PRINS Non-Coding RNA Regulates Nucleic Acid-Induced Innate Immune Responses of Human Keratinocytes.

abstract：:Common Variable Immunodeficiency (CVID) is characterized by impaired antibody production and poor terminal differentiation of the B cell compartment, yet its pathogenesis is still poorly understood. We first reported the occurrence of epigenetic alterations in CVID by high-throughput methylation analysis in CVID-disco...

journal_title：Frontiers in immunology

authors： Del Pino-Molina L,Rodríguez-Ubreva J,Torres Canizales J,Coronel-Díaz M,Kulis M,Martín-Subero JI,van der Burg M,Ballestar E,López-Granados E

更新日期：2019-04-24 00:00:00

abstract：:Recent years have seen an unprecedented rise in the incidence of multidrug-resistant (MDR) Gram-negative bacteria (GNBs) such as Acinetobacter and Klebsiella species. In view of the shortage of novel drugs in the pipeline, alternative strategies to prevent, and treat infections by GNBs are urgently needed. Previously,...

journal_title：Frontiers in immunology

authors： Youssef EG,Zhang L,Alkhazraji S,Gebremariam T,Singh S,Yount NY,Yeaman MR,Uppuluri P,Ibrahim AS

更新日期：2020-02-18 00:00:00

abstract：:Pulmonary tuberculosis (TB) is a difficult-to-eliminate disease. Although the Bacille Calmette-Guérin (BCG) vaccine against Mycobacterium tuberculosis (MTB) has been available for decades, its efficacy is variable and has lessened over time. Furthermore, the BCG vaccine no longer protects against newly emerged Beijing...

journal_title：Frontiers in immunology

authors： Yang SJ,Chen YY,Hsu CH,Hsu CW,Chang CY,Chang JR,Dou HY

更新日期：2020-06-23 00:00:00

abstract：:Immunotherapy using checkpoint blockade has revolutionized cancer treatment, improving patient survival and quality of life. Nevertheless, the clinical outcomes of such immunotherapy are highly heterogeneous between patients. Depending on the cancer type, the patient response rates to this immunotherapy are limited to...

journal_title：Frontiers in immunology

authors： Chuang YC,Tseng JC,Huang LR,Huang CM,Huang CF,Chuang TH

更新日期：2020-05-29 00:00:00

abstract：:Type I interferon is widely used for antiviral therapy, yet has yielded disappointing results toward chronic HBV infection. Here we identify that PEG-IFNα-2b therapy toward persistent infection in humans is a double-edged sword of both immunostimulation and immunomodulation. Our studies of this randomised trial showed...

journal_title：Frontiers in immunology

authors： Fu B,Wang D,Shen X,Guo C,Liu Y,Ye Y,Sun R,Li J,Tian Z,Wei H

更新日期：2020-12-23 00:00:00

abstract：:The catabolic process of autophagy plays important functions in inflammatory and immune responses by modulating innate immunity and adaptive immunity. Over the last decade, a cell-intrinsic role for autophagy in modulating CD4 T cell functions and differentiation was revealed. After the initial observation of autophag...

journal_title：Frontiers in immunology

authors： Jacquin E,Apetoh L

更新日期：2018-05-09 00:00:00

abstract：:Short-chain fatty acids (SCFAs) are mainly produced by microbiota through the fermentation of carbohydrates in the intestine. Acetate, propionate, and butyrate are the most abundant SCFA metabolites and have been shown to be important in the maintenance of host health. In this study, head kidney macrophages (HKMs) wer...

journal_title：Frontiers in immunology

authors： Zhang J,Zhang H,Liu M,Lan Y,Sun H,Mai K,Wan M

更新日期：2020-12-23 00:00:00

abstract：:Protein 4.1R, a member of the 4.1 family, functions as a bridge between cytoskeletal and plasma membrane proteins. It is expressed in T cells, where it binds to a linker for activation of T cell (LAT) family member 1 and inhibits its phosphorylation and downstream signaling events after T cell receptor triggering. The...

