Regulation of hematopoietic stem cell activity by inflammation.

abstract：:Autoinflammatory diseases are caused by defects in genes that regulate the innate immunity. Recently, the scope of autoinflammation has been broadened to include diseases that result from dysregulations in protein modifications by the highly conserved ubiquitin (Ub) peptides. Thus far these diseases consist of linear ...

journal_title：Frontiers in immunology

authors： Aksentijevich I,Zhou Q

更新日期：2017-04-19 00:00:00

abstract：:The immunopathological functions associated with human C1q are still growing in terms of novelty, diversity, and pathologic relevance. It is, therefore, not surprising that C1q is being recognized as an important molecular bridge between innate and adaptive immunity. The secret of this functional diversity, in turn, r...

journal_title：Frontiers in immunology

authors： Ghebrehiwet B,Kandov E,Kishore U,Peerschke EIB

更新日期：2018-02-05 00:00:00

abstract：:Tumors must evade the immune system to survive and metastasize, although the mechanisms that lead to tumor immunoediting and their evasion of immune surveillance are far from clear. The first line of defense against metastatic invasion is the innate immune system that provides immediate defense through humoral immunit...

journal_title：Frontiers in immunology

authors： Benito-Martin A,Di Giannatale A,Ceder S,Peinado H

更新日期：2015-02-24 00:00:00

abstract：:Cytosolic DNA fragments are recognized as pathogen- and danger-associated molecular patterns that induce a cascade of innate immune responses. Moreover, excessive cytosolic DNA can enhance chronic inflammation, predominantly by activating inflammasomes, and thereby contributing to the pathogenesis of chronic diseases,...

journal_title：Frontiers in immunology

authors： Danis J,Göblös A,Bata-Csörgő Z,Kemény L,Széll M

更新日期：2017-08-29 00:00:00

abstract：:Tissue-resident phagocytes are responsible for the routine binding, engulfment, and resolution of their meals. Such populations of cells express appropriate surface receptors that are tailored to recognize the phagocytic targets of their niche and initiate the actin polymerization that drives internalization. Tissue-r...

journal_title：Frontiers in immunology

authors： Kwon W,Freeman SA

更新日期：2020-11-13 00:00:00

abstract：:Transcriptome profiling approaches have been widely used to investigate the mechanisms underlying psoriasis pathogenesis. Most researchers have measured changes in transcript abundance in skin biopsies; relatively few have examined transcriptome changes in the blood. Although less relevant to the study of psoriasis pa...

journal_title：Frontiers in immunology

authors： Rawat A,Rinchai D,Toufiq M,Marr AK,Kino T,Garand M,Tatari-Calderone Z,Kabeer BSA,Krishnamoorthy N,Bedognetti D,Karim MY,Sastry KS,Chaussabel D

更新日期：2020-11-24 00:00:00

abstract：:The clinical experience gathered throughout the years has raised awareness of primary immunodeficiency diseases (PIDD). T cell receptor excision circles (TREC) and kappa-deleting recombination excision circles (KREC) assays for thymic and bone marrow outputs measurement have been widely implemented in newborn screenin...

journal_title：Frontiers in immunology

authors： Kwok JSY,Cheung SKF,Ho JCY,Tang IWH,Chu PWK,Leung EYS,Lee PPW,Cheuk DKL,Lee V,Ip P,Lau YL

更新日期：2020-07-16 00:00:00

abstract：:Here, we outline an overview of the mammalian immune system that updates and extends the classical clonal selection paradigm. Rather than focusing on strict self-not-self discrimination, we propose that the system orchestrates variable inflammatory responses that maintain the body and its symbiosis with the microbiome...

journal_title：Frontiers in immunology

authors： Cohen IR,Efroni S

更新日期：2019-01-22 00:00:00

abstract：:Respiratory syncytial virus (RSV) remains the most common cause of lower respiratory tract infections in children worldwide. Development of a vaccine has been hindered by the risk of developing enhanced respiratory disease (ERD) upon natural exposure to the virus. Generation of higher quality neutralizing antibodies w...

journal_title：Frontiers in immunology

authors： Eichinger KM,Kosanovich JL,Gidwani SV,Zomback A,Lipp MA,Perkins TN,Oury TD,Petrovsky N,Marshall CP,Yondola MA,Empey KM

更新日期：2020-07-29 00:00:00

abstract：:For many years, disappointing results have been generated by many investigations, which have utilized a variety of immunologic strategies to enhance the ability of a patient's immune system to recognize and eliminate malignant cells. However, in recent years, immunotherapy has been used successfully for the treatment ...

journal_title：Frontiers in immunology

authors： Caratelli S,Sconocchia T,Arriga R,Coppola A,Lanzilli G,Lauro D,Venditti A,Del Principe MI,Buccisano F,Maurillo L,Ferrone S,Sconocchia G

