Ultra-Sensitive HIV-1 Latency Viral Outgrowth Assays Using Humanized Mice.

abstract：:This article describes the work I did in Bill Paul's lab as a postdoctoral fellow between 1979 and 1983, and to a lesser extent puts that work in the context of other work on B cell activation and antibody responses that was going on in Bill's lab at that time and shortly beforehand, including the discovery of interle...

journal_title：Frontiers in immunology

authors： DeFranco AL

更新日期：2018-04-23 00:00:00

abstract：:Overwhelming infection causes significant morbidity and mortality among patients treated with bone marrow transplantation (BMT) for primary immune deficiencies, syndromes of bone marrow failure, or cancer. The polymorphonuclear leukocyte (PMN; neutrophil) is the first responder to microbial invasion and acts within th...

journal_title：Frontiers in immunology

authors： Glenn JW,Cody MJ,McManus MP,Pulsipher MA,Schiffman JD,Yost CC

更新日期：2016-06-27 00:00:00

abstract：BACKGROUND:Graft-vs-host disease (GVHD) is a major complication of allogenic bone marrow transplantation (BMT). Targeting costimulatory molecules with antagonist antibodies could dampen the excessive immune response that occurs, while preserving the beneficial graft vs leukemia (GVL) of the allogeneic response. Previou...

journal_title：Frontiers in immunology

authors： Burlion A,Brunel S,Petit NY,Olive D,Marodon G

更新日期：2017-06-30 00:00:00

abstract：:THE REGULATORY CYTOKINE TUMOR NECROSIS FACTOR (TNF) EXERTS ITS EFFECTS THROUGH TWO RECEPTORS: TNFR1 and TNFR2. Defects in TNFR2 signaling are evident in a variety of autoimmune diseases. One new treatment strategy for autoimmune disease is selective destruction of autoreactive T cells by administration of TNF, TNF ind...

journal_title：Frontiers in immunology

authors： Faustman DL,Davis M

更新日期：2013-12-23 00:00:00

abstract：:Preclinical and early human clinical studies of broadly neutralizing antibodies (bNAbs) to prevent and treat HIV infection support the clinical utility and potential of bNAbs for prevention, postexposure prophylaxis, and treatment of acute and chronic infection. Observed and potential limitations of bNAbs from these r...

journal_title：Frontiers in immunology

authors： Hua CK,Ackerman ME

更新日期：2017-11-28 00:00:00

abstract：:Background: The systemic inflammatory cascade triggered in donors after brain death enhances the ischemia-reperfusion injury after organ transplantation. Intravenous steroids are routinely used in the intensive care units for the donor preconditioning. Immunosuppressive medications could be potentially used for this p...

journal_title：Frontiers in immunology

authors： Abbasi Dezfouli S,Nikdad M,Ghamarnejad O,Khajeh E,Arefidoust A,Mohammadi S,Majlesara A,Sabagh M,Gharabaghi N,Kentar M,Younsi A,Eckert C,Poth T,Golriz M,Mehrabi A,Nickkholgh A

更新日期：2020-06-18 00:00:00

abstract：:The adaptive immune response is initiated in lymph nodes by contact between antigen-bearing dendritic cells (DCs) and antigen-specific T cells. A selected number of naïve T cells that recognize a specific antigen may proliferate into expanded clones, differentiate, and acquire an effector phenotype. Despite growing ex...

journal_title：Frontiers in immunology

authors： Azarov I,Peskov K,Helmlinger G,Kosinsky Y

更新日期：2019-06-11 00:00:00

abstract：:Immune aging is best known for its immune defects that increase susceptibility to infections and reduce adaptive immune responses to vaccination. In parallel, the aged immune system is prone to autoimmune responses and many autoimmune diseases increase in incidence with age or are even preferentially encountered in th...

journal_title：Frontiers in immunology

authors： Goronzy JJ,Li G,Yang Z,Weyand CM

更新日期：2013-06-04 00:00:00

abstract：:L-selectin (CD62L) is a type-I transmembrane glycoprotein and cell adhesion molecule that is expressed on most circulating leukocytes. Since its identification in 1983, L-selectin has been extensively characterized as a tethering/rolling receptor. There is now mounting evidence in the literature to suggest that L-sele...

journal_title：Frontiers in immunology

authors： Ivetic A,Hoskins Green HL,Hart SJ

更新日期：2019-05-14 00:00:00

abstract：:For successful bone marrow transplantation (BMT), a preconditioning regime involving chemo and radiotherapy is used that results in DNA damage to both hematopoietic and stromal elements. Following radiation exposure, it is well recognized that a single wave of host-derived thymocytes reconstitutes the irradiated thymu...

