Tailoring Immune Responses toward Autoimmunity: Transcriptional Regulators That Drive the Creation and Collusion of Autoreactive Lymphocytes.

abstract：:Toll-like receptors (TLRs) are recognition molecules for multiple pathogens, including bacteria, viruses, fungi, and parasites. TLR2 forms heterodimers with TLR1 and TLR6, which is the initial step in a cascade of events leading to significant innate immune responses, development of adaptive immunity to pathogens and ...

journal_title：Frontiers in immunology

authors： Oliveira-Nascimento L,Massari P,Wetzler LM

更新日期：2012-04-18 00:00:00

abstract：:Cancer neoantigens derived from random somatic mutations in tumor tissue represent an attractive type of targets for the cancer immunotherapies including cancer vaccine. Vaccination against the tumor-specific neoantigens minimizes the potential induction of central and peripheral tolerance as well as the risk of autoi...

journal_title：Frontiers in immunology

authors： Guo Y,Lei K,Tang L

更新日期：2018-07-02 00:00:00

abstract：:Functional impairment of T-cells and a concomitant augmented expression of programmed death-1 (PD-1) have been observed in visceral leishmaniasis patients, as well as in experimental models for visceral and cutaneous leishmaniasis. The PD-1/PD-1-ligand (PD-1/PD-L) interaction negatively regulates T-cell effector funct...

journal_title：Frontiers in immunology

authors： Filippis C,Arens K,Noubissi Nzeteu GA,Reichmann G,Waibler Z,Crauwels P,van Zandbergen G

更新日期：2017-12-22 00:00:00

abstract：:Mesenchymal stem cells (MSC) are under investigation as a therapy for a variety of disorders. Although animal models show long term regenerative and immunomodulatory effects of MSC, the fate of MSC after infusion remains to be elucidated. In the present study the localization and viability of MSC was examined by isola...

journal_title：Frontiers in immunology

authors： Eggenhofer E,Benseler V,Kroemer A,Popp FC,Geissler EK,Schlitt HJ,Baan CC,Dahlke MH,Hoogduijn MJ

更新日期：2012-09-26 00:00:00

abstract：:The T cell population in an individual needs to avoid harmful activation by self peptides while maintaining the ability to respond to an unknown set of foreign peptides. This property is acquired by a combination of thymic and extra-thymic mechanisms. We extend current models for the development of self/non-self discr...

journal_title：Frontiers in immunology

authors： Best K,Chain B,Watkins C

更新日期：2015-08-07 00:00:00

abstract：:There is far less information available about the tumor infiltrating B (TIL-B) cells, than about the tumor infiltrating T cells. We focused on discovering the features and potential role of B lymphocytes in solid tumors. Our project aimed to develop innovative strategies to define cancer membrane structures. We chose ...

journal_title：Frontiers in immunology

authors： Kotlan B,Horvath S,Eles K,Plotar VK,Naszados G,Czirbesz K,Blank M,Farkas E,Toth L,Tovari J,Szekacs A,Shoenfeld Y,Godeny M,Kasler M,Liszkay G

更新日期：2019-04-05 00:00:00

abstract：:Human noroviruses (HuNoVs) are the cause of more than 95% of epidemic non-bacterial gastroenteritis worldwide, with some lethal cases. These viral agents affect people of all ages. However, young children and older adults are the highest-risk groups, being affected with the greatest rate of hospitalizations and morbid...

journal_title：Frontiers in immunology

authors： Campillay-Véliz CP,Carvajal JJ,Avellaneda AM,Escobar D,Covián C,Kalergis AM,Lay MK

更新日期：2020-06-16 00:00:00

abstract：OBJECTIVE:Roseburia hominis is a flagellated gut anaerobic bacterium belonging to the Lachnospiraceae family within the Firmicutes phylum. A significant decrease of R. hominis colonization in the gut of ulcerative colitis patients has recently been demonstrated. In this work, we have investigated the mechanisms of R. h...

journal_title：Frontiers in immunology

authors： Patterson AM,Mulder IE,Travis AJ,Lan A,Cerf-Bensussan N,Gaboriau-Routhiau V,Garden K,Logan E,Delday MI,Coutts AGP,Monnais E,Ferraria VC,Inoue R,Grant G,Aminov RI

更新日期：2017-09-26 00:00:00

abstract：:The T lymphocyte response initiates with the recognition of MHC/peptides on antigen presenting cells by the T cell receptor (TCR). After the TCR engagement, the proximal signaling pathways are activated for downstream cellular events. Among these pathways, the calcium-signaling flux is activated through the depletion ...

