Role of Regulatory Immune Cells and Molecules in Autoimmune Bullous Dermatoses.

abstract：:Cytokines are major players regulating immune responses toward inflammatory and tolerogenic results. In organ and bone marrow transplantation, new reagents are needed to inhibit tissue destructive mechanisms and eventually induce immune tolerance without overall immunosuppression. IL-34 is a cytokine with no significa...

journal_title：Frontiers in immunology

authors： Bézie S,Freuchet A,Sérazin C,Salama A,Vimond N,Anegon I,Guillonneau C

更新日期：2020-08-11 00:00:00

abstract：:The developmental origin of allergic diseases has been suggested, but the molecular basis remains enigmatic. Exposure to environmental factors, such as di-(2-ethylhexyl) phthalate (DEHP; a common plasticizer), is suggested to be associated with increased childhood allergic asthma, but the causal relationship and its u...

journal_title：Frontiers in immunology

authors： Suen JL,Wu TT,Li YH,Lee CL,Kuo FC,Yan PS,Wu CF,Tran M,Wang CJ,Hung CH,Wu MT,Chan MWY,Huang SK

更新日期：2020-12-23 00:00:00

abstract：:Dendritic cells (DCs) are professional antigen-presenting cells that link innate and adaptive immunity and are critical for the induction of protective immune responses against pathogens. Proportions of these cells are markedly decreased in the blood of untreated HIV-1-infected individuals, suggesting they might be in...

journal_title：Frontiers in immunology

authors： Martin-Gayo E,Yu XG

更新日期：2019-06-06 00:00:00

abstract：:In response to microenvironmental cues, macrophages undergo a profound phenotypic transformation acquiring distinct activation phenotypes ranging from pro-inflammatory (M1) to anti-inflammatory (M2). To study how activation phenotype influences phagocytosis and production of reactive oxygen species (ROS) mediated by r...

journal_title：Frontiers in immunology

authors： Mendoza-Coronel E,Ortega E

更新日期：2017-03-27 00:00:00

abstract：:Gastrointestinal nematodes are among the most prevalent parasites infecting humans and livestock worldwide. Infective larvae of the soil-transmitted nematode Ascaris spp. enter the host and start tissue migration by crossing the intestinal epithelial barrier. The initial interaction of the intestinal epithelium with t...

journal_title：Frontiers in immunology

authors： Ebner F,Kuhring M,Radonić A,Midha A,Renard BY,Hartmann S

更新日期：2018-08-15 00:00:00

abstract：:Interleukin (IL)-10 and IL-22 are key members of the IL-10 cytokine family that share characteristic properties such as defined structural features, usage of IL-10R2 as one receptor chain, and activation of signal transducer and activator of transcription (STAT)-3 as dominant signaling mode. IL-10, formerly known as c...

journal_title：Frontiers in immunology

authors： Mühl H

更新日期：2013-02-04 00:00:00

abstract：:Effector T cells exit the inflamed vasculature into an environment shaped by tissue-specific structural configurations and inflammation-imposed extrinsic modifications. Once within interstitial spaces of non-lymphoid tissues, T cells migrate in an apparent random, non-directional, fashion. Efficient T cell scanning of...

journal_title：Frontiers in immunology

authors： Gaylo A,Schrock DC,Fernandes NR,Fowell DJ

更新日期：2016-10-14 00:00:00

abstract：:Specific antibody deficiency (SAD) is a primary immunodeficiency disease characterized by normal immunoglobulins (Igs), IgA, IgM, total IgG, and IgG subclass levels, but with recurrent infection and diminished antibody responses to polysaccharide antigens following vaccination. There is a lack of consensus regarding t...

journal_title：Frontiers in immunology

authors： Perez E,Bonilla FA,Orange JS,Ballow M

更新日期：2017-05-22 00:00:00

abstract：:The omentum is enriched with pro-inflammatory effector memory CD8+ T cells in patients with the obesity-associated malignancy, esophagogastric adenocarcinoma (EAC) and we have identified the chemokine macrophage inflammatory protein-1alpha as a key player in their active migration to this inflamed tissue. More recentl...

journal_title：Frontiers in immunology

authors： Conroy MJ,Maher SG,Melo AM,Doyle SL,Foley E,Reynolds JV,Long A,Lysaght J

更新日期：2018-08-13 00:00:00

abstract：Background and objectives:Mortality of patients on hemodialysis (HD) remains very high despite recent improvements in HD techniques. Cardiovascular (CV) complications and infections are the main causes of death. Some studies suggest that disturbances in the immune system could play a role in this disproportionate morta...

journal_title：Frontiers in immunology

authors： Molina M,Allende LM,Ramos LE,Gutiérrez E,Pleguezuelo DE,Hernández ER,Ríos F,Fernández C,Praga M,Morales E

更新日期：2018-06-15 00:00:00

abstract：:The diversity of the immune repertoire is important for the adaptive immune system's ability to detect pathogens. Much of this diversity is generated in two steps, first through the recombination of germline gene segments and second through hypermutation during an immune response. While both steps are to some extent b...