journal_title：Frontiers in immunology

authors： Draberova L,Draberova H,Potuckova L,Halova I,Bambouskova M,Mohandas N,Draber P

更新日期：2020-01-14 00:00:00

abstract：:γδ T cells, known to be an important source of innate IL-17 in mice, provide critical contributions to host immune responses. Development and function of γδ T cells are directed by networks of diverse transcription factors (TFs). Here, we examine the role of the zinc finger TFs, Kruppel-like factor 10 (KLF10), in the ...

journal_title：Frontiers in immunology

authors： Kim G,Gu MJ,Kim SJ,Ko KH,Kye YC,Kim CG,Cho JH,Lee WK,Song KD,Chu H,Park YM,Han SH,Yun CH

更新日期：2018-02-28 00:00:00

abstract：:iNKT cells are CD1d-restricted T cells recognizing lipid antigens. The prototypic iNKT cell-agonist α-galactosylceramide (α-GalCer) alongside compounds with similar structures induces robust proliferation and cytokine production of iNKT cells and protects against cancer in vivo. Monoclonal antibodies (mAbs) that detec...

journal_title：Frontiers in immunology

authors： Clark K,Yau J,Bloom A,Wang J,Venzon DJ,Suzuki M,Pasquet L,Compton BJ,Cardell SL,Porcelli SA,Painter GF,Zajonc DM,Berzofsky JA,Terabe M

更新日期：2019-10-09 00:00:00

abstract：:Visceral leishmaniasis is a severe form of the disease, caused by Leishmania infantum in the New World. Patients present an anergic immune response that favors parasite establishment and spreading through tissues like bone marrow and liver. On the other hand, Leishmania braziliensis causes localized cutaneous lesions,...

journal_title：Frontiers in immunology

authors： Falcão Sde A,Jaramillo TM,Ferreira LG,Bernardes DM,Santana JM,Favali CB

更新日期：2016-08-03 00:00:00

abstract：:Delayed graft function (DGF) occurs in a significant proportion of deceased donor kidney transplant recipients and was associated with graft injury and inferior clinical outcome. The aim of the present multi-center study was to identify the immunological and non-immunological predictors of DGF and to determine its inf...

journal_title：Frontiers in immunology

authors： Morath C,Döhler B,Kälble F,Pego da Silva L,Echterdiek F,Schwenger V,Živčić-Ćosić S,Katalinić N,Kuypers D,Benöhr P,Haubitz M,Ziemann M,Nitschke M,Emmerich F,Pisarski P,Karakizlis H,Weimer R,Ruhenstroth A,Scherer S,Tr

更新日期：2020-08-26 00:00:00

abstract：:Many pathogens, including the malaria parasite Plasmodium falciparum, display high levels of polymorphism within T-cell epitope regions of proteins associated with protective immunity. The T-cell epitope variants are often non-cross-reactive. Herein, we show in a murine model, which modifies a protective CD8 T-cell ep...

journal_title：Frontiers in immunology

authors： Minigo G,Flanagan KL,Slattery RM,Plebanski M

更新日期：2017-02-14 00:00:00

abstract：:Migration of human plasmablast to the bone marrow is essential for the final differentiation of plasma cells and maintenance of effective humoral immunity. This migration is controlled by CXCL12/CXCR4-mediated activation of the protein kinase AKT. Herein, we show that the CXCL12-induced migration of human plasmablasts...

journal_title：Frontiers in immunology

authors： Pak HK,Nam B,Lee YK,Kim YW,Roh J,Son J,Chung YS,Choe J,Park CS

更新日期：2018-07-27 00:00:00

abstract：:Because of a loss-of-function mutation in the GGTA1 gene, humans are unable to synthetize α1,3-Galactose (Gal) decorated glycans and develop high levels of circulating anti-α1,3-Galactose antibodies (anti-Gal Abs). Anti-Gal Abs have been identified as a major obstacle of organ xenotransplantation and play a role in se...

