IL-10 and IL-22 in Mucosal Immunity: Driving Protection and Pathology.

abstract：:Implantation of the fertilized egg into the maternal uterus is a crucial step in pregnancy establishment. Increasing evidence suggests that its success depends on various cell types of the innate immune system and on the fine balance between inflammatory and anti-inflammatory processes. In addition, it has recently be...

journal_title：Frontiers in immunology

authors： Zenclussen AC,Hämmerling GJ

更新日期：2015-06-17 00:00:00

abstract：:There have been few in vivo studies on the effect of aluminum hydroxide adjuvant and its influence on the immune response to vaccination. In this study, lambs received a parallel subcutaneous treatment with either commercial vaccines containing aluminum hydroxide or an equivalent dose of this compound only with the ai...

journal_title：Frontiers in immunology

authors： Varela-Martínez E,Abendaño N,Asín J,Sistiaga-Poveda M,Pérez MM,Reina R,de Andrés D,Luján L,Jugo BM

更新日期：2018-10-23 00:00:00

abstract：:Colony-stimulating factor 1 (CSF1) and interleukin 34 (IL34) signal via the CSF1 receptor to regulate macrophage differentiation. Studies in IL34- or CSF1-deficient mice have revealed that IL34 function is limited to the central nervous system and skin during development. However, the roles of IL34 and CSF1 at homeost...

journal_title：Frontiers in immunology

authors： Lin W,Xu D,Austin CD,Caplazi P,Senger K,Sun Y,Jeet S,Young J,Delarosa D,Suto E,Huang Z,Zhang J,Yan D,Corzo C,Barck K,Rajan S,Looney C,Gandham V,Lesch J,Liang WC,Mai E,Ngu H,Ratti N,Chen Y,Misner D,Lin T

更新日期：2019-09-04 00:00:00

abstract：:Targeting the programmed cell death protein-1 (PD-1)/PD-1 ligand (PD-L1) pathway has been shown to enhance T cell-mediated antitumor immunity. Clinical responses are limited to subgroups of patients. The search for biomarkers of response is a strategy to predict response and outcome of PD-1/PD-L1 checkpoint interventi...

journal_title：Frontiers in immunology

authors： Merhi M,Raza A,Inchakalody VP,Nashwan AJJ,Allahverdi N,Krishnankutty R,Uddin S,Zar Gul AR,Al Homsi MU,Dermime S

更新日期：2018-07-30 00:00:00

abstract：:Innate lymphoid cells (ILCs) are innate counterparts of T cells that contribute to immune responses by secreting effector cytokines and regulating the functions of other innate and adaptive immune cells. ILCs carry out some unique functions but share some tasks with T cells. ILCs are present in lymphoid and non-lympho...

journal_title：Frontiers in immunology

authors： Panda SK,Colonna M

更新日期：2019-05-07 00:00:00

abstract：:Tumor necrosis factor-α inhibitors (TNFis) have revolutionized the management of rheumatoid arthritis (RA), however despite considerable progress, only a small proportion of patients maintain long-term clinical response. Selection of, and switching between, biologics is mainly empirical, experiential, and not evidence...

journal_title：Frontiers in immunology

authors： Mehta P,Manson JJ

更新日期：2020-04-07 00:00:00

abstract：:Retinoic acid inducible gene I (RIG-I) is associated to the DExD/H box RNA helicases. It is a pattern recognition receptor (PRR), playing a crucial role in the system and is a germ line encoded host sensor to perceive pathogen-associated molecular patterns (PAMPs). So far, reports are available for the role of RIG-I i...

journal_title：Frontiers in immunology

authors： Banerjee S,Pal A,Pal A,Mandal SC,Chatterjee PN,Chatterjee JK

更新日期：2021-01-08 00:00:00

abstract：:Red blood cell (RBC) alloimmunization can make it difficult to procure compatible RBCs for future transfusion, directly leading to increased morbidity and mortality in transfusion-dependent patients. However, the factors that regulate RBC alloimmunization remain incompletely understood. As complement has been shown to...

