Phylogenetic conservation of the 3' cryptic recombination signal sequence (3'cRSS) in the VH genes of jawed vertebrates.

abstract：:Recognition of cancer antigens drives the clonal expansion of cancer-reactive T cells, which is thought to contribute to restricted T-cell receptor (TCR) repertoires in tumor-infiltrating lymphocytes (TILs). To understand how tumors escape anti-tumor immunity, we investigated tumor-associated T-cell repertoires of pat...

journal_title：Frontiers in immunology

authors： Arakawa A,Vollmer S,Tietze J,Galinski A,Heppt MV,Bürdek M,Berking C,Prinz JC

更新日期：2019-06-18 00:00:00

abstract：:The fundamental problem of autoimmune diseases is the failure of the immune system to downregulate its own potentially dangerous cells, which leads to destruction of tissue expressing the relevant autoantigens. Current immunosuppressive therapies offer relief but fail to restore the basic condition of self-tolerance. ...

journal_title：Frontiers in immunology

authors： van Eden W,Jansen MAA,Ludwig I,van Kooten P,van der Zee R,Broere F

更新日期：2017-11-21 00:00:00

abstract：:Allograft rejection constitutes a major complication of solid organ transplantation requiring prophylactic/therapeutic immunosuppression, which increases susceptibility of patients to infections and cancer. Beyond the pivotal role of alloantigen-specific T cells and antibodies in the pathogenesis of rejection, natural...

journal_title：Frontiers in immunology

authors： López-Botet M,Vilches C,Redondo-Pachón D,Muntasell A,Pupuleku A,Yélamos J,Pascual J,Crespo M

更新日期：2017-02-16 00:00:00

abstract：:Objectives: Standardization of myositis specific antibody (MSA) detection is of high importance because these antibodies are relevant for diagnosis and stratification of patients with idiopathic inflammatory myositis (IIM) and have the potential to be used in classification criteria. Many laboratories rely on immunopr...

journal_title：Frontiers in immunology

authors： Mahler M,Betteridge Z,Bentow C,Richards M,Seaman A,Chinoy H,McHugh N

更新日期：2019-04-30 00:00:00

abstract：:In contrast to peptide-recognizing T cells, invariant natural killer T (iNKT) cells express a semi-invariant T cell receptor that specifically recognizes self- or foreign-lipids presented by CD1d molecules. There are three major functionally distinct effector states for iNKT cells. Owning to these innate-like effector...

journal_title：Frontiers in immunology

authors： Wang H,Hogquist KA

更新日期：2018-06-26 00:00:00

abstract：:Abundant clinical, epidemiological, imaging, genetic, molecular, and pathophysiological data together indicate that there occur an unusual inflammatory reaction and a disruption of the innate-immune signaling system in Alzheimer's disease (AD) brain. Despite many years of intense study, the origin and molecular mechan...

journal_title：Frontiers in immunology

authors： Zhao Y,Cong L,Jaber V,Lukiw WJ

更新日期：2017-09-04 00:00:00

abstract：:Lower respiratory tract infections and tuberculosis are responsible for the death of about 4.5 million people each year and are the main causes of mortality in children under 5 years of age. Streptococcus pneumoniae is the most common bacterial pathogen associated with severe pneumonia, although other Gram-positive an...

journal_title：Frontiers in immunology

authors： Vázquez R,García E,García P

更新日期：2018-10-16 00:00:00

abstract：:Mesenchymal stem cells (MSCs) are multipotent stromal cells with immunomodulatory properties. They have emerged as a very promising treatment for autoimmunity and inflammatory diseases such as rheumatoid arthritis. Previous studies have demonstrated that MSCs, administered systemically, migrate to lymphoid tissues ass...

journal_title：Frontiers in immunology

authors： Mancheño-Corvo P,Lopez-Santalla M,Menta R,DelaRosa O,Mulero F,Del Rio B,Ramirez C,Büscher D,Bueren JA,Lopez-Belmonte J,Dalemans W,Garin MI,Lombardo E

更新日期：2017-04-21 00:00:00

abstract：:Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, is a complex immune-mediated disease of the gastrointestinal tract that increases morbidity and negatively influences the quality of life. Intestinal mononuclear phagocytes (MNPs) have a crucial role in maintaining epithelial barrier i...

journal_title：Frontiers in immunology

authors： Caër C,Wick MJ

更新日期：2020-03-18 00:00:00

abstract：:Silver nanoparticles (AgNPs) are promising new antimicrobial agents against a wide range of skin and mucosal pathogens. However, their interaction with the immune system is currently not fully understood. Dendritic cells (DCs) are crucial during development of T cell-specific responses against bacterial and viral path...

