High TLR7 Expression Drives the Expansion of CD19+CD24hiCD38hi Transitional B Cells and Autoantibody Production in SLE Patients.

abstract：:There have been exhaustive efforts to develop an efficient vaccine against leishmaniasis. Factors like host and parasite genetic characteristics, virulence, epidemiological scenarios, and, mainly, diverse immune responses triggered by Leishmania species make the achievement of this aim a complex task. It is already cl...

journal_title：Frontiers in immunology

authors： De Luca PM,Macedo AB

更新日期：2016-04-21 00:00:00

abstract：:As MSC products move from early development to clinical translation, culture conditions shift from xeno- to xeno-free systems. However, the impact of isolation and culture-expansion methods on the long-term resiliency of MSCs within challenging transplant environments is not fully understood. Recent work in our lab ha...

journal_title：Frontiers in immunology

authors： Boland LK,Burand AJ,Boyt DT,Dobroski H,Di L,Liszewski JN,Schrodt MV,Frazer MK,Santillan DA,Ankrum JA

更新日期：2019-05-10 00:00:00

abstract：:The Bacillus Calmette-Guérin (BCG) is a live attenuated tuberculosis vaccine that has the ability to induce non-specific cross-protection against pathogens that might be unrelated to the target disease. Vaccination with BCG reduces mortality in newborns and induces an improved innate immune response against microorgan...

journal_title：Frontiers in immunology

authors： Covián C,Fernández-Fierro A,Retamal-Díaz A,Díaz FE,Vasquez AE,Lay MK,Riedel CA,González PA,Bueno SM,Kalergis AM

更新日期：2019-11-29 00:00:00

abstract：:Immunotherapies based on natural killer (NK) cells are among the most promising therapies under development for the treatment of so far incurable forms of leukemia and other types of cancer. The importance of NK cells for the control of viral infections and cancer is supported among others by the findings that viruses...

journal_title：Frontiers in immunology

authors： Hofer E,Koehl U

更新日期：2017-07-12 00:00:00

abstract：Purpose:Patients with juvenile idiopathic arthritis (JIA) are prone to developing chronic anterior uveitis (JIA-U+). Although several risk factors for JIA-U+ have been identified, the underlying etiology is poorly understood. Histopathological studies demonstrate B cell infiltrates in eye tissues of patients with JIA-U...

journal_title：Frontiers in immunology

authors： Wennink RAW,Pandit A,Haasnoot AJW,Hiddingh S,Kalinina Ayuso V,Wulffraat NM,Vastert BJ,Radstake TRDJ,de Boer JH,Kuiper JJW

更新日期：2020-09-17 00:00:00

abstract：:Non-steroidal anti-inflammatory drugs (NSAIDs) induce ulcers in the gastrointestinal tract, including the stomach and small intestine. NSAID-induced gastric ulcers can be prevented by taking acid-neutralizing/inhibitory drugs and cytoprotective agents. In contrast, there are no medicines to control NSAID-induced small...

journal_title：Frontiers in immunology

authors： Park AM,Khadka S,Sato F,Omura S,Fujita M,Hsu DK,Liu FT,Tsunoda I

更新日期：2020-09-23 00:00:00

abstract：:Continued discoveries of negative regulators of inflammatory signaling provide detailed molecular insights into peripheral tolerance and anti-tumor immunity. Accumulating evidence indicates that peripheral tolerance is maintained at multiple levels of immune responses by negative regulators of proinflammatory signalin...

journal_title：Frontiers in immunology

authors： Guram K,Kim SS,Wu V,Sanders PD,Patel S,Schoenberger SP,Cohen EEW,Chen SY,Sharabi AB

更新日期：2019-03-18 00:00:00

abstract：:Aquaculture production of crustaceans (mainly shrimp and crabs) has expanded globally, but disease outbreaks and pathogenic infections have hampered production in the last two decades. As invertebrates, crustaceans lack an adaptive immune system and mainly defend and protect themselves using their innate immune system...

journal_title：Frontiers in immunology

authors： Huang Z,Aweya JJ,Zhu C,Tran NT,Hong Y,Li S,Yao D,Zhang Y

更新日期：2020-11-05 00:00:00

abstract：:Increasing evidence has revealed that the initiation and progression of breast cancer are greatly affected by the immune environment. Neutrophils are the most abundant leucocytes in circulation and act as the spearhead in inflammation, including in breast cancer. Circulating neutrophils are closely related to the prog...

journal_title：Frontiers in immunology

authors： Zhang W,Shen Y,Huang H,Pan S,Jiang J,Chen W,Zhang T,Zhang C,Ni C

更新日期：2020-08-07 00:00:00

abstract：:Monocytes that migrate into tissues during inflammatory episodes and differentiate to macrophages were previously classified as classically (M1) or alternatively (M2) activated macrophages, based on their exposure to different fate-determining mediators. These macrophage subsets display distinct molecular markers and ...

