Identification of a Consolidation Phase in Immunological Memory.

abstract：:In addition to physical barriers, neutrophils are considered a part of the first line of immune defense. They can be found in the bloodstream, with a lifespan of 6-8 h, and in tissue, where they can last up to 7 days. The mechanisms that neutrophils utilize for host defense are phagocytosis, degranulation, cytokine pr...

journal_title：Frontiers in immunology

authors： Delgado-Rizo V,Martínez-Guzmán MA,Iñiguez-Gutierrez L,García-Orozco A,Alvarado-Navarro A,Fafutis-Morris M

更新日期：2017-02-06 00:00:00

abstract：:Multiple myeloma (MM) and its pre-cancerous stage monoclonal gammopathy of undetermined significance (MGUS) allow to study immune responses and the chronology of inflammation in the context of blood malignancies. Both diseases are characterized by the production of a monoclonal immunoglobulin (mc Ig) which for subsets...

journal_title：Frontiers in immunology

authors： Bosseboeuf A,Allain-Maillet S,Mennesson N,Tallet A,Rossi C,Garderet L,Caillot D,Moreau P,Piver E,Girodon F,Perreault H,Brouard S,Nicot A,Bigot-Corbel E,Hermouet S,Harb J

更新日期：2017-10-19 00:00:00

abstract：:Food allergy is an atopic disease that is caused by the immune system targeting harmless food antigens that can result in life-threatening anaphylaxis. As humans and microbes have co-evolved, inevitably commensal microbes have a tremendous impact on our health. As such, the gut with its enormous microbial richness ref...

journal_title：Frontiers in immunology

authors： Kreft L,Hoffmann C,Ohnmacht C

更新日期：2020-08-14 00:00:00

abstract：:Natural killer (NK) cells are effective in combating infections and tumors and as such are tempting for adoptive transfer therapy. However, they are not homogeneous but can be divided into three main subsets, including cytotoxic, tolerant, and regulatory NK cells, with disparate phenotypes and functions in diverse tis...

journal_title：Frontiers in immunology

authors： Wu Y,Tian Z,Wei H

更新日期：2017-08-04 00:00:00

abstract：:A balance between co-inhibitory and co-stimulatory signals in the tumor microenvironment (TME) is critical to suppress tumor development and progression, primarily via maintaining effective immunosurveillance. Aberrant expression of immune checkpoints (ICs), including programmed cell death protein 1 (PD-1), cytotoxic ...

journal_title：Frontiers in immunology

authors： Saleh R,Toor SM,Sasidharan Nair V,Elkord E

更新日期：2020-07-14 00:00:00

abstract：:In gut epithelium, IL-22 transmits signals through STAT3 phosphorylation (pSTAT3) which provides intestinal immunity. Many components in the IL-22-pSTAT3 pathway have been identified as risk factors for inflammatory bowel disease (IBD) and some of them are considered as promising therapeutic targets. However, new pers...

journal_title：Frontiers in immunology

authors： Glal D,Sudhakar JN,Lu HH,Liu MC,Chiang HY,Liu YC,Cheng CF,Shui JW

更新日期：2018-11-05 00:00:00

abstract：:The vast initial diversity of the antibody repertoire is generated centrally by means of a complex series of V(D)J gene rearrangement events, variation in the site of gene segment joining, and TdT catalyzed N-region addition. Although the diversity is great, close inspection has revealed distinct and unique characteri...

journal_title：Frontiers in immunology

authors： Mroczek ES,Ippolito GC,Rogosch T,Hoi KH,Hwangpo TA,Brand MG,Zhuang Y,Liu CR,Schneider DA,Zemlin M,Brown EE,Georgiou G,Schroeder HW Jr

更新日期：2014-03-19 00:00:00

abstract：:A single nucleotide polymorphism, C1858T, in the gene encoding the protein tyrosine phosphatase nonreceptor type 22 (PTPN22) results in one of the strongest genetic traits associated with autoimmune disease outside of the Major Histocompatibility Complex (MHC) genes. However, the consequences of this polymorphism, whi...

journal_title：Frontiers in immunology

authors： Bray C,Wright D,Haupt S,Thomas S,Stauss H,Zamoyska R

更新日期：2018-11-12 00:00:00

abstract：:Approximately 1.2 billion people suffer from fungal diseases worldwide. Arguably, the most serious manifestation occurs when pathogenic fungi infect the brain, often causing fatal meningoencephalitis. For most fungi, infection occurs via the vascular route. The organism must first be arrested in the brain microvascula...

journal_title：Frontiers in immunology

authors： Shi M,Mody CH

更新日期：2016-08-02 00:00:00

abstract：:The extraintestinal pathogenic Escherichia coli (ExPEC) is a typical facultative intracellular bacterial pathogen. Sensing the environmental stimuli and undertaking adaptive change are crucial for ExPEC to successfully colonize in specific extraintestinal niches. The previous studies show that pathogens exploit two-co...

