Interplay of Regulatory T Cell and Th17 Cells during Infectious Diseases in Humans and Animals.

abstract：:Behçet disease (BD) is an inflammatory systemic disease with a fluctuating course, which can affect the skin, eyes, central nervous system, musculoskeletal, gastrointestinal, and vascular systems. No laboratory tests are currently available for the diagnosis of BD and monitoring disease activity. Moreover there is a l...

journal_title：Frontiers in immunology

authors： Bonacini M,Soriano A,Zerbini A,Calò E,Cimino L,Muratore F,Fontana L,Braglia L,Parmeggiani M,Salvarani C,Croci S

更新日期：2018-09-25 00:00:00

abstract：:Protein kinase C isoform θ (PKCθ) is a key modulator of TCR signaling and mediates activation of NF-κB, NF-AT, and AP-1 transcription factors. Although in vitro studies of PKCθ(-/-) T cells have shown impaired activation responses, in vivo studies indicate that PKCθ requirement is not universal. While PKCθ is importan...

journal_title：Frontiers in immunology

authors： Bronk CC,Yu XZ,Beg AA

更新日期：2012-08-14 00:00:00

abstract：:Neutrophils releasing neutrophil extracellular traps (NETs) infiltrate the pancreas prior to type 1 diabetes (T1D) onset; however, the precise nature of their contribution to disease remains poorly defined. To examine how NETs affect immune functions in T1D, we investigated NET composition and their effect on dendriti...

journal_title：Frontiers in immunology

authors： Parackova Z,Zentsova I,Vrabcova P,Klocperk A,Sumnik Z,Pruhova S,Petruzelkova L,Hasler R,Sediva A

更新日期：2020-04-14 00:00:00

abstract：:Cytotoxic T lymphocytes and NK cells play an important role in eliminating malignant tumor cells and the number and activity of tumor-infiltrating T cells represent a good marker for tumor prognosis. Based on these findings, immunotherapy, e.g., checkpoint blockade, has received considerable attention during the last ...

journal_title：Frontiers in immunology

authors： Renner K,Singer K,Koehl GE,Geissler EK,Peter K,Siska PJ,Kreutz M

更新日期：2017-03-08 00:00:00

abstract：:Autoimmune diseases involve a complex dysregulation of immunity. Autoimmune diseases include many members [e.g., rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE)], and most of them are classified according to what organs and tissues are targeted by the damaging immune response. Many studies have focuse...

journal_title：Frontiers in immunology

authors： Jin F,Hu H,Xu M,Zhan S,Wang Y,Zhang H,Chen X

更新日期：2018-10-16 00:00:00

abstract：:The immunomodulator Macrophage Migration Inhibitory Factor (MIF) exerts pleiotropic immunomodulatory activities and has been implicated in the pathogenesis of diverse inflammatory diseases. Expression levels of MIF are also significantly elevated in the skin and serum of psoriasis patients, but the pathogenic signific...

journal_title：Frontiers in immunology

authors： Bezdek S,Leng L,Busch H,Mousavi S,Rades D,Dahlke M,Zillikens D,Bucala R,Sadik CD

更新日期：2018-10-02 00:00:00

abstract：:Pathogenic bacteria possess intricate regulatory networks that temporally control the production of virulence factors and enable the bacteria to survive and proliferate within host cell. Small non-coding RNAs (sRNAs) have been identified as important regulators of gene expression in diverse biological contexts. Recent...

journal_title：Frontiers in immunology

authors： Ahmed W,Zheng K,Liu ZF

更新日期：2016-10-18 00:00:00

abstract：:Vaccines against a variety of infectious diseases have been developed and tested. Although there have been some notable successes, most are less than optimal or have failed outright. There has been discussion about whether either B cells or dendritic cells (DCs) could be useful for the development of antimicrobial vac...

journal_title：Frontiers in immunology

authors： Fujii SI,Yamasaki S,Sato Y,Shimizu K

更新日期：2018-06-04 00:00:00

abstract：:Unlike mice and humans, porcine γδ T cells represent a prominent subset of T cells in blood and secondary lymphatic organs. GATA-3, T-bet and Eomesodermin (Eomes) are transcription factors with crucial functions in T-cell development and functional differentiation, but their expression has not been investigated in por...

journal_title：Frontiers in immunology

authors： Rodríguez-Gómez IM,Talker SC,Käser T,Stadler M,Reiter L,Ladinig A,Milburn JV,Hammer SE,Mair KH,Saalmüller A,Gerner W

更新日期：2019-03-11 00:00:00

abstract：:Hematopoietic cell transplantation (HCT) is a therapy option for aggressive forms of hematopoietic malignancies that are resistant to standard antitumoral therapies. Hematoablative treatment preceding HCT, however, opens a "window of opportunity" for latent Cytomegalovirus (CMV) by releasing it from immune control wit...

