Mediation of Mucosal Immunoglobulins in Buccal Cavity of Teleost in Antibacterial Immunity.

abstract：:T-dependent humoral immune responses to infection involve a collaboration between B and CD4 T cell activation, migration, and co-stimulation, thereby culminating in the formation of germinal centers (GCs) and eventual differentiation into memory cells and long-lived plasma cells (PCs). CD4 T cell-derived signals drive...

journal_title：Frontiers in immunology

authors： Good-Jacobson KL,Groom JR

更新日期：2018-03-08 00:00:00

abstract：:A sudden outbreak of COVID-19 caused by a novel coronavirus, SARS-CoV-2, in Wuhan, China in December 2019 quickly grew into a global pandemic, putting at risk not only the global healthcare system, but also the world economy. As the disease continues to spread rapidly, the development of prophylactic and therapeutic a...

journal_title：Frontiers in immunology

authors： Liang Y,Wang ML,Chien CS,Yarmishyn AA,Yang YP,Lai WY,Luo YH,Lin YT,Chen YJ,Chang PC,Chiou SH

更新日期：2020-05-12 00:00:00

abstract：:Adult-onset primary immunodeficiency is characterized by recurrent infections, hypogammaglobulinemia, and poor antibody response to vaccines. In this study, we have analyzed targeted gene panel sequencing results of 270 patients diagnosed with antibody deficiency and identified five disease-associated variants in NFKB...

journal_title：Frontiers in immunology

authors： Schröder C,Sogkas G,Fliegauf M,Dörk T,Liu D,Hanitsch LG,Steiner S,Scheibenbogen C,Jacobs R,Grimbacher B,Schmidt RE,Atschekzei F

更新日期：2019-11-14 00:00:00

abstract：:Efficient induction of effector and long-term protective antigen-specific CD8+ T memory response by vaccination is essential to eliminate malignant and pathogen-infected cells. Intracellular infectious bacteria, including Listeria monocytogenes, have been considered potent vectors to carry multiple therapeutic protein...

journal_title：Frontiers in immunology

authors： Rana A,de Almeida FC,Paico Montero HA,Gonzales Carazas MM,Bortoluci KR,Sad S,Amarante-Mendes GP

更新日期：2020-04-09 00:00:00

abstract：:We have developed a therapeutic vaccine consisting of a mixture of lethally-irradiated allogeneic cutaneous melanoma cell lines with BCG and GM-CSF as adjuvants. The CSF-470 vaccine is currently being assayed in a Phase II-III trial against medium-dose IFN-α2b. All vaccinated patients immunized intradermally developed...

journal_title：Frontiers in immunology

authors： Aris M,Bravo AI,Barrio MM,Mordoh J

更新日期：2015-03-30 00:00:00

abstract：:There is accumulating evidence to indicate that long non-coding RNAs (lncRNAs) are important regulators of the inflammatory response. In this report, we have employed next generation sequencing to identify 14 lncRNAs that are differentially expressed in human lung fibroblasts following the induction of inflammation us...

journal_title：Frontiers in immunology

authors： Hadjicharalambous MR,Roux BT,Feghali-Bostwick CA,Murray LA,Clarke DL,Lindsay MA

更新日期：2018-12-11 00:00:00

abstract：:The role of macrophages during regeneration in zebrafish has been well-documented. Nevertheless, new evidence indicates that zebrafish macrophages are a heterogeneous population of cells, and that they can play different roles during immune responses and in tissue restoration after damage and infection. In this work, ...

journal_title：Frontiers in immunology

authors： Morales RA,Allende ML

更新日期：2019-02-15 00:00:00

abstract：:Loss-of-function mutations in the Autoimmune Regulator (AIRE) gene cause a rare inherited form of autoimmune disease, autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy, also known as autoimmune polyglandular syndrome type 1. The patients suffer from multiple endocrine deficiencies, the most common manifes...

journal_title：Frontiers in immunology

authors： Arstila TP,Jarva H

更新日期：2013-10-07 00:00:00

abstract：:Gamma delta (γδ) T cells, which possess potent cytotoxicity against a wide range of cancer cells, have become a potential avenue for adoptive immunotherapy. Decitabine (DAC) has been reported to enhance the immunogenicity of tumor cells, thereby reinstating endogenous immune recognition and tumor lysis. However, DAC h...

journal_title：Frontiers in immunology

authors： Niu C,Li M,Zhu S,Chen Y,Zhou L,Xu D,Li W,Cui J,Liu Y,Chen J

更新日期：2018-03-26 00:00:00

abstract：:The axonal guidance molecules, semaphorins, have been described to function both physiologically and pathologically outside of the nervous system. In this review, we focus on the vertebrate semaphorins found in classes 3 through 7 and their roles in vascular development and autoimmune diseases. Recent studies indicate...