journal_title：Frontiers in immunology

authors： Montassier E,Al-Ghalith GA,Mathé C,Le Bastard Q,Douillard V,Garnier A,Guimon R,Raimondeau B,Touchefeu Y,Duchalais E,Vince N,Limou S,Gourraud PA,Laplaud DA,Nicot AB,Soulillou JP,Berthelot L

更新日期：2020-01-13 00:00:00

abstract：:Delivery of high doses of radiation to thoracic region, particularly with non-small cell lung cancer patients, becomes difficult due to subsequent complications arising in the lungs of the patient. Radiation-induced pneumonitis is an early event evident in most radiation exposed patients observed within 2-4 months of ...

journal_title：Frontiers in immunology

authors： Kainthola A,Haritwal T,Tiwari M,Gupta N,Parvez S,Tiwari M,Prakash H,Agrawala PK

更新日期：2017-05-02 00:00:00

abstract：:Malaria is caused by infection with Plasmodium parasites. Various studies with knockout mice have indicated that IFN-γ plays essential roles in protective immunity against blood-stage Plasmodium infection. However, after Plasmodium infection, increased IFN-γ production by various types of cells is involved not only in...

journal_title：Frontiers in immunology

authors： Inoue S,Niikura M,Mineo S,Kobayashi F

更新日期：2013-08-29 00:00:00

abstract：:Graft versus host disease (GVHD) is the major complication of allogeneic hematopoietic stem cell transplantation. GVHD is characterized by an imbalance between the effector and regulatory arms of the immune system which results in the over production of inflammatory cytokines. Moreover, there is a persistent reduction...

journal_title：Frontiers in immunology

authors： Beres AJ,Drobyski WR

更新日期：2013-06-24 00:00:00

abstract：:Membranous nephropathy (MN), a common pathological type of adult nephrotic syndrome, is an antibody-mediated kidney disease. It is widely accepted now that MN is an immune-related disease that involves the whole immune system. In this study, we analyzed the T-cell receptor beta chain (TCRβ) repertoire of the circulati...

journal_title：Frontiers in immunology

authors： Zhang Y,Jin Y,Guan Z,Li H,Su Z,Xie C,Chen X,Liu X,Pan Y,Ye P,Zhang L,Kong Y,Luo W

更新日期：2020-03-10 00:00:00

abstract：:Pregnancy comprises a unique immunological condition, to allow fetal development and to protect the host from pathogenic infections. Viral infections during pregnancy can disrupt immunological tolerance and may generate deleterious effects on the fetus. Despite these possible links between pregnancy and infection-indu...

journal_title：Frontiers in immunology

authors： Alberca RW,Pereira NZ,Oliveira LMDS,Gozzi-Silva SC,Sato MN

更新日期：2020-07-07 00:00:00

abstract：:The apoptosis of hemocytes plays an essential function in shrimp immune defense against pathogen invasions. In order to further elucidate the differential apoptotic responses of the granulocytes and the hyalinocytes in Fenneropenaeus chinensis post WSSV infection, the characteristics of apoptotic dynamics and viral pr...

journal_title：Frontiers in immunology

authors： Cui C,Liang Q,Tang X,Xing J,Sheng X,Zhan W

更新日期：2020-12-07 00:00:00

abstract：:The main environmental risk factor associated with the development of Crohn's disease (CD) is cigarette smoking. Although the mechanism is still unknown, some studies have shown that cigarette exposure affects the intestinal barrier of the small bowel. Among the factors that may be involved in this process are Paneth ...

journal_title：Frontiers in immunology

authors： Berkowitz L,Pardo-Roa C,Salazar GA,Salazar-Echegarai F,Miranda JP,Ramírez G,Chávez JL,Kalergis AM,Bueno SM,Álvarez-Lobos M

更新日期：2019-09-25 00:00:00

abstract：:Galectins, a family of animal lectins, play central roles in immune system regulation, shaping both innate and adaptive responses in physiological and pathological processes. These include rheumatoid arthritis (RA), a chronic multifactorial autoimmune disease characterized by inflammatory responses that affects both a...

