Epigenetic and Transcriptional Regulation in the Induction, Maintenance, Heterogeneity, and Recall-Response of Effector and Memory Th2 Cells.

abstract：:Overcoming the first line of the innate immune system is a general hallmark of pathogenic microbes to avoid recognition and to enter the human host. In particular, spirochetes belonging to the Borrelia burgdorferi sensu lato complex have developed various means to counter the immune response and to successfully surviv...

journal_title：Frontiers in immunology

authors： Kraiczy P

更新日期：2016-09-26 00:00:00

abstract：:Cancer immunotherapy (CIT) with antibodies targeting the programmed cell death 1 protein (PD-1)/programmed cell death 1 ligand 1 (PD-L1) axis have changed the standard of care in multiple cancers. However, durable antitumor responses have been observed in only a minority of patients, indicating the presence of other i...

journal_title：Frontiers in immunology

authors： Hack SP,Zhu AX,Wang Y

更新日期：2020-11-05 00:00:00

abstract：:Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have been recommended as the first-line therapy for non-small cell lung cancer (NSCLC) patients harboring EGFR mutations. However, acquired resistance to EGFR-TKIs is inevitable. Although immune checkpoint blockades (ICBs) targeting the programm...

journal_title：Frontiers in immunology

authors： Wu D,Liu Y,Li X,Liu Y,Yang Q,Liu Y,Wu J,Tian C,Zeng Y,Zhao Z,Xiao Y,Gu F,Zhang K,Hu Y,Liu L

更新日期：2020-07-23 00:00:00

abstract：:Leprosy serology reflects the bacillary load of patients and multidrug therapy (MDT) reduces Mycobacterium leprae-specific antibody titers of multibacillary (MB) patients. The Clinical Trial for Uniform Multidrug Therapy Regimen for Leprosy Patients in Brazil (U-MDT/CT-BR) compared outcomes of regular 12 doses MDT/R-M...

journal_title：Frontiers in immunology

authors： Hungria EM,Bührer-Sékula S,Oliveira RM,Aderaldo LC,Pontes MAA,Cruz R,de Gonçalves HS,Penna MLF,Penna GO,Stefani MMA

更新日期：2018-05-14 00:00:00

abstract：:Nephritic factors comprise a heterogeneous group of autoantibodies against neoepitopes generated in the C3 and C5 convertases of the complement system, causing its dysregulation. Classification of these autoantibodies can be clustered according to their stabilization of different convertases either from the classical ...

journal_title：Frontiers in immunology

authors： Corvillo F,Okrój M,Nozal P,Melgosa M,Sánchez-Corral P,López-Trascasa M

更新日期：2019-04-24 00:00:00

abstract：:Major histocompatibility complex class two (MHC-II) molecules are trans-membrane proteins and key components of the cellular immune system. Upon recognition of foreign peptides expressed on the MHC-II binding groove, CD4+ T cells mount an immune response against invading pathogens. Therefore, mechanistic identificatio...

journal_title：Frontiers in immunology

authors： Degoot AM,Chirove F,Ndifon W

更新日期：2018-06-20 00:00:00

abstract：:Controversy over the frequency of human B1 cells in normal individuals has arisen as different labs have begun to employ non-uniform techniques to study this population. The phenotypic profile and relative paucity of circulating human B1 cells place constraints on methodology to identify and isolate this population. M...

journal_title：Frontiers in immunology

authors： Griffin DO,Rothstein TL

更新日期：2012-05-25 00:00:00

abstract：:Host immunity provides wide spectrum protection that serves to eradicate pathogens and cancer cells, while maintaining self-tolerance and immunological homeostasis. Ligation of the T cell receptor (TCR) by antigen activates signaling pathways that coordinately induce aerobic glycolysis, mitochondrial activity, anaboli...

journal_title：Frontiers in immunology

authors： Patsoukis N,Weaver JD,Strauss L,Herbel C,Seth P,Boussiotis VA

更新日期：2017-04-11 00:00:00

abstract：:Acute pancreatitis (AP) is a common and devastating inflammatory disorder of the pancreas. However, there are still no effective treatments available for the disease. Therefore, it is important to discover new therapeutic targets and strategies for better treatment and prognosis of AP patients. Toll-like receptor 3 (T...

journal_title：Frontiers in immunology

authors： Huang C,Chen S,Zhang T,Li D,Huang Z,Huang J,Qin Y,Chen B,Cheng G,Ma F,Zhou M

更新日期：2019-05-03 00:00:00

abstract：:Monoclonal antibodies targeting the regulatory immune "checkpoint" receptors CTLA-4, PD-1, and PD-L1 are now standard therapy for diverse malignancies including melanoma, lung cancer, and renal cell carcinoma. Although effective in many patients and able to induce cures in some, targeting these regulatory pathways has...