journal_title：Frontiers in immunology

authors： Mener A,Arthur CM,Patel SR,Liu J,Hendrickson JE,Stowell SR

更新日期：2018-06-11 00:00:00

abstract：:Monocytes in humans consist of 3 subsets; CD14+CD16- (classical), CD14+CD16+ (intermediate) and CD14dimCD16+ (non-classical), which exhibit distinct and heterogeneous responses to activation. During acute inflammation CD14+CD16- monocytes are significantly elevated and migrate to the sites of injury via the adhesion c...

journal_title：Frontiers in immunology

authors： Lee MKS,Al-Sharea A,Shihata WA,Bertuzzo Veiga C,Cooney OD,Fleetwood AJ,Flynn MC,Claeson E,Palmer CS,Lancaster GI,Henstridge DC,Hamilton JA,Murphy AJ

更新日期：2019-09-06 00:00:00

abstract：:The oral administration of Lacticaseibacillus rhamnosus CRL1505 differentially modulates the respiratory innate antiviral immune response triggered by Toll-like receptor 3 (TLR3) activation in infant mice, improving the resistance to Respiratory Syncytial Virus (RSV) infection. In this work, by using macrophages deple...

journal_title：Frontiers in immunology

authors： Garcia-Castillo V,Tomokiyo M,Raya Tonetti F,Islam MA,Takahashi H,Kitazawa H,Villena J

更新日期：2020-09-29 00:00:00

abstract：:Central memory T cell (Tcm) and polyfunctional CD4 T cell responses contribute to vaccine-elicited protection with both human and bovine tuberculosis (TB); however, their combined role in protective immunity to TB is unclear. To address this question, we evaluated polyfunctional cytokine responses by CD4 T cell effect...

journal_title：Frontiers in immunology

authors： Maggioli MF,Palmer MV,Thacker TC,Vordermeier HM,McGill JL,Whelan AO,Larsen MH,Jacobs WR Jr,Waters WR

更新日期：2016-10-17 00:00:00

abstract：:In human brucellosis, the liver is frequently affected. Brucella abortus triggers a profibrotic response on hepatic stellate cells (HSCs) characterized by inhibition of MMP-9 with concomitant collagen deposition and TGF-β1 secretion through type 4 secretion system (T4SS). Taking into account that it has been reported ...

journal_title：Frontiers in immunology

authors： Arriola Benitez PC,Pesce Viglietti AI,Gomes MTR,Oliveira SC,Quarleri JF,Giambartolomei GH,Delpino MV

更新日期：2020-01-21 00:00:00

abstract：:Acquired generalized lipodystrophy (AGL) is a rare condition characterized by an altered distribution of adipose tissue and predisposition to develop hepatic steatosis and fibrosis, diabetes, and hypertriglyceridemia. Diagnosis of AGL is based on the observation of generalized fat loss, autoimmunity and lack of family...

journal_title：Frontiers in immunology

authors： Corvillo F,Aparicio V,López-Lera A,Garrido S,Araújo-Vilar D,de Miguel MP,López-Trascasa M

更新日期：2018-09-19 00:00:00

abstract：:Susceptibility to ankylosing spondylitis (AS) is polygenic with more than 100 genes identified to date. These include HLA-B27 and the aminopeptidases (ERAP1, ERAP2, and LNPEPS), which are involved in antigen processing and presentation to T-cells, and several genes (IL23R, IL6R, STAT3, JAK2, IL1R1/2, IL12B, and IL7R) ...

journal_title：Frontiers in immunology

authors： Vecellio M,Cohen CJ,Roberts AR,Wordsworth PB,Kenna TJ

更新日期：2019-01-10 00:00:00

abstract：:Multiple myeloma (MM) and its pre-cancerous stage monoclonal gammopathy of undetermined significance (MGUS) allow to study immune responses and the chronology of inflammation in the context of blood malignancies. Both diseases are characterized by the production of a monoclonal immunoglobulin (mc Ig) which for subsets...

