00:00:00

  • Immunoglobulin M in Health and Diseases: How Far Have We Come and What Next?

    abstract::B lymphocytes are important in secreting antibodies that protect against invading pathogens such as viruses, bacteria, parasites, and also in mediating pathogenesis of allergic diseases and autoimmunity. B lymphocytes develop in the bone marrow and contain heavy and light chains, which upon ligation form an immunoglob...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Jones K,Savulescu AF,Brombacher F,Hadebe S

    更新日期:2020-10-30 00:00:00

  • Autologous Hematopoietic Stem Cell Transplantation for Treatment of Systemic Sclerosis.

    abstract::Systemic Sclerosis (SSc) is a complex autoimmune disease, characterized by high mortality and morbidity. The heterogeneity in terms of extent, severity, and rate of progression of skin and internal organ involvement gives rise to many difficulties in finding the optimal therapeutic interventions for SSc and, to date, ...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Del Papa N,Pignataro F,Zaccara E,Maglione W,Minniti A

    更新日期:2018-10-16 00:00:00

  • Blimp-1-Mediated Pathway Promotes Type I IFN Production in Plasmacytoid Dendritic Cells by Targeting to Interleukin-1 Receptor-Associated Kinase M.

    abstract::Plasmacytoid dendritic cells (pDCs) are a specialized subset of DCs capable of rapidly producing copious amounts of type I IFN (IFN-I) in response to viral infections. The mechanism regulating rapid production of IFN-I after pDCs are exposed to viral nucleic acids remains elusive. Here, we show that the transcription ...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Ko YA,Chan YH,Liu CH,Liang JJ,Chuang TH,Hsueh YP,Lin YL,Lin KI

    更新日期:2018-08-07 00:00:00

  • Improved Cytotoxic T Lymphocyte Responses to Vaccination with Porcine Reproductive and Respiratory Syndrome Virus in 4-1BB Transgenic Pigs.

    abstract::Vaccination is the most reliable measure to prevent infectious diseases in domestic animals. Development of novel vaccines demands extensive studies with new technologies, such as using novel adjuvants and immunomodulatory molecules. The co-stimulatory molecule 4-1BB provides a key signal that directs the fate of T ce...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Huang G,Liu X,Duszynski DW,Tang X,El-Ashram S,Liu Z,Suo X,Li Q

    更新日期:2017-12-18 00:00:00

  • Natural Killer Cells in the Lungs.

    abstract::The lungs, a special site that is frequently challenged by tumors, pathogens and other environmental insults, are populated by large numbers of innate immune cells. Among these, natural killer (NK) cells are gaining increasing attention. Recent studies have revealed that NK cells are heterogeneous populations consisti...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Cong J,Wei H

    更新日期:2019-06-25 00:00:00

  • Manipulation of Gut Microbiota Influences Immune Responses, Axon Preservation, and Motor Disability in a Model of Progressive Multiple Sclerosis.

    abstract::Gut microbiota dysbiosis has been implicated in MS and other immune diseases, although it remains unclear how manipulating the gut microbiota may affect the disease course. Using a well-established model of progressive MS triggered by intracranial infection with Theiler's murine encephalomyelitis virus (TMEV), we soug...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Mestre L,Carrillo-Salinas FJ,Mecha M,Feliú A,Espejo C,Álvarez-Cermeño JC,Villar LM,Guaza C

    更新日期:2019-06-14 00:00:00

  • Different Life Cycle Stages of Plasmodium falciparum Induce Contrasting Responses in Dendritic Cells.

    abstract::Dendritic cells are key linkers of innate and adaptive immunity. Efficient dendritic cell activation is central to the acquisition of immunity and the efficacy of vaccines. Understanding how dendritic cells are affected by Plasmodium falciparum blood-stage parasites will help to understand how immunity is acquired and...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Yap XZ,Lundie RJ,Feng G,Pooley J,Beeson JG,O'Keeffe M

    更新日期:2019-01-31 00:00:00

  • Activation of the MEK-ERK Pathway Is Necessary but Not Sufficient for Breaking Central B Cell Tolerance.

    abstract::Newly generated bone marrow B cells are positively selected into the peripheral lymphoid tissue only when they express a B cell receptor (BCR) that is nonautoreactive or one that binds self-antigen with only minimal avidity. This positive selection process, moreover, is critically contingent on the ligand-independent ...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Greaves SA,Peterson JN,Torres RM,Pelanda R