更新日期：2017-04-27 00:00:00

abstract：:Mast cells are implicated as detrimental players in inflammatory lung diseases, particularly asthma. Mast cells respond to activating stimuli by releasing a wide panel of pro-inflammatory compounds that can contribute profoundly to the pathology, and there is currently an unmet need for strategies that efficiently ame...

journal_title：Frontiers in immunology

authors： Paivandy A,Sandelin M,Igelström H,Landelius P,Janson C,Melo FR,Pejler G

更新日期：2017-11-27 00:00:00

abstract：:Scavenger receptors are cell surface membrane-bound receptors that typically bind multiple ligands and promote the removal of endogenous proteins and pathogens. In this study, we characterized a novel scavenger receptor-like protein, namely, SpBark. SpBark was upregulated in hemocytes after challenges with bacteria, s...

journal_title：Frontiers in immunology

authors： Li XC,Zhou J,Zhou JF,Wang Y,Ma H,Wang Y,Zhao S,Fang WH

更新日期：2019-08-23 00:00:00

abstract：:Obesity and associated liver diseases (Non Alcoholic Fatty Liver Disease, NAFLD) are a major public health problem with increasing incidence in Western countries (25% of the affected population). These complications develop from a fatty liver (steatosis) to an inflammatory state (steatohepatitis) evolving toward fibro...

journal_title：Frontiers in immunology

authors： Luci C,Vieira E,Perchet T,Gual P,Golub R

更新日期：2019-05-28 00:00:00

abstract：:In response to the global burden of liver disease there has been a commensurate increase in the demand for liver transplantation. However, due to a paucity of donor organs many centers have moved toward the routine use of marginal allografts, which can be associated with a greater risk of complications and poorer clin...

journal_title：Frontiers in immunology

authors： Owen A,Newsome PN

更新日期：2020-06-19 00:00:00

abstract：:While developing adaptive immune responses, young infants are especially vulnerable to serious infections, including sepsis, meningitis, and pneumonia. Antimicrobial proteins and peptides (APPs) are key effectors that function as broad-spectrum anti-infectives. This review seeks to summarize the clinically relevant fu...

journal_title：Frontiers in immunology

authors： Battersby AJ,Khara J,Wright VJ,Levy O,Kampmann B

更新日期：2016-08-18 00:00:00

abstract：:Major histocompatibility complex class two (MHC-II) molecules are trans-membrane proteins and key components of the cellular immune system. Upon recognition of foreign peptides expressed on the MHC-II binding groove, CD4+ T cells mount an immune response against invading pathogens. Therefore, mechanistic identificatio...

journal_title：Frontiers in immunology

authors： Degoot AM,Chirove F,Ndifon W

更新日期：2018-06-20 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fimmu.2019.00917.]. ...

journal_title：Frontiers in immunology

authors： Magcwebeba T,Dorhoi A,du Plessis N

更新日期：2019-07-02 00:00:00

abstract：:A single nucleotide polymorphism, C1858T, in the gene encoding the protein tyrosine phosphatase nonreceptor type 22 (PTPN22) results in one of the strongest genetic traits associated with autoimmune disease outside of the Major Histocompatibility Complex (MHC) genes. However, the consequences of this polymorphism, whi...

journal_title：Frontiers in immunology

authors： Bray C,Wright D,Haupt S,Thomas S,Stauss H,Zamoyska R

更新日期：2018-11-12 00:00:00

abstract：:After birth, the intestinal immune system enters a critical developmental stage, in which tolerogenic and pro-inflammatory cells emerge to contribute to the overall health of the host. The neonatal health is continuously challenged by microbial colonization and food intake, first in the form of breast milk or formula ...

journal_title：Frontiers in immunology

authors： Parigi SM,Eldh M,Larssen P,Gabrielsson S,Villablanca EJ

更新日期：2015-08-19 00:00:00

abstract：:Tumor necrosis factor (TNF)-α is a major pro-inflammatory cytokine produced in response to toll-like receptor stimulation. TNF-α release is controlled by the activity of TNF-α converting enzyme (TACE) that cut membrane-bound TNF-α to shed its ectodomain as a soluble cytokine. The purinergic receptor P2X ligand-gated i...

journal_title：Frontiers in immunology

authors： Barberà-Cremades M,Gómez AI,Baroja-Mazo A,Martínez-Alarcón L,Martínez CM,de Torre-Minguela C,Pelegrín P

更新日期：2017-07-24 00:00:00

abstract：:Over the last decade, the acceleration in the clinical use of mesenchymal stromal cells (MSCs) has been nothing short of spectacular. Perhaps most surprising is how little we know about the "MSC product." Although MSCs are being delivered to patients at an alarming rate, the regulatory requirements for MSC therapies (...