journal_title：Frontiers in immunology

authors： Dougan M

更新日期：2017-11-15 00:00:00

abstract：Background:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is spreading worldwide. Measuring the prevention and control of the disease has become a matter requiring urgent focus. Objective:Based on coronavirus disease 2019 (COVID-19) clinical data from Wuhan, we conducted an in-depth analysis to...

journal_title：Frontiers in immunology

authors： Qun S,Wang Y,Chen J,Huang X,Guo H,Lu Z,Wang J,Zheng C,Ma Y,Zhu Y,Xia D,Wang Y,He H,Wang Y,Fei M,Yin Y,Zheng M,Xu Y,Ge W,Hu F,Zhou J

更新日期：2020-09-02 00:00:00

abstract：:Interleukin-1 (IL-1) family cytokines are key signaling molecules in both the innate and adaptive immune systems, mediating inflammation in response to a wide range of stimuli. The basic mechanism of signal initiation is a stepwise process in which an agonist cytokine binds its cognate receptor. Together, this cytokin...

journal_title：Frontiers in immunology

authors： Fields JK,Günther S,Sundberg EJ

更新日期：2019-06-20 00:00:00

abstract：:Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the only treatment with curative potential for certain aggressive hematopoietic malignancies. Its success is limited by acute graft-versus-host disease (GVHD), a life-threatening complication that occurs when allo-reactive donor T cells attack recipient...

journal_title：Frontiers in immunology

authors： Heidegger S,van den Brink MR,Haas T,Poeck H

更新日期：2014-07-18 00:00:00

abstract：:T follicular helper CD4 cells (Tfh) are essential for the development and maintenance of germinal center (GC) reactions, a critical process that promotes the generation of long-lived high affinity humoral immunity. It is becoming increasingly evident that GC-Tfh cells are heterogeneous in nature with some cellular cha...

journal_title：Frontiers in immunology

authors： Velu V,Mylvaganam G,Ibegbu C,Amara RR

更新日期：2018-06-06 00:00:00

abstract：:Diet composition may affect the onset and progression of chronic degenerative diseases, including cancer, whose pathogenesis relies on inflammatory processes. Growing evidence indicates that diet and its components critically contribute to human health, affecting the immune system, secretion of adipokines, and metabol...

journal_title：Frontiers in immunology

authors： Miccadei S,Masella R,Mileo AM,Gessani S

更新日期：2016-11-15 00:00:00

abstract：:The glycans on the plasma membrane of cells manifest as the glycocalyx, which serves as an information-rich frontier that is directly in contact with its immediate milieu. The glycoconjugates (GCs) that adorn most of the mammalian cells are also abundant in gametes, especially the spermatozoa where they perform unique...

journal_title：Frontiers in immunology

authors： Batra V,Dagar K,Nayak S,Kumaresan A,Kumar R,Datta TK

更新日期：2020-08-28 00:00:00

abstract：:Mast cells are immune cells of the myeloid lineage and are present in connective tissues throughout the body. The activation and degranulation of mast cells significantly modulates many aspects of physiological and pathological conditions in various settings. With respect to normal physiological functions, mast cells ...

journal_title：Frontiers in immunology

authors： Krystel-Whittemore M,Dileepan KN,Wood JG

更新日期：2016-01-06 00:00:00

abstract：:Proteinuria has been identified as prognosticator of renal outcome in patients with ANCA-associated glomerulonephritis, but whether proteinuria is related to podocyte abnormalities in these patients is largely unknown. We here investigate podocyte foot process width and number of podocytes positive for the podocyte ma...

journal_title：Frontiers in immunology

authors： van Daalen EE,Neeskens P,Zandbergen M,Harper L,Karras A,Vaglio A,de Zoysa J,Bruijn JA,Bajema IM

更新日期：2019-06-26 00:00:00

abstract：:Hemagglutinin glycoprotein (HA) is a principle influenza vaccine antigen. Recombinant HA-based vaccines become a potential alternative for traditional approach. Complexity and variation of HA N-glycosylation are considered as the important factors for the vaccine design. The number and location of glycan moieties in t...

journal_title：Frontiers in immunology

authors： Macioła AK,Pietrzak MA,Kosson P,Czarnocki-Cieciura M,Śmietanka K,Minta Z,Kopera E

更新日期：2017-04-20 00:00:00

abstract：:Both CD4+ and CD8+ Tregs play a critical role in the control of immune responses and immune tolerance; however, our understanding of CD8+ Tregs is limited while they are particularly promising for therapeutic application. We report here existence of highly suppressive human CD8+CD45RClow/- Tregs expressing Foxp3 and p...

journal_title：Frontiers in immunology

authors： Bézie S,Meistermann D,Boucault L,Kilens S,Zoppi J,Autrusseau E,Donnart A,Nerrière-Daguin V,Bellier-Waast F,Charpentier E,Duteille F,David L,Anegon I,Guillonneau C

更新日期：2018-01-31 00:00:00

abstract：:The so-called shock and kill therapies aim to combine HIV-1 reactivation by latency-reversing agents (LRA) with immune clearance to purge the HIV-1 reservoir. The clinical use of LRA has demonstrated detectable perturbations in the HIV-1 reservoir without measurable reductions to date. Consequently, fundamental questi...

