Several Follicular Regulatory T Cell Subsets With Distinct Phenotype and Function Emerge During Germinal Center Reactions.

abstract：:MicroRNAs (miRNAs) are a class of small, non-coding RNAs that are recognized as critical regulators of immune gene expression during infection. Many immunologically significant human miRNAs have been found to be conserved in agriculturally important species, including cattle. Discovering how bovine miRNAs mediate the ...

journal_title：Frontiers in immunology

authors： Lawless N,Vegh P,O'Farrelly C,Lynn DJ

更新日期：2014-11-27 00:00:00

abstract：:The immune system is composed of two subsystems-the innate immune system and the adaptive immune system. The innate immune system is the first to respond to pathogens and does not retain memory of previous responses. Innate immune responses are evolutionarily older than adaptive responses and elements of innate immuni...

journal_title：Frontiers in immunology

authors： Smith NC,Rise ML,Christian SL

更新日期：2019-10-10 00:00:00

abstract：:Functional impairment of T-cells and a concomitant augmented expression of programmed death-1 (PD-1) have been observed in visceral leishmaniasis patients, as well as in experimental models for visceral and cutaneous leishmaniasis. The PD-1/PD-1-ligand (PD-1/PD-L) interaction negatively regulates T-cell effector funct...

journal_title：Frontiers in immunology

authors： Filippis C,Arens K,Noubissi Nzeteu GA,Reichmann G,Waibler Z,Crauwels P,van Zandbergen G

更新日期：2017-12-22 00:00:00

abstract：:Hematopoietic stem cells (HSCs) are quiescent cells with self-renewal capacity and the ability to generate all mature blood cells. HSCs normally reside in specialized niches in the bone marrow that help maintain their quiescence and long-term repopulating activity. There is emerging evidence that certain cytokines ind...

journal_title：Frontiers in immunology

authors： Schuettpelz LG,Link DC

更新日期：2013-07-19 00:00:00

abstract：:Adaptation of antibody-mediated immunity occurs in germinal centers (GC). It is where affinity maturation, class switching, memory and plasma cell differentiation synergize to generate specific high-affinity antibodies that aid both to clear and protect against reinfection of invading pathogens. Within GCs, light and ...

journal_title：Frontiers in immunology

authors： Weber TS

更新日期：2018-06-12 00:00:00

abstract：:The lymphoid follicle is critical for the development of humoral immune responses. Cell circulation to this site is highly regulated by the differential expression of chemokine receptors. This feature contributes to the establishment of viral reservoirs in lymphoid follicles and the development of some types of malign...

journal_title：Frontiers in immunology

authors： Perdomo-Celis F,Taborda NA,Rugeles MT

更新日期：2017-09-29 00:00:00

abstract：:Obstructive nephropathy constitutes a major cause of pediatric renal progressive disease. The mechanisms leading to disease progression are still poorly understood. Kidney fibrotic lesions are reproduced using a model of partial unilateral ureteral obstruction (pUUO) in newborn mice. Based on data showing significant ...

journal_title：Frontiers in immunology

authors： Pons M,Ali L,Beghdadi W,Danelli L,Alison M,Madjène LC,Calvo J,Claver J,Vibhushan S,Åbrink M,Pejler G,Poli-Mérol ML,Peuchmaur M,El Ghoneimi A,Blank U

更新日期：2017-05-04 00:00:00

abstract：:Toll-like receptors (TLR) triggering of B cells are known to promote B cell expansion, differentiation of B cells into antibody-producing and memory cells, but the TLR responses of porcine B cells is poorly characterized. Therefore, this study investigated the response pattern of porcine B cell subsets to a large coll...

journal_title：Frontiers in immunology

authors： Braun RO,Python S,Summerfield A

更新日期：2017-08-25 00:00:00

abstract：:In recent decades, there has been substantial growth in our understanding of the immune system and its role in tumor growth and overall survival. A central finding has been the cross-talk between tumor cells and the surrounding environment or stroma. This tumor stroma, comprised of various cells, and extracellular mat...

journal_title：Frontiers in immunology

authors： Menon H,Ramapriyan R,Cushman TR,Verma V,Kim HH,Schoenhals JE,Atalar C,Selek U,Chun SG,Chang JY,Barsoumian HB,Nguyen QN,Altan M,Cortez MA,Hahn SM,Welsh JW

更新日期：2019-02-15 00:00:00

abstract：:Approximately 10% of individuals latently infected with Mycobacterium tuberculosis (Mtb) develop active tuberculosis (TB) during their lifetime. Although it is well recognized that T-helper 1 immune responses are crucial for containing latent TB infection, the full array of host factors conferring protective immunity ...

journal_title：Frontiers in immunology

authors： Ronacher K,Sinha R,Cestari M

更新日期：2018-09-25 00:00:00

abstract：:Antibody-derived chimeric antigen receptor (CAR) T cell therapy has achieved gratifying breakthrough in hematologic malignancies but has shown limited success in solid tumor immunotherapy. Monoclonal antibody, TAB004, specifically recognizes the aberrantly glycosylated tumor form of MUC1 (tMUC1) in all subtypes of bre...