journal_title：Frontiers in immunology

authors： Calvo-Asensio I,Sugrue T,Bosco N,Rolink A,Ceredig R

更新日期：2018-06-11 00:00:00

abstract：:Anti-drug antibodies to coagulation factor VIII (fVIII), often termed inhibitors, present the greatest economical and treatment related obstacle in the management of hemophilia A. Although several genetic and environmental risk factors associated with inhibitor development have been identified, the precise mechanisms ...

journal_title：Frontiers in immunology

authors： Zakas PM,Healey JF,Smith IW,Lillicrap D,Lollar P

更新日期：2020-02-07 00:00:00

abstract：:Mouse allergy has become increasingly common, mainly affecting laboratory workers and inner-city households. To date, only one major allergen, namely Mus m 1, has been described. We sought to identify T cell targets in mouse allergic patients. PBMC from allergic donors were expanded with either murine urine or epithel...

journal_title：Frontiers in immunology

authors： Schulten V,Westernberg L,Birrueta G,Sidney J,Paul S,Busse P,Peters B,Sette A

更新日期：2018-02-13 00:00:00

abstract：:The immunization of allogeneic hematopoietic cell transplantation (HCT) recipients against vaccine-preventable diseases is a part of posttransplantation guidelines. We conducted a prospective study to assess clinical and immunological parameters that would determine the response and long-term maintenance of protective...

journal_title：Frontiers in immunology

authors： Piekarska A,Wisniewski P,Lewandowski K,Gil L,Trzonkowski P,Bieniaszewska M,Zaucha JM

更新日期：2020-11-24 00:00:00

abstract：:Intrarenal robust inflammatory response following ischemia-reperfusion injury (IRI) is a major factor in the pathogenesis of renal injury in ischemic acute kidney injury (AKI). Although numerous studies have investigated various agents of immune modulation or suppression for ischemic AKI, few showed reproducible effec...

journal_title：Frontiers in immunology

authors： Jang HR,Lee K,Jeon J,Kim JR,Lee JE,Kwon GY,Kim YG,Kim DJ,Ko JW,Huh W

更新日期：2020-10-14 00:00:00

abstract：:Granulocytes, the most abundant types of leukocytes, are the first line of defense against pathogen invasion. However, the plasticity and diversity of granulocytes have been increasingly revealed, especially with regard to their versatile functions in orchestrating adaptive immune responses. A substantial body of rece...

journal_title：Frontiers in immunology

authors： Lin A,Loré K

更新日期：2017-12-11 00:00:00

abstract：:Interleukin-1 (IL-1) family cytokines are key signaling molecules in both the innate and adaptive immune systems, mediating inflammation in response to a wide range of stimuli. The basic mechanism of signal initiation is a stepwise process in which an agonist cytokine binds its cognate receptor. Together, this cytokin...

journal_title：Frontiers in immunology

authors： Fields JK,Günther S,Sundberg EJ

更新日期：2019-06-20 00:00:00

abstract：:Immunotherapies are rapidly being integrated into standard of care (SOC) therapy in conjunction with surgery, chemotherapy, and radiotherapy for many cancers and a large number of clinical studies continue to explore immunotherapy alone and as part of combination therapies in patients with cancer. It is evident that c...

journal_title：Frontiers in immunology

authors： Holl EK,Frazier VN,Landa K,Beasley GM,Hwang ES,Nair SK

更新日期：2019-07-31 00:00:00

abstract：:The mucin gene, MUC5AC, is highly expressed both in chronic respiratory inflammatory diseases and inflammatory bowel disease where mucin secretion is regulated by members of the interleukin IL-20 subfamily. This study was conducted to determine the roles and mechanisms of IL-19, a member of the IL-20 subfamily, in reg...

journal_title：Frontiers in immunology

authors： Lai X,Li X,Chang L,Chen X,Huang Z,Bao H,Huang J,Yang L,Wu X,Wang Z,Bellanti JA,Zheng SG,Zhang G

更新日期：2019-07-17 00:00:00

abstract：:Background: Variants in recombination-activating genes (RAG) are common genetic causes of autosomal recessive forms of combined immunodeficiencies (CID) ranging from severe combined immunodeficiency (SCID), Omenn syndrome (OS), leaky SCID, and CID with granulomas and/or autoimmunity (CID-G/AI), and even milder present...

journal_title：Frontiers in immunology

authors： Sharapova SO,Skomska-Pawliszak M,Rodina YA,Wolska-Kuśnierz B,Dabrowska-Leonik N,Mikołuć B,Pashchenko OE,Pasic S,Freiberger T,Milota T,Formánková R,Szaflarska A,Siedlar M,Avčin T,Markelj G,Ciznar P,Kalwak K,Kołtan S,Ja