journal_title：Frontiers in immunology

authors： Ariel A,Serhan CN

更新日期：2012-01-31 00:00:00

abstract：:Mast cells are immune cells of the myeloid lineage and are present in connective tissues throughout the body. The activation and degranulation of mast cells significantly modulates many aspects of physiological and pathological conditions in various settings. With respect to normal physiological functions, mast cells ...

journal_title：Frontiers in immunology

authors： Krystel-Whittemore M,Dileepan KN,Wood JG

更新日期：2016-01-06 00:00:00

abstract：:Effector T cells exit the inflamed vasculature into an environment shaped by tissue-specific structural configurations and inflammation-imposed extrinsic modifications. Once within interstitial spaces of non-lymphoid tissues, T cells migrate in an apparent random, non-directional, fashion. Efficient T cell scanning of...

journal_title：Frontiers in immunology

authors： Gaylo A,Schrock DC,Fernandes NR,Fowell DJ

更新日期：2016-10-14 00:00:00

abstract：:Non-alcoholic fatty liver disease (NAFLD) is currently the most common liver disease worldwide, both in adults and children. It is characterized by an aberrant lipid storage in hepatocytes, named hepatic steatosis. Simple steatosis remains a benign process in most affected patients, while some of them develop superimp...

journal_title：Frontiers in immunology

authors： Meli R,Mattace Raso G,Calignano A

更新日期：2014-04-23 00:00:00

abstract：:Unlike mice and humans, porcine γδ T cells represent a prominent subset of T cells in blood and secondary lymphatic organs. GATA-3, T-bet and Eomesodermin (Eomes) are transcription factors with crucial functions in T-cell development and functional differentiation, but their expression has not been investigated in por...

journal_title：Frontiers in immunology

authors： Rodríguez-Gómez IM,Talker SC,Käser T,Stadler M,Reiter L,Ladinig A,Milburn JV,Hammer SE,Mair KH,Saalmüller A,Gerner W

更新日期：2019-03-11 00:00:00

abstract：:Memory B cells that are generated during an infection or following vaccination act as sentinels to guard against future infections. Upon repeat antigen exposure memory B cells differentiate into new antibody-secreting plasma cells to provide rapid and sustained protection. Some pathogens evade or suppress the humoral ...

journal_title：Frontiers in immunology

authors： Shah HB,Smith K,Wren JD,Webb CF,Ballard JD,Bourn RL,James JA,Lang ML

更新日期：2019-01-15 00:00:00

abstract：:Monoclonal antibody (mAb)-based therapeutics are the fastest growing class of human pharmaceuticals. They are typically IgG1 molecules with N-glycans attached to the N297 residue on crystallizable fragment (Fc). Different Fc glycoforms impact their effector function, pharmacokinetics, stability, aggregation, safety, a...

journal_title：Frontiers in immunology

authors： Li W,Zhu Z,Chen W,Feng Y,Dimitrov DS

更新日期：2017-11-13 00:00:00

abstract：:Induced expression of serum amyloid A (SAA) is a hallmark of many inflammatory diseases, but whether SAA exacerbates inflammation or protects tissues against injury remains unclear. In dextran sulfate sodium (DSS)-induced colitis, SAA3 is the predominant isoform of inducible SAA proteins that also include SAA1 and SAA...

journal_title：Frontiers in immunology

authors： Zhang G,Liu J,Wu L,Fan Y,Sun L,Qian F,Chen D,Ye RD

更新日期：2018-06-29 00:00:00

abstract：:Type 2 diabetes is a metabolic disorder characterized by persistently elevated glucose levels. There is no effective treatment strategy for this condition, and it poses a massive economic burden globally. Schistosoma soluble egg antigen (SEA)-induced immunomodulatory mechanisms have been reported in the treatment of a...

journal_title：Frontiers in immunology

authors： Tang CL,Yu XH,Li Y,Zhang RH,Xie J,Liu ZM

更新日期：2019-06-26 00:00:00

abstract：:Single trauma injuries or isolated fractures are often manageable and generally heal without complications. In contrast, high-energy trauma results in multi/poly-trauma injury patterns presenting imbalanced pro- and anti- inflammatory responses often leading to immune dysfunction. These injuries often exhibit delayed ...

journal_title：Frontiers in immunology

authors： Muire PJ,Mangum LH,Wenke JC

更新日期：2020-06-04 00:00:00

abstract：:Mucosal epithelia encounter both physicochemical and biological stress during their life and have evolved several mechanisms to deal with them, including regulation of immune cell functions. Stressed and damaged cells need to be cleared to control local inflammation and trigger tissue healing. Engagement of the activa...

journal_title：Frontiers in immunology

authors： Antonangeli F,Soriani A,Cerboni C,Sciumè G,Santoni A

更新日期：2017-11-20 00:00:00

abstract：:A hallmark of cystic fibrosis (CF) chronic respiratory disease is an extensive neutrophil infiltrate in the mucosa filling the bronchial lumen, starting early in life for CF infants. The genetic defect of the CF Transmembrane conductance Regulator (CFTR) ion channel promotes dehydration of the airway surface liquid, a...

