Glycolysis Is Required for LPS-Induced Activation and Adhesion of Human CD14+CD16- Monocytes.

abstract：:The neonatal Fc receptor (FcRn) plays key roles in IgG and albumin homeostasis, maternal IgG transport, and antigen presentation of IgG-opsonized antigens. Previously, we reported that transgenic (Tg) mice that overexpress the bovine FcRn (bFcRn) have augmented T-dependent humoral immune response with increased IgG pr...

journal_title：Frontiers in immunology

authors： Schneider Z,Jani PK,Szikora B,Végh A,Kövesdi D,Iliás A,Cervenak J,Balogh P,Kurucz I,Kacskovics I

更新日期：2015-07-20 00:00:00

abstract：:Functional impairment of T-cells and a concomitant augmented expression of programmed death-1 (PD-1) have been observed in visceral leishmaniasis patients, as well as in experimental models for visceral and cutaneous leishmaniasis. The PD-1/PD-1-ligand (PD-1/PD-L) interaction negatively regulates T-cell effector funct...

journal_title：Frontiers in immunology

authors： Filippis C,Arens K,Noubissi Nzeteu GA,Reichmann G,Waibler Z,Crauwels P,van Zandbergen G

更新日期：2017-12-22 00:00:00

abstract：:Nutrition plays a major role in the management of both acute and chronic diseases, in terms of body's response to the pathogenic organism. An array of nutrients like macro- and micro-nutrients, vitamins, etc., are associated with boosting the host's immune responses against intracellular pathogens including mycobacter...

journal_title：Frontiers in immunology

authors： Chandrasekaran P,Saravanan N,Bethunaickan R,Tripathy S

更新日期：2017-10-18 00:00:00

abstract：:Fish red blood cells (RBCs), are integral in several biologic processes relevant to immunity, such as pathogen recognition, pathogen binding and clearance, and production of effector molecules and cytokines. So far, one of the best strategies to control and prevent viral diseases in aquaculture is DNA immunization. DN...

journal_title：Frontiers in immunology

authors： Puente-Marin S,Nombela I,Chico V,Ciordia S,Mena MC,Coll J,Mercado L,Ortega-Villaizan MDM

更新日期：2018-10-29 00:00:00

abstract：:Vaccination is one of the most cost-effective health interventions and, with the exception of water sanitization, no other action has had such a major effect in mortality reduction. Combined with other approaches, such as clean water, better hygiene, and health education, vaccination contributed to prevent millions of...

journal_title：Frontiers in immunology

authors： Vo HTM,Baudner BC,Sammicheli S,Iannacone M,D'Oro U,Piccioli D

更新日期：2018-04-09 00:00:00

abstract：:Blood-borne monocyte derived cells play a pivotal, initially unrecognized, role in most central nervous system disorders, including diseases initially classified as purely neurodegenerative (i.e., Alzheimer's disease, Parkinson's disease, and ALS). Their trafficking to the brain and spinal cord has been extensively st...

journal_title：Frontiers in immunology

authors： Nigro A,Colombo F,Casella G,Finardi A,Verderio C,Furlan R

更新日期：2016-01-29 00:00:00

abstract：:Clinical management of neuropathic pain is unsatisfactory, mainly due to its resistance to the effects of available analgesics, including opioids. Converging evidence indicates the functional interactions between chemokine and opioid receptors and their influence on nociceptive processes. Recent studies highlight that...

journal_title：Frontiers in immunology

authors： Kwiatkowski K,Pawlik K,Ciapała K,Piotrowska A,Makuch W,Mika J

更新日期：2020-12-21 00:00:00

abstract：:Epstein-Barr virus (EBV) is an oncogenic human herpes virus that was discovered in 1964. Viral non-coding RNAs, such as BamHI-A rightward fragment-derived microRNAs (BART miRNAs) or BamHI-H rightward fragment 1-derived miRNAs (BHRF1 miRNA) in EBV-infected cells have been recently reported. Host miRNAs are also upregul...

journal_title：Frontiers in immunology

authors： Iizasa H,Kim H,Kartika AV,Kanehiro Y,Yoshiyama H

更新日期：2020-03-03 00:00:00

abstract：:Despite the role of pigs as a source of new Influenza A Virus viruses (IAV) potentially capable of initiating human pandemics, immune responses to swine influenza virus (SwIV) in pigs are not fully understood. Several SwIV epitopes presented by swine MHC (SLA) class I have been identified using different approaches ei...

journal_title：Frontiers in immunology

authors： Baratelli M,Morgan S,Hemmink JD,Reid E,Carr BV,Lefevre E,Montaner-Tarbes S,Charleston B,Fraile L,Tchilian E,Montoya M

更新日期：2020-09-16 00:00:00

abstract：:Microparticles (MPs) are vesicles derived from the plasma membrane of different cells, are considered a source of circulating autoantigens, and can form immune complexes (MPs-ICs). The number of MPs and MPs-ICs increases in patients with systemic lupus erythematosus (SLE). MPs activate myeloid cells by inducing IL-6 a...

