The Contribution of CD40/CD40L Axis in Inflammatory Bowel Disease: An Update.


:Inflammatory bowel disease (IBD) is a chronic and multifactorial disease of the gastrointestinal tract. The exact etiology of IBD remains complex and unclear involving an inadequately defined relationship between microbial insult, genetic predisposition, altered intestinal barrier permeability, oxidative stress components and abnormal immune responses. The role of the co-stimulatory system made up of cluster of differentiation 40 protein (CD40) and its ligand (CD40L) in the response of the immune system to pathogens is now widely accepted. The implication of CD40/CD40L axis in immune system disorders due to its important role as signal transduction pathway among immune cells is well documented. Several studies have suggested that CD40/CD40L interactions regulate oxidative stress; this can affect various signaling pathways leading to IBD development. Hence, CD40/CD40L signaling pathway may become a new target for IBD treatment. This review will cover the general contribution of the CD40/CD40L dyad in the development of IBD in order to facilitate future approaches aiming to elucidate the immunological mechanisms that control gut inflammation.


Front Immunol


Frontiers in immunology


Senhaji N,Kojok K,Darif Y,Fadainia C,Zaid Y




Has Abstract


2015-10-16 00:00:00








  • Unraveling the Role of Allo-Antibodies and Transplant Injury.

    abstract::Alloimmunity driving rejection in the context of solid organ transplantation can be grossly divided into mechanisms predominantly driven by either T cell-mediated rejection (TCMR) and antibody-mediated rejection (ABMR), though the co-existence of both types of rejections can be seen in a variable number of sampled gra...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Matsuda Y,Sarwal MM

    更新日期:2016-10-21 00:00:00

  • Effects of Omalizumab on FcεRI and IgE Expression in Lesional Skin of Bullous Pemphigoid.

    abstract::Recent studies suggest an important role of immunoglobulin E (IgE) as an alternative pathogenic pathway in the development of bullous pemphigoid (BP), as the most frequent subepidermal blistering disease of the skin Use of IgE targeted therapies, such as omalizumab, has been shown promising in recent studies. The aim ...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Seyed Jafari SM,Gadaldi K,Feldmeyer L,Yawalkar N,Borradori L,Schlapbach C

    更新日期:2019-08-14 00:00:00

  • Toll-Like Receptor 8 Is a Major Sensor of Group B Streptococcus But Not Escherichia coli in Human Primary Monocytes and Macrophages.

    abstract::TLR8 is the major endosomal sensor of degraded RNA in human monocytes and macrophages. It has been implicated in the sensing of viruses and more recently also bacteria. We previously identified a TLR8-IFN regulatory factor 5 (IRF5) signaling pathway that mediates IFNβ and interleukin-12 (IL-12) induction by Staphyloco...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Ehrnström B,Beckwith KS,Yurchenko M,Moen SH,Kojen JF,Lentini G,Teti G,Damås JK,Espevik T,Stenvik J

    更新日期:2017-10-03 00:00:00

  • Killer Ig-Like Receptors (KIRs): Their Role in NK Cell Modulation and Developments Leading to Their Clinical Exploitation.

    abstract::Natural killer (NK) cells contribute to the first line of defense against viruses and to the control of tumor growth and metastasis spread. The discovery of HLA class I specific inhibitory receptors, primarily of killer Ig-like receptors (KIRs), and of activating receptors has been fundamental to unravel NK cell funct...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Pende D,Falco M,Vitale M,Cantoni C,Vitale C,Munari E,Bertaina A,Moretta F,Del Zotto G,Pietra G,Mingari MC,Locatelli F,Moretta L

    更新日期:2019-05-28 00:00:00

  • Allies or Enemies-The Multifaceted Role of Myeloid Cells in the Tumor Microenvironment.

    abstract::For decades, cancer was considered a disease driven by genetic mutations in tumor cells, therefore afflicting a single cell type. This simplified view was slowly replaced by the understanding that interactions between malignant cells and neighboring stromal and immune cells-the tumor microenvironment (TME)-profoundly ...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Haas L,Obenauf AC

    更新日期:2019-11-28 00:00:00

  • Cytotoxic Activity and Memory T Cell Subset Distribution of in vitro-Stimulated CD8+ T Cells Specific for HER2/neu Epitopes.

    abstract::Minimal residual disease remaining after resection of primary tumors can lead to tumor recurrence and metastasis, increasing mortality and morbidity rates among cancer patients. Thus, there is a need for new technologies for recognition and elimination of single cancer cells remaining in a patient's body after radiati...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Kuznetsova M,Lopatnikova J,Shevchenko J,Silkov A,Maksyutov A,Sennikov S