journal_title：Frontiers in immunology

authors： Bosseboeuf A,Allain-Maillet S,Mennesson N,Tallet A,Rossi C,Garderet L,Caillot D,Moreau P,Piver E,Girodon F,Perreault H,Brouard S,Nicot A,Bigot-Corbel E,Hermouet S,Harb J

更新日期：2017-10-19 00:00:00

abstract：:Specific antibody deficiency (SAD) is a primary immunodeficiency disease characterized by normal immunoglobulins (Igs), IgA, IgM, total IgG, and IgG subclass levels, but with recurrent infection and diminished antibody responses to polysaccharide antigens following vaccination. There is a lack of consensus regarding t...

journal_title：Frontiers in immunology

authors： Perez E,Bonilla FA,Orange JS,Ballow M

更新日期：2017-05-22 00:00:00

abstract：:Immune evasion is an important cancer hallmark and the understanding of its mechanisms has generated successful therapeutic approaches. Induction of immunogenic cell death (ICD) is expected to attract immune cell populations that promote innate and adaptive immune responses. Here, we present a critical advance for our...

journal_title：Frontiers in immunology

authors： Cerqueira OLD,Clavijo-Salomon MA,Cardoso EC,Citrangulo Tortelli Junior T,Mendonça SA,Barbuto JAM,Strauss BE

更新日期：2020-10-22 00:00:00

abstract：:Experimental animal models of tuberculosis (TB) have convincingly demonstrated that inhaled dose predicts immunopathology and survival. In contrast, the importance of inhaled dose has generally not been appreciated in TB epidemiology, clinical science, or the practice of TB control. Infectiousness of TB patients has t...

journal_title：Frontiers in immunology

authors： Fennelly KP,Jones-López EC

更新日期：2015-06-29 00:00:00

abstract：:Treatment with the macrolide antibiotic azithromycin (AZM) is an important intervention for controlling infection of children with Bordetella pertussis and as a prophylaxis for preventing transmission to family members. However, antibiotics are known to have immunomodulatory effects independent of their antimicrobial ...

journal_title：Frontiers in immunology

authors： Borkner L,Misiak A,Wilk MM,Mills KHG

更新日期：2018-07-30 00:00:00

abstract：:The mechanistic requirements of antigen recognition by T cells expressing a γδ TCR has revealed important differences with those of αβ TCR cells and, despite impressive new data generated in the very recent years, they remain poorly understood. Based on the structure of the TCR chains and the tissue distribution, γδ c...

journal_title：Frontiers in immunology

authors： De Libero G,Lau SY,Mori L

更新日期：2015-01-15 00:00:00

abstract：:Ageing, like obesity, is often associated with alterations in metabolic and inflammatory processes resulting in morbidity from diseases characterised by poor metabolic control, insulin insensitivity, and inflammation. Ageing populations also exhibit a decline in immune competence referred to as immunosenescence, which...

journal_title：Frontiers in immunology

authors： Trim W,Turner JE,Thompson D

更新日期：2018-02-09 00:00:00

abstract：:Modern animal and crop production practices are associated with the regular use of antimicrobials, potentially increasing selection pressure on bacteria to become resistant. Alternative approaches are needed in order to satisfy the demands of the growing human population without the indiscriminate use of antimicrobial...

journal_title：Frontiers in immunology

authors： Villena J,Kitazawa H,Van Wees SCM,Pieterse CMJ,Takahashi H

更新日期：2018-09-27 00:00:00

abstract：:Genetic mismatches in protein coding genes between allogeneic hematopoietic stem cell transplantation (allo-HSCT) recipient and donor can elicit an alloimmunity response via peptides presented by the recipient HLA receptors as minor histocompatibility antigens (mHAs). While the impact of individual mHAs on allo-HSCT o...

journal_title：Frontiers in immunology

authors： Ritari J,Hyvärinen K,Koskela S,Niittyvuopio R,Nihtinen A,Salmenniemi U,Putkonen M,Volin L,Kwan T,Pastinen T,Itälä-Remes M,Partanen J

