The Effect of Interference on the CD8(+) T Cell Escape Rates in HIV.

abstract：:Behavioral comorbidities (depression, anxiety, fatigue, cognitive disturbances, and neuropathic pain) are prevalent in cancer patients and survivors. These mental and neurological health issues reduce quality-of-life, which is a significant societal concern given the increasing rates of long-term survival after variou...

journal_title：Frontiers in immunology

authors： Santos JC,Pyter LM

更新日期：2018-06-07 00:00:00

abstract：:Increasing prevalence in obesity has become a significant public concern. C57BL/6J mice are prone to diet-induced obesity (DIO) when fed high-fat diet (HFD), and develop chronic inflammation and metabolic syndrome, making them a good model to analyze mechanisms whereby obesity elicits pathologies. DIO mice demonstrate...

journal_title：Frontiers in immunology

authors： Lainez NM,Jonak CR,Nair MG,Ethell IM,Wilson EH,Carson MJ,Coss D

更新日期：2018-09-11 00:00:00

abstract：:Pleural effusions, when benign, are attributed to cardiac events and suffusion of fluid within the pleural space. When malignant, lymphatic obstruction by tumor and failure to absorb constitutively produced fluid is the predominant formulation. The prevailing view has been challenged recently, namely that the lymphati...

journal_title：Frontiers in immunology

authors： Soloff AC,Jones KE,Powers AA,Murthy P,Wang Y,Russell KL,Byrne-Steele M,Lund AW,Yuan JM,Monaco SE,Han J,Dhupar R,Lotze MT

更新日期：2020-09-04 00:00:00

abstract：:Food allergies are common, costly and potentially life-threatening disorders. They are driven by Th2, but inhibited by Th1 reactions. There is also evidence indicating that IL-2 agonist treatment inhibits allergic sensitization through expansion of regulatory T cells. Here, we tested the impact of an IL-2 agonist in a...

journal_title：Frontiers in immunology

authors： Link CWM,Rau CN,Udoye CC,Ragab M,Korkmaz RÜ,Comdühr S,Clauder AK,Lindemann T,Frehse B,Hofmann K,Almeida LN,Laumonnier Y,Beidaq AE,Finkelman FD,Manz RA

更新日期：2020-12-11 00:00:00

abstract：:DNA vaccines have great potential to control infectious disease, particularly those caused by intracellular organisms. They are inexpensive to produce and can be quickly modified to combat emerging infectious threats, but often fail to generate a strong immunologic response limiting enthusiasm for their use in humans ...

journal_title：Frontiers in immunology

authors： Solodushko V,Bitko V,Barrington R,Fouty B

更新日期：2019-10-11 00:00:00

abstract：:Mucin 1 (MUC1) is a transmembrane mucin glycoprotein that is over-expressed and aberrantly glycosylated in >80% of human pancreatic ductal adenocarcinoma (PDA) and is associated with poor prognosis. To understand the role of MUC1 in PDA, we have recently developed two mouse models of spontaneous PDA, one that expresse...

journal_title：Frontiers in immunology

authors： Kidiyoor A,Schettini J,Besmer DM,Rego SL,Nath S,Curry JM,Roy LD,Dréau D,Mukherjee P

更新日期：2014-02-24 00:00:00

abstract：:THE REGULATORY CYTOKINE TUMOR NECROSIS FACTOR (TNF) EXERTS ITS EFFECTS THROUGH TWO RECEPTORS: TNFR1 and TNFR2. Defects in TNFR2 signaling are evident in a variety of autoimmune diseases. One new treatment strategy for autoimmune disease is selective destruction of autoreactive T cells by administration of TNF, TNF ind...

journal_title：Frontiers in immunology

authors： Faustman DL,Davis M

更新日期：2013-12-23 00:00:00

abstract：:Leprosy, a disease caused by the intracellular parasite Mycobacterium leprae or Mycobacterium lepromatosis, has affected humans for more than 4,000 years and is a stigmatized disease even now. Since clinical manifestations of leprosy patients present as an immune-related spectrum, leprosy is regarded as an ideal model...

journal_title：Frontiers in immunology

authors： Mi Z,Liu H,Zhang F

更新日期：2020-04-16 00:00:00

abstract：:The complement system is a major component of the immune system and plays a central role in many protective immune processes, including circulating immune complex processing and clearance, recognition of foreign antigens, modulation of humoral and cellular immunity, removal of apoptotic and dead cells, and engagement ...

journal_title：Frontiers in immunology

authors： Holers VM,Banda NK

更新日期：2018-05-28 00:00:00

abstract：:Complement plays an essential role in the opsonophagocytic clearance of apoptotic/necrotic cells. Dysregulation of this process may lead to inflammatory and autoimmune diseases. Factor H (FH), a major soluble complement inhibitor, binds to dead cells and inhibits excessive complement activation on their surface, preve...

journal_title：Frontiers in immunology

authors： Kárpáti É,Papp A,Schneider AE,Hajnal D,Cserhalmi M,Csincsi ÁI,Uzonyi B,Józsi M