journal_title：Frontiers in immunology

authors： Mendez-Huergo SP,Hockl PF,Stupirski JC,Maller SM,Morosi LG,Pinto NA,Berón AM,Musuruana JL,Nasswetter GG,Cavallasca JA,Rabinovich GA

更新日期：2019-01-09 00:00:00

abstract：:Sepsis is characterized by injury of pulmonary microvascular endothelial cells (PMVEC) leading to barrier dysfunction. Multiple mechanisms promote septic PMVEC barrier dysfunction, including interaction with circulating leukocytes and PMVEC apoptotic death. Our previous work demonstrated a strong correlation between s...

journal_title：Frontiers in immunology

authors： Wang L,Mehta S,Ahmed Y,Wallace S,Pape MC,Gill SE

更新日期：2018-08-02 00:00:00

abstract：:Leprosy serology reflects the bacillary load of patients and multidrug therapy (MDT) reduces Mycobacterium leprae-specific antibody titers of multibacillary (MB) patients. The Clinical Trial for Uniform Multidrug Therapy Regimen for Leprosy Patients in Brazil (U-MDT/CT-BR) compared outcomes of regular 12 doses MDT/R-M...

journal_title：Frontiers in immunology

authors： Hungria EM,Bührer-Sékula S,Oliveira RM,Aderaldo LC,Pontes MAA,Cruz R,de Gonçalves HS,Penna MLF,Penna GO,Stefani MMA

更新日期：2018-05-14 00:00:00

abstract：:The identification of recurrent human leukocyte antigen (HLA) neoepitopes driving T cell responses against tumors poses a significant bottleneck in the development of approaches for precision cancer therapeutics. Here, we employ a bioinformatics method, Prediction of T Cell Epitopes for Cancer Therapy, to analyze sequ...

journal_title：Frontiers in immunology

authors： Toor JS,Rao AA,McShan AC,Yarmarkovich M,Nerli S,Yamaguchi K,Madejska AA,Nguyen S,Tripathi S,Maris JM,Salama SR,Haussler D,Sgourakis NG

更新日期：2018-01-30 00:00:00

abstract：:Hemolysis-associated anemia is characteristic of diseases such as atherosclerosis, lupus, malaria, and leishmaniasis; the toxic effects of free hemoglobin (Hb) have been extensively described. This study was based on the premise that release of this sequestered, inflammatory molecule can result in deleterious immunolo...

journal_title：Frontiers in immunology

authors： Jain S,Bose A,Bastia B,Sharma H,Sachdeva R,Jain AK,Pal R

更新日期：2017-06-26 00:00:00

abstract：:Dendritic cells are considered as the main coordinators of both mucosal and systemic immune responses, thus playing a determining role in shaping the outcome of effector cell responses. However, it is still uncovered how primary human monocyte-derived DC (moDC) populations drive the polarization of helper T (Th) cells...

journal_title：Frontiers in immunology

authors： Bene K,Varga Z,Petrov VO,Boyko N,Rajnavolgyi E

更新日期：2017-04-18 00:00:00

abstract：:Neurological disorders caused by neuroviral infections are an obvious pathogenic manifestation. However, non-neurotropic viruses or peripheral viral infections pose a considerable challenge as their neuropathological manifestations do not emerge because of primary infection. Their secondary or bystander pathologies de...

journal_title：Frontiers in immunology

authors： Mishra R,Banerjea AC

更新日期：2020-09-10 00:00:00

abstract：:Background: Optimal timing of gestational tetanus-diphtheria-acellular pertussis (Tdap) vaccination is not well-defined. No well-established specific anti-pertussis antibody level correlates with protection, suggesting the importance of antibody quality such as avidity. We aimed to determine the effect of timing of va...

journal_title：Frontiers in immunology

authors： Abu-Raya B,Giles ML,Kollmann TR,Sadarangani M

更新日期：2019-10-11 00:00:00