journal_title：Frontiers in immunology

authors： Burbano C,Villar-Vesga J,Orejuela J,Muñoz C,Vanegas A,Vásquez G,Rojas M,Castaño D

更新日期：2018-03-01 00:00:00

abstract：:Sepsis is life-threatening organ dysfunction due to dysregulated response to infection. Patients with sepsis exhibit wide heterogeneity stemming from genetic, molecular, and clinical factors as well as differences in pathogens, creating challenges for the development of effective treatments. Several gaps in knowledge ...

journal_title：Frontiers in immunology

authors： Talisa VB,Yende S,Seymour CW,Angus DC

更新日期：2018-06-28 00:00:00

abstract：:B7 proteins CD80 (B7-1) and CD86 (B7-2) are expressed on most antigen-presenting cells and provide critical co-stimulatory or inhibitory input to T cells via their T-cell-expressed receptors: CD28 and CTLA-4. CD28 is expressed on effector T cells and regulatory T cells (Tregs), and CD28-dependent signals are required ...

journal_title：Frontiers in immunology

authors： Brzostek J,Gascoigne NR,Rybakin V

更新日期：2016-02-04 00:00:00

abstract：:The identification of recurrent human leukocyte antigen (HLA) neoepitopes driving T cell responses against tumors poses a significant bottleneck in the development of approaches for precision cancer therapeutics. Here, we employ a bioinformatics method, Prediction of T Cell Epitopes for Cancer Therapy, to analyze sequ...

journal_title：Frontiers in immunology

authors： Toor JS,Rao AA,McShan AC,Yarmarkovich M,Nerli S,Yamaguchi K,Madejska AA,Nguyen S,Tripathi S,Maris JM,Salama SR,Haussler D,Sgourakis NG

更新日期：2018-01-30 00:00:00

abstract：:Borrelia burgdorferi sensu lato species complex is capable of establishing persistent infections in a wide variety of species, particularly rodents. Infection is asymptomatic or mild in most reservoir host species, indicating successful co-evolution of the pathogen with its natural hosts. However, infected humans and ...

journal_title：Frontiers in immunology

authors： Tracy KE,Baumgarth N

更新日期：2017-02-20 00:00:00

abstract：:Leprosy, a disease caused by the intracellular parasite Mycobacterium leprae or Mycobacterium lepromatosis, has affected humans for more than 4,000 years and is a stigmatized disease even now. Since clinical manifestations of leprosy patients present as an immune-related spectrum, leprosy is regarded as an ideal model...

journal_title：Frontiers in immunology

authors： Mi Z,Liu H,Zhang F

更新日期：2020-04-16 00:00:00

abstract：:Acute infection of bovine viral diarrhea virus (BVDV) is associated with immune dysfunction and can cause peripheral blood lymphopenia and lymphocyte apoptosis. Our previous study has confirmed that programmed death-1 (PD-1) blockade inhibits peripheral blood lymphocyte (PBL) apoptosis and restores proliferation and a...

journal_title：Frontiers in immunology

authors： Liu Y,Liu S,Wu C,Huang W,Xu B,Lian S,Wang L,Yue S,Chen N,Zhu Z

更新日期：2020-03-17 00:00:00

abstract：:Antibodies against HLA and non-HLA are associated with transplantation outcome. Recently, pretransplant serum IgG antibody levels against apoptotic cells were found to correlate with kidney allograft loss. We investigated the presence of these antibodies in lung transplantation (LTx) patients and evaluated the correla...

journal_title：Frontiers in immunology

authors： Budding K,van de Graaf EA,Kardol-Hoefnagel T,Oudijk ED,Kwakkel-van Erp JM,Hack CE,Otten HG

更新日期：2017-03-21 00:00:00

abstract：:The management of chronic inflammatory diseases, such as inflammatory bowel disease, psoriasis, and rheumatoid arthritis has significantly improved over the last decade with the clinical availability of anti-TNF-α biologics. Despite this undoubted treatment success, a combination of acquired resistance together with a...

journal_title：Frontiers in immunology

authors： Ubah OC,Steven J,Kovaleva M,Ferguson L,Barelle C,Porter AJR,Barelle CJ

更新日期：2017-12-22 00:00:00

abstract：:The dual potential to promote tolerance or inflammation to self-antigens makes dendritic cells (DCs) fundamental players in autoimmunity. Previous results have shown that stimulation of dopamine receptor D5 (DRD5) in DCs potentiates their inflammatory behaviour, favouring the development of experimental autoimmune enc...

journal_title：Frontiers in immunology

authors： Prado C,Gaiazzi M,González H,Ugalde V,Figueroa A,Osorio-Barrios FJ,López E,Lladser A,Rasini E,Marino F,Zaffaroni M,Cosentino M,Pacheco R

更新日期：2018-03-21 00:00:00

abstract：:NK cells play an important role in the innate defenses against tumor growth and metastases. Human NK cell activation and function are regulated by an array of HLA class I-specific inhibitory receptors and activating receptors recognizing ligands expressed de novo on tumor or virus-infected cells. NK cells have been ex...

