Serum Amyloid A Stimulates Vascular and Renal Dysfunction in Apolipoprotein E-Deficient Mice Fed a Normal Chow Diet.

abstract：:Human monocyte-derived dendritic cells (DCs) exposed to pathogen-associated molecular patterns (PAMPs) undergo bioenergetic changes that influence the immune response. We found that stimulation with PAMPs enhanced glycolysis in DCs, whereas oxidative phosphorylation remained unaltered. Glucose starvation and the hexok...

journal_title：Frontiers in immunology

authors： Márquez S,Fernández JJ,Terán-Cabanillas E,Herrero C,Alonso S,Azogil A,Montero O,Iwawaki T,Cubillos-Ruiz JR,Fernández N,Crespo MS

更新日期：2017-06-19 00:00:00

abstract：:Neddylation is a type of post-translational protein modifications, in which neural precursor cell expressed developmentally downregulated protein 8 (NEDD8) is covalently conjugated to the lysine residues of target substrates. The best characterized principal substrates of neddylation are the cullin-RING ligases (CRLs)...

journal_title：Frontiers in immunology

authors： Yu G,Liu X,Tang J,Xu C,Ouyang G,Xiao W

更新日期：2019-06-25 00:00:00

abstract：:The actin cytoskeleton is composed of a dynamic filament meshwork that builds the architecture of the cell to sustain its fundamental properties. This physical structure is characterized by a continuous remodeling, which allows cells to accomplish complex motility steps such as directed migration, crossing of biologic...

journal_title：Frontiers in immunology

authors： Dupré L,Houmadi R,Tang C,Rey-Barroso J

更新日期：2015-11-18 00:00:00

abstract：:Macrophages, as professional phagocytes of the immune system, possess the ability to detect and clear invading pathogens and apoptotic cells through phagocytosis. Phagocytosis involves membrane reorganization and remodeling events on the cell surface, which play an essential role in innate immunity and tissue homeosta...

journal_title：Frontiers in immunology

authors： Rubio JM,Astudillo AM,Casas J,Balboa MA,Balsinde J

更新日期：2018-07-24 00:00:00

abstract：:Multiple Myeloma (MM) is a hematological cancer characterized by proliferation of malignant plasma cells in the bone marrow (BM). MM represents the second most frequent hematological malignancy, accounting 1% of all cancer and 13% of hematological tumors, with ~9,000 new cases per year. Patients with monoclonal gammop...

journal_title：Frontiers in immunology

authors： Morandi F,Horenstein AL,Costa F,Giuliani N,Pistoia V,Malavasi F

更新日期：2018-11-28 00:00:00

abstract：:Tissue macrophages play a crucial role in the maintenance of tissue homeostasis and also contribute to inflammatory and reparatory responses during pathogenic infection and tissue injury. The high heterogeneity of these macrophages is consistent with their adaptation to distinct tissue environments and specialization ...

journal_title：Frontiers in immunology

authors： Cassado Ados A,D'Império Lima MR,Bortoluci KR

更新日期：2015-05-19 00:00:00

abstract：:Virus-specific CD4(+) T cells play a major role in viral infections, such as hepatitis C virus (HCV). Viral clearance is associated with vigorous and multi-specific CD4(+) T-cell responses, while chronic infection has been shown to be associated with weak or absent T-cell responses. Most of these studies have used fun...

journal_title：Frontiers in immunology

authors： Lokhande MU,Thimme R,Klenerman P,Semmo N

更新日期：2015-02-25 00:00:00

abstract：Background:Multiple sclerosis (MS) is a chronic, progressive autoimmune disease of the central nervous system in which inflammation plays a key role in the induction, development, and progression. Most of the MS patients present with relapsing-remitting (RR) form, characterized by flare-ups followed by periods of recov...

journal_title：Frontiers in immunology

authors： D'Angelo C,Reale M,Costantini E,Di Nicola M,Porfilio I,de Andrés C,Fernández-Paredes L,Sánchez-Ramón S,Pasquali L

更新日期：2018-06-04 00:00:00

abstract：:iNKT cells are CD1d-restricted T cells recognizing lipid antigens. The prototypic iNKT cell-agonist α-galactosylceramide (α-GalCer) alongside compounds with similar structures induces robust proliferation and cytokine production of iNKT cells and protects against cancer in vivo. Monoclonal antibodies (mAbs) that detec...

journal_title：Frontiers in immunology

authors： Clark K,Yau J,Bloom A,Wang J,Venzon DJ,Suzuki M,Pasquet L,Compton BJ,Cardell SL,Porcelli SA,Painter GF,Zajonc DM,Berzofsky JA,Terabe M

更新日期：2019-10-09 00:00:00

abstract：:Long lasting antibody responses and immunological memory are the desired outcomes of vaccination. In general, multiple vaccine doses result in enhanced immune responses, a notable exception being booster-induced hyporesponsiveness, which has been observed with polysaccharide and glycoconjugate vaccines. In this study,...

