Refractory Chronic Spontaneous Urticaria Treated With Omalizumab in an Adolescent With Common Variable Immunodeficiency.

abstract：:The last decade has seen much progress in adjunctive cell therapy for immune disorders. Both corporate and institutional Phase III studies have been run using mesenchymal stromal cells (MSC) for treatment of Graft versus Host Disease (GvHD), and product approval has been achieved for treatment of pediatric GvHD in Can...

journal_title：Frontiers in immunology

authors： Vaes B,Van't Hof W,Deans R,Pinxteren J

更新日期：2012-11-27 00:00:00

abstract：:Antigen-specific CD8+ tissue-resident memory T cells (TRM cells) persist in the lung following resolution of a respiratory virus infection and provide first-line defense against reinfection. In contrast to other memory T cell populations, such as central memory T cells that circulate between lymph and blood, and effec...

journal_title：Frontiers in immunology

authors： Takamura S,Kohlmeier JE

更新日期：2019-04-05 00:00:00

abstract：:Memory CD8+ T cells have long been considered a promising population for adoptive cell therapy (ACT) due to their long-term persistence and robust re-stimulatory response. NIH3T3 is an immortalized mouse embryonic fibroblast cell line. We report that NIH3T3-conditioned medium (CM) can augment effector functions of CTL...

journal_title：Frontiers in immunology

authors： Qin Y,Lee Y,Seo J,Kim T,Shin JH,Park SH

更新日期：2019-04-11 00:00:00

abstract：:Background: Characterization of the intracellular biochemical processes that regulate the generation and maintenance of effector and memory CD8+ T-cells from naïve precursors is essential for our understanding of adaptive immune responses and the development of immunotherapies. However, the metabolic determinants of a...

journal_title：Frontiers in immunology

authors： Nicoli F,Papagno L,Frere JJ,Cabral-Piccin MP,Clave E,Gostick E,Toubert A,Price DA,Caputo A,Appay V

更新日期：2018-12-21 00:00:00

abstract：Background:Human pregnancy alters profoundly the immune system. The local involvement and mechanisms of activation of the complement system in the cervicovaginal milieu during pregnancy and delivery remain unexplored. Objectives:To determine whether normal pregnancy and delivery are associated with local activation of...

journal_title：Frontiers in immunology

authors： Livson S,Jarva H,Kalliala I,Lokki AI,Heikkinen-Eloranta J,Nieminen P,Meri S

更新日期：2021-01-11 00:00:00

abstract：:Prolonged shedding of viral RNA occurs in some individuals following SARS-CoV-2 infection. We perform comprehensive immunologic evaluation of one individual with prolonged shedding. The case subject recovered from severe COVID-19 and tested positive for SARS-CoV-2 viral RNA repeatedly as many as 87 days after the firs...

journal_title：Frontiers in immunology

authors： Turner JS,Day A,Alsoussi WB,Liu Z,O'Halloran JA,Presti RM,Patterson BK,Whelan SPJ,Ellebedy AH,Mudd PA

更新日期：2021-01-08 00:00:00

abstract：:Migration of human plasmablast to the bone marrow is essential for the final differentiation of plasma cells and maintenance of effective humoral immunity. This migration is controlled by CXCL12/CXCR4-mediated activation of the protein kinase AKT. Herein, we show that the CXCL12-induced migration of human plasmablasts...

journal_title：Frontiers in immunology

authors： Pak HK,Nam B,Lee YK,Kim YW,Roh J,Son J,Chung YS,Choe J,Park CS

更新日期：2018-07-27 00:00:00

abstract：:The neonatal Fc receptor (FcRn) plays key roles in IgG and albumin homeostasis, maternal IgG transport, and antigen presentation of IgG-opsonized antigens. Previously, we reported that transgenic (Tg) mice that overexpress the bovine FcRn (bFcRn) have augmented T-dependent humoral immune response with increased IgG pr...

journal_title：Frontiers in immunology

authors： Schneider Z,Jani PK,Szikora B,Végh A,Kövesdi D,Iliás A,Cervenak J,Balogh P,Kurucz I,Kacskovics I

更新日期：2015-07-20 00:00:00

abstract：:Tuberculosis (TB) is a major health issue globally. Although typically the disease can be cured by chemotherapy in all age groups, and prevented in part in newborn by vaccination, general consensus exists that development of novel intervention measures requires better understanding of disease mechanisms. Human TB is c...

journal_title：Frontiers in immunology

authors： Dorhoi A,Iannaccone M,Maertzdorf J,Nouailles G,Weiner J 3rd,Kaufmann SH

更新日期：2014-02-05 00:00:00

abstract：:Inflammation plays vital roles in protective responses against pathogens and tissue repair, however, improper resolution of inflammatory networks is centrally involved in the pathogenesis of many acute and chronic diseases. Extensive advances have been made in recent years to define the inflammatory processes that are...