    更新日期:2018-04-09 00:00:00

  • Donor Genotype in the Interleukin-7 Receptor α-Chain Predicts Risk of Graft-versus-Host Disease and Cytomegalovirus Infection after Allogeneic Hematopoietic Stem Cell Transplantation.

    abstract::The efficacy of allogeneic hematopoietic stem cell transplantation (HSCT) is challenged by acute and chronic graft-versus-host disease (aGVHD and cGVHD) and viral infections due to long-lasting immunodeficiency. Interleukin-7 (IL-7) is a cytokine essential for de novo T cell generation in thymus and peripheral T cell ...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Kielsen K,Enevold C,Heilmann C,Sengeløv H,Pedersen AE,Ryder LP,Müller K

    更新日期:2018-02-02 00:00:00

  • The Diversity of Mammalian Hemoproteins and Microbial Heme Scavengers Is Shaped by an Arms Race for Iron Piracy.

    abstract::Iron is an essential micronutrient for most living species. In mammals, hemoglobin (Hb) stores more than two thirds of the body's iron content. In the bloodstream, haptoglobin (Hp) and hemopexin (Hpx) sequester free Hb or heme. Pathogenic microorganisms usually acquire iron from their hosts and have evolved complex sy...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Mozzi A,Forni D,Clerici M,Cagliani R,Sironi M

    更新日期:2018-09-11 00:00:00

  • Exploiting Human NK Cells in Tumor Therapy.

    abstract::NK cells play an important role in the innate defenses against tumor growth and metastases. Human NK cell activation and function are regulated by an array of HLA class I-specific inhibitory receptors and activating receptors recognizing ligands expressed de novo on tumor or virus-infected cells. NK cells have been ex...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Vacca P,Pietra G,Tumino N,Munari E,Mingari MC,Moretta L

    更新日期:2020-01-17 00:00:00

  • NF-κB Pathway in Autoinflammatory Diseases: Dysregulation of Protein Modifications by Ubiquitin Defines a New Category of Autoinflammatory Diseases.

    abstract::Autoinflammatory diseases are caused by defects in genes that regulate the innate immunity. Recently, the scope of autoinflammation has been broadened to include diseases that result from dysregulations in protein modifications by the highly conserved ubiquitin (Ub) peptides. Thus far these diseases consist of linear ...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Aksentijevich I,Zhou Q

    更新日期:2017-04-19 00:00:00

  • Distinct Dysfunctional States of Circulating Innate-Like T Cells in Metabolic Disease.

    abstract::The immune system plays a significant role in controlling systemic metabolism. Innate-like T (ILT) cells in particular, such as mucosal-associated invariant T (MAIT) cells, invariant natural killer T (iNKT) cells and γδ T cell receptor expressing cells, have been reported to promote metabolic homeostasis. However, the...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Li Y,Woods K,Parry-Strong A,Anderson RJ,Capistrano C,Gestin A,Painter GF,Hermans IF,Krebs J,Gasser O

    更新日期:2020-03-13 00:00:00

  • Phagocytosis by the Retinal Pigment Epithelium: Recognition, Resolution, Recycling.

    abstract::Tissue-resident phagocytes are responsible for the routine binding, engulfment, and resolution of their meals. Such populations of cells express appropriate surface receptors that are tailored to recognize the phagocytic targets of their niche and initiate the actin polymerization that drives internalization. Tissue-r...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Kwon W,Freeman SA

    更新日期:2020-11-13 00:00:00

  • Clinical, Immunological, and Molecular Heterogeneity of 173 Patients With the Phenotype of Immune Dysregulation, Polyendocrinopathy, Enteropathy, X-Linked (IPEX) Syndrome.

    abstract::Background: Immune Dysregulation, Polyendocrinopathy, Enteropathy, X-linked (IPEX) Syndrome is a rare recessive disorder caused by mutations in the FOXP3 gene. In addition, there has been an increasing number of patients with wild-type FOXP3 gene and, in some cases, mutations in other immune regulatory genes. Objectiv...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Gambineri E,Ciullini Mannurita S,Hagin D,Vignoli M,Anover-Sombke S,DeBoer S,Segundo GRS,Allenspach EJ,Favre C,Ochs HD,Torgerson TR

    更新日期:2018-11-01 00:00:00

  • Altered Immune Response and Implantation Failure in Progesterone-Induced Blocking Factor-Deficient Mice.

