Human Norovirus Proteins: Implications in the Replicative Cycle, Pathogenesis, and the Host Immune Response.

abstract：:Piscirickettsia salmonis, an aggressive intracellular pathogen, is the etiological agent of salmonid rickettsial septicemia (SRS). This is a chronic multisystemic disease that generates high mortalities and large losses in Chilean salmon farming, threatening the sustainability of the salmon industry. Previous reports ...

journal_title：Frontiers in immunology

authors： Pérez-Stuardo D,Espinoza A,Tapia S,Morales-Reyes J,Barrientos C,Vallejos-Vidal E,Sandino AM,Spencer E,Toro-Ascuy D,Rivas-Pardo JA,Reyes-López FE,Reyes-Cerpa S

更新日期：2020-11-12 00:00:00

abstract：:Unlike mice and humans, porcine γδ T cells represent a prominent subset of T cells in blood and secondary lymphatic organs. GATA-3, T-bet and Eomesodermin (Eomes) are transcription factors with crucial functions in T-cell development and functional differentiation, but their expression has not been investigated in por...

journal_title：Frontiers in immunology

authors： Rodríguez-Gómez IM,Talker SC,Käser T,Stadler M,Reiter L,Ladinig A,Milburn JV,Hammer SE,Mair KH,Saalmüller A,Gerner W

更新日期：2019-03-11 00:00:00

abstract：:Anemia of inflammation (AI) is the second most prevalent anemia after iron deficiency anemia and results in persistent low blood erythrocytes and hemoglobin, fatigue, weakness, and early death. Anemia of inflammation is common in people with chronic inflammation, chronic infections, or sepsis. Although several studies...

journal_title：Frontiers in immunology

authors： Bisht K,Tay J,Wellburn RN,McGirr C,Fleming W,Nowlan B,Barbier V,Winkler IG,Levesque JP

更新日期：2020-10-06 00:00:00

abstract：:Autoantibodies directed against citrullinated epitopes of proteins are highly diagnostic of rheumatoid arthritis (RA), and elevated levels of protein citrullination can be found in the joints of patients with RA. Calcium-dependent peptidyl-arginine deiminases (PAD) are the enzymes responsible for citrullination. PAD2 ...

journal_title：Frontiers in immunology

authors： Zhou Y,Chen B,Mittereder N,Chaerkady R,Strain M,An LL,Rahman S,Ma W,Low CP,Chan D,Neal F,Bingham CO 3rd,Sampson K,Darrah E,Siegel RM,Hasni S,Andrade F,Vousden KA,Mustelin T,Sims GP

更新日期：2017-09-25 00:00:00

abstract：:Overwhelming infection causes significant morbidity and mortality among patients treated with bone marrow transplantation (BMT) for primary immune deficiencies, syndromes of bone marrow failure, or cancer. The polymorphonuclear leukocyte (PMN; neutrophil) is the first responder to microbial invasion and acts within th...

journal_title：Frontiers in immunology

authors： Glenn JW,Cody MJ,McManus MP,Pulsipher MA,Schiffman JD,Yost CC

更新日期：2016-06-27 00:00:00

abstract：:Lower respiratory infection caused by human pathogens such as influenza and respiratory syncytial virus (RSV) is a significant healthcare burden that must be addressed. The preferred options to achieve this goal are usually to develop vaccines for prophylaxis and to develop antiviral small molecules to treat infected ...

journal_title：Frontiers in immunology

authors： Nyanguile O

更新日期：2019-06-21 00:00:00

abstract：:Adenosine triphosphate (ATP) is released by bacteria and host cells during bacterial infection as well as sterile tissue injury, acting as an inducer of inflammasome activation. Previous studies have shown that ATP treatment leads to AMP-activated protein kinase (AMPK) activation. However, it is unclear whether AMPK s...

journal_title：Frontiers in immunology

authors： Zha QB,Wei HX,Li CG,Liang YD,Xu LH,Bai WJ,Pan H,He XH,Ouyang DY

更新日期：2016-12-12 00:00:00

abstract：Background:Selenium (Se) levels decrease in the circulation during acute inflammatory states and sepsis, and are inversely associated with morbidity and mortality. A more specific understanding of where selenoproteins and Se processing are compromised during insult is needed. We investigated the acute signaling respons...

journal_title：Frontiers in immunology

authors： Sherlock LG,Sjostrom K,Sian L,Delaney C,Tipple TE,Krebs NF,Nozik-Grayck E,Wright CJ

更新日期：2020-11-05 00:00:00

abstract：:Regulatory T cells play an important role in the control of autoimmune diseases and maintenance of tolerance. In the context of transplantation, regulatory T cells (Tregs) have been proposed as new therapeutic tools that may induce allospecific tolerance toward the graft, avoiding the side effects induced by generaliz...

journal_title：Frontiers in immunology

authors： Alvarez-Salazar EK,Cortés-Hernández A,Arteaga-Cruz S,Alberú-Gómez J,Soldevila G