更新日期：2020-07-16 00:00:00

abstract：:Soil-transmitted helminths represent a major global health burden with infections and infection-related comorbidities causing significant reductions in the quality of life for individuals living in endemic areas. Repeated infections and chronic colonization by these large extracellular worms in mammals led to the evol...

journal_title：Frontiers in immunology

authors： Miller MM,Reinhardt RL

更新日期：2020-07-23 00:00:00

abstract：:We have developed a therapeutic vaccine consisting of a mixture of lethally-irradiated allogeneic cutaneous melanoma cell lines with BCG and GM-CSF as adjuvants. The CSF-470 vaccine is currently being assayed in a Phase II-III trial against medium-dose IFN-α2b. All vaccinated patients immunized intradermally developed...

journal_title：Frontiers in immunology

authors： Aris M,Bravo AI,Barrio MM,Mordoh J

更新日期：2015-03-30 00:00:00

abstract：:Psoriasis is a common inflammatory skin disease characterized by the appearance of red scaly plaques that can affect any part of the body. High prevalence, chronicity, disfiguration, disability, and associated comorbidity make it a challenge for clinicians of multiple specialties. Likewise, its complex pathogenesis, c...

journal_title：Frontiers in immunology

authors： Boehncke WH

更新日期：2018-04-05 00:00:00

abstract：:Our aim was to analyze the relationship between plasma inflammatory biomarkers and CD4+ T-cells evolution in human immunodeficiency virus (HIV) elite controllers (HIV-ECs) with a suppressed viremia. We carried out a retrospective study in 30 HIV-ECs classified into two groups: those showing no significant loss of CD4+...

journal_title：Frontiers in immunology

authors： Gutiérrez-Rivas M,Jiménez-Sousa MÁ,Rallón N,Jiménez JL,Restrepo C,León A,Montero-Alonso M,González-García J,Muñoz-Fernández MÁ,Benito JM,Resino S,ECRIS Integrated in the Spanish AIDS Research Network.

更新日期：2018-06-18 00:00:00

abstract：:MAIT cells are MR1-restricted T cells that are well-known for their anti-microbial properties, but they have recently been associated with different forms of cancer. Several studies have reported activated MAIT cells within the microenvironment of colorectal tumors, but there is conjecture about the nature of their re...

journal_title：Frontiers in immunology

authors： Berzins SP,Wallace ME,Kannourakis G,Kelly J

更新日期：2020-05-20 00:00:00

abstract：:Objective: Postoperative ileus (POI) is an inflammation-mediated complication of abdominal surgery, characterized by intestinal dysmotility and leukocyte infiltration into the muscularis externa (ME). Previous studies indicated that interleukin (IL)-10 is crucial for the resolution of a variety of inflammation-driven ...

journal_title：Frontiers in immunology

authors： Stein K,Lysson M,Schumak B,Vilz T,Specht S,Heesemann J,Roers A,Kalff JC,Wehner S

更新日期：2018-11-13 00:00:00

abstract：:The immunomodulator Macrophage Migration Inhibitory Factor (MIF) exerts pleiotropic immunomodulatory activities and has been implicated in the pathogenesis of diverse inflammatory diseases. Expression levels of MIF are also significantly elevated in the skin and serum of psoriasis patients, but the pathogenic signific...

journal_title：Frontiers in immunology

authors： Bezdek S,Leng L,Busch H,Mousavi S,Rades D,Dahlke M,Zillikens D,Bucala R,Sadik CD

更新日期：2018-10-02 00:00:00

abstract：:Tuberculosis (TB) is currently one of the leading causes of global mortality. Medical non-compliance due to the length of the treatment and antibiotic side effects has led to the emergence of multidrug-resistant (MDR) strains of Mycobacterium tuberculosis (M. tb) that are difficult to treat. A current therapeutic stra...

journal_title：Frontiers in immunology

authors： Hernandez J,Ashley D,Cao R,Abrahem R,Nguyen T,To K,Yegiazaryan A,Akinwale David A,Kumar Tiwari R,Venketaraman V

更新日期：2020-08-13 00:00:00

abstract：:Clonal evolution of B cells in germinal centers (GCs) is central to affinity maturation of antibodies in response to pathogens. Permanent or tamoxifen-induced multi-color recombination of B cells based on the brainbow allele allows monitoring the degree of color dominance in the course of the GC reaction. Here, we use...

journal_title：Frontiers in immunology

authors： Meyer-Hermann M,Binder SC,Mesin L,Victora GD

更新日期：2018-09-25 00:00:00

abstract：:Cancer stem cells (CSCs) have been identified as the source of tumor growth and disease recurrence. Eradication of CSCs is thus essential to achieve durable responses, but CSCs are resistant to current anti-tumor therapies. Novel therapeutic approaches that specifically target CSCs will, therefore, be crucial to impro...

