L-selectin: A Major Regulator of Leukocyte Adhesion, Migration and Signaling.

abstract：:A process is a function of time; in immunometabolism, this is reflected by the stepwise adaptation of metabolism to sustain the bio-energetic demand of an immune-response in its various states and shades. This perspective article starts by presenting an early attempt to investigate the physiology of inflammation, in o...

journal_title：Frontiers in immunology

authors： Nagy C,Haschemi A

更新日期：2015-04-08 00:00:00

abstract：:Common Variable Immunodeficiency (CVID) is characterized by impaired antibody production and poor terminal differentiation of the B cell compartment, yet its pathogenesis is still poorly understood. We first reported the occurrence of epigenetic alterations in CVID by high-throughput methylation analysis in CVID-disco...

journal_title：Frontiers in immunology

authors： Del Pino-Molina L,Rodríguez-Ubreva J,Torres Canizales J,Coronel-Díaz M,Kulis M,Martín-Subero JI,van der Burg M,Ballestar E,López-Granados E

更新日期：2019-04-24 00:00:00

abstract：:Antibody evolution studies have been traditionally limited to either tracing a single clonal lineage (B cells derived from a single V-(D)-J recombination) over time or examining bulk functionality changes (e.g., tracing serum polyclonal antibody proteins). Studying a single B cell disregards the majority of the humora...

journal_title：Frontiers in immunology

authors： Yermanos AD,Dounas AK,Stadler T,Oxenius A,Reddy ST

更新日期：2018-10-02 00:00:00

abstract：:Mast cells constitutively express ß-catenin and expand in solid tumors such as colon and skin cancer. However, the role of ß-catenin signaling in mast cells and the cause or effect of mast cell expansion and tumor growth has yet to be established. In earlier studies we used mast cell depletion and protease staining ap...

journal_title：Frontiers in immunology

authors： Saadalla A,Lima MM,Tsai F,Osman A,Singh MP,Linden DR,Dennis KL,Haeryfar SMM,Gurish MF,Gounari F,Khazaie K

更新日期：2019-12-03 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fimmu.2018.00707.]. ...

journal_title：Frontiers in immunology

authors： Greaves SA,Peterson JN,Torres RM,Pelanda R

更新日期：2018-09-27 00:00:00

abstract：:The gastrointestinal tract hosts the largest collection of commensal microbes in the body. Infections at this site can cause significant perturbations in the microbiota, known as dysbiosis, that facilitate the expansion of pathobionts, and can elicit inappropriate immune responses that impair the intestinal barrier fu...

journal_title：Frontiers in immunology

authors： Cervantes-Barragan L,Cortez VS,Wang Q,McDonald KG,Chai JN,Di Luccia B,Gilfillan S,Hsieh CS,Newberry RD,Sibley LD,Colonna M

更新日期：2019-07-02 00:00:00

abstract：:Recent studies suggest that the cross-talk between the gut microbiota and human immune system during the first year of life is an important regulator of the later development of atopic diseases. We explored the changes in the gut microbiota, blood regulatory T cells, and atopic sensitization in a birth-cohort of Eston...

journal_title：Frontiers in immunology

authors： Ruohtula T,de Goffau MC,Nieminen JK,Honkanen J,Siljander H,Hämäläinen AM,Peet A,Tillmann V,Ilonen J,Niemelä O,Welling GW,Knip M,Harmsen HJ,Vaarala O

更新日期：2019-10-23 00:00:00

abstract：:Understanding the mechanisms of human immunodeficiency virus type I (HIV-1) pathogenesis would facilitate the identification of new therapeutic targets to control the infection in face of current antiretroviral therapy limitations. CD74 membrane expression is upregulated in HIV-1-infected cells and the magnitude of it...

journal_title：Frontiers in immunology

authors： Trifone C,Salido J,Ruiz MJ,Leng L,Quiroga MF,Salomón H,Bucala R,Ghiglione Y,Turk G

更新日期：2018-06-27 00:00:00

abstract：:Dengue is considered the most important emerging, human arboviruses, with worldwide distribution in the tropics. Unfortunately, there are no licensed dengue vaccines available or specific anti-viral drugs. The development of a dengue vaccine faces unique challenges. The four serotypes co-circulate in endemic areas, an...

journal_title：Frontiers in immunology

authors： Sariol CA,White LJ

更新日期：2014-09-24 00:00:00

abstract：Objectives:We explored histological and transcriptomic profiles of paired synovial biopsies from rheumatoid arthritis (RA) patients, in order to assess homogeneity in synovial tissue at the individual level. Methods:Synovial biopsies were performed simultaneously in one small and one large joint per patient using need...

journal_title：Frontiers in immunology

authors： Triaille C,Vansteenkiste L,Constant M,Ambroise J,Méric de Bellefon L,Nzeusseu Toukap A,Sokolova T,Galant C,Coulie P,Carrasco J,Durez P,Lauwerys BR

