Novel Chimeric Protein Vaccines Against Clostridium difficile Infection.

abstract：:Uncontrolled activation of transforming growth factor (TGF)-β results in a wide range of pathologic conditions. Therapeutic interventions to regulate TGF-β signaling during fibrosis have been developed but the effectiveness is still limited. Here, we show that developmental endothelial locus-1 (Del-1) ameliorates fibr...

journal_title：Frontiers in immunology

authors： Kim DY,Lee SH,Fu Y,Jing F,Kim WY,Hong SB,Song JA,Choe H,Ryu HJ,Kim M,Lim D,Kim MS,Yun CO,Lee T,Hyun H,Choi EY

更新日期：2020-02-07 00:00:00

abstract：:Natural killer (NK) cells contribute to immunosurveillance and first-line defense in the control of tumor growth and metastasis diffusion. NK-cell-derived extracellular vesicles (NKEVs) are constitutively secreted and biologically active. They reflect the protein and genetic repertoire of originating cells, and exert ...

journal_title：Frontiers in immunology

authors： Federici C,Shahaj E,Cecchetti S,Camerini S,Casella M,Iessi E,Camisaschi C,Paolino G,Calvieri S,Ferro S,Cova A,Squarcina P,Bertuccini L,Iosi F,Huber V,Lugini L

更新日期：2020-03-13 00:00:00

abstract：:Signaling through Toll-like receptor 7 (TLR7) drives the production of type I IFN and promotes the activation of autoreactive B cells and is implicated in the pathogenesis of systemic lupus erythematosus (SLE). While TLR7 has been extensively studied in murine lupus, much less is known about its role in the pathogenes...

journal_title：Frontiers in immunology

authors： Wang T,Marken J,Chen J,Tran VB,Li QZ,Li M,Cerosaletti K,Elkon KB,Zeng X,Giltiay NV

更新日期：2019-06-04 00:00:00

abstract：:Major trauma-induced tissue injury causes a dysregulation of the immune system. Severe systemic inflammation occurs early after the insult. Later on, an enhanced risk for life-threatening opportunistic infections develops that culminates at the end of the first week after trauma. CD56bright Natural killer (NK) cells p...

journal_title：Frontiers in immunology

authors： Bösken B,Hepner-Schefczyk M,Vonderhagen S,Dudda M,Flohé SB

更新日期：2020-06-25 00:00:00

abstract：:According to the "two-step model," the intrathymic generation of CD4⁺ regulatory T (T(reg)) cells segregates into a first, T cell receptor (TCR)-driven phase and a second, cytokine-dependent phase. The initial TCR stimulus gives rise to a CD25⁺Foxp3⁻ developmental intermediate. These precursors subsequently require cy...

journal_title：Frontiers in immunology

authors： Hinterberger M,Wirnsberger G,Klein L

更新日期：2011-07-25 00:00:00

abstract：:Disease suppressive T cell regulation may depend on cognate interactions of regulatory T cells with self-antigens that are abundantly expressed in the inflamed tissues. Heat shock proteins (HSPs) are by their nature upregulated in stressed cells and therefore abundantly present as potential targets for such regulation...

journal_title：Frontiers in immunology

authors： van Eden W,Jansen MAA,de Wolf ACM,Ludwig IS,Leufkens P,Broere F

更新日期：2017-11-30 00:00:00

abstract：:Mild modification of intravenous immunoglobulin (IVIG) has been reported to result in enhanced polyspecificity and leveraged therapeutic effects in animal models of inflammation. Here, we observed that IVIG modification by ferrous ions, heme or low pH exposure, shifted the repertoires of specificities in different dir...

journal_title：Frontiers in immunology

authors： Graeter S,Schneider C,Verschoor D,von Däniken S,Seibold F,Yawalkar N,Villiger P,Dimitrov JD,Smith DF,Cummings RD,Simon HU,Vassilev T,von Gunten S

更新日期：2020-05-19 00:00:00

abstract：:The pathogenesis of many retinal degenerations, such as age-related macular degeneration (AMD), is punctuated by an ill-defined network of sterile inflammatory responses. The delineation of innate and adaptive immune milieu among the broad leukocyte infiltrate, and the gene networks, which construct these responses, a...

journal_title：Frontiers in immunology

authors： Natoli R,Mason E,Jiao H,Chuah A,Patel H,Fernando N,Valter K,Wells CA,Provis J,Rutar M

更新日期：2018-07-18 00:00:00

abstract：:COVID-19 is a distinctive infection characterized by elevated inter-human transmission and presenting from absence of symptoms to severe cytokine storm that can lead to dismal prognosis. Like for HIV, lymphopenia and drastic reduction of CD4+ T cell counts in COVID-19 patients have been linked with poor clinical outco...

journal_title：Frontiers in immunology

authors： Peng X,Ouyang J,Isnard S,Lin J,Fombuena B,Zhu B,Routy JP

更新日期：2020-12-15 00:00:00

abstract：:TILRR (Toll-like interleukin-1 receptor regulator), a transcript variant of FREM1, is a novel regulatory component, which stimulates innate immune responses through binding to IL-1R1 (Interleukin-1 receptor, type 1) and TLR (Toll-like receptor) complex. However, it is not known whether TILRR expression influences othe...