journal_title：Frontiers in immunology

authors： Zhou R,Yazdanifar M,Roy LD,Whilding LM,Gavrill A,Maher J,Mukherjee P

更新日期：2019-05-24 00:00:00

abstract：:Low vitamin D and insufficient sun exposure are additive independent risk factors for the development of multiple sclerosis (MS). The usual measure of vitamin D status, serum 25-hydroxy vitamin D [25(OH)D], is also a marker of recent exposure to the UVB rays of sunshine. The main evidence for a protective effect for M...

journal_title：Frontiers in immunology

authors： Hart PH,Lucas RM,Booth DR,Carroll WM,Nolan D,Cole JM,Jones AP,Kermode AG

更新日期：2017-01-24 00:00:00

abstract：:Unlike mice and humans, porcine γδ T cells represent a prominent subset of T cells in blood and secondary lymphatic organs. GATA-3, T-bet and Eomesodermin (Eomes) are transcription factors with crucial functions in T-cell development and functional differentiation, but their expression has not been investigated in por...

journal_title：Frontiers in immunology

authors： Rodríguez-Gómez IM,Talker SC,Käser T,Stadler M,Reiter L,Ladinig A,Milburn JV,Hammer SE,Mair KH,Saalmüller A,Gerner W

更新日期：2019-03-11 00:00:00

abstract：:Atopic dermatitis (AD) is a complex multifactorial inflammatory skin disease that affects ~280 million people worldwide. About 85% of AD cases begin in childhood, a significant portion of which can persist into adulthood. Moreover, a typical progression of children with AD to food allergy, asthma or allergic rhinitis ...

journal_title：Frontiers in immunology

authors： Ghosh D,Bernstein JA,Khurana Hershey GK,Rothenberg ME,Mersha TB

更新日期：2018-12-12 00:00:00

abstract：:Behavioral comorbidities (depression, anxiety, fatigue, cognitive disturbances, and neuropathic pain) are prevalent in cancer patients and survivors. These mental and neurological health issues reduce quality-of-life, which is a significant societal concern given the increasing rates of long-term survival after variou...

journal_title：Frontiers in immunology

authors： Santos JC,Pyter LM

更新日期：2018-06-07 00:00:00

abstract：:Cytolytic CD4+ T cells play a prominent role in chronic viral infection. CD4+ CTLs clones specific for HIV-1 Nef and Gag are capable of killing HIV-1 infected CD4+ T cells and macrophages. Additionally, HIV-specific cytolytic CD4+ T cell responses in acute HIV infection are predictive of disease progression. CD57 expr...

journal_title：Frontiers in immunology

authors： Phetsouphanh C,Aldridge D,Marchi E,Munier CML,Meyerowitz J,Murray L,Van Vuuren C,Goedhals D,Fidler S,Kelleher A,Klenerman P,Frater J

更新日期：2019-08-08 00:00:00

abstract：:T cells play a vital role in eliminating pathogenic infections. To activate, naïve T cells search lymph nodes (LNs) for dendritic cells (DCs). Positioning and movement of T cells in LNs is influenced by chemokines including CCL21 as well as multiple cell types and structures in the LNs. Previous studies have suggested...

journal_title：Frontiers in immunology

authors： Tasnim H,Fricke GM,Byrum JR,Sotiris JO,Cannon JL,Moses ME

更新日期：2018-07-26 00:00:00

abstract：:The development of autoimmunity involves complex interactions between genetics and environmental triggers. The gut microbiota is an important environmental constituent that can heavily influence both local and systemic immune reactivity through distinct mechanisms. It is therefore a relevant environmental trigger or a...

journal_title：Frontiers in immunology

authors： Brown J,Robusto B,Morel L

更新日期：2020-08-04 00:00:00

abstract：:Chronic lymphocytic leukemia (CLL) can be divided into prognostically distinct subsets with stereotyped or non-stereotyped, mutated or unmutated B cell receptors (BCRs). Individual subsets vary in antigen specificity and origin, but the impact of antigenic pressure on the CLL BCR repertoire remains unknown. Here, we e...

journal_title：Frontiers in immunology

authors： Pal Singh S,de Bruijn MJW,de Almeida MP,Meijers RWJ,Nitschke L,Langerak AW,Pillai SY,Stadhouders R,Hendriks RW

更新日期：2018-09-13 00:00:00

abstract：:Systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS) are two autoimmune diseases that can occur together or separately. Insights into the pathogenesis have revealed similarities, such as development of autoantibodies targeting subcellular antigens as well as a shared increased risk of cardiovascular ...

journal_title：Frontiers in immunology

authors： Wirestam L,Arve S,Linge P,Bengtsson AA

更新日期：2019-11-22 00:00:00

abstract：:Two decades of clinical cancer research with dendritic cell (DC)-based vaccination have proved that this type of personalized medicine is safe and has the capacity to improve survival, but monotherapy is unlikely to cure the cancer. Designed to empower the patient's antitumor immunity, huge research efforts are set to...

