IL-1 family cytokines trigger sterile inflammatory disease.

Abstract:

:Inflammation plays vital roles in protective responses against pathogens and tissue repair, however, improper resolution of inflammatory networks is centrally involved in the pathogenesis of many acute and chronic diseases. Extensive advances have been made in recent years to define the inflammatory processes that are required for pathogen clearance, however, in comparison, less is known about the regulation of inflammation in sterile settings. Over the past decade non-communicable chronic diseases that are potentiated by sterile inflammation have replaced infectious diseases as the major threat to global human health. Thus, improved understanding of the sterile inflammatory process has emerged as one of the most important areas of biomedical investigation during our time. In this review we highlight the central role that interleukin-1 family cytokines play in sterile inflammatory diseases.

journal_name

Front Immunol

journal_title

Frontiers in immunology

authors

Lukens JR,Gross JM,Kanneganti TD

doi

10.3389/fimmu.2012.00315

subject

Has Abstract

pub_date

2012-10-09 00:00:00

pages

315

issn

1664-3224

journal_volume

3

pub_type

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