更新日期：2019-07-16 00:00:00

abstract：:Neuroinflammation in utero may result in lifelong neurological disabilities. Astrocytes play a pivotal role in this process, but the mechanisms are poorly understood. No early postnatal treatment strategies exist to enhance neuroprotective potential of astrocytes. We hypothesized that agonism on α7 nicotinic acetylcho...

journal_title：Frontiers in immunology

authors： Cao M,MacDonald JW,Liu HL,Weaver M,Cortes M,Durosier LD,Burns P,Fecteau G,Desrochers A,Schulkin J,Antonelli MC,Bernier RA,Dorschner M,Bammler TK,Frasch MG

更新日期：2019-05-09 00:00:00

abstract：:Inflammation is a crucial defense mechanism that protects the body from the devastating effects of invading pathogens. However, an unrestrained inflammatory reaction may result in systemic manifestations with dire consequences to the host. The extent of activation of the inflammatory response is tightly regulated thro...

journal_title：Frontiers in immunology

authors： Al-Barazie RM,Bashir GH,Qureshi MM,Mohamed YA,Al-Sbiei A,Tariq S,Lammers WJ,Al-Ramadi BK,Fernandez-Cabezudo MJ

更新日期：2018-03-19 00:00:00

abstract：:Transcriptome profiling approaches have been widely used to investigate the mechanisms underlying psoriasis pathogenesis. Most researchers have measured changes in transcript abundance in skin biopsies; relatively few have examined transcriptome changes in the blood. Although less relevant to the study of psoriasis pa...

journal_title：Frontiers in immunology

authors： Rawat A,Rinchai D,Toufiq M,Marr AK,Kino T,Garand M,Tatari-Calderone Z,Kabeer BSA,Krishnamoorthy N,Bedognetti D,Karim MY,Sastry KS,Chaussabel D

更新日期：2020-11-24 00:00:00

abstract：:T lymphocytes first carried foreign genes safely into humans over two decades ago. Since these pioneering studies, scientific techniques to better understand the genomic landscape of cells has directly led to a more sophisticated appreciation of the diversity, functional complexity, and therapeutic potential of T cell...

journal_title：Frontiers in immunology

authors： Kerkar SP

更新日期：2013-09-27 00:00:00

abstract：:Neutrophil extracellular trap (NET) formation requires chromatin decondensation before nuclear swelling and eventual extracellular release of DNA, which occurs together with nuclear and cytoplasmic antimicrobial proteins. A key mediator of chromatin decondensation is protein deiminase 4 (PAD4), which catalyzes histone...

journal_title：Frontiers in immunology

authors： Clark HL,Abbondante S,Minns MS,Greenberg EN,Sun Y,Pearlman E

更新日期：2018-05-29 00:00:00

abstract：:Silver nanoparticles (AgNPs) are promising new antimicrobial agents against a wide range of skin and mucosal pathogens. However, their interaction with the immune system is currently not fully understood. Dendritic cells (DCs) are crucial during development of T cell-specific responses against bacterial and viral path...

journal_title：Frontiers in immunology

authors： Orlowski P,Tomaszewska E,Ranoszek-Soliwoda K,Gniadek M,Labedz O,Malewski T,Nowakowska J,Chodaczek G,Celichowski G,Grobelny J,Krzyzowska M

更新日期：2018-05-22 00:00:00

abstract：:Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is the most common antibody-mediated encephalitis. There are several studies on B cell repertoire of anti-NMDAR encephalitis in Caucasians. Here, the cerebrospinal fluid (CSF) samples of 12 Chinese patients with first-episode anti-NMDAR encephalitis were collecte...

journal_title：Frontiers in immunology

authors： Feng J,Fan S,Sun Y,Zhang Z,Ren H,Li W,Cui L,Peng B,Ren X,Zhang W,Guan H,Wang J

更新日期：2020-07-29 00:00:00