B7/CD28 in central tolerance: costimulation promotes maturation of regulatory T cell precursors and prevents their clonal deletion.

abstract：:In early human immunodeficiency virus (HIV) infection, the virus population escapes from multiple CD8(+) cell responses. The later an escape mutation emerges, the slower it outgrows its competition, i.e., the escape rate is lower. This pattern could indicate that the strength of the CD8(+) cell responses is waning, or...

journal_title：Frontiers in immunology

authors： Garcia V,Regoes RR

更新日期：2015-01-13 00:00:00

abstract：:Paclitaxel is a chemotherapeutic drug commonly used to treat different types of cancer. In addition to its antitumor effect, paclitaxel is also known to promote Toll-like receptor (TLR) 4-dependent inflammatory responses, which may lower its chemotherapeutic efficacy. However, it remains unclear whether paclitaxel is ...

journal_title：Frontiers in immunology

authors： Son S,Shim DW,Hwang I,Park JH,Yu JW

更新日期：2019-05-16 00:00:00

abstract：:In the current quest for a complete cure for HIV/AIDS, highly sensitive HIV-1 latency detection methods are critical to verify full viral eradication. Until now, the in vitro quantitative viral outgrowth assays (qVOA) have been the gold standard for assessing latent HIV-1 viral burden. However, these assays have been ...

journal_title：Frontiers in immunology

authors： Schmitt K,Akkina R

更新日期：2018-03-05 00:00:00

abstract：:Cholera toxin (CT) is one of most strong mucosal adjuvants, but it cannot be clinically used owing to its toxicity. The cytosolic A1 subunit of CT (CTA1) is the molecule responsible for its immunostimulatory activity, which increases the concentration of cyclic AMP and causes the induction of pro-inflammatory cytokine...

journal_title：Frontiers in immunology

authors： Kim MS,Yi EJ,Kim YI,Kim SH,Jung YS,Kim SR,Iwawaki T,Ko HJ,Chang SY

更新日期：2019-06-04 00:00:00

abstract：:Psoriatic arthritis (PsA) is an inflammatory arthritis, characterized by inflammation of entheses and synovium, leading to joint erosions and new bone formation. It affects 10-30% of patients with psoriasis, and has an estimated prevalence of approximately 1%. PsA is considered to be primarily an autoimmune disease, d...

journal_title：Frontiers in immunology

authors： Dolcino M,Pelosi A,Fiore PF,Patuzzo G,Tinazzi E,Lunardi C,Puccetti A

更新日期：2018-07-16 00:00:00

abstract：Background and objectives:Mortality of patients on hemodialysis (HD) remains very high despite recent improvements in HD techniques. Cardiovascular (CV) complications and infections are the main causes of death. Some studies suggest that disturbances in the immune system could play a role in this disproportionate morta...

journal_title：Frontiers in immunology

authors： Molina M,Allende LM,Ramos LE,Gutiérrez E,Pleguezuelo DE,Hernández ER,Ríos F,Fernández C,Praga M,Morales E

更新日期：2018-06-15 00:00:00

abstract：:Significant advances in our understanding of neutrophil biology were made in the past several years. The exciting discovery that neutrophils deploy neutrophil extracellular traps (NETs) to catch pathogens paved the way for a series of additional studies to define the molecular mechanisms of NET generation and the biol...

journal_title：Frontiers in immunology

authors： Rahman S,Gadjeva M

更新日期：2014-08-11 00:00:00

abstract：:Female sex hormones have long been suspected to have an effect on mast cell (MC) behavior. This assumption is based on the expression of hormone receptors in MCs as well as on the fact that many MC-related pathophysiological alterations have a different prevalence in females than in males. Further, serum IgE levels ar...

journal_title：Frontiers in immunology

authors： Zierau O,Zenclussen AC,Jensen F

更新日期：2012-06-19 00:00:00

abstract：:Have potential clues to an effective gonorrhea vaccine been lurking in international disease surveillance data for decades? While no clinically effective vaccines against gonorrhea have been developed we present direct and indirect evidence that a vaccine is not only possible, but may already exist. Experience from Cu...

journal_title：Frontiers in immunology

authors： Petousis-Harris H,Radcliff FJ

更新日期：2019-04-09 00:00:00

abstract：:The human bone marrow (BM) gives rise to all distinct blood cell lineages, including CD1c+ (cDC2) and CD141+ (cDC1) myeloid dendritic cells (DC) and monocytes. These cell subsets are also present in peripheral blood (PB) and lymphoid tissues. However, the difference between the BM and PB compartment in terms of differ...

journal_title：Frontiers in immunology

authors： van Leeuwen-Kerkhoff N,Lundberg K,Westers TM,Kordasti S,Bontkes HJ,Lindstedt M,de Gruijl TD,van de Loosdrecht AA