journal_title：Frontiers in immunology

authors： Jia W,He MX,McLeod IX,He YW

更新日期：2013-07-04 00:00:00

abstract：:NK cells are capable of an array of functions that range widely from their classic anti-tumor and anti-viral cytotoxic effector functions, to their critical regulatory roles in controlling inflammatory immune responses and promoting tissue growth. However, the mechanisms that polarize NK cells to these distinct and op...

journal_title：Frontiers in immunology

authors： Poznanski SM,Ashkar AA

更新日期：2019-06-19 00:00:00

abstract：:Ruggero Ceppellini, who died at the age of 71 in 1988, was one of the most stimulating and original human geneticists of his generation (1). Ceppellini's outstanding contributions to the genetics of the human blood groups, immunoglobulin allotypes and the HLA system epitomize the study of immunogenetics. By using his ...

journal_title：Frontiers in immunology

authors： Bodmer W

更新日期：2019-06-05 00:00:00

abstract：:In dairy herds, mastitis caused by Staphylococcus aureus is difficult to completely cure on the account that S. aureus can invade bovine mammary epithelial cells (BMECs) and result in persistent infection in the mammary gland. Recent studies have demonstrated that autophagy can participate in cell homeostasis by elimi...

journal_title：Frontiers in immunology

authors： Geng N,Wang X,Yu X,Wang R,Zhu Y,Zhang M,Liu J,Liu Y

更新日期：2020-05-05 00:00:00

abstract：:The barrier surfaces of the gastrointestinal tract are in constant contact with various microorganisms. Cytokines orchestrate the mucosal adaptive and innate immune cells in the defense against pathogens. IL-10 and IL-22 are the best studied members of the IL-10 family and play essential roles in maintaining mucosal h...

journal_title：Frontiers in immunology

authors： Wei HX,Wang B,Li B

更新日期：2020-06-26 00:00:00

abstract：:Intestinal dysbiosis associated with immunological deregulation, leaky gut, bacterial translocation, and systemic inflammation has been associated with autoimmune diseases, such as type 1 diabetes (T1D). The aim of this study was to investigate the intestinal dysbiosis in T1D patients and correlate these results with ...

journal_title：Frontiers in immunology

authors： Higuchi BS,Rodrigues N,Gonzaga MI,Paiolo JCC,Stefanutto N,Omori WP,Pinheiro DG,Brisotti JL,Matheucci E Jr,Mariano VS,de Oliveira GLV

更新日期：2018-07-25 00:00:00

abstract：:The immune system and inflammation plays a significant role in tumour immune evasion enhancing disease progression and reducing survival in colorectal cancer (CRC). Patients with advanced stages of colorectal cancer will all undergo treatment with cytotoxic chemotherapy which may alter the complexity of immune cell po...

journal_title：Frontiers in immunology

authors： Shinko D,McGuire HM,Diakos CI,Pavlakis N,Clarke SJ,Byrne SN,Charles KA

更新日期：2019-11-05 00:00:00

abstract：:Cerebral malaria is a life-threatening complication of malaria in humans, and the underlying pathogenic mechanisms are widely analyzed in a murine model of experimental cerebral malaria (ECM). Here, we show abrogation of ECM by hemocoel sporozoite-induced infection of a transgenic Plasmodium berghei line that overexpr...

journal_title：Frontiers in immunology

authors： Sato Y,Ries S,Stenzel W,Fillatreau S,Matuschewski K

更新日期：2019-11-01 00:00:00

abstract：:In recent decades, there has been substantial growth in our understanding of the immune system and its role in tumor growth and overall survival. A central finding has been the cross-talk between tumor cells and the surrounding environment or stroma. This tumor stroma, comprised of various cells, and extracellular mat...

journal_title：Frontiers in immunology

authors： Menon H,Ramapriyan R,Cushman TR,Verma V,Kim HH,Schoenhals JE,Atalar C,Selek U,Chun SG,Chang JY,Barsoumian HB,Nguyen QN,Altan M,Cortez MA,Hahn SM,Welsh JW

更新日期：2019-02-15 00:00:00

abstract：:Background: CXCL13 is preferentially secreted by Follicular Helper T cells (TFH) to attract B cells to germinal centers. Plasma levels of CXCL13 have been reported to be elevated during chronic HIV-infection, however there is limited data on such elevation during early phases of infection and on the effect of ART. Mor...

journal_title：Frontiers in immunology

authors： Mehraj V,Ramendra R,Isnard S,Dupuy FP,Lebouché B,Costiniuk C,Thomas R,Szabo J,Baril JG,Trottier B,Coté P,LeBlanc R,Durand M,Chartrand-Lefebvre C,Kema I,Zhang Y,Finkelman M,Tremblay C,Routy JP

更新日期：2019-02-21 00:00:00

abstract：:Under normal conditions our intestines are inhabited by trillions of diverse microorganisms composing the intestinal microbiota, which are mostly non-pathogenic anaerobic commensal bacteria vital for the maintenance of immune homeostasis. The composition and diversity of the intestinal microbiota can be disturbed by v...