journal_title：Frontiers in immunology

authors： Zhuge X,Sun Y,Xue F,Tang F,Ren J,Li D,Wang J,Jiang M,Dai J

更新日期：2018-04-17 00:00:00

abstract：:In addition to their detrimental role in allergic diseases, mast cells (MCs) are well known to be important cells of the innate immune system. In the last decade, they have been shown to contribute significantly to optimal host defense against numerous pathogens including parasites, bacteria, and viruses. The contribu...

journal_title：Frontiers in immunology

authors： Saluja R,Metz M,Maurer M

更新日期：2012-06-13 00:00:00

abstract：:Antibodies that block the immune checkpoint receptors PD1 and CTLA4 have revolutionized the treatment of melanoma and several other cancers, but in the process, a new class of drug side effect has emerged-immune related adverse events. The observation that therapeutic blockade of these inhibitory receptors is sufficie...

journal_title：Frontiers in immunology

authors： Paluch C,Santos AM,Anzilotti C,Cornall RJ,Davis SJ

更新日期：2018-10-08 00:00:00

abstract：:Sensing of microbe-associated molecular patterns or danger signals by innate immune receptors drives a complex exchange of information. Innate receptor signaling not only triggers transcriptional events but also induces profound changes in metabolic fluxes, redox balance, and metabolite abundance thereby influencing i...

journal_title：Frontiers in immunology

authors： Sancho D,Enamorado M,Garaude J

更新日期：2017-05-08 00:00:00

abstract：:Science can move ahead by questioning established or canonical views and, so it may be with the enzymes, nitric oxide synthases (NOS). Nitric oxide (NO) is generated by NOS isoforms that are often described by their tissue-specific expression patterns. NOS1 (nNOS) is abundant in neural tissue, NOS2 is upregulated in a...

journal_title：Frontiers in immunology

authors： Mattila JT,Thomas AC

更新日期：2014-10-09 00:00:00

abstract：:Arginine methylation is a post-translational modification that regulates many biological processes. However, the role of arginine methylation in immune cells is not well studied. Here we report an essential role of protein arginine methyltransferase 5 (PRMT5) in T cell homeostasis and activation-induced expansion. Usi...

journal_title：Frontiers in immunology

authors： Tanaka Y,Nagai Y,Okumura M,Greene MI,Kambayashi T

更新日期：2020-04-09 00:00:00

abstract：:Obesity-induced chronic low-grade inflammation, in particular in adipose tissue, contributes to the development of insulin resistance and type 2 diabetes. However, the mechanism by which obesity induces adipose tissue inflammation has not been completely elucidated. Recent studies suggest that alteration of the nuclea...

journal_title：Frontiers in immunology

authors： Kim Y,Bayona PW,Kim M,Chang J,Hong S,Park Y,Budiman A,Kim YJ,Choi CY,Kim WS,Lee J,Cho KW

更新日期：2018-04-20 00:00:00

abstract：:Natural killer (NK) cells are lymphocytes of the innate immune system able to kill different targets such as cancer cells and virally infected cells without prior activation making then attractive candidates for cancer immunotherapy. Umbilical cord blood (UCB) has become a source of hematopoietic stem cells for transp...

journal_title：Frontiers in immunology

authors： Sarvaria A,Jawdat D,Madrigal JA,Saudemont A

更新日期：2017-03-23 00:00:00

abstract：:In order to combat invading pathogens neutrophils can release neutrophil extracellular traps (NETs). However, since NETs can also damage endogenous cells, several control mechanisms for the formation of NETs must work effectively. For instance, neutrophil activation is silenced within blood circulation by the binding ...

journal_title：Frontiers in immunology

authors： Bornhöfft KF,Rebl A,Gallagher ME,Viergutz T,Zlatina K,Reid C,Galuska SP

更新日期：2019-11-06 00:00:00

abstract：:Antiretroviral therapy (ART) for human immunodeficiency virus (HIV) infections has been designed to optimize CD4 T-cell survival and limit HIV replication. Cell types other than CD4 T cells such as monocytes/macrophage, dendritic cells, and granulocytes (collectively known as myeloid cells), are generally not consider...

journal_title：Frontiers in immunology

authors： Murray SM,Zhang Y,Douek DC,Sekaly RP

更新日期：2020-03-04 00:00:00

abstract：:The small GTPase Rab5 is one of the master regulators of vesicular trafficking that participates in early stages of the endocytic pathway, such as endocytosis and endosome maturation. Three Rab5 isoforms (a, b, and c) share high sequence identity, and exhibit complex functions. However, the role of Rab5c in virus infe...

journal_title：Frontiers in immunology

authors： Wang L,Li C,Zhang X,Yang M,Wei S,Huang Y,Qin Q,Wang S

更新日期：2020-09-02 00:00:00

abstract：:A growing number of diseases in humans, including trauma, certain cancers, and infection, are known to be associated with l-arginine deficiency. In addition, l-arginine must be supplemented by diet during pregnancy to aid fetal development. In conditions of l-arginine depletion, T cell proliferation is impaired. We ha...