    abstract::Earlier data suggest that progesterone-induced blocking factor (PIBF) is involved in implantation. The present study therefore aims to investigate the consequences of functional PIBF deficiency during the peri-implantation period. CD1 female mice were injected intraperitoneally with 2 μg anti-PIBF monoclonal antibody ...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Csabai T,Pallinger E,Kovacs AF,Miko E,Bognar Z,Szekeres-Bartho J

    更新日期:2020-03-11 00:00:00

  • Novel Modulators of Asthma and Allergy: Exosomes and MicroRNAs.

    abstract::Intercellular communication is crucial to the immune system response. In the recent years, the discovery of exosomes has changed the way immune response orchestration was understood. Exosomes are able to operate as independent units that act as mediators in both physiological and pathological conditions. These structu...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Sastre B,Cañas JA,Rodrigo-Muñoz JM,Del Pozo V

    更新日期:2017-07-21 00:00:00

  • Abrogation of Endogenous Glycolipid Antigen Presentation on Myelin-Laden Macrophages by D-Sphingosine Ameliorates the Pathogenesis of Experimental Autoimmune Encephalomyelitis.

    abstract::Background: Although myelin is composed of mostly lipids, the pathological role of myelin lipids in demyelinating diseases remains elusive. The principal lipid of the myelin sheath is β-galactosylceramide (β-Galcer). Its α-anomer (α-Galcer) has been demonstrated to be antigenically presented by macrophages via CD1d, a...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Ban Y,Dong W,Zhang L,Zhou T,Altiti AS,Ali K,Mootoo DR,Blaho VA,Hla T,Ren Y,Ma X

    更新日期:2019-03-19 00:00:00

  • From Human Megakaryocytes to Platelets: Effects of Aspirin on High-Mobility Group Box 1/Receptor for Advanced Glycation End Products Axis.

    abstract::Platelets (PLTs) are the major source of high-mobility group box 1 (HMGB1), a protein that is involved in sterile inflammation of blood vessels and thrombosis. Megakaryocytes (MKs) synthesize HMGB1 and transfer both protein and mRNA into PLTs and PLT-derived microvesicles (MV). Free HMGB1 found in supernatants of in v...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Mardente S,Mari E,Massimi I,Tafani M,Guerriero R,Morsilli O,Pulcinelli FM,Bianchi ME,Zicari A

    更新日期:2018-01-12 00:00:00

  • Generation and function of induced regulatory T cells.

    abstract::CD4(+) CD25(+) Foxp3(+) regulatory T (Treg) cells are essential to the balance between pro- and anti-inflammatory responses. There are two major subsets of Treg cells, "natural" Treg (nTreg) cells that develop in the thymus, and "induced" Treg (iTreg) cells that arise in the periphery from CD4(+) Foxp3(-) conventional...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Schmitt EG,Williams CB

    更新日期:2013-06-19 00:00:00

  • Persistent Immune Activation in CVID and the Role of IVIg in Its Suppression.

    abstract::Common variable immunodeficiency (CVID) is one of the most common and clinically important primary immune deficiencies. CVID patients have poor humoral immunity, resulting in recurrent infections of the gastrointestinal and upper respiratory tracts, as well as increased incidence of some forms of cancers and autoimmun...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Paquin-Proulx D,Sandberg JK

    更新日期:2014-12-16 00:00:00

  • Increasing the Clinical Potential and Applications of Anti-HIV Antibodies.

    abstract::Preclinical and early human clinical studies of broadly neutralizing antibodies (bNAbs) to prevent and treat HIV infection support the clinical utility and potential of bNAbs for prevention, postexposure prophylaxis, and treatment of acute and chronic infection. Observed and potential limitations of bNAbs from these r...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Hua CK,Ackerman ME

    更新日期:2017-11-28 00:00:00

  • Distinctive Expression of Bcl-2 Factors in Regulatory T Cells Determines a Pharmacological Target to Induce Immunological Tolerance.

    abstract::Distinctive molecular characteristics of functionally diverse lymphocyte populations may represent novel pharmacological targets for immunotherapy. The intrinsic apoptosis pathway is differently regulated among conventional and regulatory T cells (Tregs). Targeted pharmacological modulation of this pathway with a smal...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Gabriel SS,Bon N,Chen J,Wekerle T,Bushell A,Fehr T,Cippà PE

    更新日期:2016-03-01 00:00:00