NIH3T3 Directs Memory-Fated CTL Programming and Represses High Expression of PD-1 on Antitumor CTLs.

abstract：:In human brucellosis, the liver is frequently affected. Brucella abortus triggers a profibrotic response on hepatic stellate cells (HSCs) characterized by inhibition of MMP-9 with concomitant collagen deposition and TGF-β1 secretion through type 4 secretion system (T4SS). Taking into account that it has been reported ...

journal_title：Frontiers in immunology

authors： Arriola Benitez PC,Pesce Viglietti AI,Gomes MTR,Oliveira SC,Quarleri JF,Giambartolomei GH,Delpino MV

更新日期：2020-01-21 00:00:00

abstract：:Platelets are anucleate cells produced by megakaryocytes. In recent years, a robust body of literature supports the evolving role of platelets as key sentinel and effector cells in infectious diseases, especially critical in bridging hemostatic, inflammatory, and immune continuums. Upon intravascular pathogen invasion...

journal_title：Frontiers in immunology

authors： Guo L,Rondina MT

更新日期：2019-09-13 00:00:00

abstract：:Background: Characterization of the intracellular biochemical processes that regulate the generation and maintenance of effector and memory CD8+ T-cells from naïve precursors is essential for our understanding of adaptive immune responses and the development of immunotherapies. However, the metabolic determinants of a...

journal_title：Frontiers in immunology

authors： Nicoli F,Papagno L,Frere JJ,Cabral-Piccin MP,Clave E,Gostick E,Toubert A,Price DA,Caputo A,Appay V

更新日期：2018-12-21 00:00:00

abstract：:Multiple sclerosis (MS) is a neurodegenerative disease resulting from an autoimmune attack on central nervous system (CNS) myelin. Although CD4(+) T cell function in MS pathology has been extensively studied, there is also strong evidence that CD8(+) T lymphocytes play a key role. Intriguingly, CD8(+) T cells accumula...

journal_title：Frontiers in immunology

authors： Ignatius Arokia Doss PM,Roy AP,Wang A,Anderson AC,Rangachari M

更新日期：2015-10-22 00:00:00

abstract：:Ectoenzyme and receptor BST-1/CD157 has been considered as a key molecule involved in the regulation of functional activity of cells in various tissues and organs. It is commonly accepted that CD157 catalyzes NAD+ hydrolysis and acts as a component of integrin adhesion receptor complex. Such properties are important f...

journal_title：Frontiers in immunology

authors： Lopatina OL,Komleva YK,Malinovskaya NA,Panina YA,Morgun AV,Salmina AB

更新日期：2020-11-10 00:00:00

abstract：:Periprosthetic inflammatory osteolysis and subsequent aseptic loosening are commonly observed in total joint arthroplasty. Other than revision surgery, few approved treatments are available for this complication. Wear particle-induced inflammation and macrophage polarization state play critical roles in periprosthetic...

journal_title：Frontiers in immunology

authors： Li B,Hu Y,Zhao Y,Cheng M,Qin H,Cheng T,Wang Q,Peng X,Zhang X

更新日期：2017-01-31 00:00:00

abstract：:During hypoxia, cells undergo transcriptional changes to adjust to metabolic stress, to promote cell survival, and to induce pro-angiogenic factors. Hypoxia-induced factors (HIFs) regulate these transcriptional alterations. Failure to restore oxygen levels results in cell death by necrosis. IL-1α is one of the most im...

journal_title：Frontiers in immunology

authors： Rider P,Kaplanov I,Romzova M,Bernardis L,Braiman A,Voronov E,Apte RN

更新日期：2012-09-14 00:00:00

abstract：:The Kallikrein-Kinin System (KKS), comprised of kallikreins (klks), bradykinins (BKs) angiotensin-converting enzyme (ACE), and many other molecules, regulates a number of physiological processes, including inflammation, coagulation, angiogenesis, and control of blood pressure. In this report, we show that KKS regulate...

journal_title：Frontiers in immunology

authors： Seliga A,Lee MH,Fernandes NC,Zuluaga-Ramirez V,Didukh M,Persidsky Y,Potula R,Gallucci S,Sriram U

更新日期：2018-02-02 00:00:00

abstract：:Heavy chain-only antibodies (HCAbs) do not associate with light chains and their VH regions are functional as single domains, forming the smallest active antibody fragment. These VH regions are ideal building blocks for a variety of antibody-based biologics because they tolerate fusion to other molecules and may also ...

journal_title：Frontiers in immunology

authors： Clarke SC,Ma B,Trinklein ND,Schellenberger U,Osborn MJ,Ouisse LH,Boudreau A,Davison LM,Harris KE,Ugamraj HS,Balasubramani A,Dang KH,Jorgensen B,Ogana HAN,Pham DT,Pratap PP,Sankaran P,Anegon I,van Schooten WC,Brüggem