journal_title：Frontiers in immunology

authors： Yu HR,Tsai CC,Chang LS,Huang HC,Cheng HH,Wang JY,Sheen JM,Kuo HC,Hsieh KS,Huang YH,Yang KD,Hsu TY

更新日期：2017-04-25 00:00:00

abstract：:Avian influenza A of the subtype H7N9 has been responsible for almost 1,600 confirmed human infections and more than 600 deaths since its first outbreak in 2013. Although sustained human-to-human transmission has not been reported yet, further adaptations to humans in the viral genome could potentially lead to an infl...

journal_title：Frontiers in immunology

authors： de Bree LCJ,Marijnissen RJ,Kel JM,Rosendahl Huber SK,Aaby P,Benn CS,Wijnands MVW,Diavatopoulos DA,van Crevel R,Joosten LAB,Netea MG,Dulos J

更新日期：2018-04-30 00:00:00

abstract：Background:Interleukin-9 (IL9) plays a critical role in immunity and the pathogenesis of endometrial cancer (EC), especially endometrioid EC (EEC). This study aimed to identify the IL9+ immune cell subsets and their pleiotropic functions and establish an optimized prognostic nomogram towards the promotion of personaliz...

journal_title：Frontiers in immunology

authors： Tong H,Feng H,Hu X,Wang MF,Song YF,Wen XL,Li YR,Wan XP

更新日期：2020-11-19 00:00:00

abstract：:The ubiquitously expressed, monomorphic MHC class Ib molecule MHC class I-related protein 1 (MR1) presents microbial metabolites to mucosal-associated invariant T (MAIT) cells. However, recent work demonstrates that both the ligands bound by MR1 and the T cells restricted by it are more diverse than originally thought...

journal_title：Frontiers in immunology

authors： Kulicke C,Karamooz E,Lewinsohn D,Harriff M

更新日期：2020-09-02 00:00:00

abstract：:[This corrects the article on p. 1376 in vol. 8, PMID: 29104576.]. ...

journal_title：Frontiers in immunology

authors： Kim JH,Sim JH,Lee S,Seol MA,Ye SK,Shin HM,Lee EB,Lee YJ,Choi YJ,Yoo WH,Kim JH,Kim WU,Lee DS,Kim JH,Kang I,Kang SW,Kim HR

更新日期：2017-12-07 00:00:00

abstract：:Objectives: Standardization of myositis specific antibody (MSA) detection is of high importance because these antibodies are relevant for diagnosis and stratification of patients with idiopathic inflammatory myositis (IIM) and have the potential to be used in classification criteria. Many laboratories rely on immunopr...

journal_title：Frontiers in immunology

authors： Mahler M,Betteridge Z,Bentow C,Richards M,Seaman A,Chinoy H,McHugh N

更新日期：2019-04-30 00:00:00

abstract：:Endometriosis is an estrogen-dependent disease with symptoms of dysmenorrhea, chronic pain, and infertility that affects 6-10% of women of reproductive age. Medical or surgical therapy, such as administration of an anti-gonadotropin or ovarian cystectomy, provide effective pain relief. However, neither therapy can be ...

journal_title：Frontiers in immunology

authors： Kato T,Yasuda K,Matsushita K,Ishii KJ,Hirota S,Yoshimoto T,Shibahara H

更新日期：2019-08-22 00:00:00

abstract：:Ischemic stroke is among the leading causes of disability and death worldwide. In acute ischemic stroke, the rapid recanalization of occluded cranial vessels is the primary therapeutic aim. However, experimental data (obtained using mostly the transient middle cerebral artery occlusion model) indicates that progressiv...

journal_title：Frontiers in immunology

authors： Stegner D,Klaus V,Nieswandt B

更新日期：2019-11-01 00:00:00

abstract：:The limited efficacy of seasonal influenza vaccines is usually attributed to ongoing variation in the major antigenic targets for protective antibody responses including hemagglutinin (HA) and neuraminidase (NA). Hence, vaccine development has largely focused on broadening antigenic epitopes to generate cross-reactive...

journal_title：Frontiers in immunology

authors： Sato-Kaneko F,Yao S,Lao FS,Shpigelman J,Messer K,Pu M,Shukla NM,Cottam HB,Chan M,Chu PJ,Burkhart D,Schoener R,Matsutani T,Carson DA,Corr M,Hayashi T

更新日期：2020-06-19 00:00:00

abstract：:In this study we demonstrate the feasibility of direct, quantitative measurement of cytokine proteins in single human CD8 lymphocytes from fresh peripheral blood of healthy donors following a brief ex vivo stimulation. Cytokine-secreting cells were identified using cell surface "catch" reagents and single cell data we...

journal_title：Frontiers in immunology

authors： Saxena A,Dagur PK,Desai A,McCoy JP Jr

更新日期：2018-10-23 00:00:00