journal_title：Frontiers in immunology

authors： Kashem MA,Li H,Toledo NP,Omange RW,Liang B,Liu LR,Li L,Yang X,Yuan XY,Kindrachuk J,Plummer FA,Luo M

更新日期：2019-02-28 00:00:00

abstract：:Pathogenic bacteria possess intricate regulatory networks that temporally control the production of virulence factors and enable the bacteria to survive and proliferate within host cell. Small non-coding RNAs (sRNAs) have been identified as important regulators of gene expression in diverse biological contexts. Recent...

journal_title：Frontiers in immunology

authors： Ahmed W,Zheng K,Liu ZF

更新日期：2016-10-18 00:00:00

abstract：:Cervical cancer remains a global health burden despite the introduction of highly effective vaccines for the prophylaxis of causative human papillomavirus infection (HPV). Current efforts to eradicate cervical cancer focus on the development of broadly protective, cost-effective approaches. HPV minor capsid protein L2...

journal_title：Frontiers in immunology

authors： Yang F,Mariz FC,Zhao X,Spagnoli G,Ottonello S,Müller M

更新日期：2020-12-04 00:00:00

abstract：:CD1d-restricted invariant natural killer T (iNKT) cells are innate-like T cells that express an invariant T cell receptor (TCR) α-chain and recognize self and foreign glycolipid antigens. They can rapidly respond to agonist activation and stimulate an extensive array of immune responses. Thymic development and functio...

journal_title：Frontiers in immunology

authors： Yang G,Driver JP,Van Kaer L

更新日期：2018-11-14 00:00:00

abstract：:Human Campylobacter infections are progressively rising and of high socioeconomic impact. In the present preclinical intervention study we investigated anti-pathogenic, immuno-modulatory, and intestinal epithelial barrier preserving properties of vitamin D applying an acute campylobacteriosis model. Therefore, seconda...

journal_title：Frontiers in immunology

authors： Mousavi S,Lobo de Sá FD,Schulzke JD,Bücker R,Bereswill S,Heimesaat MM

更新日期：2019-09-03 00:00:00

abstract：:Therapeutic approaches that engage immune cells to treat cancer are becoming increasingly utilized in the clinics and demonstrated durable clinical benefit in several solid tumor types. Most of the current immunotherapies focus on manipulating T cells, however, the tumor microenvironment (TME) is abundantly infiltrate...

journal_title：Frontiers in immunology

authors： Clappaert EJ,Murgaski A,Van Damme H,Kiss M,Laoui D

更新日期：2018-10-08 00:00:00

abstract：:Regulatory T cells (Tregs) are considered key players in the prevention of allograft rejection in transplanted patients. Belatacept (BLT) is an effective alternative to calcineurin inhibitors that appears to preserve graft survival and function; however, the impact of this drug in the homeostasis of Tregs in transplan...

journal_title：Frontiers in immunology

authors： Alvarez Salazar EK,Cortés-Hernández A,Alemán-Muench GR,Alberú J,Rodríguez-Aguilera JR,Recillas-Targa F,Chagoya de Sánchez V,Cuevas E,Mancilla-Urrea E,Pérez García M,Mondragón-Ramírez G,Vilatobá M,Bostock I,Hernández-Méndez E,

更新日期：2017-03-03 00:00:00

abstract：:Sensing of microbe-associated molecular patterns or danger signals by innate immune receptors drives a complex exchange of information. Innate receptor signaling not only triggers transcriptional events but also induces profound changes in metabolic fluxes, redox balance, and metabolite abundance thereby influencing i...

journal_title：Frontiers in immunology

authors： Sancho D,Enamorado M,Garaude J

更新日期：2017-05-08 00:00:00

abstract：:Multiple sclerosis (MS) is assumed to be an autoimmune disease initiated by autoreactive T cells that recognize central nervous system antigens. Although adaptive immunity is clearly involved in MS pathogenesis, innate immunity increasingly appears to be implicated in the disease. We and others have presented evidence...

journal_title：Frontiers in immunology

authors： Chanvillard C,Jacolik RF,Infante-Duarte C,Nayak RC

更新日期：2013-03-13 00:00:00

abstract：:There have been exhaustive efforts to develop an efficient vaccine against leishmaniasis. Factors like host and parasite genetic characteristics, virulence, epidemiological scenarios, and, mainly, diverse immune responses triggered by Leishmania species make the achievement of this aim a complex task. It is already cl...

journal_title：Frontiers in immunology

authors： De Luca PM,Macedo AB

更新日期：2016-04-21 00:00:00

abstract：:Schnitzler syndrome (SchS) is a rare autoinflammatory disease, characterized by urticarial rash, recurrent fever, osteo-articular pain/arthritis with bone condensation, and monoclonal gammopathy. Diagnosis may be difficult due to overlapping signs with other diseases. Here, we describe the case of a 62-year-old man wi...