journal_title：Frontiers in immunology

authors： Cabrini G,Rimessi A,Borgatti M,Lampronti I,Finotti A,Pinton P,Gambari R

更新日期：2020-08-04 00:00:00

abstract：Background:Allergic rhinitis is a common disorder that affects 10% to 40% of the population worldwide. Allergen immunotherapy (AIT) represents the only therapy that has the potential to resolve clinical symptoms of allergic rhinitis. However, up to 30% of patients do not respond to AIT. Biomarkers predicting the clinic...

journal_title：Frontiers in immunology

authors： Ma TT,Cao MD,Yu RL,Shi HY,Yan WJ,Liu JG,Pan C,Sun J,Wei QY,Wang DY,Wei JF,Wang XY,Yin JS

更新日期：2020-11-24 00:00:00

abstract：:Dendritic cell (DC)-based immunotherapies are being explored for over 20 years and found to be very safe. Most often, granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-4 (IL-4)-induced monocyte-derived DCs (moDCs) are being used, which have demonstrated some life-prolonging benefit to patients ...

journal_title：Frontiers in immunology

authors： Zeng Q,Zhou Y,Schwarz H

更新日期：2019-10-02 00:00:00

abstract：:In lymphocytes, immune receptor signals induce the rapid nuclear translocation of preformed cytosolic NFAT proteins. Along with co-stimulatory signals, persistent immune receptor signals lead to high levels of NFATc1/αA, a short NFATc1 isoform, in effector lymphocytes. Whereas NFATc1 is not expressed in plasma cells, ...

journal_title：Frontiers in immunology

authors： Muhammad K,Rudolf R,Pham DAT,Klein-Hessling S,Takata K,Matsushita N,Ellenrieder V,Kondo E,Serfling E

更新日期：2018-01-24 00:00:00

abstract：:Vaccination is one of the most cost-effective health interventions and, with the exception of water sanitization, no other action has had such a major effect in mortality reduction. Combined with other approaches, such as clean water, better hygiene, and health education, vaccination contributed to prevent millions of...

journal_title：Frontiers in immunology

authors： Vo HTM,Baudner BC,Sammicheli S,Iannacone M,D'Oro U,Piccioli D

更新日期：2018-04-09 00:00:00

abstract：:Cross-presentation of endocytosed antigen as peptide/class I major histocompatibility complex complexes plays a central role in the elicitation of CD8(+) T cell clones that mediate anti-viral and anti-tumor immune responses. While it has been clear that there are specific subsets of professional antigen presenting cel...

journal_title：Frontiers in immunology

authors： Compeer EB,Flinsenberg TW,van der Grein SG,Boes M

更新日期：2012-03-07 00:00:00

abstract：:Despite advances, identification and formulation of safe and effective vaccine for long-lasting protection against leishmaniasis is still inadequate. In this study, we have identified a novel antigen, leishmanial elongation factor-1α (EF1-α), as an immunodominant component of solubilized leishmanial membrane antigens ...

journal_title：Frontiers in immunology

authors： Sabur A,Bhowmick S,Chhajer R,Ejazi SA,Didwania N,Asad M,Bhattacharyya A,Sinha U,Ali N

更新日期：2018-01-30 00:00:00

abstract：:Osteocytes are terminally differentiated cells of the osteoblast lineage. They are involved in the regulation of bone remodeling by increasing osteoclast formation or decreasing bone formation by the secretion of the osteoblast inhibitor sclerostin. Monoclonal antibody anti-sclerostin, Romosozumab, has been developed ...

journal_title：Frontiers in immunology

authors： Toscani D,Bolzoni M,Ferretti M,Palumbo C,Giuliani N

更新日期：2018-10-24 00:00:00

abstract：:Malaria is a public health concern worldwide, and Togo has proven to be no exception. Effective approaches to provide information on biological insights for disease elimination are therefore a research priority. Local selection on malaria pathogens is due to multiple factors including host immunity. We undertook genom...

journal_title：Frontiers in immunology

authors： Kassegne K,Komi Koukoura K,Shen HM,Chen SB,Fu HT,Chen YQ,Zhou XN,Chen JH,Cheng Y

更新日期：2020-10-23 00:00:00

abstract：:Delivery of cell-associated antigen represents an important strategy for vaccination. While many experimental models have been developed in order to define the critical parameters for efficient cross-priming, few have utilized quantitative methods that permit the study of the endogenous repertoire. Comparing different...

journal_title：Frontiers in immunology

authors： Bouvier I,Jusforgues-Saklani H,Lim A,Lemaître F,Lemercier B,Auriau C,Nicola MA,Leroy S,Law HK,Bandeira A,Moon JJ,Bousso P,Albert ML

更新日期：2011-12-08 00:00:00