journal_title：Frontiers in immunology

authors： Iragavarapu-Charyulu V,Wojcikiewicz E,Urdaneta A

更新日期：2020-03-05 00:00:00

abstract：:Although the role that Autoimmune Regulator (Aire) plays in the induction of central tolerance is well known, the precise cellular and molecular mechanisms are still unclear and debated. In the prevailing view, Aire serves mainly as a direct inducer of tissue-specific antigens. However, there is a growing amount of ev...

journal_title：Frontiers in immunology

authors： Laan M,Peterson P

更新日期：2013-10-11 00:00:00

abstract：:The NT5E (CD73) molecule represents an ecto-5'-nucleotidase expressed on the cell surface of various cell types. Hydrolyzing extracellular adenosine monophosphate into adenosine and inorganic phosphate, NT5E performs numerous homeostatic functions in healthy organs and tissues. Importantly, NT5E can act as inhibitory ...

journal_title：Frontiers in immunology

authors： Kordaß T,Osen W,Eichmüller SB

更新日期：2018-04-18 00:00:00

abstract：:Ischemic stroke is among the leading causes of disability and death worldwide. In acute ischemic stroke, the rapid recanalization of occluded cranial vessels is the primary therapeutic aim. However, experimental data (obtained using mostly the transient middle cerebral artery occlusion model) indicates that progressiv...

journal_title：Frontiers in immunology

authors： Stegner D,Klaus V,Nieswandt B

更新日期：2019-11-01 00:00:00

abstract：:The study of molecular host-parasite interactions is essential to understand parasitic infection and adaptation within the host system. As well, prevention and treatment of infectious diseases require a clear understanding of the molecular crosstalk between parasites and their hosts. Yet, large-scale experimental iden...

journal_title：Frontiers in immunology

authors： Cuesta-Astroz Y,Santos A,Oliveira G,Jensen LJ

更新日期：2019-02-13 00:00:00

abstract：:Asthma is a chronic airway disease often due to sensitization to aeroallergens, especially house dust mite allergens (HDMs). The Dermatophagoides pteronyssinus group 2 (Der p 2), is one of the most representative HDM allergens and is recognized by more than 90% of HDM-allergic patients. In mouse models, all asthma-rel...

journal_title：Frontiers in immunology

authors： Klein M,Colas L,Cheminant MA,Brosseau C,Sauzeau V,Magnan A,Bouchaud G

更新日期：2020-11-18 00:00:00

abstract：:Myasthenia gravis is an autoimmune disease in which immunoglobulin G (IgG) autoantibodies are formed against the nicotinic acetylcholine receptor (AChR) or other components of the neuromuscular junction. Though effective treatments are currently available, many commonly used therapies have important limitations and al...

journal_title：Frontiers in immunology

authors： Gable KL,Guptill JT

更新日期：2020-01-10 00:00:00

abstract：:Increasing prevalence in obesity has become a significant public concern. C57BL/6J mice are prone to diet-induced obesity (DIO) when fed high-fat diet (HFD), and develop chronic inflammation and metabolic syndrome, making them a good model to analyze mechanisms whereby obesity elicits pathologies. DIO mice demonstrate...

journal_title：Frontiers in immunology

authors： Lainez NM,Jonak CR,Nair MG,Ethell IM,Wilson EH,Carson MJ,Coss D

更新日期：2018-09-11 00:00:00

abstract：:Transition from resting to cell cycle in response to antigenic stimulation is an essential step for naïve CD8+ T cells to differentiate to effector and memory cells. Leaving the resting state requires dramatic changes of chromatin status in the key cell cycle inhibitors but the details of these concerted events are no...

journal_title：Frontiers in immunology

authors： Chen G,Subedi K,Chakraborty S,Sharov A,Lu J,Kim J,Mi X,Wersto R,Sung MH,Weng NP

更新日期：2018-03-26 00:00:00

abstract：:Influenza virus NS2 is well known for its role in viral ribonucleoprotein nuclear export; however, its function has not been fully understood. A recent study showed that NS2 might interact with HIST1H1C (H1C, H1.2). Histones have been found to affect influenza virus replication, such as the H2A, H2B, H3, and H4, but H...

journal_title：Frontiers in immunology

authors： Liu X,Yang C,Hu Y,Lei E,Lin X,Zhao L,Zou Z,Zhang A,Zhou H,Chen H,Qian P,Jin M

更新日期：2017-03-24 00:00:00

abstract：:pH is highly variable in different tissues and affects many enzymatic reactions in neutrophils. In response to calcium ionophores such as A23187 and ionomycin, neutrophils undergo nicotinamide adenine dinucleotide phosphate oxidase (NOX)-independent neutrophil extracellular trap (NET) formation (NETosis). However, how...

journal_title：Frontiers in immunology

authors： Naffah de Souza C,Breda LCD,Khan MA,de Almeida SR,Câmara NOS,Sweezey N,Palaniyar N