journal_title：Frontiers in immunology

authors： Wefers C,Schreibelt G,Massuger LFAG,de Vries IJM,Torensma R

更新日期：2018-06-19 00:00:00

abstract：:Because Peyer's patches (PP) are the main inductive sites for gut IgA responses we have focused this review on what we know about the function of PP germinal centers (GC). The vast majority of IgA gene sequences in the gut lamina propria (LP) are heavily mutated arguing for an origin in GC. Because PP GC formation is ...

journal_title：Frontiers in immunology

authors： Lycke NY,Bemark M

更新日期：2012-11-07 00:00:00

abstract：:B7 proteins CD80 (B7-1) and CD86 (B7-2) are expressed on most antigen-presenting cells and provide critical co-stimulatory or inhibitory input to T cells via their T-cell-expressed receptors: CD28 and CTLA-4. CD28 is expressed on effector T cells and regulatory T cells (Tregs), and CD28-dependent signals are required ...

journal_title：Frontiers in immunology

authors： Brzostek J,Gascoigne NR,Rybakin V

更新日期：2016-02-04 00:00:00

abstract：:Bovine neonatal pancytopenia (BNP) was a vaccine-induced alloimmune disease observed in young calves and characterized by hemorrhages, pancytopenia, and severe destruction of the hematopoietic tissues. BNP was induced by alloreactive maternal antibodies present in the colostrum of certain cows vaccinated with a highly...

journal_title：Frontiers in immunology

authors： Kasonta R,Mauritz J,Spohr C,Sauter-Louis C,Duchow K,Cussler K,Holsteg M,Bastian M

更新日期：2018-08-14 00:00:00

abstract：:Acute graft-vs.-host disease (GVHD) limits the efficacy of allogeneic hematopoietic stem cell transplantation (allo-HSCT), a main therapy to treat various hematological disorders. Despite rapid progress in understanding GVHD pathogenesis, broad immunosuppressive agents are most often used to prevent and remain the fir...

journal_title：Frontiers in immunology

authors： Thangavelu G,Blazar BR

更新日期：2019-03-06 00:00:00

abstract：:This study aimed to investigate the adipokine and cytokine profiles of adipocytes from epicardial and subcutaneous adipose tissues in interconnection with the visceral adipose tissue area and the biochemical and clinical characteristics of patients with coronary artery disease. We assessed 84 patients with coronary ar...

journal_title：Frontiers in immunology

authors： Gruzdeva O,Uchasova E,Dyleva Y,Borodkina D,Akbasheva O,Antonova L,Matveeva V,Belik E,Ivanov S,Sotnikov A,Kozyrin K,Brel N,Sinitsky M,Karetnikova V,Kokov A,Bychkova E,Pecherina T,Barbarash O

更新日期：2019-09-19 00:00:00

abstract：:Normal function of the adaptive immune system requires trafficking of T cells between the blood and lymphoid organs. Lymphocyte homing to lymph nodes requires that they cross endothelial barriers present in blood vessels and lymphatics. This multi-step process requires a remodeling of the lymphocyte plasma membrane, w...

journal_title：Frontiers in immunology

authors： Dios-Esponera A,Melis N,Subramanian BC,Weigert R,Samelson LE

更新日期：2019-03-05 00:00:00

abstract：:T lymphocytes first carried foreign genes safely into humans over two decades ago. Since these pioneering studies, scientific techniques to better understand the genomic landscape of cells has directly led to a more sophisticated appreciation of the diversity, functional complexity, and therapeutic potential of T cell...

journal_title：Frontiers in immunology

authors： Kerkar SP

更新日期：2013-09-27 00:00:00

abstract：:COVID-19 is a global pandemic currently in an acute phase of rapid expansion. While public health measures remain the most effective protection strategy at this stage, when the peak passes, it will leave in its wake important health problems. Historically, very few viruses have ever been eradicated. Instead, the virus...

journal_title：Frontiers in immunology

authors： Sviridov D,Miller YI,Ballout RA,Remaley AT,Bukrinsky M

更新日期：2020-09-29 00:00:00

abstract：:The intestinal microbiome maintains a close relationship with the host immunity. This connection fosters a health state by direct and indirect mechanisms. Direct influences occur mainly through the production of short-chain fatty acids (SCFAs), gastrointestinal hormones and precursors of bioactive molecules. Indirect ...

journal_title：Frontiers in immunology

authors： Elias-Oliveira J,Leite JA,Pereira ÍS,Guimarães JB,Manso GMDC,Silva JS,Tostes RC,Carlos D

更新日期：2020-08-11 00:00:00

abstract：:Mesenchymal stem cells (MSC) are under investigation as a therapy for a variety of disorders. Although animal models show long term regenerative and immunomodulatory effects of MSC, the fate of MSC after infusion remains to be elucidated. In the present study the localization and viability of MSC was examined by isola...

journal_title：Frontiers in immunology

authors： Eggenhofer E,Benseler V,Kroemer A,Popp FC,Geissler EK,Schlitt HJ,Baan CC,Dahlke MH,Hoogduijn MJ

更新日期：2012-09-26 00:00:00