journal_title：Frontiers in immunology

authors： Hodl I,Bosch P,Dreo B,Stradner MH

更新日期：2020-09-30 00:00:00

abstract：:Borrelia burgdorferi sensu lato species complex is capable of establishing persistent infections in a wide variety of species, particularly rodents. Infection is asymptomatic or mild in most reservoir host species, indicating successful co-evolution of the pathogen with its natural hosts. However, infected humans and ...

journal_title：Frontiers in immunology

authors： Tracy KE,Baumgarth N

更新日期：2017-02-20 00:00:00

abstract：:The salivary scavenger and agglutinin (SALSA), also known as gp340, salivary agglutinin and deleted in malignant brain tumor 1, is a 340-kDa glycoprotein expressed on mucosal surfaces and secreted into several body fluids. SALSA binds to a broad variety of microbes and endogenous ligands, such as complement factor C1q...

journal_title：Frontiers in immunology

authors： Reichhardt MP,Loimaranta V,Thiel S,Finne J,Meri S,Jarva H

更新日期：2012-07-16 00:00:00

abstract：:Elevated serum amyloid A (SAA) levels may promote endothelial dysfunction, which is linked to cardiovascular and renal pathologies. We investigated the effect of SAA on vascular and renal function in apolipoprotein E-deficient (ApoE-/-) mice. Male ApoE-/- mice received vehicle (control), low-level lipopolysaccharide (...

journal_title：Frontiers in immunology

authors： Chami B,Hossain F,Hambly TW,Cai X,Aran R,Fong G,Vellajo A,Martin NJJ,Wang X,Dennis JM,Sharma A,Shihata WA,Chin-Dusting JPF,de Haan JB,Sharland A,Geczy CL,Freedman B,Witting PK

更新日期：2019-03-07 00:00:00

abstract：:We have recently designed a soluble synthetic peptide that functionally mimics the HIV-1 coreceptor CXCR4, which is a chemokine receptor that belongs to the family of seven-transmembrane GPCRs. This CXCR4 mimetic peptide, termed CX4-M1, presents the three extracellular loops (ECLs) of the receptor. In binding assays i...

journal_title：Frontiers in immunology

authors： Groß A,Möbius K,Haußner C,Donhauser N,Schmidt B,Eichler J

更新日期：2013-09-03 00:00:00

abstract：:Among kidney transplant recipients, the treatment of choice for acute T cell-mediated rejection (TCMR) with pulse steroids or antibody protocols has variable outcomes. Some rejection episodes are resistant to an initial steroid pulse, but respond to subsequent antibody protocols. The biological mechanisms causing the ...

journal_title：Frontiers in immunology

authors： Kadota PO,Hajjiri Z,Finn PW,Perkins DL

更新日期：2015-11-06 00:00:00

abstract：:Human pathogen Campylobacter jejuni is a significant risk factor for the development of long-term intestinal dysfunction although the cellular and molecular mechanisms remain scantily defined. IL-23 is an emerging therapeutic target for the treatment of inflammatory intestinal diseases, however its role in C. jejuni-d...

journal_title：Frontiers in immunology

authors： Jing X,Korchagina AA,Shein SA,Muraoka WT,Koroleva E,Tumanov AV

更新日期：2021-01-06 00:00:00

abstract：:Background: The relationship between SARS-CoV-2-carrying time and specific antibody production has not yet been reported in re-admitted COVID-19 patients. We reported a case of mild COVID-19 with long virus-carrying time, weak production of virus-specific IgG and IgM antibodies, and recurrence of positive SARS-CoV-2 R...

journal_title：Frontiers in immunology

authors： Guo X,Zeng L,Huang Z,He Y,Zhang Z,Zhong Z

更新日期：2020-08-07 00:00:00

abstract：:The progressive infiltration of immune cells is associated with the progression of melanoma. Specifically, Th17 cells in melanoma microenvironment have both antitumor and protumor effects. It is now necessary to understand the contradictory data associated with how Th17 cells play a role in melanoma. This review will ...

journal_title：Frontiers in immunology

authors： Chen C,Gao FH

更新日期：2019-02-08 00:00:00

abstract：:Background: Sex differences in immune responses to influenza vaccine may impact efficacy across populations. Methods: In a cohort of 138 older adults (50-74 years old), we measured influenza A/H1N1 antibody titers, B-cell ELISPOT response, PBMC transcriptomics, and PBMC cell compositions at 0, 3, and 28 days post-immu...

journal_title：Frontiers in immunology

authors： Voigt EA,Ovsyannikova IG,Kennedy RB,Grill DE,Goergen KM,Schaid DJ,Poland GA

更新日期：2019-02-27 00:00:00

abstract：:Epithelial damage and loss of intestinal barrier function are hallmark pathologies of the mucosal inflammation associated with conditions such as inflammatory bowel disease. In order to resolve inflammation and restore intestinal integrity the mucosa must rapidly and effectively repair the epithelial barrier. Epitheli...

journal_title：Frontiers in immunology

authors： Goggins BJ,Chaney C,Radford-Smith GL,Horvat JC,Keely S

更新日期：2013-09-11 00:00:00