    更新日期:2019-05-09 00:00:00

  • Neutrophil Inflammatory Response Is Downregulated by Uptake of Superparamagnetic Iron Oxide Nanoparticle Therapeutics.

    abstract::Superparamagnetic iron oxide nanoparticles (SPION) are employed as diagnostics and therapeutics following intravenous delivery for the treatment of iron deficiency anemia (IDA) in adult patients with chronic kidney failure. Neutrophils are the first defense against blood borne foreign insult and recruit to vascular si...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Garcia G,Kim MH,Morikis VA,Simon SI

    更新日期:2020-12-09 00:00:00

  • Novel Immunomodulatory Proteins Generated via Directed Evolution of Variant IgSF Domains.

    abstract::Immunoglobulin superfamily member (IgSF) proteins play a significant role in regulating immune responses with surface expression on all immune cell subsets, making the IgSF an attractive family of proteins for therapeutic targeting in human diseases. We have developed a directed evolution platform capable of engineeri...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Levin SD,Evans LS,Bort S,Rickel E,Lewis KE,Wu RP,Hoover J,MacNeil S,La D,Wolfson MF,Rixon MW,Dillon SR,Kornacker MG,Swanson R,Peng SL

    更新日期:2020-01-21 00:00:00

  • Modulation of Crustacean Innate Immune Response by Amino Acids and Their Metabolites: Inferences From Other Species.

    abstract::Aquaculture production of crustaceans (mainly shrimp and crabs) has expanded globally, but disease outbreaks and pathogenic infections have hampered production in the last two decades. As invertebrates, crustaceans lack an adaptive immune system and mainly defend and protect themselves using their innate immune system...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Huang Z,Aweya JJ,Zhu C,Tran NT,Hong Y,Li S,Yao D,Zhang Y

    更新日期:2020-11-05 00:00:00

  • Corticosterone Preexposure Increases NF-κB Translocation and Sensitizes IL-1β Responses in BV2 Microglia-Like Cells.

    abstract::Corticosterone (CORT), a critical mediator of the hypothalamus pituitary adrenal axis in rodents, is a stress hormone that is classically viewed as possessing immune-suppressive properties. CORT is now appreciated to also mediate the neuroimmune-priming effect of stress to innate-immune stimulation, and hence serves a...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Liu J,Mustafa S,Barratt DT,Hutchinson MR

    更新日期:2018-01-22 00:00:00

  • Interaction of the Factor H Family Proteins FHR-1 and FHR-5 With DNA and Dead Cells: Implications for the Regulation of Complement Activation and Opsonization.

    abstract::Complement plays an essential role in the opsonophagocytic clearance of apoptotic/necrotic cells. Dysregulation of this process may lead to inflammatory and autoimmune diseases. Factor H (FH), a major soluble complement inhibitor, binds to dead cells and inhibits excessive complement activation on their surface, preve...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Kárpáti É,Papp A,Schneider AE,Hajnal D,Cserhalmi M,Csincsi ÁI,Uzonyi B,Józsi M

    更新日期:2020-07-16 00:00:00

  • Natural Killer Cells for Immunotherapy - Advantages of the NK-92 Cell Line over Blood NK Cells.

    abstract::Natural killer (NK) cells are potent cytotoxic effector cells for cancer therapy and potentially for severe viral infections. However, there are technical challenges to obtain sufficient numbers of functionally active NK cells from a patient's blood since they represent only 10% of the lymphocytes and are often dysfun...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Klingemann H,Boissel L,Toneguzzo F

    更新日期:2016-03-14 00:00:00

  • Role of C5b-9 and RGC-32 in Cancer.

    abstract::The complement system represents an effective arsenal of innate immunity as well as an interface between innate and adaptive immunity. Activation of the complement system culminates with the assembly of the C5b-9 terminal complement complex on cell membranes, inducing target cell lysis. Translation of this sequence of...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Vlaicu SI,Tatomir A,Rus V,Rus H

    更新日期:2019-05-09 00:00:00

  • Activation of the Complement System in the Lower Genital Tract During Pregnancy and Delivery.

    abstract:Background:Human pregnancy alters profoundly the immune system. The local involvement and mechanisms of activation of the complement system in the cervicovaginal milieu during pregnancy and delivery remain unexplored. Objectives:To determine whether normal pregnancy and delivery are associated with local activation of...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Livson S,Jarva H,Kalliala I,Lokki AI,Heikkinen-Eloranta J,Nieminen P,Meri S

    更新日期:2021-01-11 00:00:00

  • p38 MAPK Facilitates Crosstalk Between Endoplasmic Reticulum Stress and IL-6 Release in the Intervertebral Disc.