更新日期：2020-11-23 00:00:00

abstract：:CD27 expression has been used to distinguish between memory and naive B cells in humans. However, low levels of mutated and isotype-switched CD27-IgD- cells are seen in healthy adults, and these are increased in some autoimmune diseases and in the elderly. Thus CD27 is not a universal marker of memory B cells in human...

journal_title：Frontiers in immunology

authors： Wu YC,Kipling D,Dunn-Walters DK

更新日期：2011-12-26 00:00:00

abstract：:During the acute phase of Trypanosoma cruzi infection, macrophages can act as host cells for the parasites as well as effector cells in the early anti-parasitic immune response. Thus, the targeting of specific signaling pathways could modulate macrophages response to restrict parasite replication and instruct an appro...

journal_title：Frontiers in immunology

authors： Volpini X,Ambrosio LF,Fozzatti L,Insfran C,Stempin CC,Cervi L,Motran CC

更新日期：2018-04-23 00:00:00

abstract：:Stromal cells provide the structural foundation of secondary lymphoid organs (SLOs), and regulate leukocyte access and cell migration within the different compartments of spleen and lymph nodes (LNs). Furthermore, several stromal cell subsets have been implied in shaping of T cell responses through direct presentation...

journal_title：Frontiers in immunology

authors： Onder L,Scandella E,Chai Q,Firner S,Mayer CT,Sparwasser T,Thiel V,Rülicke T,Ludewig B

更新日期：2011-10-12 00:00:00

abstract：:T-cell tolerance to self-antigens is established in the thymus through the recognition by developing thymocytes of self-peptide-MHC complexes and induced and maintained in the periphery. Efficient negative selection of auto-reactive T cells in the thymus is dependent on the in situ expression of both ubiquitous and ti...

journal_title：Frontiers in immunology

authors： Collado JA,Guitart C,Ciudad MT,Alvarez I,Jaraquemada D

更新日期：2013-12-17 00:00:00

abstract：:The pathogenesis of many retinal degenerations, such as age-related macular degeneration (AMD), is punctuated by an ill-defined network of sterile inflammatory responses. The delineation of innate and adaptive immune milieu among the broad leukocyte infiltrate, and the gene networks, which construct these responses, a...

journal_title：Frontiers in immunology

authors： Natoli R,Mason E,Jiao H,Chuah A,Patel H,Fernando N,Valter K,Wells CA,Provis J,Rutar M

更新日期：2018-07-18 00:00:00

abstract：:Vaccines aiming to promote T-cell-mediated immune responses have so far showed limited efficacy, and there is a need for novel strategies. Studies indicate that autophagy plays an inherent role in antigen processing and presentation for CD4(+) and CD8(+) T cells. Here, we report a novel vaccine strategy based on fusio...

journal_title：Frontiers in immunology

authors： Andersen AN,Landsverk OJ,Simonsen A,Bogen B,Corthay A,Øynebråten I

更新日期：2016-05-10 00:00:00

abstract：:Degeneration of central cholinergic neurons impairs memory, and enhancement of cholinergic synapses improves cognitive processes. Cholinergic signaling is also anti-inflammatory, and neuroinflammation is increasingly linked to adverse memory, especially in Alzheimer's disease. Much of the evidence surrounding choliner...

journal_title：Frontiers in immunology

authors： Maurer SV,Williams CL

更新日期：2017-11-08 00:00:00

abstract：:The oral administration of Lacticaseibacillus rhamnosus CRL1505 differentially modulates the respiratory innate antiviral immune response triggered by Toll-like receptor 3 (TLR3) activation in infant mice, improving the resistance to Respiratory Syncytial Virus (RSV) infection. In this work, by using macrophages deple...

journal_title：Frontiers in immunology

authors： Garcia-Castillo V,Tomokiyo M,Raya Tonetti F,Islam MA,Takahashi H,Kitazawa H,Villena J

更新日期：2020-09-29 00:00:00

abstract：:Hemagglutinin glycoprotein (HA) is a principle influenza vaccine antigen. Recombinant HA-based vaccines become a potential alternative for traditional approach. Complexity and variation of HA N-glycosylation are considered as the important factors for the vaccine design. The number and location of glycan moieties in t...

journal_title：Frontiers in immunology

authors： Macioła AK,Pietrzak MA,Kosson P,Czarnocki-Cieciura M,Śmietanka K,Minta Z,Kopera E

更新日期：2017-04-20 00:00:00

abstract：:Major trauma-induced tissue injury causes a dysregulation of the immune system. Severe systemic inflammation occurs early after the insult. Later on, an enhanced risk for life-threatening opportunistic infections develops that culminates at the end of the first week after trauma. CD56bright Natural killer (NK) cells p...

journal_title：Frontiers in immunology

authors： Bösken B,Hepner-Schefczyk M,Vonderhagen S,Dudda M,Flohé SB

更新日期：2020-06-25 00:00:00

abstract：:Background: Optimal timing of gestational tetanus-diphtheria-acellular pertussis (Tdap) vaccination is not well-defined. No well-established specific anti-pertussis antibody level correlates with protection, suggesting the importance of antibody quality such as avidity. We aimed to determine the effect of timing of va...

