Protein Kinase C-θ (PKC-θ) in Natural Killer Cell Function and Anti-Tumor Immunity.

abstract：:Diabetic retinopathy is a vision-threatening disease affecting neurons and microvasculature of the retina. The development of this disease is associated with the action of inflammatory factors that are connected to the activation of microglial cells, the resident tissue macrophages of the CNS. In the quiescent state, ...

journal_title：Frontiers in immunology

authors： Kinuthia UM,Wolf A,Langmann T

更新日期：2020-11-06 00:00:00

abstract：:Hematopoietic stem cells (HSCs) are quiescent cells with self-renewal capacity and the ability to generate all mature blood cells. HSCs normally reside in specialized niches in the bone marrow that help maintain their quiescence and long-term repopulating activity. There is emerging evidence that certain cytokines ind...

journal_title：Frontiers in immunology

authors： Schuettpelz LG,Link DC

更新日期：2013-07-19 00:00:00

abstract：:Recently, the chemokine receptor XCR1 has been found to be exclusively expressed on a subset of dendritic cell (DC) known to be involved in antigen cross-presentation. This review aims to summarize the known biology of the XCR1 receptor and its chemokine ligand XCL1, both in the mouse and the human. Further, any invol...

journal_title：Frontiers in immunology

authors： Kroczek RA,Henn V

更新日期：2012-02-10 00:00:00

abstract：:Shiga-toxin (Stx)-producing Escherichia coli hemolytic-uremic syndrome (STEC-HUS) is one of the most common causes of acute kidney injury in children. Stx-mediated endothelial injury initiates the cascade leading to thrombotic microangiopathy (TMA), still the exact pathogenesis remains elusive. Interestingly, there is...

journal_title：Frontiers in immunology

authors： Wijnsma KL,Veissi ST,de Wijs S,van der Velden T,Volokhina EB,Wagener FADTG,van de Kar NCAJ,van den Heuvel LP

更新日期：2020-12-22 00:00:00

abstract：:The complement system is a key component of innate immunity which readily responds to invading microorganisms. Activation of the complement system typically occurs via three main pathways and can induce various antimicrobial effects, including: neutralization of pathogens, regulation of inflammatory responses, promoti...

journal_title：Frontiers in immunology

authors： Mellors J,Tipton T,Longet S,Carroll M

更新日期：2020-07-09 00:00:00

abstract：:Strategies targeting T cells are the cornerstone of immunosuppression after solid organ transplantation. The transcription factor NF-κB is a key regulator of downstream T-cell activation and induction of inflammatory mediators; its full activation via antigen receptor engagement requires both the scaffold and the prot...

journal_title：Frontiers in immunology

authors： Govender L,Mikulic J,Wyss JC,Gaide O,Thome M,Golshayan D

更新日期：2020-09-11 00:00:00

abstract：:Background and Aims: Despite the negative results of blocking IL-17 in Crohn's disease (CD) patients, selective modulation of Th17-dependent responses warrants further study. Inhibition of retinoic acid-related orphan receptor gamma (RORγt), the master regulator of the Th17 signature, is currently being explored in in...

journal_title：Frontiers in immunology

authors： Bassolas-Molina H,Raymond E,Labadia M,Wahle J,Ferrer-Picón E,Panzenbeck M,Zheng J,Harcken C,Hughes R,Turner M,Smith D,Calderón-Gómez E,Esteller M,Carrasco A,Esteve M,Dotti I,Corraliza AM,Masamunt MC,Arajol C,Guardio

更新日期：2018-10-22 00:00:00

abstract：:Ubiquitin-specific protease 14 (USP14), one of three proteasome-associated deubiquitinating enzymes, has multifunctional roles in cellular context. Here, we report a novel molecular mechanism and function of USP14 in regulating autophagy induction and nuclear factor-kappa B (NF-κB) activation induced by toll-like rece...

journal_title：Frontiers in immunology

authors： Min Y,Lee S,Kim MJ,Chun E,Lee KY

更新日期：2017-12-15 00:00:00

abstract：:Multiple sclerosis (MS) is a chronic inflammatory disorder of the central nervous system (CNS) characterized by the presence of focal demyelinated plaques. Sufficient clearance of myelin and cellular debris is one of the requirements for proper tissue repair and remyelination. The mechanisms underlying the clearance o...

journal_title：Frontiers in immunology

authors： Kamermans A,Rijnsburger M,Chakraborty A,van der Pol S,de Vries HE,van Horssen J

更新日期：2019-05-03 00:00:00

abstract：:The close association between cardiovascular pathology and renal dysfunction is well documented and significant. Patients with conventional risk factors for cardiovascular disease like diabetes and hypertension also suffer renal dysfunction. This is unsurprising if the kidney is simply regarded as a "modified blood ve...