更新日期：2018-07-16 00:00:00

abstract：:In response to microenvironmental cues, macrophages undergo a profound phenotypic transformation acquiring distinct activation phenotypes ranging from pro-inflammatory (M1) to anti-inflammatory (M2). To study how activation phenotype influences phagocytosis and production of reactive oxygen species (ROS) mediated by r...

journal_title：Frontiers in immunology

authors： Mendoza-Coronel E,Ortega E

更新日期：2017-03-27 00:00:00

abstract：:The spectrum of clinical forms observed in leprosy and its pathogenesis are dictated by the host's immune response against Mycobacterium leprae, the etiological agent of leprosy. Previous results, based on metabolomics studies, demonstrated a strong relationship between clinical manifestations of leprosy and alteratio...

journal_title：Frontiers in immunology

authors： Silva CAM,Belisle JT

更新日期：2018-02-02 00:00:00

abstract：:Virus-specific CD4(+) T cells play a major role in viral infections, such as hepatitis C virus (HCV). Viral clearance is associated with vigorous and multi-specific CD4(+) T-cell responses, while chronic infection has been shown to be associated with weak or absent T-cell responses. Most of these studies have used fun...

journal_title：Frontiers in immunology

authors： Lokhande MU,Thimme R,Klenerman P,Semmo N

更新日期：2015-02-25 00:00:00

abstract：:T follicular helper CD4 cells (Tfh) are essential for the development and maintenance of germinal center (GC) reactions, a critical process that promotes the generation of long-lived high affinity humoral immunity. It is becoming increasingly evident that GC-Tfh cells are heterogeneous in nature with some cellular cha...

journal_title：Frontiers in immunology

authors： Velu V,Mylvaganam G,Ibegbu C,Amara RR

更新日期：2018-06-06 00:00:00

abstract：:Dendritic cells (DCs) are antigen-presenting cells essential for the induction of adaptive immune responses. Their unprecedented ability to present antigens to T cells has made them excellent targets for vaccine development. In the last years, a new technology based on antigen delivery directly to different DC subsets...

journal_title：Frontiers in immunology

authors： Antonialli R,Sulczewski FB,Amorim KNDS,Almeida BDS,Ferreira NS,Yamamoto MM,Soares IS,Ferreira LCS,Rosa DS,Boscardin SB

更新日期：2017-12-04 00:00:00

abstract：:Formation of pathological anti-FVIII antibodies, or "inhibitors," is the most serious complication of therapeutic FVIII infusions, affecting up to 1/3 of severe Hemophilia A (HA) patients. Inhibitor formation is a classical T-cell dependent adaptive immune response. As such, it requires help from the innate immune sys...

journal_title：Frontiers in immunology

authors： Karim AF,Soltis AR,Sukumar G,Königs C,Ewing NP,Dalgard CL,Wilkerson MD,Pratt KP

更新日期：2020-06-12 00:00:00

abstract：:Background: Although myelin is composed of mostly lipids, the pathological role of myelin lipids in demyelinating diseases remains elusive. The principal lipid of the myelin sheath is β-galactosylceramide (β-Galcer). Its α-anomer (α-Galcer) has been demonstrated to be antigenically presented by macrophages via CD1d, a...

journal_title：Frontiers in immunology

authors： Ban Y,Dong W,Zhang L,Zhou T,Altiti AS,Ali K,Mootoo DR,Blaho VA,Hla T,Ren Y,Ma X

更新日期：2019-03-19 00:00:00

abstract：:Tissue-resident phagocytes are responsible for the routine binding, engulfment, and resolution of their meals. Such populations of cells express appropriate surface receptors that are tailored to recognize the phagocytic targets of their niche and initiate the actin polymerization that drives internalization. Tissue-r...

journal_title：Frontiers in immunology

authors： Kwon W,Freeman SA

更新日期：2020-11-13 00:00:00

abstract：:Inflammation is a crucial defense mechanism that protects the body from the devastating effects of invading pathogens. However, an unrestrained inflammatory reaction may result in systemic manifestations with dire consequences to the host. The extent of activation of the inflammatory response is tightly regulated thro...

journal_title：Frontiers in immunology

authors： Al-Barazie RM,Bashir GH,Qureshi MM,Mohamed YA,Al-Sbiei A,Tariq S,Lammers WJ,Al-Ramadi BK,Fernandez-Cabezudo MJ

更新日期：2018-03-19 00:00:00

abstract：:Human immunodeficiency virus type-1 (HIV-1) elite controllers (ELCs) represent a unique population that control viral replication in the absence of antiretroviral therapy (cART). It is well established that expression of multiple inhibitory receptors on CD8+ T cells is associated with HIV-1 disease progression. Howeve...

journal_title：Frontiers in immunology

authors： Noyan K,Nguyen S,Betts MR,Sönnerborg A,Buggert M

更新日期：2018-01-22 00:00:00

abstract：:Preclinical and clinical studies have shown that prior receipt of radiotherapy enhances antitumor immune responses, a phenomenon we call the "radio-memory effect." However, all of the evidence regarding this effect to date comes from work with PD1/PDL1 inhibitors. Here we explored whether this effect also occurs with ...