journal_title：Frontiers in immunology

authors： Vacca P,Pietra G,Tumino N,Munari E,Mingari MC,Moretta L

更新日期：2020-01-17 00:00:00

abstract：:In adaptation to rising stimulant strength, innate monocytes can be dynamically programed to preferentially express either pro- or anti-inflammatory mediators. Such dynamic innate adaptation or programing may bear profound relevance in host health and disease. However, molecular mechanisms that govern innate adaptatio...

journal_title：Frontiers in immunology

authors： Yuan R,Geng S,Li L

更新日期：2016-11-10 00:00:00

abstract：:Tumor necrosis factor (TNF)-α is a major pro-inflammatory cytokine produced in response to toll-like receptor stimulation. TNF-α release is controlled by the activity of TNF-α converting enzyme (TACE) that cut membrane-bound TNF-α to shed its ectodomain as a soluble cytokine. The purinergic receptor P2X ligand-gated i...

journal_title：Frontiers in immunology

authors： Barberà-Cremades M,Gómez AI,Baroja-Mazo A,Martínez-Alarcón L,Martínez CM,de Torre-Minguela C,Pelegrín P

更新日期：2017-07-24 00:00:00

abstract：:Enamel matrix derivatives (EMDs)-based periodontal tissue regenerative therapy is known to promote healing with minimal inflammatory response after periodontal surgery, i. e., it promotes wound healing with reduced pain and swelling. It has also been reported that macrophages stimulated with amelogenin, a major compon...

journal_title：Frontiers in immunology

authors： Yotsumoto K,Sanui T,Tanaka U,Yamato H,Alshargabi R,Shinjo T,Nakao Y,Watanabe Y,Hayashi C,Taketomi T,Fukuda T,Nishimura F

更新日期：2020-04-21 00:00:00

abstract：:Degenerative disc disease is associated with increased expression of pro-inflammatory cytokines in the intervertebral disc (IVD). However, it is not completely clear how inflammation arises in the IVD and which cellular compartments are involved in this process. Recently, the endoplasmic reticulum (ER) has emerged as ...

journal_title：Frontiers in immunology

authors： Krupkova O,Sadowska A,Kameda T,Hitzl W,Hausmann ON,Klasen J,Wuertz-Kozak K

更新日期：2018-08-17 00:00:00

abstract：:Fas and Fas Ligand (FasL) are two molecules involved in the regulation of cell death. Their interaction leads to apoptosis of thymocytes that fail to rearrange correctly their T cell receptor (TCR) genes and of those that recognize self-antigens, a process called negative selection; moreover, Fas-FasL interaction lead...

journal_title：Frontiers in immunology

authors： Volpe E,Sambucci M,Battistini L,Borsellino G

更新日期：2016-09-27 00:00:00

abstract：:In addition to physical barriers, neutrophils are considered a part of the first line of immune defense. They can be found in the bloodstream, with a lifespan of 6-8 h, and in tissue, where they can last up to 7 days. The mechanisms that neutrophils utilize for host defense are phagocytosis, degranulation, cytokine pr...

journal_title：Frontiers in immunology

authors： Delgado-Rizo V,Martínez-Guzmán MA,Iñiguez-Gutierrez L,García-Orozco A,Alvarado-Navarro A,Fafutis-Morris M

更新日期：2017-02-06 00:00:00

abstract：:Worldwide, breast cancer (BC) is the leading cause of cancer death among women. For many patients the most effective treatment is a resection surgery that removes the tumor. Within this subset, patients sometimes receive chemotherapy treatment (CT) prior to surgery aiming to reduce tumor size in order to preserve heal...

journal_title：Frontiers in immunology

authors： Valdés-Ferrada J,Muñoz-Durango N,Pérez-Sepulveda A,Muñiz S,Coronado-Arrázola I,Acevedo F,Soto JA,Bueno SM,Sánchez C,Kalergis AM

更新日期：2020-07-09 00:00:00

abstract：:Myasthenia gravis is an autoimmune disease in which immunoglobulin G (IgG) autoantibodies are formed against the nicotinic acetylcholine receptor (AChR) or other components of the neuromuscular junction. Though effective treatments are currently available, many commonly used therapies have important limitations and al...

journal_title：Frontiers in immunology

authors： Gable KL,Guptill JT

更新日期：2020-01-10 00:00:00

abstract：:The homeostasis of T cell populations depends on migration, division and death of individual cells (1). T cells migrate between spatial compartments (spleen, lymph nodes, lung, liver, etc.), where they may divide or differentiate, and eventually die (2). The kinetics of recirculation influences the speed at which loca...

journal_title：Frontiers in immunology

authors： de la Higuera L,López-García M,Castro M,Abourashchi N,Lythe G,Molina-París C

更新日期：2019-03-06 00:00:00

abstract：:Fracture repair is initiated by a multitude of immune cells and induction of an inflammatory cascade. Alterations in the early healing response due to an aged adaptive immune system leads to impaired bone repair, delayed healing or even formation of non-union. However, immuno-senescence is not limited to the adaptive ...

journal_title：Frontiers in immunology

authors： Löffler J,Sass FA,Filter S,Rose A,Ellinghaus A,Duda GN,Dienelt A

更新日期：2019-10-18 00:00:00