    abstract::Degenerative disc disease is associated with increased expression of pro-inflammatory cytokines in the intervertebral disc (IVD). However, it is not completely clear how inflammation arises in the IVD and which cellular compartments are involved in this process. Recently, the endoplasmic reticulum (ER) has emerged as ...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Krupkova O,Sadowska A,Kameda T,Hitzl W,Hausmann ON,Klasen J,Wuertz-Kozak K

    更新日期:2018-08-17 00:00:00

  • Effects of Soluble Corn Fiber Alone or in Synbiotic Combination with Lactobacillus rhamnosus GG and the Pilus-Deficient Derivative GG-PB12 on Fecal Microbiota, Metabolism, and Markers of Immune Function: A Randomized, Double-Blind, Placebo-Controlled, Cro

    abstract:Background:The aging process leads to a potential decline in immune function and adversely affects the gut microbiota. To date, many in vitro and in vivo studies focused on the application of synbiotics (prebiotics combined with probiotics) as a promising dietary approach to affect gut microbiota composition and improv...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Costabile A,Bergillos-Meca T,Rasinkangas P,Korpela K,de Vos WM,Gibson GR

    更新日期:2017-12-12 00:00:00

  • Novel Genome-Editing Tools to Model and Correct Primary Immunodeficiencies.

    abstract::Severe combined immunodeficiency (SCID) and other severe non-SCID primary immunodeficiencies (non-SCID PID) can be treated by allogeneic hematopoietic stem cell (HSC) transplantation, but when histocompatibility leukocyte antigen-matched donors are lacking, this can be a high-risk procedure. Correcting the patient's o...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Ott de Bruin LM,Volpi S,Musunuru K

    更新日期:2015-05-21 00:00:00

  • Aerobic Exercise Attenuates Acute Lung Injury Through NET Inhibition.

    abstract::Introduction: Aerobic exercise improves lung inflammation in acute lung injury (ALI), but its mechanism remains unknown. Neutrophil extracellular traps (NETs) play an important role in LPS-induced ALI, and a positive correlation exists between NET formation and proinflammatory macrophage polarization. This study inves...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Shi Y,Liu T,Nieman DC,Cui Y,Li F,Yang L,Shi H,Chen P

    更新日期:2020-03-19 00:00:00

  • Point-Of-Care CAR T-Cell Production (ARI-0001) Using a Closed Semi-automatic Bioreactor: Experience From an Academic Phase I Clinical Trial.

    abstract::Development of semi-automated devices that can reduce the hands-on time and standardize the production of clinical-grade CAR T-cells, such as CliniMACS Prodigy from Miltenyi, is key to facilitate the development of CAR T-cell therapies, especially in academic institutions. However, the feasibility of manufacturing CAR...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Castella M,Caballero-Baños M,Ortiz-Maldonado V,González-Navarro EA,Suñé G,Antoñana-Vidósola A,Boronat A,Marzal B,Millán L,Martín-Antonio B,Cid J,Lozano M,García E,Tabera J,Trias E,Perpiña U,Canals JM,Baumann T,Benítez

    更新日期:2020-03-20 00:00:00

  • Piperlongumine Acts as an Immunosuppressant by Exerting Prooxidative Effects in Human T Cells Resulting in Diminished TH17 but Enhanced Treg Differentiation.

    abstract::Piperlongumine (PL), a natural small molecule derived from the Piper longum Linn plant, has received growing interest as a prooxidative drug with promising anticancer properties. Yet, the influence of PL on primary human T cells remained elusive. Knowledge of this is of crucial importance, however, since T cells in pa...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Liang J,Ziegler JD,Jahraus B,Orlik C,Blatnik R,Blank N,Niesler B,Wabnitz G,Ruppert T,Hübner K,Balta E,Samstag Y

    更新日期:2020-06-12 00:00:00

  • Association of Clinical Phenotypes in Haploinsufficiency A20 (HA20) With Disrupted Domains of A20.

    abstract::Background: Haploinsufficiency A20 (HA20) is a newly described monogenic disease characterized by a wide spectrum of manifestations and caused by heterozygous mutations in TNFAIP3 which encodes A20 protein. TNFAIP3 mutation leads to disruption of the A20 ovarian tumor (OTU) domain and/or the zinc finger (ZnF) domain. ...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Chen Y,Ye Z,Chen L,Qin T,Seidler U,Tian D,Xiao F

    更新日期:2020-09-23 00:00:00

  • Blimp-1-Mediated Pathway Promotes Type I IFN Production in Plasmacytoid Dendritic Cells by Targeting to Interleukin-1 Receptor-Associated Kinase M.