journal_title：Frontiers in immunology

authors： Schwartz GW,Hershberg U

更新日期：2013-11-08 00:00:00

abstract：:Despite the role of pigs as a source of new Influenza A Virus viruses (IAV) potentially capable of initiating human pandemics, immune responses to swine influenza virus (SwIV) in pigs are not fully understood. Several SwIV epitopes presented by swine MHC (SLA) class I have been identified using different approaches ei...

journal_title：Frontiers in immunology

authors： Baratelli M,Morgan S,Hemmink JD,Reid E,Carr BV,Lefevre E,Montaner-Tarbes S,Charleston B,Fraile L,Tchilian E,Montoya M

更新日期：2020-09-16 00:00:00

abstract：:Immunosuppressive factors, such as soluble major histocompatibility complex class I chain-related peptide A (sMICA) and transforming growth factor beta 1 (TGF-β1), are involved in tumor immune escape mechanisms (TIEMs) exhibited by head and neck squamous cell carcinomas (HNSCCs) and may represent opportunities for the...

journal_title：Frontiers in immunology

authors： Klöss S,Chambron N,Gardlowski T,Weil S,Koch J,Esser R,Pogge von Strandmann E,Morgan MA,Arseniev L,Seitz O,Köhl U

更新日期：2015-11-02 00:00:00

abstract：:Under non-inflammatory conditions HLA class II is predominantly expressed on hematopoietic cells. Therefore, donor CD4 T-cells after allogeneic stem cell transplantation (alloSCT) may mediate graft-vs.-leukemia reactivity without graft-vs.-host disease (GVHD). We analyzed immune responses in four patients converting f...

journal_title：Frontiers in immunology

authors： van Balen P,van Bergen CAM,van Luxemburg-Heijs SAP,de Klerk W,van Egmond EHM,Veld SAJ,Halkes CJM,Zwaginga JJ,Griffioen M,Jedema I,Falkenburg JHF

更新日期：2018-12-18 00:00:00

abstract：:Immunoglobulin (Ig) replacement therapy dramatically changed the clinical course of primary hypogammaglobulinemias, significantly reducing the incidence of infectious events. Over the last two decades its use has been extended to secondary antibody deficiencies, particularly those related to hematological disorders as...

journal_title：Frontiers in immunology

authors： Compagno N,Malipiero G,Cinetto F,Agostini C

更新日期：2014-12-08 00:00:00

abstract：:Breast cancer is characterized by cellular and molecular heterogeneity. Several molecular events are involved in controlling malignant cell process. In this sense, the importance of studying multiple cell alterations in this pathology is overriding. A well-identified fact on immune response is that it can vary depend ...

journal_title：Frontiers in immunology

authors： Segovia-Mendoza M,Morales-Montor J

更新日期：2019-03-01 00:00:00

abstract：:As we have suggested, epigenetic factors, such as microRNAs (miRNAs), can interact with genetic programs to regulate B cell functions, thereby informing antibody and autoantibody responses. We have shown that histone deacetylase (HDAC) inhibitors (HDI) inhibit the differentiation events critical to the maturation of t...

journal_title：Frontiers in immunology

authors： Shen T,Sanchez HN,Zan H,Casali P

更新日期：2015-12-14 00:00:00

abstract：:Chemokine biology is mediated by more complex interactions than simple monomolecular ligand-receptor interactions, as chemokines can form higher order quaternary structures, which can also be formed after binding to glycosaminoglycans (GAGs) on endothelial cells, and their receptors are found as dimers and/or oligomer...

journal_title：Frontiers in immunology

authors： Proudfoot AE,Uguccioni M

更新日期：2016-05-19 00:00:00

abstract：:In humans, NK cells are mainly identified by the surface expression levels of CD56 and CD16, which differentiate between five functionally different NK cell subsets. However, nowadays NK cells are considered as a more heterogeneous population formed by various subsets differing in function, surface phenotype, and anat...

journal_title：Frontiers in immunology

authors： Cristiani CM,Palella E,Sottile R,Tallerico R,Garofalo C,Carbone E

更新日期：2016-12-27 00:00:00

abstract：:The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor initially identified because of its role in controlling the cellular response to environmental molecules. More recently, AHR has been shown to play a crucial role in controlling innate and adaptive immune responses through several mechanism...

journal_title：Frontiers in immunology

authors： Jaronen M,Quintana FJ

更新日期：2014-10-20 00:00:00

abstract：:Normal function of the adaptive immune system requires trafficking of T cells between the blood and lymphoid organs. Lymphocyte homing to lymph nodes requires that they cross endothelial barriers present in blood vessels and lymphatics. This multi-step process requires a remodeling of the lymphocyte plasma membrane, w...