journal_title：Frontiers in immunology

authors： Orlowski P,Tomaszewska E,Ranoszek-Soliwoda K,Gniadek M,Labedz O,Malewski T,Nowakowska J,Chodaczek G,Celichowski G,Grobelny J,Krzyzowska M

更新日期：2018-05-22 00:00:00

abstract：:The lymphoid follicle is critical for the development of humoral immune responses. Cell circulation to this site is highly regulated by the differential expression of chemokine receptors. This feature contributes to the establishment of viral reservoirs in lymphoid follicles and the development of some types of malign...

journal_title：Frontiers in immunology

authors： Perdomo-Celis F,Taborda NA,Rugeles MT

更新日期：2017-09-29 00:00:00

abstract：:The recent discoveries of broadly potent neutralizing human monoclonal antibodies represent a new generation of antiretrovirals for the treatment and prophylaxis. Antibodies are generally considered more effective and safer and have been proved to provide passive protection against mucosal challenge in humanized mice ...

journal_title：Frontiers in immunology

authors： Sun M,Li Y,Zheng H,Shao Y

更新日期：2016-09-30 00:00:00

abstract：:Because Peyer's patches (PP) are the main inductive sites for gut IgA responses we have focused this review on what we know about the function of PP germinal centers (GC). The vast majority of IgA gene sequences in the gut lamina propria (LP) are heavily mutated arguing for an origin in GC. Because PP GC formation is ...

journal_title：Frontiers in immunology

authors： Lycke NY,Bemark M

更新日期：2012-11-07 00:00:00

abstract：:NK cells are capable of an array of functions that range widely from their classic anti-tumor and anti-viral cytotoxic effector functions, to their critical regulatory roles in controlling inflammatory immune responses and promoting tissue growth. However, the mechanisms that polarize NK cells to these distinct and op...

journal_title：Frontiers in immunology

authors： Poznanski SM,Ashkar AA

更新日期：2019-06-19 00:00:00

abstract：:Cancer is a complex disease and a leading cause of death worldwide. Immunity is critical for cancer control. Cancer cells exhibit high mutational rates and therefore altered self or neo-antigens, eliciting an immune response to promote tumor eradication. Failure to mount a proper immune response leads to cancer progre...

journal_title：Frontiers in immunology

authors： Guri Y,Nordmann TM,Roszik J

更新日期：2018-03-27 00:00:00

abstract：:The lungs, a special site that is frequently challenged by tumors, pathogens and other environmental insults, are populated by large numbers of innate immune cells. Among these, natural killer (NK) cells are gaining increasing attention. Recent studies have revealed that NK cells are heterogeneous populations consisti...

journal_title：Frontiers in immunology

authors： Cong J,Wei H

更新日期：2019-06-25 00:00:00

abstract：:Immune checkpoint blockade therapy has prevailed for several types of cancer; however, its effectiveness as a single therapy is still limited. In principle, dendritic cells (DCs) should be able to control the post-therapy immune response, in particular since they can link the two major arms of the immune system: innat...

journal_title：Frontiers in immunology

authors： Fujii SI,Shimizu K

更新日期：2017-07-31 00:00:00

abstract：BACKGROUND:Subjects are considered infected with Trypanosoma cruzi when tested positive by at least two out of three serological tests, whereas a positive result in only one of up to three tests is termed "serodiscordant" (SD). Assessment of parasite-specific T-cell responses may help discriminate the uninfected from i...

journal_title：Frontiers in immunology

authors： Castro Eiro MD,Alvarez MG,Cooley G,Viotti RJ,Bertocchi GL,Lococo B,Albareda MC,De Rissio AM,Natale MA,Parodi C,Tarleton RL,Laucella SA

更新日期：2017-09-15 00:00:00

abstract：:There is accumulating evidence to indicate that long non-coding RNAs (lncRNAs) are important regulators of the inflammatory response. In this report, we have employed next generation sequencing to identify 14 lncRNAs that are differentially expressed in human lung fibroblasts following the induction of inflammation us...

journal_title：Frontiers in immunology

authors： Hadjicharalambous MR,Roux BT,Feghali-Bostwick CA,Murray LA,Clarke DL,Lindsay MA

更新日期：2018-12-11 00:00:00

abstract：:Immunomodulation and chronic inflammation are important mechanisms utilized by cancer cells to evade the immune defense and promote tumor progression. Therefore, various efforts were focused on the development of approaches to reprogram the immune response to increase the immune detection of cancer cells and enhance p...

journal_title：Frontiers in immunology

authors： Hammoudeh SM,Venkatachalam T,Ansari AW,Bendardaf R,Hamid Q,Rahmani M,Hamoudi R