journal_title：Frontiers in immunology

authors： Lukens JR,Gross JM,Kanneganti TD

更新日期：2012-10-09 00:00:00

abstract：:Betaine is a critical nutrient for mammal health, and has been found to alleviate inflammation by lowering interleukin (IL)-1β secretion; however, the underlying mechanisms by which betaine inhibits IL-1β secretion remain to be uncovered. In this review, we summarize the current understanding about the mechanisms of b...

journal_title：Frontiers in immunology

authors： Xia Y,Chen S,Zhu G,Huang R,Yin Y,Ren W

更新日期：2018-11-20 00:00:00

abstract：Background and objectives:Mortality of patients on hemodialysis (HD) remains very high despite recent improvements in HD techniques. Cardiovascular (CV) complications and infections are the main causes of death. Some studies suggest that disturbances in the immune system could play a role in this disproportionate morta...

journal_title：Frontiers in immunology

authors： Molina M,Allende LM,Ramos LE,Gutiérrez E,Pleguezuelo DE,Hernández ER,Ríos F,Fernández C,Praga M,Morales E

更新日期：2018-06-15 00:00:00

abstract：:Among interferon (IFN) inducible antiviral factors both tripartite motif-containing protein 22 (TRIM22) and class II transactivator (CIITA) share the capacity of repressing human immunodeficiency virus type 1 (HIV-1) proviral transcription. TRIM22 is constitutively expressed in a subset of U937 cell clones poorly perm...

journal_title：Frontiers in immunology

authors： Forlani G,Tosi G,Turrini F,Poli G,Vicenzi E,Accolla RS

更新日期：2017-05-15 00:00:00

abstract：:Blood-feeding enriched gut-microbiota boosts mosquitoes' anti-Plasmodium immunity. Here, we ask how Plasmodium vivax alters gut-microbiota, anti-Plasmodial immunity, and impacts tripartite Plasmodium-mosquito-microbiota interactions in the gut lumen. We used a metagenomics and RNAseq strategy to address these question...

journal_title：Frontiers in immunology

authors： Sharma P,Rani J,Chauhan C,Kumari S,Tevatiya S,Das De T,Savargaonkar D,Pandey KC,Dixit R

更新日期：2020-05-14 00:00:00

abstract：:In the last two decades, extracellular vesicles (EVs) have aroused wide interest among researchers in basic and clinical research. EVs, small membrane vesicles are released by almost all kinds of cells into the extracellular environment. According to many recent studies, EVs participate in immunomodulation and play an...

journal_title：Frontiers in immunology

authors： Zhang B,Zhao M,Lu Q

更新日期：2021-01-14 00:00:00

abstract：:Tumor necrosis factor receptor-associated factor (TRAF) proteins are key signaling molecules that function in various cellular signaling events including immune response, cell death and survival, development, and thrombosis. Their roles in cellular signaling are mediated mostly by direct interactions with various rece...

journal_title：Frontiers in immunology

authors： Park HH

更新日期：2018-08-30 00:00:00

abstract：:Multiple sclerosis is a chronic auto-inflammatory disease of the central nervous system affecting patients worldwide. Neuroinflammation in multiple sclerosis is mainly driven by peripheral immune cells which invade the central nervous system and cause neurodegenerative inflammation. To enter the target tissue, immune ...

journal_title：Frontiers in immunology

authors： Zondler L,Herich S,Kotte P,Körner K,Schneider-Hohendorf T,Wiendl H,Schwab N,Zarbock A

更新日期：2020-12-14 00:00:00

abstract：:Systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS) are two autoimmune diseases that can occur together or separately. Insights into the pathogenesis have revealed similarities, such as development of autoantibodies targeting subcellular antigens as well as a shared increased risk of cardiovascular ...

journal_title：Frontiers in immunology

authors： Wirestam L,Arve S,Linge P,Bengtsson AA

更新日期：2019-11-22 00:00:00

abstract：:Tissue-resident phagocytes are responsible for the routine binding, engulfment, and resolution of their meals. Such populations of cells express appropriate surface receptors that are tailored to recognize the phagocytic targets of their niche and initiate the actin polymerization that drives internalization. Tissue-r...

journal_title：Frontiers in immunology

authors： Kwon W,Freeman SA

更新日期：2020-11-13 00:00:00

abstract：:Vaccines aiming to promote T-cell-mediated immune responses have so far showed limited efficacy, and there is a need for novel strategies. Studies indicate that autophagy plays an inherent role in antigen processing and presentation for CD4(+) and CD8(+) T cells. Here, we report a novel vaccine strategy based on fusio...