journal_title：Frontiers in immunology

authors： Reddehase MJ

更新日期：2016-08-04 00:00:00

abstract：:Natural antibodies (NAbs) are pre-existing antibodies with germline origin that arise in the absence of previous exposure to foreign antigens. NAbs are produced by B-1 lymphocytes and are primarily of the IgM isotype. There is accumulating evidence that - in addition to their role in antimicrobial host defense - NAbs ...

journal_title：Frontiers in immunology

authors： Tsiantoulas D,Gruber S,Binder CJ

更新日期：2013-01-09 00:00:00

abstract：:The dynamics of skin-draining cells following infection or vaccination provide important insight into the initiation of immune responses. In this study, the local recruitment and activation of immune cells in draining lymph nodes (LNs) was studied in calves in an adjuvant-induced inflammation. A transient but remarkab...

journal_title：Frontiers in immunology

authors： Lund H,Boysen P,Åkesson CP,Lewandowska-Sabat AM,Storset AK

更新日期：2016-08-29 00:00:00

abstract：:Autophagy comprises a heterogeneous group of cellular pathways that enables eukaryotic cells to deliver cytoplasmic constituents for lysosomal degradation, to recycle nutrients, and to survive during starvation. In addition to these primordial functions, autophagy has emerged as a key mechanism in orchestrating innate...

journal_title：Frontiers in immunology

authors： Keller CW,Lünemann JD

更新日期：2017-02-27 00:00:00

abstract：:T follicular helper (Tfh) cells are a subset of CD4 T cells that provide critical signals to antigen-primed B cells in germinal centers to undergo proliferation, isotype switching, and somatic hypermutation to generate long-lived plasma cells and memory B cells during an immune response. The quantity and quality of Tf...

journal_title：Frontiers in immunology

authors： Pallikkuth S,de Armas L,Rinaldi S,Pahwa S

更新日期：2017-10-23 00:00:00

abstract：:The apparition of adaptive immunity in Gnathostomata correlates with the expansion of the E-protein family to encompass E2-2, HEB, and E2A. Within the family, E2-2 and HEB are more closely evolutionarily related but their concerted action in hematopoiesis remains to be explored. Here we show that the combined disrupti...

journal_title：Frontiers in immunology

authors： Bouderlique T,Peña-Pérez L,Kharazi S,Hils M,Li X,Krstic A,De Paepe A,Schachtrup C,Gustafsson C,Holmberg D,Schachtrup K,Månsson R

更新日期：2019-03-18 00:00:00

abstract：:Studies to develop cell-based therapies for cancer and other diseases have consistently shown that purified human natural killer (NK) cells secrete cytokines and kill target cells after in vitro culture with high concentrations of cytokines. However, these assays poorly reflect the conditions that are likely to prevai...

journal_title：Frontiers in immunology

authors： Nielsen CM,Wolf AS,Goodier MR,Riley EM

更新日期：2016-03-22 00:00:00

abstract：:We have developed a therapeutic vaccine consisting of a mixture of lethally-irradiated allogeneic cutaneous melanoma cell lines with BCG and GM-CSF as adjuvants. The CSF-470 vaccine is currently being assayed in a Phase II-III trial against medium-dose IFN-α2b. All vaccinated patients immunized intradermally developed...

journal_title：Frontiers in immunology

authors： Aris M,Bravo AI,Barrio MM,Mordoh J

更新日期：2015-03-30 00:00:00

abstract：:Chronic spontaneous urtcaria (CSU) can represent the leading sign of a wide spectrum of systemic diseases, including primary immunodeficiencies. We describe the case of a young adult female with coexisting CSU and common variable immunodeficiency (CVID) successfully treated with omalizumab. The patient, with a history...

journal_title：Frontiers in immunology

authors： Comberiati P,Costagliola G,Carli N,Legitimo A,D'Elios S,Consolini R,Peroni DG

更新日期：2019-07-17 00:00:00

abstract：:Head and neck cancer (HNC) is a heterogeneous group of squamous cell cancers that affect the oral cavity, pharynx, and larynx. Worldwide, it is the sixth most common cancer but in parts of Southern and South-East Asia, HNC is one of the most common cancers. A significant proportion of HNC is driven by human papillomav...

journal_title：Frontiers in immunology

authors： Wang C,Dickie J,Sutavani RV,Pointer C,Thomas GJ,Savelyeva N

更新日期：2018-04-23 00:00:00

abstract：:The induction and modulation of the immune response to vaccination can be rationally designed by combining different vaccine formulations for priming and boosting. Here, we investigated the impact of heterologous prime-boost approaches on the vaccine-specific cellular and humoral responses specific for a mycobacterial...