journal_title：Frontiers in immunology

authors： Mantile F,Capasso A,De Berardinis P,Prisco A

更新日期：2019-03-19 00:00:00

abstract：:In humans, NK cells are mainly identified by the surface expression levels of CD56 and CD16, which differentiate between five functionally different NK cell subsets. However, nowadays NK cells are considered as a more heterogeneous population formed by various subsets differing in function, surface phenotype, and anat...

journal_title：Frontiers in immunology

authors： Cristiani CM,Palella E,Sottile R,Tallerico R,Garofalo C,Carbone E

更新日期：2016-12-27 00:00:00

abstract：:The close association between cardiovascular pathology and renal dysfunction is well documented and significant. Patients with conventional risk factors for cardiovascular disease like diabetes and hypertension also suffer renal dysfunction. This is unsurprising if the kidney is simply regarded as a "modified blood ve...

journal_title：Frontiers in immunology

authors： Hewitson TD,Holt SG,Smith ER

更新日期：2015-09-17 00:00:00

abstract：:Background: Elevated interleukin-6 (IL-6) and complement activation are associated with detrimental effects of inflammation in coronary artery disease (CAD). The complement anaphylatoxins C5a and C3a interact with their receptors; the highly inflammatory C5aR1, and the C5aR2 and C3aR. We evaluated the effect of the IL...

journal_title：Frontiers in immunology

authors： Orrem HL,Nilsson PH,Pischke SE,Kleveland O,Yndestad A,Ekholt K,Damås JK,Espevik T,Bendz B,Halvorsen B,Gregersen I,Wiseth R,Andersen GØ,Ueland T,Gullestad L,Aukrust P,Barratt-Due A,Mollnes TE

更新日期：2018-09-12 00:00:00

abstract：:Immune checkpoint inhibition has been shown to successfully reactivate endogenous T cell responses directed against tumor-associated antigens, resulting in significantly prolonged overall survival in patients with various tumor entities. For malignancies with low endogenous immune responses, this approach has not show...

journal_title：Frontiers in immunology

authors： Lichtenegger FS,Rothe M,Schnorfeil FM,Deiser K,Krupka C,Augsberger C,Schlüter M,Neitz J,Subklewe M

更新日期：2018-02-27 00:00:00

abstract：:Disialoganglioside GD2 is an important target on several pediatric and adult cancer types including neuroblastoma, retinoblastoma, melanoma, small-cell lung cancer, brain tumors, sarcomas, and cancer stem cells. We have utilized structural and computational methods to refine the framework of humanized monoclonal antib...

journal_title：Frontiers in immunology

authors： Ahmed M,Hu J,Cheung NK

更新日期：2014-08-14 00:00:00

abstract：:A new paradigm of mucosal vaccination against human immunodeficiency virus (HIV) infection has been investigated in the macaque model. A vaccine consisting of inactivated simian immunodeficiency virus (SIV)mac239 particles together with a living bacterial adjuvant (either the Calmette and Guerin bacillus, Lactobacillu...

journal_title：Frontiers in immunology

authors： Andrieu JM,Chen S,Lai C,Guo W,Lu W

更新日期：2014-06-30 00:00:00

abstract：:The porcine reproductive and respiratory syndrome virus (PRRSV) is the cause of one of the most economically important diseases affecting swine worldwide. Efforts to develop a next-generation vaccine have largely focused on envelope glycoproteins to target virus-neutralizing antibody responses. However, these approach...

journal_title：Frontiers in immunology

authors： Mokhtar H,Pedrera M,Frossard JP,Biffar L,Hammer SE,Kvisgaard LK,Larsen LE,Stewart GR,Somavarapu S,Steinbach F,Graham SP

更新日期：2016-02-16 00:00:00

abstract：:Clostridium difficile infection (CDI) is the leading cause of world-wide nosocomial acquired diarrhea in adults. Active vaccination is generally accepted as a logical and cost-effective approach to prevent CDI. In this paper, we have generated two novel chimeric proteins; one designated Tcd169, comprised of the glucos...

journal_title：Frontiers in immunology

authors： Wang S,Wang Y,Cai Y,Kelly CP,Sun X

更新日期：2018-10-22 00:00:00

abstract：:Regulatory T cells (Tregs) are considered key players in the prevention of allograft rejection in transplanted patients. Belatacept (BLT) is an effective alternative to calcineurin inhibitors that appears to preserve graft survival and function; however, the impact of this drug in the homeostasis of Tregs in transplan...

journal_title：Frontiers in immunology

authors： Alvarez Salazar EK,Cortés-Hernández A,Alemán-Muench GR,Alberú J,Rodríguez-Aguilera JR,Recillas-Targa F,Chagoya de Sánchez V,Cuevas E,Mancilla-Urrea E,Pérez García M,Mondragón-Ramírez G,Vilatobá M,Bostock I,Hernández-Méndez E,

更新日期：2017-03-03 00:00:00

abstract：:Free heme is an inflammatory molecule capable of inducing migration and activation of neutrophils. Here, we examine the heme-driven oxidative stress-associated cell death mechanisms in human neutrophils infected with Leishmania infantum, an etiologic agent of visceral leishmaniasis (VL). We first performed exploratory...