journal_title：Frontiers in immunology

authors： Andersen AN,Landsverk OJ,Simonsen A,Bogen B,Corthay A,Øynebråten I

更新日期：2016-05-10 00:00:00

abstract：:Clostridium difficile infection (CDI) is the leading cause of world-wide nosocomial acquired diarrhea in adults. Active vaccination is generally accepted as a logical and cost-effective approach to prevent CDI. In this paper, we have generated two novel chimeric proteins; one designated Tcd169, comprised of the glucos...

journal_title：Frontiers in immunology

authors： Wang S,Wang Y,Cai Y,Kelly CP,Sun X

更新日期：2018-10-22 00:00:00

abstract：:Anaphylaxis in humans is inherently difficult to study due to the acuteness of symptoms and the lack of biomarkers serving as risk predictors. Most cases are related to IgE sensitizations to foods, insect venoms, and drugs with mastocytosis patients forming a smaller risk group. However, identifying the relatively sma...

journal_title：Frontiers in immunology

authors： Poulsen LK,Jensen BM,Esteban V,Garvey LH

更新日期：2017-08-10 00:00:00

abstract：:The barrier surfaces of the gastrointestinal tract are in constant contact with various microorganisms. Cytokines orchestrate the mucosal adaptive and innate immune cells in the defense against pathogens. IL-10 and IL-22 are the best studied members of the IL-10 family and play essential roles in maintaining mucosal h...

journal_title：Frontiers in immunology

authors： Wei HX,Wang B,Li B

更新日期：2020-06-26 00:00:00

abstract：:Allograft rejection constitutes a major complication of solid organ transplantation requiring prophylactic/therapeutic immunosuppression, which increases susceptibility of patients to infections and cancer. Beyond the pivotal role of alloantigen-specific T cells and antibodies in the pathogenesis of rejection, natural...

journal_title：Frontiers in immunology

authors： López-Botet M,Vilches C,Redondo-Pachón D,Muntasell A,Pupuleku A,Yélamos J,Pascual J,Crespo M

更新日期：2017-02-16 00:00:00

abstract：:The main environmental risk factor associated with the development of Crohn's disease (CD) is cigarette smoking. Although the mechanism is still unknown, some studies have shown that cigarette exposure affects the intestinal barrier of the small bowel. Among the factors that may be involved in this process are Paneth ...

journal_title：Frontiers in immunology

authors： Berkowitz L,Pardo-Roa C,Salazar GA,Salazar-Echegarai F,Miranda JP,Ramírez G,Chávez JL,Kalergis AM,Bueno SM,Álvarez-Lobos M

更新日期：2019-09-25 00:00:00

abstract：:The cyclic AMP/protein kinase A (cAMP/PKA) pathway is one of the most common and versatile signal pathways in eukaryotic cells. A-kinase anchoring proteins (AKAPs) target PKA to specific substrates and distinct subcellular compartments providing spatial and temporal specificity for mediation of biological effects chan...

journal_title：Frontiers in immunology

authors： Wehbi VL,Taskén K

更新日期：2016-06-08 00:00:00

abstract：:Common variable immunodeficiency (CVID) is one of the most common and clinically important primary immune deficiencies. CVID patients have poor humoral immunity, resulting in recurrent infections of the gastrointestinal and upper respiratory tracts, as well as increased incidence of some forms of cancers and autoimmun...

journal_title：Frontiers in immunology

authors： Paquin-Proulx D,Sandberg JK

更新日期：2014-12-16 00:00:00

abstract：:Immune checkpoint inhibitors that block the programmed cell death protein 1/PD-L1 pathway have significantly improved the survival of patients with advanced melanoma. Immunotherapies are only effective in 15-40% of melanoma patients and resistance is associated with defects in antigen presentation and interferon signa...

journal_title：Frontiers in immunology

authors： Alavi S,Stewart AJ,Kefford RF,Lim SY,Shklovskaya E,Rizos H

更新日期：2018-06-21 00:00:00

abstract：:Cytokines are major players regulating immune responses toward inflammatory and tolerogenic results. In organ and bone marrow transplantation, new reagents are needed to inhibit tissue destructive mechanisms and eventually induce immune tolerance without overall immunosuppression. IL-34 is a cytokine with no significa...

journal_title：Frontiers in immunology

authors： Bézie S,Freuchet A,Sérazin C,Salama A,Vimond N,Anegon I,Guillonneau C

更新日期：2020-08-11 00:00:00

abstract：:The apparition of adaptive immunity in Gnathostomata correlates with the expansion of the E-protein family to encompass E2-2, HEB, and E2A. Within the family, E2-2 and HEB are more closely evolutionarily related but their concerted action in hematopoiesis remains to be explored. Here we show that the combined disrupti...

journal_title：Frontiers in immunology

authors： Bouderlique T,Peña-Pérez L,Kharazi S,Hils M,Li X,Krstic A,De Paepe A,Schachtrup C,Gustafsson C,Holmberg D,Schachtrup K,Månsson R

更新日期：2019-03-18 00:00:00