更新日期：2018-01-09 00:00:00

abstract：:Cow's milk protein allergy (CMPA) is the most common allergy in the first year of life. Non-IgE mediated CMPA is characterized by digestive symptoms and tolerance development before the age of three. Gut microbiota composition in early life has been associated with food allergy. The ingestion of different foods/nutrie...

journal_title：Frontiers in immunology

authors： Guadamuro L,Diaz M,Jiménez S,Molinos-Norniella C,Pérez-Solis D,Rodríguez JM,Bousoño C,Gueimonde M,Margolles A,Delgado S,Díaz JJ

更新日期：2019-08-02 00:00:00

abstract：:Acute graft-vs.-host disease (GVHD) limits the efficacy of allogeneic hematopoietic stem cell transplantation (allo-HSCT), a main therapy to treat various hematological disorders. Despite rapid progress in understanding GVHD pathogenesis, broad immunosuppressive agents are most often used to prevent and remain the fir...

journal_title：Frontiers in immunology

authors： Thangavelu G,Blazar BR

更新日期：2019-03-06 00:00:00

abstract：:Cooperation between the innate and adaptive immune responses is critical for enabling protective immunity against various invading microbes. Distinct types of effector T cells have different functions in adaptive immune responses. Th1 cells play important roles in the control of intracellular bacteria by producing IFN...

journal_title：Frontiers in immunology

authors： Koyasu S,Moro K

更新日期：2012-05-07 00:00:00

abstract：:Short-chain fatty acids (SCFAs) are mainly produced by microbiota through the fermentation of carbohydrates in the intestine. Acetate, propionate, and butyrate are the most abundant SCFA metabolites and have been shown to be important in the maintenance of host health. In this study, head kidney macrophages (HKMs) wer...

journal_title：Frontiers in immunology

authors： Zhang J,Zhang H,Liu M,Lan Y,Sun H,Mai K,Wan M

更新日期：2020-12-23 00:00:00

abstract：:The influence of CD4(+)CD25(+)Foxp3(+) regulatory T-cells (Tregs) on cancer progression has been demonstrated in a large number of preclinical models and confirmed in several types of malignancies. Neoplastic processes trigger an increase of Treg numbers in draining lymph nodes, spleen, blood, and tumors, leading to t...

journal_title：Frontiers in immunology

authors： Darrasse-Jèze G,Podsypanina K

更新日期：2013-09-26 00:00:00

abstract：:The limited efficacy of seasonal influenza vaccines is usually attributed to ongoing variation in the major antigenic targets for protective antibody responses including hemagglutinin (HA) and neuraminidase (NA). Hence, vaccine development has largely focused on broadening antigenic epitopes to generate cross-reactive...

journal_title：Frontiers in immunology

authors： Sato-Kaneko F,Yao S,Lao FS,Shpigelman J,Messer K,Pu M,Shukla NM,Cottam HB,Chan M,Chu PJ,Burkhart D,Schoener R,Matsutani T,Carson DA,Corr M,Hayashi T

更新日期：2020-06-19 00:00:00

abstract：:Invariant natural killer T (iNKT) cells produce copious amounts of cytokines in response to T-cell receptor (TCR) stimulation by recognizing antigens such as α-galactosylceramide (α-GalCer) presented on CD1d; thus, orchestrating other immune cells to fight against pathogen infection and tumors. Because of their abilit...

journal_title：Frontiers in immunology

authors： Takami M,Ihara F,Motohashi S

更新日期：2018-09-07 00:00:00

abstract：:Mycobacterium tuberculosis continues to be one of the most successful pathogens on earth. Upon inhalation of M. tuberculosis by a healthy individual, the host immune system will attempt to eliminate these pathogens using a combination of immune defense strategies. These include the recruitment of macrophages and other...

journal_title：Frontiers in immunology

authors： BoseDasgupta S,Pieters J

更新日期：2014-10-08 00:00:00

abstract：:The apparition of adaptive immunity in Gnathostomata correlates with the expansion of the E-protein family to encompass E2-2, HEB, and E2A. Within the family, E2-2 and HEB are more closely evolutionarily related but their concerted action in hematopoiesis remains to be explored. Here we show that the combined disrupti...

journal_title：Frontiers in immunology

authors： Bouderlique T,Peña-Pérez L,Kharazi S,Hils M,Li X,Krstic A,De Paepe A,Schachtrup C,Gustafsson C,Holmberg D,Schachtrup K,Månsson R

更新日期：2019-03-18 00:00:00

abstract：:Impairment or stimulation of the immune system by ionizing radiation (IR) impacts on immune surveillance of tumor cells and non-malignant cells and can either foster therapy response or side effects/toxicities of radiation therapy. For a better understanding of the mechanisms by which IR modulates T-cell activation an...

journal_title：Frontiers in immunology

authors： Voos P,Fuck S,Weipert F,Babel L,Tandl D,Meckel T,Hehlgans S,Fournier C,Moroni A,Rödel F,Thiel G

更新日期：2018-04-30 00:00:00