journal_title：Frontiers in immunology

authors： Quintela-Carvalho G,Luz NF,Celes FS,Zanette DL,Andrade D,Menezes D,Tavares NM,Brodskyn CI,Prates DB,Gonçalves MS,de Oliveira CI,Almeida RP,Bozza MT,Andrade BB,Borges VM

更新日期：2017-11-23 00:00:00

abstract：:Lower respiratory tract infections and tuberculosis are responsible for the death of about 4.5 million people each year and are the main causes of mortality in children under 5 years of age. Streptococcus pneumoniae is the most common bacterial pathogen associated with severe pneumonia, although other Gram-positive an...

journal_title：Frontiers in immunology

authors： Vázquez R,García E,García P

更新日期：2018-10-16 00:00:00

abstract：:Lyme disease (Borrelia burgdorferi infection) is increasingly recognized as a significant source of morbidity worldwide. Here, we show that blood plasmablasts and CD27- memory B cells are elevated in untreated Lyme disease, with higher plasmablast levels associated with more rapid resolution of clinical symptoms. Stro...

journal_title：Frontiers in immunology

authors： Blum LK,Adamska JZ,Martin DS,Rebman AW,Elliott SE,Cao RRL,Embers ME,Aucott JN,Soloski MJ,Robinson WH

更新日期：2018-07-18 00:00:00

abstract：:A domain that is often neglected in the assessment of chimeric antigen receptor (CAR) functionality is the extracellular spacer module. However, several studies have elucidated that membrane proximal epitopes are best targeted through CARs comprising long spacers, while short spacer CARs exhibit highest activity on di...

journal_title：Frontiers in immunology

authors： Schäfer D,Henze J,Pfeifer R,Schleicher A,Brauner J,Mockel-Tenbrinck N,Barth C,Gudert D,Al Rawashdeh W,Johnston ICD,Hardt O

更新日期：2020-08-07 00:00:00

abstract：:Newborns are at significantly increased risk of severe disease following infection with influenza virus. This is the collective result of their naïve status, altered immune responsiveness, and the lack of a vaccine that is effective in these individuals. Numerous studies have revealed impairments in both the innate an...

journal_title：Frontiers in immunology

authors： Alexander-Miller MA

更新日期：2020-09-16 00:00:00

abstract：:The identification of recurrent human leukocyte antigen (HLA) neoepitopes driving T cell responses against tumors poses a significant bottleneck in the development of approaches for precision cancer therapeutics. Here, we employ a bioinformatics method, Prediction of T Cell Epitopes for Cancer Therapy, to analyze sequ...

journal_title：Frontiers in immunology

authors： Toor JS,Rao AA,McShan AC,Yarmarkovich M,Nerli S,Yamaguchi K,Madejska AA,Nguyen S,Tripathi S,Maris JM,Salama SR,Haussler D,Sgourakis NG

更新日期：2018-01-30 00:00:00

abstract：:The recent discoveries of broadly potent neutralizing human monoclonal antibodies represent a new generation of antiretrovirals for the treatment and prophylaxis. Antibodies are generally considered more effective and safer and have been proved to provide passive protection against mucosal challenge in humanized mice ...

journal_title：Frontiers in immunology

authors： Sun M,Li Y,Zheng H,Shao Y

更新日期：2016-09-30 00:00:00

abstract：:Celiac Disease (CD) is a multifactorial, autoimmune enteropathy activated by cereal proteins in genetically predisposed individuals carrying HLA DQ2/8 genes. A heterogenous gene combination of the cereal prolamins is documented in different wheat genotypes, which is suggestive of their variable immunogenic potential. ...

journal_title：Frontiers in immunology

authors： Grover J,Chhuneja P,Midha V,Ghia JE,Deka D,Mukhopadhyay CS,Sood N,Mahajan R,Singh A,Verma R,Bansal E,Sood A

更新日期：2019-02-04 00:00:00

abstract：:The immune system is composed of two subsystems-the innate immune system and the adaptive immune system. The innate immune system is the first to respond to pathogens and does not retain memory of previous responses. Innate immune responses are evolutionarily older than adaptive responses and elements of innate immuni...

journal_title：Frontiers in immunology

authors： Smith NC,Rise ML,Christian SL

更新日期：2019-10-10 00:00:00

abstract：:Approximately 1.2 billion people suffer from fungal diseases worldwide. Arguably, the most serious manifestation occurs when pathogenic fungi infect the brain, often causing fatal meningoencephalitis. For most fungi, infection occurs via the vascular route. The organism must first be arrested in the brain microvascula...

journal_title：Frontiers in immunology

authors： Shi M,Mody CH

更新日期：2016-08-02 00:00:00

abstract：:Ectoenzyme and receptor BST-1/CD157 has been considered as a key molecule involved in the regulation of functional activity of cells in various tissues and organs. It is commonly accepted that CD157 catalyzes NAD+ hydrolysis and acts as a component of integrin adhesion receptor complex. Such properties are important f...

journal_title：Frontiers in immunology

authors： Lopatina OL,Komleva YK,Malinovskaya NA,Panina YA,Morgun AV,Salmina AB

更新日期：2020-11-10 00:00:00