journal_title：Frontiers in immunology

authors： Hewitson TD,Holt SG,Smith ER

更新日期：2015-09-17 00:00:00

abstract：:Interleukin (IL)-1β is a potential target for treatment of several inflammatory diseases, including envenomation by the scorpion Tityus serrulatus. In this context, bioactive lipids such as prostaglandin (PG)E2 and leukotriene (LT)B4 modulate the production of IL-1β by innate immune cells. Pattern recognition receptor...

journal_title：Frontiers in immunology

authors： Zoccal KF,Gardinassi LG,Sorgi CA,Meirelles AFG,Bordon KCF,Glezer I,Cupo P,Matsuno AK,Bollela VR,Arantes EC,Guimarães FS,Faccioli LH

更新日期：2018-04-27 00:00:00

abstract：:Due to their overall immunocompromised state, lung transplant recipients (LTRs) are at increased risk for the development of viral respiratory infections compared to the general population. Such respiratory infections often lead to poor transplant outcomes. We performed a systematic review of the last 30 years of medi...

journal_title：Frontiers in immunology

authors： Bailey ES,Zemke JN,Choi JY,Gray GC

更新日期：2019-12-19 00:00:00

abstract：Background:CD1d restricted invariant natural killer T (iNKT) cells are important in the activation and regulation of immune responses. Limited information is available regarding the functional role of iNKT cells in the human immunodeficiency virus (HIV) disease progression. Methodology:α-GalCer stimulated iNKT cells w...

journal_title：Frontiers in immunology

authors： Singh D,Ghate M,Godbole S,Kulkarni S,Thakar M

更新日期：2018-05-24 00:00:00

abstract：:Overwhelming infection causes significant morbidity and mortality among patients treated with bone marrow transplantation (BMT) for primary immune deficiencies, syndromes of bone marrow failure, or cancer. The polymorphonuclear leukocyte (PMN; neutrophil) is the first responder to microbial invasion and acts within th...

journal_title：Frontiers in immunology

authors： Glenn JW,Cody MJ,McManus MP,Pulsipher MA,Schiffman JD,Yost CC

更新日期：2016-06-27 00:00:00

abstract：:Over the past few decades, we have witnessed a decline in the rates of acute rejection without significant improvement in chronic rejection. Current treatment strategies principally target the adaptive immune response and not the innate response. Therefore, better understanding of innate immunity in transplantation an...

journal_title：Frontiers in immunology

authors： Zhao D,Abou-Daya KI,Dai H,Oberbarnscheidt MH,Li XC,Lakkis FG

更新日期：2020-05-28 00:00:00

abstract：:This article describes the work I did in Bill Paul's lab as a postdoctoral fellow between 1979 and 1983, and to a lesser extent puts that work in the context of other work on B cell activation and antibody responses that was going on in Bill's lab at that time and shortly beforehand, including the discovery of interle...

journal_title：Frontiers in immunology

authors： DeFranco AL

更新日期：2018-04-23 00:00:00

abstract：:The autoimmune regulator (Aire)-directed ectopic expression of tissue-specific antigens (TSAs) by mature medullary thymic epithelial cells (mTECs) has been viewed as an essential mechanism in the induction of central tolerance. Recent data suggest that the survival of mTECs extends beyond the Aire+ cell population to ...

journal_title：Frontiers in immunology

authors： Wang X,Laan M,Bichele R,Kisand K,Scott HS,Peterson P

更新日期：2012-03-01 00:00:00

abstract：:Degenerative disc disease is associated with increased expression of pro-inflammatory cytokines in the intervertebral disc (IVD). However, it is not completely clear how inflammation arises in the IVD and which cellular compartments are involved in this process. Recently, the endoplasmic reticulum (ER) has emerged as ...

journal_title：Frontiers in immunology

authors： Krupkova O,Sadowska A,Kameda T,Hitzl W,Hausmann ON,Klasen J,Wuertz-Kozak K

更新日期：2018-08-17 00:00:00

abstract：:Objectives: Fibrosis is a hallmark of systemic sclerosis (SSc), an intractable disease where innovative strategies are still being sought. Among novel anti-fibrotic approaches, mesenchymal stromal/stem cell (MSC)-based therapy appears promising. Previously, we reported anti-fibrotic effects of MSC in an experimental m...

journal_title：Frontiers in immunology

authors： Maria ATJ,Rozier P,Fonteneau G,Sutra T,Maumus M,Toupet K,Cristol JP,Jorgensen C,Guilpain P,Noël D

更新日期：2018-12-21 00:00:00

abstract：:NLRC5 is a member of the NLR family that acts as a transcriptional activator of MHC class I genes. In line with the function of several related NLR proteins in innate immune responses, there is, however, also ample evidence that NLRC5 contributes to innate and adaptive immune responses beyond the regulation of MHC cla...

journal_title：Frontiers in immunology

authors： Benkő S,Kovács EG,Hezel F,Kufer TA

更新日期：2017-02-17 00:00:00

abstract：:In vertebrate animals, the sterol metabolic network is emerging as a central player in immunity and inflammation. Upon infection, flux in the network is acutely moderated by the interferon (IFN) response through direct molecular and bi-directional communications. How sterol metabolism became linked to IFN control and ...