更新日期：2020-04-02 00:00:00

abstract：:Tolerogenic dendritic cells (DCs) work through silencing of differentiated antigen-specific T cells, activation and expansion of naturally occurring T regulatory cells (Tregs), transfer of regulatory properties to T cells, and the differentiation of naïve T cells into Tregs. Due to an operational definition based on T...

journal_title：Frontiers in immunology

authors： Nikolic T,Roep BO

更新日期：2013-05-14 00:00:00

abstract：:Arginine methylation is a post-translational modification that regulates many biological processes. However, the role of arginine methylation in immune cells is not well studied. Here we report an essential role of protein arginine methyltransferase 5 (PRMT5) in T cell homeostasis and activation-induced expansion. Usi...

journal_title：Frontiers in immunology

authors： Tanaka Y,Nagai Y,Okumura M,Greene MI,Kambayashi T

更新日期：2020-04-09 00:00:00

abstract：:People are constantly exposed to airborne fungal spores, including Aspergillus fumigatus conidia that can cause life-threatening conditions in immunocompromised patients or acute exacerbations in allergics. However, immunocompetent hosts do not exhibit mycoses or systemic inflammation, due to the sufficient but not ex...

journal_title：Frontiers in immunology

authors： Bogorodskiy AO,Bolkhovitina EL,Gensch T,Troyanova NI,Mishin AV,Okhrimenko IS,Braun A,Spies E,Gordeliy VI,Sapozhnikov AM,Borshchevskiy VI,Shevchenko MA

更新日期：2020-02-25 00:00:00

abstract：:The glycans on the plasma membrane of cells manifest as the glycocalyx, which serves as an information-rich frontier that is directly in contact with its immediate milieu. The glycoconjugates (GCs) that adorn most of the mammalian cells are also abundant in gametes, especially the spermatozoa where they perform unique...

journal_title：Frontiers in immunology

authors： Batra V,Dagar K,Nayak S,Kumaresan A,Kumar R,Datta TK

更新日期：2020-08-28 00:00:00

abstract：:Hematopoietic cell transplantation (HCT) is a therapy option for aggressive forms of hematopoietic malignancies that are resistant to standard antitumoral therapies. Hematoablative treatment preceding HCT, however, opens a "window of opportunity" for latent Cytomegalovirus (CMV) by releasing it from immune control wit...

journal_title：Frontiers in immunology

authors： Reddehase MJ

更新日期：2016-08-04 00:00:00

abstract：:Myeloid cells play an important role in the pathogenesis of multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE). Monocytes, macrophages, and microglia can adopt two distinct phenotypes, with M1-polarized cells being more related to inflammation and autoimmunity while M2-polariz...

journal_title：Frontiers in immunology

authors： Montes-Cobos E,Schweingruber N,Li X,Fischer HJ,Reichardt HM,Lühder F

更新日期：2017-10-13 00:00:00

abstract：:Although NGS technologies fuel advances in high-throughput HLA genotyping methods for identification and classification of HLA genes to assist with precision medicine efforts in disease and transplantation, the efficiency of these methods are impeded by the absence of adequately-characterized high-frequency HLA allele...

journal_title：Frontiers in immunology

authors： Suzuki S,Ranade S,Osaki K,Ito S,Shigenari A,Ohnuki Y,Oka A,Masuya A,Harting J,Baybayan P,Kitazume M,Sunaga J,Morishima S,Morishima Y,Inoko H,Kulski JK,Shiina T

更新日期：2018-10-04 00:00:00

abstract：:The innate immune system plays a critical early role in host defense against viruses, bacteria, and tumor cells. Until recently, natural killer (NK) cells and lymphoid tissue inducer (LTi) cells were the primary members of the innate lymphocyte family: NK cells form the front-line interface between the external enviro...

journal_title：Frontiers in immunology

authors： Rankin L,Groom J,Mielke LA,Seillet C,Belz GT

更新日期：2013-03-04 00:00:00

abstract：:Human cytomegalovirus (HCMV) is under constant selective pressure from the immune system in vivo. Study of HCMV genes that have been lost in the absence of, or genetically altered by, such selection can focus research toward findings of in vivo significance. We have been particularly interested in the most pronounced ...

journal_title：Frontiers in immunology

authors： Patel M,Vlahava VM,Forbes SK,Fielding CA,Stanton RJ,Wang ECY

更新日期：2018-10-01 00:00:00

abstract：:Aim: We assessed whether different complement factors and complement activation products were associated with poor outcome in patients with necrotizing soft-tissue infection (NSTI). Methods: We conducted a prospective, observational study in an intensive care unit where treatment of NSTI is centralized at a national l...

journal_title：Frontiers in immunology

authors： Kristensen MK,Hansen MB,Madsen MB,Hansen CB,Pilely K,Hyldegaard O,Garred P

更新日期：2020-01-31 00:00:00

abstract：:Mucin 1 (MUC1) is a transmembrane mucin glycoprotein that is over-expressed and aberrantly glycosylated in >80% of human pancreatic ductal adenocarcinoma (PDA) and is associated with poor prognosis. To understand the role of MUC1 in PDA, we have recently developed two mouse models of spontaneous PDA, one that expresse...