更新日期：2020-12-14 00:00:00

abstract：:Glioblastoma is one of the most common neoplasms in the central nervous system characterized by limited immune response and unlimited expansion capability. Cancer stem cells (GSCs), a small fraction of the tumor cells, possess a pivotal regulation capability in the tumor microenvironment with a superior proliferation ...

journal_title：Frontiers in immunology

authors： Zhai Y,Li G,Li R,Chang Y,Feng Y,Wang D,Wu F,Zhang W

更新日期：2020-10-08 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fimmu.2017.01609.]. ...

journal_title：Frontiers in immunology

authors： Xu C,Lu Y,Zheng X,Feng X,Yang X,Timm J,Wu J,Wang B,Lu M,Yang D,Liu J

更新日期：2020-07-24 00:00:00

abstract：:Approximately 40% of preterm births are preceded by microbial invasion of the intrauterine space; ascent from the vagina being the most common pathway. Within the cervical canal, antimicrobial peptides and proteins (AMPs) are important components of the cervical barrier which help to prevent ascending vaginal infectio...

journal_title：Frontiers in immunology

authors： Suff N,Karda R,Diaz JA,Ng J,Baruteau J,Perocheau D,Taylor PW,Alber D,Buckley SMK,Bajaj-Elliott M,Waddington SN,Peebles D

更新日期：2020-02-11 00:00:00

abstract：:Exhaustion of CD8+ T cells and increased IL-10 production is well-known in chronic viral infections but mechanisms leading to loss of their cytotoxic capabilities and consequent exhaustion remain unclear. Exhausted CD8+T cells also called T suppressors are highly immune suppressive with altered T cell receptor signali...

journal_title：Frontiers in immunology

authors： Mohanty S,Barik P,Debata N,Nagarajan P,Devadas S

更新日期：2020-03-06 00:00:00

abstract：:The immune response of a host to a pathogen is typically described as either innate or adaptive. The innate form of the immune response is conserved across all organisms, including insects. Previous and recent research has focused on the nature of the insect immune system and the results imply that the innate immune r...

journal_title：Frontiers in immunology

authors： Cooper D,Eleftherianos I

更新日期：2017-05-09 00:00:00

abstract：:Background: More than 50 different monogenic disorders have been identified as directly causing inflammatory bowel diseases, typically manifesting in the first years of life. We present the clinical course and immunological work-up of an adult patient who presented in adolescent years with an atypical gastrointestinal...

journal_title：Frontiers in immunology

authors： Vardi I,Chermesh I,Werner L,Barel O,Freund T,McCourt C,Fisher Y,Pinsker M,Javasky E,Weiss B,Rechavi G,Hagin D,Snapper SB,Somech R,Konnikova L,Shouval DS

更新日期：2020-09-04 00:00:00

abstract：:Platelets (PLTs) are the major source of high-mobility group box 1 (HMGB1), a protein that is involved in sterile inflammation of blood vessels and thrombosis. Megakaryocytes (MKs) synthesize HMGB1 and transfer both protein and mRNA into PLTs and PLT-derived microvesicles (MV). Free HMGB1 found in supernatants of in v...

journal_title：Frontiers in immunology

authors： Mardente S,Mari E,Massimi I,Tafani M,Guerriero R,Morsilli O,Pulcinelli FM,Bianchi ME,Zicari A

更新日期：2018-01-12 00:00:00

abstract：:Shiga-toxin (Stx)-producing Escherichia coli hemolytic-uremic syndrome (STEC-HUS) is one of the most common causes of acute kidney injury in children. Stx-mediated endothelial injury initiates the cascade leading to thrombotic microangiopathy (TMA), still the exact pathogenesis remains elusive. Interestingly, there is...

journal_title：Frontiers in immunology

authors： Wijnsma KL,Veissi ST,de Wijs S,van der Velden T,Volokhina EB,Wagener FADTG,van de Kar NCAJ,van den Heuvel LP

更新日期：2020-12-22 00:00:00

abstract：:Heterogeneous populations of myeloid regulatory cells (MRC), including monocytes, macrophages, dendritic cells, and neutrophils, are found in cancer and infectious diseases. The inflammatory environment in solid tumors as well as infectious foci with persistent pathogens promotes the development and recruitment of MRC...

journal_title：Frontiers in immunology

authors： Dorhoi A,Du Plessis N

更新日期：2018-01-04 00:00:00

abstract：:Neosporosis is considered as one of the main causes of abortion and severe economic losses in dairy industry. The Canis genus serving as one of the confirmed definitive hosts of the apicomplexan parasite Neospora caninum (N. caninum) plays a critical role in its life cycle. However, the effects of N. caninum on its de...

journal_title：Frontiers in immunology

authors： Wei Z,Hermosilla C,Taubert A,He X,Wang X,Gong P,Li J,Yang Z,Zhang X

更新日期：2016-10-31 00:00:00