journal_title：Frontiers in immunology

authors： Newmark H,Dantoft W,Ghazal P

更新日期：2017-02-09 00:00:00

abstract：:Maternal immune activation (MIA) caused by exposure to pathogens or inflammation during critical periods of neurodevelopment is a major risk factor for behavioral deficits and psychiatric illness in offspring. A spectrum of behavioral abnormalities can be recapitulated in rodents by inducing MIA using the viral mimeti...

journal_title：Frontiers in immunology

authors： Baines KJ,Hillier DM,Haddad FL,Rajakumar N,Schmid S,Renaud SJ

更新日期：2020-06-09 00:00:00

abstract：:DiGeorge syndrome is an immunodeficiency characterized by thymic dysplasia resulting in T cell lymphopenia. Most patients suffer from increased susceptibility to infections and heightened prevalence of autoimmune disorders, such as autoimmune thrombocytopenia. B cells in DiGeorge syndrome show impaired maturation, wit...

journal_title：Frontiers in immunology

authors： Klocperk A,Paračková Z,Bloomfield M,Rataj M,Pokorný J,Unger S,Warnatz K,Šedivá A

更新日期：2018-07-23 00:00:00

abstract：:Genetic mismatches in protein coding genes between allogeneic hematopoietic stem cell transplantation (allo-HSCT) recipient and donor can elicit an alloimmunity response via peptides presented by the recipient HLA receptors as minor histocompatibility antigens (mHAs). While the impact of individual mHAs on allo-HSCT o...

journal_title：Frontiers in immunology

authors： Ritari J,Hyvärinen K,Koskela S,Niittyvuopio R,Nihtinen A,Salmenniemi U,Putkonen M,Volin L,Kwan T,Pastinen T,Itälä-Remes M,Partanen J

更新日期：2019-07-16 00:00:00

abstract：:CD4(+) CD25(+) Foxp3(+) regulatory T (Treg) cells are essential to the balance between pro- and anti-inflammatory responses. There are two major subsets of Treg cells, "natural" Treg (nTreg) cells that develop in the thymus, and "induced" Treg (iTreg) cells that arise in the periphery from CD4(+) Foxp3(-) conventional...

journal_title：Frontiers in immunology

authors： Schmitt EG,Williams CB

更新日期：2013-06-19 00:00:00

abstract：:Activation of the aryl hydrocarbon receptor (AhR) by its prototypic ligand, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), mediates potent suppression of T-cell dependent immune responses. The suppressive effects of TCDD occur early during CD4(+) T-cell differentiation in the absence of effects on proliferation and have ...

journal_title：Frontiers in immunology

authors： Rohlman D,Pham D,Yu Z,Steppan LB,Kerkvliet NI

更新日期：2012-08-06 00:00:00

abstract：:Elevated serum amyloid A (SAA) levels may promote endothelial dysfunction, which is linked to cardiovascular and renal pathologies. We investigated the effect of SAA on vascular and renal function in apolipoprotein E-deficient (ApoE-/-) mice. Male ApoE-/- mice received vehicle (control), low-level lipopolysaccharide (...

journal_title：Frontiers in immunology

authors： Chami B,Hossain F,Hambly TW,Cai X,Aran R,Fong G,Vellajo A,Martin NJJ,Wang X,Dennis JM,Sharma A,Shihata WA,Chin-Dusting JPF,de Haan JB,Sharland A,Geczy CL,Freedman B,Witting PK

更新日期：2019-03-07 00:00:00

abstract：:Background: This retrospective study assessed the use and long-term outcome of allogeneic hematopoietic stem cell transplantation (HSCT) in patients with severe autoimmune diseases (ADs), reported to the European Society for Blood and Marrow Transplantation (EBMT) registry. Methods: Between 1997 and 2014, 128 patients...

journal_title：Frontiers in immunology

authors： Greco R,Labopin M,Badoglio M,Veys P,Furtado Silva JM,Abinun M,Gualandi F,Bornhauser M,Ciceri F,Saccardi R,Lankester A,Alexander T,Gennery AR,Bader P,Farge D,Snowden JA

更新日期：2019-07-04 00:00:00

abstract：:Ruggero Ceppellini, who died at the age of 71 in 1988, was one of the most stimulating and original human geneticists of his generation (1). Ceppellini's outstanding contributions to the genetics of the human blood groups, immunoglobulin allotypes and the HLA system epitomize the study of immunogenetics. By using his ...

journal_title：Frontiers in immunology

authors： Bodmer W

更新日期：2019-06-05 00:00:00

abstract：:Antibodies that block the immune checkpoint receptors PD1 and CTLA4 have revolutionized the treatment of melanoma and several other cancers, but in the process, a new class of drug side effect has emerged-immune related adverse events. The observation that therapeutic blockade of these inhibitory receptors is sufficie...

journal_title：Frontiers in immunology

authors： Paluch C,Santos AM,Anzilotti C,Cornall RJ,Davis SJ

更新日期：2018-10-08 00:00:00