更新日期：2020-06-10 00:00:00

abstract：:Natural killer (NK) cells are lymphocytes of the innate immune system able to kill different targets such as cancer cells and virally infected cells without prior activation making then attractive candidates for cancer immunotherapy. Umbilical cord blood (UCB) has become a source of hematopoietic stem cells for transp...

journal_title：Frontiers in immunology

authors： Sarvaria A,Jawdat D,Madrigal JA,Saudemont A

更新日期：2017-03-23 00:00:00

abstract：:In this study we demonstrate the feasibility of direct, quantitative measurement of cytokine proteins in single human CD8 lymphocytes from fresh peripheral blood of healthy donors following a brief ex vivo stimulation. Cytokine-secreting cells were identified using cell surface "catch" reagents and single cell data we...

journal_title：Frontiers in immunology

authors： Saxena A,Dagur PK,Desai A,McCoy JP Jr

更新日期：2018-10-23 00:00:00

abstract：:Neurological disorders caused by neuroviral infections are an obvious pathogenic manifestation. However, non-neurotropic viruses or peripheral viral infections pose a considerable challenge as their neuropathological manifestations do not emerge because of primary infection. Their secondary or bystander pathologies de...

journal_title：Frontiers in immunology

authors： Mishra R,Banerjea AC

更新日期：2020-09-10 00:00:00

abstract：:Acrylamide is a toxic chemical substance produced when starch-rich foods are fried at high temperatures. Asthma is a chronic and complicated respiratory disease, of which genetic and environmental factors are the main triggers. Orally-received components may have an effect on asthma pathophysiology. The aim of this st...

journal_title：Frontiers in immunology

authors： Hajimohammadi B,Athari SM,Abdollahi M,Vahedi G,Athari SS

更新日期：2020-10-09 00:00:00

abstract：:The protein kinase C-θ (PKCθ), which is essential for T cell function and survival, is also required for efficient anti-tumor immune surveillance. Natural killer (NK) cells, which express PKCθ, play a prominent role in this process, mainly by elimination of tumor cells with reduced or absent major histocompatibility c...

journal_title：Frontiers in immunology

authors： Anel A,Aguiló JI,Catalán E,Garaude J,Rathore MG,Pardo J,Villalba M

更新日期：2012-07-05 00:00:00

abstract：:HLA antibodies are primary causes of transplant rejection; they recognize epitopes that can be structurally defined by eplets. There are many reviews about HLA epitope-based matching in transplantation. This article describes some personal reflections about epitopes including a historical perspective of HLA typing at ...

journal_title：Frontiers in immunology

authors： Duquesnoy RJ

更新日期：2016-11-28 00:00:00

abstract：:Loss-of-function mutations in the Autoimmune Regulator (AIRE) gene cause a rare inherited form of autoimmune disease, autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy, also known as autoimmune polyglandular syndrome type 1. The patients suffer from multiple endocrine deficiencies, the most common manifes...

journal_title：Frontiers in immunology

authors： Arstila TP,Jarva H

更新日期：2013-10-07 00:00:00

abstract：:Treatment with the macrolide antibiotic azithromycin (AZM) is an important intervention for controlling infection of children with Bordetella pertussis and as a prophylaxis for preventing transmission to family members. However, antibiotics are known to have immunomodulatory effects independent of their antimicrobial ...

journal_title：Frontiers in immunology

authors： Borkner L,Misiak A,Wilk MM,Mills KHG

更新日期：2018-07-30 00:00:00

abstract：:The dynamics of skin-draining cells following infection or vaccination provide important insight into the initiation of immune responses. In this study, the local recruitment and activation of immune cells in draining lymph nodes (LNs) was studied in calves in an adjuvant-induced inflammation. A transient but remarkab...

journal_title：Frontiers in immunology

authors： Lund H,Boysen P,Åkesson CP,Lewandowska-Sabat AM,Storset AK

更新日期：2016-08-29 00:00:00

abstract：:Monocytes and macrophages play pivotal roles in inflammation and homeostasis. Recent studies suggest that dynamic programing of macrophages and monocytes may give rise to distinct "memory" states. Lipopolysaccharide (LPS), a classical pattern recognition molecule, dynamically programs innate immune responses. Emerging...

journal_title：Frontiers in immunology

authors： Morris MC,Gilliam EA,Li L

更新日期：2015-01-06 00:00:00

abstract：:Viral defense at mucosal sites depends on interferons (IFN) and IFN stimulated genes (ISGs), either of which may be constitutively expressed to maintain an "antiviral state" (AVS). However, the mechanisms that govern the AVS are poorly defined. Using a BEAS-2B respiratory epithelial cell line deficient in IRF1, we dem...

journal_title：Frontiers in immunology

authors： Panda D,Gjinaj E,Bachu M,Squire E,Novatt H,Ozato K,Rabin RL

更新日期：2019-05-15 00:00:00