    abstract::Plasmacytoid dendritic cells (pDCs) are a specialized subset of DCs capable of rapidly producing copious amounts of type I IFN (IFN-I) in response to viral infections. The mechanism regulating rapid production of IFN-I after pDCs are exposed to viral nucleic acids remains elusive. Here, we show that the transcription ...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Ko YA,Chan YH,Liu CH,Liang JJ,Chuang TH,Hsueh YP,Lin YL,Lin KI

    更新日期:2018-08-07 00:00:00

  • Septic Shock and the Aging Process: A Molecular Comparison.

    abstract::Aging is a continuous process promoted by both intrinsic and extrinsic factors that each trigger a multitude of molecular events. Increasing evidence supports a central role for inflammation in this progression. Here, we discuss how the low-grade chronic inflammation that characterizes aging is tightly interconnected ...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Pinheiro da Silva F,Machado MCC

    更新日期:2017-10-25 00:00:00

  • Tumor-Associated Neutrophils and Macrophages-Heterogenous but Not Chaotic.

    abstract::Tumor-associated macrophages (TAMs) and tumor-associated neutrophils (TANs) have been extensively studied. Their pleotropic roles were observed in multiple steps of tumor progression and metastasis, and sometimes appeared to be inconsistent across different studies. In this review, we collectively discussed many lines...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Wu L,Zhang XH

    更新日期:2020-12-02 00:00:00

  • Utility, limitations, and future of non-human primates for dengue research and vaccine development.

    abstract::Dengue is considered the most important emerging, human arboviruses, with worldwide distribution in the tropics. Unfortunately, there are no licensed dengue vaccines available or specific anti-viral drugs. The development of a dengue vaccine faces unique challenges. The four serotypes co-circulate in endemic areas, an...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Sariol CA,White LJ

    更新日期:2014-09-24 00:00:00

  • Short-Chain Fatty Acids Promote Intracellular Bactericidal Activity in Head Kidney Macrophages From Turbot (Scophthalmus maximus L.) via Hypoxia Inducible Factor-1α.

    abstract::Short-chain fatty acids (SCFAs) are mainly produced by microbiota through the fermentation of carbohydrates in the intestine. Acetate, propionate, and butyrate are the most abundant SCFA metabolites and have been shown to be important in the maintenance of host health. In this study, head kidney macrophages (HKMs) wer...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Zhang J,Zhang H,Liu M,Lan Y,Sun H,Mai K,Wan M

    更新日期:2020-12-23 00:00:00

  • Adipocyte Ceramides-The Nexus of Inflammation and Metabolic Disease.

    abstract::Adipose depots are heterogeneous tissues that store and sense fuel levels. Through the secretion of lipids, cytokines, and protein hormones (adipokines), they communicate with other organ systems, informing them of the organism's nutritional status. The adipose tissues include diverse types of adipocytes (white, beige...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Chaurasia B,Talbot CL,Summers SA

    更新日期:2020-09-23 00:00:00

  • B-Cell Activating Factor Secreted by Neutrophils Is a Critical Player in Lung Inflammation to Cigarette Smoke Exposure.

    abstract::Cigarette smoke (CS) is the major cause of chronic lung injuries, such as chronic obstructive pulmonary disease (COPD). In patients with severe COPD, tertiary lymphoid follicles containing B lymphocytes and B cell-activating factor (BAFF) overexpression are associated with disease severity. In addition, BAFF promotes ...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Nascimento M,Huot-Marchand S,Gombault A,Panek C,Bourinet M,Fanny M,Savigny F,Schneider P,Le Bert M,Ryffel B,Riteau N,Quesniaux VFJ,Couillin I

    更新日期:2020-07-29 00:00:00

  • Peripheral Macrophages Promote Tissue Regeneration in Zebrafish by Fine-Tuning the Inflammatory Response.

    abstract::The role of macrophages during regeneration in zebrafish has been well-documented. Nevertheless, new evidence indicates that zebrafish macrophages are a heterogeneous population of cells, and that they can play different roles during immune responses and in tissue restoration after damage and infection. In this work, ...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Morales RA,Allende ML

    更新日期:2019-02-15 00:00:00

  • Overexpression of Bovine FcRn in Mice Enhances T-Dependent Immune Responses by Amplifying T Helper Cell Frequency and Germinal Center Enlargement in the Spleen.

    abstract::The neonatal Fc receptor (FcRn) plays key roles in IgG and albumin homeostasis, maternal IgG transport, and antigen presentation of IgG-opsonized antigens. Previously, we reported that transgenic (Tg) mice that overexpress the bovine FcRn (bFcRn) have augmented T-dependent humoral immune response with increased IgG pr...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Schneider Z,Jani PK,Szikora B,Végh A,Kövesdi D,Iliás A,Cervenak J,Balogh P,Kurucz I,Kacskovics I

    更新日期:2015-07-20 00:00:00