journal_title：Frontiers in immunology

authors： Dios-Esponera A,Melis N,Subramanian BC,Weigert R,Samelson LE

更新日期：2019-03-05 00:00:00

abstract：:Infiltration of immune cells into the tumor microenvironment (TME) can regulate growth and survival of neoplastic cells, impacting tumorigenesis and tumor progression. Correlations between the number of effector immune cells present in a tumor and clinical outcomes in many human tumors, including breast, have been wid...

journal_title：Frontiers in immunology

authors： Pachynski RK,Wang P,Salazar N,Zheng Y,Nease L,Rosalez J,Leong WI,Virdi G,Rennier K,Shin WJ,Nguyen V,Butcher EC,Zabel BA

更新日期：2019-05-08 00:00:00

abstract：:Patients with severe eosinophilic asthma (SEA; characterized by persistent eosinophilia in blood and airway tissues) experience frequent asthma exacerbations with poor clinical outcomes. Interleukin 5 (IL-5) and IL-5 receptor alpha subunit (IL-5α) play key roles in eosinophilia maintenance, and relevant therapeutic st...

journal_title：Frontiers in immunology

authors： Kim JE,Lee DH,Jung K,Kim EJ,Choi Y,Park HS,Kim YS

更新日期：2021-01-08 00:00:00

abstract：:Viral infections have a major impact on morbidity and mortality of immunosuppressed solid organ transplant (SOT) patients because of missing or failure of adequate pharmacologic antiviral treatment. Adoptive antiviral T-cell therapy (AVTT), regenerating disturbed endogenous T-cell immunity, emerged as an attractive al...

journal_title：Frontiers in immunology

authors： Amini L,Vollmer T,Wendering DJ,Jurisch A,Landwehr-Kenzel S,Otto NM,Jürchott K,Volk HD,Reinke P,Schmueck-Henneresse M

更新日期：2019-05-28 00:00:00

abstract：:Both CD4+ and CD8+ Tregs play a critical role in the control of immune responses and immune tolerance; however, our understanding of CD8+ Tregs is limited while they are particularly promising for therapeutic application. We report here existence of highly suppressive human CD8+CD45RClow/- Tregs expressing Foxp3 and p...

journal_title：Frontiers in immunology

authors： Bézie S,Meistermann D,Boucault L,Kilens S,Zoppi J,Autrusseau E,Donnart A,Nerrière-Daguin V,Bellier-Waast F,Charpentier E,Duteille F,David L,Anegon I,Guillonneau C

更新日期：2018-01-31 00:00:00

abstract：:The CD83 molecule has been identified to be expressed on numerous activated immune cells, including B and T lymphocytes, monocytes, dendritic cells, microglia, and neutrophils. Both isoforms of CD83, the membrane-bound as well as its soluble form are topic of intensive research investigations. Several studies revealed...

journal_title：Frontiers in immunology

authors： Grosche L,Knippertz I,König C,Royzman D,Wild AB,Zinser E,Sticht H,Muller YA,Steinkasserer A,Lechmann M

更新日期：2020-04-17 00:00:00

abstract：:A sudden outbreak of COVID-19 caused by a novel coronavirus, SARS-CoV-2, in Wuhan, China in December 2019 quickly grew into a global pandemic, putting at risk not only the global healthcare system, but also the world economy. As the disease continues to spread rapidly, the development of prophylactic and therapeutic a...

journal_title：Frontiers in immunology

authors： Liang Y,Wang ML,Chien CS,Yarmishyn AA,Yang YP,Lai WY,Luo YH,Lin YT,Chen YJ,Chang PC,Chiou SH

更新日期：2020-05-12 00:00:00

abstract：:Amino acids (AAs) are necessary nutrients which act not only as building blocks in protein synthesis but also in crucial anabolic cellular signaling pathways. It has been demonstrated that SLC7A5 is a critical transporter that mediates uptake of several essential amino acids in highly proliferative tumors and activate...

journal_title：Frontiers in immunology

authors： Yoon BR,Oh YJ,Kang SW,Lee EB,Lee WW

更新日期：2018-01-25 00:00:00

abstract：:CD83 is a member of the immunoglobulin (Ig) superfamily and is expressed in membrane bound or soluble forms. Membrane CD83 (mCD83) can be detected on a variety of activated immune cells, although it is most highly and stably expressed by mature dendritic cells (DC). mCD83 regulates maturation, activation and homeostas...

journal_title：Frontiers in immunology

authors： Li Z,Ju X,Silveira PA,Abadir E,Hsu WH,Hart DNJ,Clark GJ

更新日期：2019-06-07 00:00:00

abstract：:Background: Characterization of the intracellular biochemical processes that regulate the generation and maintenance of effector and memory CD8+ T-cells from naïve precursors is essential for our understanding of adaptive immune responses and the development of immunotherapies. However, the metabolic determinants of a...

journal_title：Frontiers in immunology

authors： Nicoli F,Papagno L,Frere JJ,Cabral-Piccin MP,Clave E,Gostick E,Toubert A,Price DA,Caputo A,Appay V

更新日期：2018-12-21 00:00:00