journal_title：Frontiers in immunology

authors： Kidiyoor A,Schettini J,Besmer DM,Rego SL,Nath S,Curry JM,Roy LD,Dréau D,Mukherjee P

更新日期：2014-02-24 00:00:00

abstract：Background:Multiple sclerosis (MS) is a chronic, progressive autoimmune disease of the central nervous system in which inflammation plays a key role in the induction, development, and progression. Most of the MS patients present with relapsing-remitting (RR) form, characterized by flare-ups followed by periods of recov...

journal_title：Frontiers in immunology

authors： D'Angelo C,Reale M,Costantini E,Di Nicola M,Porfilio I,de Andrés C,Fernández-Paredes L,Sánchez-Ramón S,Pasquali L

更新日期：2018-06-04 00:00:00

abstract：:The adaptive immune response begins when CD4+ T cells recognize antigenic peptides bound to class II molecules of the Major Histocompatibility Complex (MHCII). The interaction between peptides and MHCII has been historically interpreted as a rigid docking event. However, this model has been challenged by the evidence ...

journal_title：Frontiers in immunology

authors： Ferrante A

更新日期：2013-10-01 00:00:00

abstract：:Background: Chagas cardiomyopathy is the main fibrosing myocarditis among known heart diseases. Development of cardiomyopathy has been related to extracellular matrix (ECM) remodeling, which are controlled by matrix metalloproteinases (MMPs) and cytokines, especially interleukin (IL)-1β. The convertion of 31KDa inacti...

journal_title：Frontiers in immunology

authors： Medeiros NI,Pinto BF,Elói-Santos SM,Teixeira-Carvalho A,Magalhães LMD,Dutra WO,Correa-Oliveira R,Gomes JAS

更新日期：2019-04-18 00:00:00

abstract：:Gastrointestinal (GI) cancers, especially gastric cancer and colorectal cancer (CRC), represent a major global health burden. A large population of microorganisms residing in the GI tract regulate physiological processes, such as the immune response, metabolic balance, and homeostasis. Accumulating evidence has reveal...

journal_title：Frontiers in immunology

authors： Peng C,Ouyang Y,Lu N,Li N

更新日期：2020-06-30 00:00:00

abstract：:In recent years, regulatory T cells (Treg)-based immunotherapy has emerged as a promising strategy to promote operational tolerance after solid organ transplantation (SOT). However, a main hurdle for the therapeutic use of Treg in transplantation is their low frequency, particularly in non-lymphopenic hosts. We aimed ...

journal_title：Frontiers in immunology

authors： Govender L,Wyss JC,Kumar R,Pascual M,Golshayan D

更新日期：2017-04-21 00:00:00

abstract：:Mycobacteria propelled modulation of host responses is of considerable interest in the face of emerging drug resistance. Although it is known that Abl tyrosine kinases affect entry and persistence of mycobacteria, mechanisms that couple c-Abl to proximal signaling pathways during immunity are poorly understood. Loss-o...

journal_title：Frontiers in immunology

authors： Mahadik K,Prakhar P,Rajmani RS,Singh A,Balaji KN

更新日期：2018-02-01 00:00:00

abstract：:Antigen-primed T cells respond to restimulation much faster than naïve T cells and form the cellular basis of immunological memory. The formation of memory Th2 cells starts when naïve CD4 T cells are transformed into effector Th2 cells and is completed after antigen clearance and a long-term resting phase accompanied ...

journal_title：Frontiers in immunology

authors： Onodera A,Kokubo K,Nakayama T

更新日期：2018-12-12 00:00:00

abstract：:Abnormal gene expression patterns underlie many diseases that represent major public health concerns and robust therapeutic challenges. Posttranscriptional gene regulation by RNA-binding proteins (RBPs) is well-recognized, and the biological functions of RBPs have been implicated in many diseases, such as autoimmune d...

journal_title：Frontiers in immunology

authors： Nyati KK,Agarwal RG,Sharma P,Kishimoto T

更新日期：2019-12-05 00:00:00

abstract：:T follicular helper (Tfh) cells are the subset of CD4 T helper cells that are required for generation and maintenance of germinal center reactions and the generation of long-lived humoral immunity. This specialized T helper subset provides help to cognate B cells via their expression of CD40 ligand, IL-21, IL-4, and o...

journal_title：Frontiers in immunology

authors： Hale JS,Ahmed R

更新日期：2015-02-02 00:00:00

abstract：:Metabolic reprogramming is rapidly gaining appreciation in the etiology of immune cell dysfunction in a variety of diseases. Tuberculosis, schistosomiasis, and sarcoidosis represent an important class of diseases characterized by the formation of granulomas, where macrophages are causatively implicated in disease path...

journal_title：Frontiers in immunology

authors： Wilson JL,Mayr HK,Weichhart T

更新日期：2019-10-04 00:00:00