Abstract:
:HERV-H endogenous retroviruses are thought to be essential to stem cell identity in humans. We embrace several decades of HERV-H research in order to relate the transcription of HERV-H loci to their genomic structure. We find that highly transcribed HERV-H loci are younger, more fragmented, and less likely to be present in other primate genomes. We also show that repeats in HERV-H LTRs are correlated to where loci are transcribed: type-I LTRs associate with stem cells while type-II repeats associate with embryonic cells. Our findings are generally in line with what is known about endogenous retrovirus biology but we find that the presence of the zinc finger motif containing region of gag is positively correlated with transcription. This leads us to suggest a possible explanation for why an unusually large proportion of HERV-H loci have been preserved in non-solo-LTR form.
journal_name
Front Immunoljournal_title
Frontiers in immunologyauthors
Gemmell P,Hein J,Katzourakis Adoi
10.3389/fimmu.2019.01339subject
Has Abstractpub_date
2019-07-09 00:00:00pages
1339issn
1664-3224journal_volume
10pub_type
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.3389/fimmu.2018.02184
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pub_type: 杂志文章
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abstract::[This corrects the article DOI: 10.3389/fimmu.2017.01609.]. ...
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pub_type: 已发布勘误
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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