更新日期：2019-01-07 00:00:00

abstract：:During the acute phase of Trypanosoma cruzi infection, macrophages can act as host cells for the parasites as well as effector cells in the early anti-parasitic immune response. Thus, the targeting of specific signaling pathways could modulate macrophages response to restrict parasite replication and instruct an appro...

journal_title：Frontiers in immunology

authors： Volpini X,Ambrosio LF,Fozzatti L,Insfran C,Stempin CC,Cervi L,Motran CC

更新日期：2018-04-23 00:00:00

abstract：:Defective complement action is a cause of several human glomerular diseases including atypical hemolytic uremic syndrome (aHUS), anti-neutrophil cytoplasmic antibody mediated vasculitis (ANCA), C3 glomerulopathy, IgA nephropathy, immune complex membranoproliferative glomerulonephritis, ischemic reperfusion injury, lup...

journal_title：Frontiers in immunology

authors： Zipfel PF,Wiech T,Rudnick R,Afonso S,Person F,Skerka C

更新日期：2019-09-27 00:00:00

abstract：:The use of serotype 5 adenovirus (Ad)-derived vectors in vaccination is confronted to preexisting anti-Ad immunity. Epitope display on Ad capsid is currently being investigated as an alternative approach of vaccination. The present study seeks to better understand virus- and host-related factors controlling the effica...

journal_title：Frontiers in immunology

authors： Anchim A,Raddi N,Zig L,Perrieau P,Le Goffic R,Ryffel B,Benihoud K

更新日期：2018-02-05 00:00:00

abstract：:Older adults are more vulnerable to influenza virus infection and at higher risk for severe complications and influenza-related death compared to younger adults. Unfortunately, influenza vaccine responses tend to be impaired in older adults due to aging of the immune system (immunosenescence). Latent infection with cy...

journal_title：Frontiers in immunology

authors： van den Berg SPH,Wong A,Hendriks M,Jacobi RHJ,van Baarle D,van Beek J

更新日期：2018-01-29 00:00:00

abstract：:Studying the evolutionary diversification of mammalian antiviral defenses is of main importance to better understand our innate immune repertoire. The small HERC proteins are part of a multigene family, including HERC5 and HERC6, which have probably diversified through complex evolutionary history in mammals. Here, we...

journal_title：Frontiers in immunology

authors： Jacquet S,Pontier D,Etienne L

更新日期：2020-12-18 00:00:00

abstract：:Neuroblastoma (NB) is the most common extra-cranial solid tumor of childhood and arises from developing sympathetic nervous system. Most primary tumors localize in the abdomen, the adrenal gland, or lumbar sympathetic ganglia. Amplification in tumor cells of MYCN, the major oncogenic driver, patients' age over 18 mont...

journal_title：Frontiers in immunology

authors： Bottino C,Dondero A,Bellora F,Moretta L,Locatelli F,Pistoia V,Moretta A,Castriconi R

更新日期：2014-02-12 00:00:00

abstract：:CD8+ T cells represent one of the most versatile immune cells critical for clearing away viral infections. Due to their important role, CD8+ T cell activation and memory formation during viral infection have been the focus of several studies recently. Although CD8+ T cell activation and memory formation have been asso...

journal_title：Frontiers in immunology

authors： Gupta SS,Wang J,Chen M

更新日期：2020-05-22 00:00:00

abstract：:The buccal mucosa (BM) of vertebrates is a critical mucosal barrier constantly exposed to rich and diverse pathogens from air, water, and food. While mammals are known to contain a mucosal associated lymphoid tissue (MALT) in the buccal cavity which induces B-cells and immunoglobulins (Igs) responses against bacterial...

journal_title：Frontiers in immunology

authors： Xu HY,Dong F,Zhai X,Meng KF,Han GK,Cheng GF,Wu ZB,Li N,Xu Z

更新日期：2020-09-23 00:00:00

abstract：:Several approaches have been developed to improve or replace the only available vaccine for tuberculosis (TB), BCG (Bacille Calmette Guerin). The development of subunit protein vaccines is a promising strategy because it combines specificity and safety. In addition, subunit protein vaccines can be designed to have sel...

journal_title：Frontiers in immunology

authors： Junqueira-Kipnis AP,Marques Neto LM,Kipnis A

更新日期：2014-04-23 00:00:00

abstract：:Dendritic cells (DCs) are uniquely potent antigen presenting cells that acquire microbial products and prime adaptive immune responses against pathogens. Furthermore, DCs also play a key role in induction and maintenance of tolerance. Although numerous studies have assessed the diverse functions of DCs, many unanswere...

journal_title：Frontiers in immunology

authors： Zelante T,Fric J,Wong AY,Ricciardi-Castagnoli P

更新日期：2012-06-18 00:00:00

abstract：:The role of intestinal epithelial cells (IECs) in mucosal tolerance and immunity remains poorly understood. We present a method for inducing MHC class II (MHC-II) in human enteroids, "mini-guts" derived from small intestinal crypt stem cells, and show that the intracellular MHC-II peptide-pathway is intact and functio...