journal_title：Frontiers in immunology

authors： Abu-Raya B,Giles ML,Kollmann TR,Sadarangani M

更新日期：2019-10-11 00:00:00

abstract：:Experimental animal models of tuberculosis (TB) have convincingly demonstrated that inhaled dose predicts immunopathology and survival. In contrast, the importance of inhaled dose has generally not been appreciated in TB epidemiology, clinical science, or the practice of TB control. Infectiousness of TB patients has t...

journal_title：Frontiers in immunology

authors： Fennelly KP,Jones-López EC

更新日期：2015-06-29 00:00:00

abstract：:Acute infection of bovine viral diarrhea virus (BVDV) is associated with immune dysfunction and can cause peripheral blood lymphopenia and lymphocyte apoptosis. Our previous study has confirmed that programmed death-1 (PD-1) blockade inhibits peripheral blood lymphocyte (PBL) apoptosis and restores proliferation and a...

journal_title：Frontiers in immunology

authors： Liu Y,Liu S,Wu C,Huang W,Xu B,Lian S,Wang L,Yue S,Chen N,Zhu Z

更新日期：2020-03-17 00:00:00

abstract：:Human noroviruses (HuNoVs) are the cause of more than 95% of epidemic non-bacterial gastroenteritis worldwide, with some lethal cases. These viral agents affect people of all ages. However, young children and older adults are the highest-risk groups, being affected with the greatest rate of hospitalizations and morbid...

journal_title：Frontiers in immunology

authors： Campillay-Véliz CP,Carvajal JJ,Avellaneda AM,Escobar D,Covián C,Kalergis AM,Lay MK

更新日期：2020-06-16 00:00:00

abstract：:The developmental origin of allergic diseases has been suggested, but the molecular basis remains enigmatic. Exposure to environmental factors, such as di-(2-ethylhexyl) phthalate (DEHP; a common plasticizer), is suggested to be associated with increased childhood allergic asthma, but the causal relationship and its u...

journal_title：Frontiers in immunology

authors： Suen JL,Wu TT,Li YH,Lee CL,Kuo FC,Yan PS,Wu CF,Tran M,Wang CJ,Hung CH,Wu MT,Chan MWY,Huang SK

更新日期：2020-12-23 00:00:00

abstract：:Free heme is an inflammatory molecule capable of inducing migration and activation of neutrophils. Here, we examine the heme-driven oxidative stress-associated cell death mechanisms in human neutrophils infected with Leishmania infantum, an etiologic agent of visceral leishmaniasis (VL). We first performed exploratory...

journal_title：Frontiers in immunology

authors： Quintela-Carvalho G,Luz NF,Celes FS,Zanette DL,Andrade D,Menezes D,Tavares NM,Brodskyn CI,Prates DB,Gonçalves MS,de Oliveira CI,Almeida RP,Bozza MT,Andrade BB,Borges VM

更新日期：2017-11-23 00:00:00

abstract：:The so-called shock and kill therapies aim to combine HIV-1 reactivation by latency-reversing agents (LRA) with immune clearance to purge the HIV-1 reservoir. The clinical use of LRA has demonstrated detectable perturbations in the HIV-1 reservoir without measurable reductions to date. Consequently, fundamental questi...

journal_title：Frontiers in immunology

authors： Ruiz A,Blanch-Lombarte O,Jimenez-Moyano E,Ouchi D,Mothe B,Peña R,Galvez C,Genescà M,Martinez-Picado J,Goulder P,Barnard R,Howell B,Clotet B,Prado JG

更新日期：2019-01-22 00:00:00

abstract：:Inflammation plays important roles at different stages of diabetes mellitus, tumorigenesis, and cardiovascular diseases. (-)-Epigallocatechin gallate (EGCG) can attenuate inflammatory responses effectively. However, the immediate early mechanism of EGCG in inflammation remains unclear. Here, we showed that EGCG attenu...

journal_title：Frontiers in immunology

authors： Wang T,Xiang Z,Wang Y,Li X,Fang C,Song S,Li C,Yu H,Wang H,Yan L,Hao S,Wang X,Sheng J

更新日期：2017-04-10 00:00:00

abstract：:The induction of donor-specific transplant tolerance is one of the main goals of modern immunology. Establishment of a mixed chimerism state in the transplant recipient has proven to be a suitable strategy for the induction of long-term allograft tolerance; however, current experimental recipient preconditioning proto...

journal_title：Frontiers in immunology

authors： Ruiz P,Maldonado P,Hidalgo Y,Sauma D,Rosemblatt M,Bono MR

更新日期：2015-11-23 00:00:00

abstract：:The cytosolic adhesion and degranulation-promoting adapter protein ADAP is expressed in various hematopoietic cells including T cells, NK cells, myeloid cells, and platelets but absent in mature B cells. The role of ADAP in T cell activation, proliferation and integrin activation is well-accepted. We previously demons...

journal_title：Frontiers in immunology

authors： Rudolph J,Meinke C,Voss M,Guttek K,Kliche S,Reinhold D,Schraven B,Reinhold A

更新日期：2019-10-01 00:00:00