journal_title：Frontiers in immunology

authors： Ciabattini A,Pettini E,Fiorino F,Lucchesi S,Pastore G,Brunetti J,Santoro F,Andersen P,Bracci L,Pozzi G,Medaglini D

更新日期：2018-03-12 00:00:00

abstract：:Defense peptides protect multicellular eukaryotes from infections. In biomedical sciences, a dominant conceptual framework refers to defense peptides as host-defense peptides (HDPs), which are bifunctional peptides with both direct antimicrobial and immunomodulatory activities. No HDP has been reported in plants so fa...

journal_title：Frontiers in immunology

authors： Petre B

更新日期：2020-08-21 00:00:00

abstract：:The efficacy of allogeneic hematopoietic stem cell transplantation (HSCT) is challenged by acute and chronic graft-versus-host disease (aGVHD and cGVHD) and viral infections due to long-lasting immunodeficiency. Interleukin-7 (IL-7) is a cytokine essential for de novo T cell generation in thymus and peripheral T cell ...

journal_title：Frontiers in immunology

authors： Kielsen K,Enevold C,Heilmann C,Sengeløv H,Pedersen AE,Ryder LP,Müller K

更新日期：2018-02-02 00:00:00

abstract：:Memory B cells that are generated during an infection or following vaccination act as sentinels to guard against future infections. Upon repeat antigen exposure memory B cells differentiate into new antibody-secreting plasma cells to provide rapid and sustained protection. Some pathogens evade or suppress the humoral ...

journal_title：Frontiers in immunology

authors： Shah HB,Smith K,Wren JD,Webb CF,Ballard JD,Bourn RL,James JA,Lang ML

更新日期：2019-01-15 00:00:00

abstract：:M1 and M2 macrophage-type responses kill or repair in vivo. The unique ability of macrophages to make these polar opposite type of responses provides primary host protection and maintains tissue homeostasis throughout the animal kingdom. In humans and other higher animals, M1 and M2-type macrophage responses also init...

journal_title：Frontiers in immunology

authors： Mills CD

更新日期：2015-05-05 00:00:00

abstract：:The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor initially identified because of its role in controlling the cellular response to environmental molecules. More recently, AHR has been shown to play a crucial role in controlling innate and adaptive immune responses through several mechanism...

journal_title：Frontiers in immunology

authors： Jaronen M,Quintana FJ

更新日期：2014-10-20 00:00:00

abstract：:The classical model of cytokine signaling dominates our view of specific gene activation by cytokines such as the interferons (IFNs). The importance of the model extends beyond cytokines and applies to hormones such as growth hormone (GH) and insulin, and growth factors such as epidermal growth factor (EGF) and fibrob...

journal_title：Frontiers in immunology

authors： Johnson HM,Noon-Song EN,Dabelic R,Ahmed CM

更新日期：2013-07-25 00:00:00

abstract：:IL-1β plays a crucial role in the differentiation of human Th17 cells. We report here that IL-1RI expression is significantly increased in both naive and memory CD4+ T cells derived from relapsing-remitting multiple sclerosis (RR MS) patients in comparison to healthy controls. Interleukin 1 receptor (IL-1R)I expressio...

journal_title：Frontiers in immunology

authors： Sha Y,Markovic-Plese S

更新日期：2016-11-29 00:00:00

abstract：:New approaches are needed to develop more effective interventions to prevent long-term rejection of organ allografts. Computational biology provides a powerful tool to assess the large amount of complex data that is generated in longitudinal studies in this area. This manuscript outlines how our two groups are using m...

journal_title：Frontiers in immunology

authors： Stegall MD,Borrows R

更新日期：2015-08-03 00:00:00

abstract：:Multiple sclerosis (MS) is a neurodegenerative disease resulting from an autoimmune attack on central nervous system (CNS) myelin. Although CD4(+) T cell function in MS pathology has been extensively studied, there is also strong evidence that CD8(+) T lymphocytes play a key role. Intriguingly, CD8(+) T cells accumula...

journal_title：Frontiers in immunology

authors： Ignatius Arokia Doss PM,Roy AP,Wang A,Anderson AC,Rangachari M

更新日期：2015-10-22 00:00:00

abstract：:Background: Infection with HIV-2, a retrovirus that is closely related to HIV-1, is characterized by slower disease progression and transmission, longer latency period and low or undetectable viremia. Host immunity, including production of potent neutralizing antibodies, may be one of the possible contributors to the ...

journal_title：Frontiers in immunology

authors： Vidyavijayan KK,Cheedarala N,Babu H,Precilla LK,Sathyamurthi P,Chandrasekaran P,Murugavel KG,Swaminathan S,Tripathy SP,Hanna LE

更新日期：2018-12-17 00:00:00