journal_title：Frontiers in immunology

authors： Wosen JE,Ilstad-Minnihan A,Co JY,Jiang W,Mukhopadhyay D,Fernandez-Becker NQ,Kuo CJ,Amieva MR,Mellins ED

更新日期：2019-08-20 00:00:00

abstract：:Salmonella infections remain a big problem worldwide, causing enteric fever by Salmonella Typhi (or Paratyphi) or self-limiting gastroenteritis by non-typhoidal Salmonella (NTS) in healthy individuals. NTS may become invasive and cause septicemia in elderly or immuno-compromised individuals, leading to high mortality ...

journal_title：Frontiers in immunology

authors： Li P,Liu Q,Luo H,Liang K,Yi J,Luo Y,Hu Y,Han Y,Kong Q

更新日期：2017-12-04 00:00:00

abstract：:MicroRNAs (miRNAs) are a class of small, non-coding RNAs that are recognized as critical regulators of immune gene expression during infection. Many immunologically significant human miRNAs have been found to be conserved in agriculturally important species, including cattle. Discovering how bovine miRNAs mediate the ...

journal_title：Frontiers in immunology

authors： Lawless N,Vegh P,O'Farrelly C,Lynn DJ

更新日期：2014-11-27 00:00:00

abstract：:Background: B-1a B cells and gut secretory IgA (SIgA) are absent in asplenic mice. Human immunoglobulin M (IgM) memory B cells, which are functionally equivalent to mouse B-1a B cells, are reduced after splenectomy. Objective: To demonstrate whether IgM memory B cells are necessary for generating IgA-secreting plasma ...

journal_title：Frontiers in immunology

authors： Carsetti R,Di Sabatino A,Rosado MM,Cascioli S,Piano Mortari E,Milito C,Grimsholm O,Aranburu A,Giorda E,Tinozzi FP,Pulvirenti F,Donato G,Morini F,Bagolan P,Corazza GR,Quinti I

更新日期：2020-01-08 00:00:00

abstract：:DExD/H-box helicase 36 (DHX36) is known to be an ATP-dependent RNA helicase that unwinds the guanine-quadruplexes DNA or RNA, but emerging data suggest that it also functions as pattern recognition receptor in innate immunity. Porcine reproductive and respiratory syndrome virus (PRRSV) is an Arterivirus that has been ...

journal_title：Frontiers in immunology

authors： Jing H,Zhou Y,Fang L,Ding Z,Wang D,Ke W,Chen H,Xiao S

更新日期：2017-10-23 00:00:00

abstract：UNLABELLED:Multiple sclerosis (MS) is an inflammatory and demyelinating disease of the central nervous system (CNS). Accumulation of brain damage in progressive MS is partly the result of mononuclear phagocytes (MPs) attacking myelin sheaths in the CNS. Although there is no cure yet for MS, significant advances have be...

journal_title：Frontiers in immunology

authors： Tannahill GM,Iraci N,Gaude E,Frezza C,Pluchino S

更新日期：2015-03-11 00:00:00

abstract：:Plasma cells (PCs) are essentially characterized by the co-expression of CD138 and CD38, which allows their identification in flow cytometry in bone marrow (BM), peripheral blood, or cell suspensions from tissues. These terminally differentiated B-cells may lose the expression of surface CD19 and that of CD20 while re...

journal_title：Frontiers in immunology

authors： Robillard N,Wuillème S,Moreau P,Béné MC

更新日期：2014-03-31 00:00:00

abstract：:The recombinant adeno-associated virus (rAAV) gene delivery system is entering a crucial and exciting phase with the promise of more than 20 years of intense research now realized in a number of successful human clinical trials. However, as a natural host to AAV infection, anti-AAV antibodies are prevalent in the huma...

journal_title：Frontiers in immunology

authors： Tseng YS,Agbandje-McKenna M

更新日期：2014-01-30 00:00:00

abstract：:The critical role of interferons (IFNs) in mediating the innate immune response to cytomegalovirus (CMV) infection is well established. However, in recent years the functional importance of the IFN-independent antiviral response has become clearer. IFN-independent, IFN regulatory factor 3 (IRF3)-dependent interferon-s...

journal_title：Frontiers in immunology

authors： Ashley CL,Abendroth A,McSharry BP,Slobedman B

更新日期：2019-12-11 00:00:00

abstract：:Ischemic Stroke is a major cause of morbidity and mortality worldwide. Sterile inflammation occurs after both stroke subtypes and contributes to neuronal injury and damage to the blood-brain barrier with release of brain antigens and a potential induction of autoimmune responses that escape central and peripheral tole...

journal_title：Frontiers in immunology

authors： Javidi E,Magnus T

更新日期：2019-04-02 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is a multi-system autoimmune disease including the cardiovascular system. Atherosclerosis is the most common cardiovascular complication of SLE and a significant risk factor for morbidity and mortality. Vascular damage/protection mechanism in SLE patients is out of balance, caused by...

journal_title：Frontiers in immunology

authors： Ding X,Xiang W,He X

更新日期：2020-11-11 00:00:00