Abstract:
:The salivary scavenger and agglutinin (SALSA), also known as gp340, salivary agglutinin and deleted in malignant brain tumor 1, is a 340-kDa glycoprotein expressed on mucosal surfaces and secreted into several body fluids. SALSA binds to a broad variety of microbes and endogenous ligands, such as complement factor C1q, surfactant proteins D and A, and IgA. Our search for novel ligands of SALSA by direct protein-interaction studies led to the identification of mannan-binding lectin (MBL) as a new binding partner. We observed that surface-associated SALSA activates complement via binding of MBL. On the other hand, soluble SALSA was found to inhibit Candida albicans-induced complement activation. Thus, SALSA has a dual complement activation modifying function. It activates the lectin pathway when bound to a surface and inhibits it when free in the fluid phase. These activities are mediated via a direct interaction with MBL. This suggests that SALSA could target the innate immune responses to certain microorganisms and simultaneously limit complement activation in the fluid phase.
journal_name
Front Immunoljournal_title
Frontiers in immunologyauthors
Reichhardt MP,Loimaranta V,Thiel S,Finne J,Meri S,Jarva Hdoi
10.3389/fimmu.2012.00205subject
Has Abstractpub_date
2012-07-16 00:00:00pages
205issn
1664-3224journal_volume
3pub_type
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journal_title:Frontiers in immunology
pub_type: 杂志文章
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journal_title:Frontiers in immunology
pub_type: 杂志文章,评审
doi:10.3389/fimmu.2020.01788
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
doi:10.3389/fimmu.2020.00083
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
doi:10.3389/fimmu.2020.00367
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
doi:10.3389/fimmu.2019.02668
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pub_type: 杂志文章
doi:10.3389/fimmu.2020.515556
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pub_type: 杂志文章
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pub_type: 杂志文章,meta分析
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
doi:10.3389/fimmu.2014.00060
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pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章
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pub_type: 杂志文章,随机对照试验
doi:10.3389/fimmu.2018.02035
更新日期:2018-09-12 00:00:00