journal_title：Frontiers in immunology

authors： Ruiz A,Blanch-Lombarte O,Jimenez-Moyano E,Ouchi D,Mothe B,Peña R,Galvez C,Genescà M,Martinez-Picado J,Goulder P,Barnard R,Howell B,Clotet B,Prado JG

更新日期：2019-01-22 00:00:00

abstract：:Leishmaniasis is the third most important vector-borne disease worldwide. Visceral leishmaniasis (VL) is a severe and frequently lethal protozoan disease of increasing incidence and severity due to infected human and dog migration, new geographical distribution of the insect due to global warming, coinfection with imm...

journal_title：Frontiers in immunology

authors： Palatnik-de-Sousa CB

更新日期：2012-04-17 00:00:00

abstract：:Disturbed homeostasis as a result of tissue stress can provoke leukocyte responses enabling recovery. Since mild hypothermia displays specific clinically relevant tissue-protective properties and interleukin (IL)-22 promotes healing at host/environment interfaces, effects of lowered ambient temperature on IL-22 were s...

journal_title：Frontiers in immunology

authors： Chichelnitskiy E,Himmelseher B,Bachmann M,Pfeilschifter J,Mühl H

更新日期：2017-06-29 00:00:00

abstract：:The development of autoimmunity involves complex interactions between genetics and environmental triggers. The gut microbiota is an important environmental constituent that can heavily influence both local and systemic immune reactivity through distinct mechanisms. It is therefore a relevant environmental trigger or a...

journal_title：Frontiers in immunology

authors： Brown J,Robusto B,Morel L

更新日期：2020-08-04 00:00:00

abstract：:Monocyte differentiation to macrophages is triggered by migration across the endothelial barrier, which is constituted by both endothelial cells and their underlying basement membrane. We address here the role of the endothelial basement membrane laminins (laminins 411 and 511) in this monocyte to macrophage switch. C...

journal_title：Frontiers in immunology

authors： Li L,Song J,Chuquisana O,Hannocks MJ,Loismann S,Vogl T,Roth J,Hallmann R,Sorokin L

更新日期：2020-10-30 00:00:00

abstract：:Intralesional Mycobacterium bovis bacillus Calmette-Guérin (BCG) has long been a relatively inexpensive therapy for inoperable cutaneous metastatic melanoma (CMM), although intralesional BCG skin mechanisms remain understudied. We analyzed intralesional BCG-treated CMM lesions combined with in vitro studies to further...

journal_title：Frontiers in immunology

authors： Lardone RD,Chan AA,Lee AF,Foshag LJ,Faries MB,Sieling PA,Lee DJ

更新日期：2017-08-11 00:00:00

abstract：:Two decades of clinical cancer research with dendritic cell (DC)-based vaccination have proved that this type of personalized medicine is safe and has the capacity to improve survival, but monotherapy is unlikely to cure the cancer. Designed to empower the patient's antitumor immunity, huge research efforts are set to...

journal_title：Frontiers in immunology

authors： Versteven M,Van den Bergh JMJ,Marcq E,Smits ELJ,Van Tendeloo VFI,Hobo W,Lion E

更新日期：2018-03-01 00:00:00

abstract：:Regulatory T cells (Tregs) play an important role by controlling allergic inflammation of airways. Recently, it has been shown that statins have immunomodulatory properties, probably mediated by their effects on Tregs. Therefore, we evaluated the in vivo effect of atorvastatin (ATV) on Tregs and its association with t...

journal_title：Frontiers in immunology

authors： Blanquiceth Y,Rodríguez-Perea AL,Tabares Guevara JH,Correa LA,Sánchez MD,Ramírez-Pineda JR,Velilla PA

更新日期：2016-12-21 00:00:00

abstract：:Duck plague virus (DPV) is a representative pathogen transmitted among aquatic animals that causes gross lesions and immune inhibition in geese and ducks. The mechanism of organ tropism and innate immune evasion of DPV has not been completely deciphered due to a lack of cell models to study the innate immune manipulat...

journal_title：Frontiers in immunology

authors： Tian B,Cai D,He T,Deng L,Wu L,Wang M,Jia R,Zhu D,Liu M,Yang Q,Wu Y,Zhao X,Chen S,Zhang S,Huang J,Ou X,Mao S,Yu Y,Zhang L,Liu Y,Cheng A

更新日期：2020-01-28 00:00:00

abstract：:Because Peyer's patches (PP) are the main inductive sites for gut IgA responses we have focused this review on what we know about the function of PP germinal centers (GC). The vast majority of IgA gene sequences in the gut lamina propria (LP) are heavily mutated arguing for an origin in GC. Because PP GC formation is ...

journal_title：Frontiers in immunology

authors： Lycke NY,Bemark M

更新日期：2012-11-07 00:00:00