journal_title：Frontiers in immunology

authors： Chen D,Song X,Wang H,Gao Z,Meng W,Chen S,Ma Y,Wang Y,Li K,Yu J,Yue J

更新日期：2018-12-11 00:00:00

abstract：:The ubiquitously expressed, monomorphic MHC class Ib molecule MHC class I-related protein 1 (MR1) presents microbial metabolites to mucosal-associated invariant T (MAIT) cells. However, recent work demonstrates that both the ligands bound by MR1 and the T cells restricted by it are more diverse than originally thought...

journal_title：Frontiers in immunology

authors： Kulicke C,Karamooz E,Lewinsohn D,Harriff M

更新日期：2020-09-02 00:00:00

abstract：:Cancer immunotherapy (CIT) with antibodies targeting the programmed cell death 1 protein (PD-1)/programmed cell death 1 ligand 1 (PD-L1) axis have changed the standard of care in multiple cancers. However, durable antitumor responses have been observed in only a minority of patients, indicating the presence of other i...

journal_title：Frontiers in immunology

authors： Hack SP,Zhu AX,Wang Y

更新日期：2020-11-05 00:00:00

abstract：:The advent of induced pluripotent stem cells (iPSCs) has begun to revolutionize cell therapy by providing a convenient source of rare cell types not normally available from patients in sufficient numbers for therapeutic purposes. In particular, the development of protocols for the differentiation of populations of leu...

journal_title：Frontiers in immunology

authors： Sachamitr P,Leishman AJ,Davies TJ,Fairchild PJ

更新日期：2018-01-08 00:00:00

abstract：:Objective: Intestinal Behcet's disease (iBD) is an autoimmune disorder diagnosed by typical intestinal ulcers and systemic Behcet's disease (BD) manifestations. Haploinsufficiency of A20 (HA20) is a recently described autoinflammatory disease with a phenotype resembling BD, caused by heterozygous loss-of-function muta...

journal_title：Frontiers in immunology

authors： Chen Y,Huang H,He Y,Chen M,Seidler U,Tian D,Xiao F

更新日期：2020-07-03 00:00:00

abstract：Background:Ischemia-reperfusion (IR) is a major contributor to graft rejection after liver transplantation. During IR injury, an intense inflammatory process occurs in the liver. Neutrophils are considered central players in the events that lead to liver injury. CXC chemokines mediate hepatic inflammation following rep...

journal_title：Frontiers in immunology

authors： de Oliveira THC,Marques PE,Poosti F,Ruytinx P,Amaral FA,Brandolini L,Allegretti M,Proost P,Teixeira MM

更新日期：2018-01-05 00:00:00

abstract：:Shiga-toxin (Stx)-producing Escherichia coli hemolytic-uremic syndrome (STEC-HUS) is one of the most common causes of acute kidney injury in children. Stx-mediated endothelial injury initiates the cascade leading to thrombotic microangiopathy (TMA), still the exact pathogenesis remains elusive. Interestingly, there is...

journal_title：Frontiers in immunology

authors： Wijnsma KL,Veissi ST,de Wijs S,van der Velden T,Volokhina EB,Wagener FADTG,van de Kar NCAJ,van den Heuvel LP

更新日期：2020-12-22 00:00:00

abstract：:Virus infected immune cells can rapidly respond to the invader by activating the inflammasome and as a consequence release proinflammatory cytokines and eventually die by pyroptosis. In human adenovirus-5 (Ad5) infected THP-1 cells, inhibition of NLRP3 inflammasome activation was demonstrated by a decreased secretion ...

journal_title：Frontiers in immunology

authors： Darweesh M,Kamel W,Gavrilin MA,Akusjärvi G,Svensson C

更新日期：2019-11-28 00:00:00

abstract：:The latest advancements in oncology research are focused on autologous immune cell therapy. However, the effectiveness of this type of immunotherapy for cancer remediation is not equivalent for all patients or cancer types. This suggests the need for better preclinical screening models that more closely recapitulate i...

journal_title：Frontiers in immunology

authors： Sherman H,Gitschier HJ,Rossi AE

更新日期：2018-04-23 00:00:00

abstract：:Vitamin A deficiency affects over 250 million preschool-age children worldwide and is associated with increased childhood mortality and risk of developing enteric infections. Vitamin A deficient (A-) mice developed chronic Citrobacter rodentium infection. A single oral dose of retinoic acid (RA) at d7 post-infection w...

journal_title：Frontiers in immunology

authors： Snyder LM,McDaniel KL,Tian Y,Wei CH,Kennett MJ,Patterson AD,Ross AC,Cantorna MT

更新日期：2019-01-08 00:00:00