journal_title：Frontiers in immunology

authors： Versteven M,Van den Bergh JMJ,Marcq E,Smits ELJ,Van Tendeloo VFI,Hobo W,Lion E

更新日期：2018-03-01 00:00:00

abstract：:Eosinophilic granulomatosis with polyangiitis (EGPA) is a multisystemic disorder, belonging to the small vessel anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis, defined as an eosinophil-rich and necrotizing granulomatous inflammation often involving the respiratory tract, and necrotizing vasculitis p...

journal_title：Frontiers in immunology

authors： Gioffredi A,Maritati F,Oliva E,Buzio C

更新日期：2014-11-03 00:00:00

abstract：:Psoriatic arthritis (PsA) is an inflammatory arthritis, characterized by inflammation of entheses and synovium, leading to joint erosions and new bone formation. It affects 10-30% of patients with psoriasis, and has an estimated prevalence of approximately 1%. PsA is considered to be primarily an autoimmune disease, d...

journal_title：Frontiers in immunology

authors： Dolcino M,Pelosi A,Fiore PF,Patuzzo G,Tinazzi E,Lunardi C,Puccetti A

更新日期：2018-07-16 00:00:00

abstract：:Macrophage plasticity is a process that allows macrophages to switch between two opposing phenotypes based on differential stimuli. Interferon γ (IFNγ)-primed macrophages stimulated with lipopolysaccharide (LPS) [M(IFNγ+LPS)] produce high levels of pro-inflammatory cytokines such as IL-12, TNFα, and IL-6 and low level...

journal_title：Frontiers in immunology

authors： Ruenjaiman V,Butta P,Leu YW,Pongpanich M,Leelahavanichkul A,Kueanjinda P,Palaga T

更新日期：2020-01-10 00:00:00

abstract：Background:A plurality of neurological syndromes is associated with autoantibodies against neural antigens relevant for diagnosis and therapy. Identification of these antigens is crucial to understand the pathogenesis and to develop specific immunoassays. Using an indirect immunofluorescence assay (IFA)-based approach ...

journal_title：Frontiers in immunology

authors： Scharf M,Miske R,Kade S,Hahn S,Denno Y,Begemann N,Rochow N,Radzimski C,Brakopp S,Probst C,Teegen B,Stöcker W,Komorowski L

更新日期：2018-07-09 00:00:00

abstract：:The Janus kinase 2 (JAK2)-driven myeloproliferative neoplasms (MPNs) are associated with clonal myelopoiesis, elevated risk of death due to thrombotic complications, and transformation to acute myeloid leukemia (AML). JAK2 inhibitors improve the quality of life for MPN patients, but these approved therapeutics do not ...

journal_title：Frontiers in immunology

authors： Sharma V,Wright KL,Epling-Burnette PK,Reuther GW

更新日期：2020-11-30 00:00:00

abstract：:Glycoproteins perform extra- and intracellular functions in innate and adaptive immunity by lectin-based interactions to exposed glyco-determinants. Herein, we document and mechanistically explain the formation of subcellular-specific N-glycosylation determinants on glycoproteins trafficking through the shared biosynt...

journal_title：Frontiers in immunology

authors： Lee LY,Lin CH,Fanayan S,Packer NH,Thaysen-Andersen M

更新日期：2014-08-25 00:00:00

abstract：:Advances in the understanding of leishmaniasis progression indicate that cellular interactions more complex than the Th1/Th2 paradigm define the course of infection. Th17 cells are a crucial modulator of adaptive immunity against Leishmania parasites acting mainly on neutrophil recruitment and playing a dual role at t...

journal_title：Frontiers in immunology

authors： Gonçalves-de-Albuquerque SDC,Pessoa-E-Silva R,Trajano-Silva LAM,de Goes TC,de Morais RCS,da C Oliveira CN,de Lorena VMB,de Paiva-Cavalcanti M

更新日期：2017-10-30 00:00:00

abstract：:Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the only treatment with curative potential for certain aggressive hematopoietic malignancies. Its success is limited by acute graft-versus-host disease (GVHD), a life-threatening complication that occurs when allo-reactive donor T cells attack recipient...

journal_title：Frontiers in immunology

authors： Heidegger S,van den Brink MR,Haas T,Poeck H

更新日期：2014-07-18 00:00:00

abstract：:Microparticles (MPs) are vesicles derived from the plasma membrane of different cells, are considered a source of circulating autoantigens, and can form immune complexes (MPs-ICs). The number of MPs and MPs-ICs increases in patients with systemic lupus erythematosus (SLE). MPs activate myeloid cells by inducing IL-6 a...

journal_title：Frontiers in immunology

authors： Burbano C,Villar-Vesga J,Orejuela J,Muñoz C,Vanegas A,Vásquez G,Rojas M,Castaño D

更新日期：2018-03-01 00:00:00