journal_title：Frontiers in immunology

authors： Wilson A,Hodgson-Garms M,Frith JE,Genever P

更新日期：2019-05-16 00:00:00

abstract：:Natural killer (NK) cells play an important role in the containment of HIV replication during primary infection, though their functions are impaired during chronic HIV infection. Infants experience more rapid HIV disease progression than adults, but contributions of infant NK cells to containing HIV infection are unkn...

journal_title：Frontiers in immunology

authors： Slyker JA,Lohman-Payne B,John-Stewart GC,Dong T,Mbori-Ngacha D,Tapia K,Atzberger A,Taylor S,Rowland-Jones SL,Blish CA

更新日期：2012-12-31 00:00:00

abstract：:Many a disease associates with inflammation. Upon binding of antigen-antibody complexes to immunoglobulin-like receptors, mast cells release tumor necrosis factor-α and proteases, causing fibroblasts to release endogenous antigens that may be cross reactive with exogenous antigens. We made a predictive dynamic map of ...

journal_title：Frontiers in immunology

authors： Abudukelimu A,Barberis M,Redegeld FA,Sahin N,Westerhoff HV

更新日期：2018-08-07 00:00:00

abstract：:Both CD4+ and CD8+ Tregs play a critical role in the control of immune responses and immune tolerance; however, our understanding of CD8+ Tregs is limited while they are particularly promising for therapeutic application. We report here existence of highly suppressive human CD8+CD45RClow/- Tregs expressing Foxp3 and p...

journal_title：Frontiers in immunology

authors： Bézie S,Meistermann D,Boucault L,Kilens S,Zoppi J,Autrusseau E,Donnart A,Nerrière-Daguin V,Bellier-Waast F,Charpentier E,Duteille F,David L,Anegon I,Guillonneau C

更新日期：2018-01-31 00:00:00

abstract：:Influenza virus NS2 is well known for its role in viral ribonucleoprotein nuclear export; however, its function has not been fully understood. A recent study showed that NS2 might interact with HIST1H1C (H1C, H1.2). Histones have been found to affect influenza virus replication, such as the H2A, H2B, H3, and H4, but H...

journal_title：Frontiers in immunology

authors： Liu X,Yang C,Hu Y,Lei E,Lin X,Zhao L,Zou Z,Zhang A,Zhou H,Chen H,Qian P,Jin M

更新日期：2017-03-24 00:00:00

abstract：:Multiple sclerosis is a chronic auto-inflammatory disease of the central nervous system affecting patients worldwide. Neuroinflammation in multiple sclerosis is mainly driven by peripheral immune cells which invade the central nervous system and cause neurodegenerative inflammation. To enter the target tissue, immune ...

journal_title：Frontiers in immunology

authors： Zondler L,Herich S,Kotte P,Körner K,Schneider-Hohendorf T,Wiendl H,Schwab N,Zarbock A

更新日期：2020-12-14 00:00:00

abstract：:Borrelia burgdorferi sensu lato species complex is capable of establishing persistent infections in a wide variety of species, particularly rodents. Infection is asymptomatic or mild in most reservoir host species, indicating successful co-evolution of the pathogen with its natural hosts. However, infected humans and ...

journal_title：Frontiers in immunology

authors： Tracy KE,Baumgarth N

更新日期：2017-02-20 00:00:00

abstract：:Immunodeficiency, centromeric instability, and facial anomaly (ICF) syndrome is a rare autosomal recessive genetic condition with severe immunodeficiency, which leads to lethal infections if not recognized and treated in early childhood. Up-to-date treatment regimens consist of prophylactic and supportive treatment of...

journal_title：Frontiers in immunology

authors： Gössling KL,Schipp C,Fischer U,Babor F,Koch G,Schuster FR,Dietzel-Dahmen J,Wieczorek D,Borkhardt A,Meisel R,Kuhlen M

更新日期：2017-06-30 00:00:00

abstract：:Adjuvanted whole inactivated virus (WIV) influenza vaccines show promise as broadly protective influenza vaccine candidates. Using WIV as basis we assessed the relative efficacy of different adjuvants by carrying out a head-to-head comparison of the liposome-based adjuvants CAF01 and CAF09 and the protein-based adjuva...

journal_title：Frontiers in immunology

authors： Bhide Y,Dong W,Gribonika I,Voshart D,Meijerhof T,de Vries-Idema J,Norley S,Guilfoyle K,Skeldon S,Engelhardt OG,Boon L,Christensen D,Lycke N,Huckriede A

更新日期：2019-03-29 00:00:00

abstract：:Human papillomavirus (HPV) is the most common sexually transmitted virus. The high-risk HPV types (i.e., HPV16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59) are considered to be the main etiological agents of genital tract cancers, such as cervical, vulvar, vaginal, penile, and anal cancers, and of a subset of head and...

journal_title：Frontiers in immunology

authors： Garbuglia AR,Lapa D,Sias C,Capobianchi MR,Del Porto P

更新日期：2020-02-18 00:00:00