journal_title：Frontiers in immunology

authors： Köhler N,Zeiser R

更新日期：2019-01-17 00:00:00

abstract：:Asthma is a chronic airway disease often due to sensitization to aeroallergens, especially house dust mite allergens (HDMs). The Dermatophagoides pteronyssinus group 2 (Der p 2), is one of the most representative HDM allergens and is recognized by more than 90% of HDM-allergic patients. In mouse models, all asthma-rel...

journal_title：Frontiers in immunology

authors： Klein M,Colas L,Cheminant MA,Brosseau C,Sauzeau V,Magnan A,Bouchaud G

更新日期：2020-11-18 00:00:00

abstract：:Piscirickettsia salmonis, an aggressive intracellular pathogen, is the etiological agent of salmonid rickettsial septicemia (SRS). This is a chronic multisystemic disease that generates high mortalities and large losses in Chilean salmon farming, threatening the sustainability of the salmon industry. Previous reports ...

journal_title：Frontiers in immunology

authors： Pérez-Stuardo D,Espinoza A,Tapia S,Morales-Reyes J,Barrientos C,Vallejos-Vidal E,Sandino AM,Spencer E,Toro-Ascuy D,Rivas-Pardo JA,Reyes-López FE,Reyes-Cerpa S

更新日期：2020-11-12 00:00:00

abstract：:Extrapulmonary tuberculosis (EPTB) has become more common in recent years; however, the diagnosis of EPTB remains a challenge. In this study, we analyzed the performance of the ratio of TB-specific antigen (TBAg) to phytohemagglutinin (PHA) (TBAg/PHA ratio) in T-SPOT.TB (T-SPOT) assay for diagnosis and treatment monit...

journal_title：Frontiers in immunology

authors： Wang F,Yu J,Zhou Y,Luo Y,Wu S,Huang M,Yin B,Huang J,Mao L,Sun Z

更新日期：2018-05-14 00:00:00

abstract：:Proteinase 3 (PR3) is the autoantigen in granulomatosis with polyangiitis, an autoimmune necrotizing vasculitis associated with anti-neutrophil cytoplasmic antibodies (ANCAs). Moreover, PR3 is a serine protease whose membrane expression can potentiate inflammatory diseases such as ANCA-associated vasculitis and rheuma...

journal_title：Frontiers in immunology

authors： Tacnet-Delorme P,Gabillet J,Chatfield S,Thieblemont N,Frachet P,Witko-Sarsat V

更新日期：2018-04-25 00:00:00

abstract：:Current pain therapeutics offer inadequate relief to patients with chronic pain. A growing literature supports that pro-inflammatory cytokine signaling between immune, glial, and neural cells is integral to the development of pathological pain. Modulation of these communications may hold the key to improved pain manag...

journal_title：Frontiers in immunology

authors： Vanderwall AG,Milligan ED

更新日期：2019-12-23 00:00:00

abstract：:Immunoglobulin G (IgG), a glycoprotein secreted by plasma B-cells, plays a major role in the human adaptive immune response and are associated with a wide range of diseases. Glycosylation of the Fc binding region of IgGs, responsible for the antibody's effector function, is essential for prompting a proper immune resp...

journal_title：Frontiers in immunology

authors： Wahl A,van den Akker E,Klaric L,Štambuk J,Benedetti E,Plomp R,Razdorov G,Trbojević-Akmačić I,Deelen J,van Heemst D,Slagboom PE,Vučković F,Grallert H,Krumsiek J,Strauch K,Peters A,Meitinger T,Hayward C,Wuhrer M,Beekm

更新日期：2018-02-26 00:00:00

abstract：:Leprosy, a disease caused by the intracellular parasite Mycobacterium leprae or Mycobacterium lepromatosis, has affected humans for more than 4,000 years and is a stigmatized disease even now. Since clinical manifestations of leprosy patients present as an immune-related spectrum, leprosy is regarded as an ideal model...

journal_title：Frontiers in immunology

authors： Mi Z,Liu H,Zhang F

更新日期：2020-04-16 00:00:00

abstract：:High aspect ratio zinc oxide nanowires (ZnONWs) have become one of the most important products in nanotechnology. The wide range applications of ZnONWs have heightened the need for evaluating the risks and biological consequences to these particles. In this study, we investigated inflammatory pathways activated by ZnO...

journal_title：Frontiers in immunology

authors： Alghsham RS,Satpathy SR,Bodduluri SR,Hegde B,Jala VR,Twal W,Burlison JA,Sunkara M,Haribabu B

更新日期：2019-11-08 00:00:00

abstract：:Tumor necrosis factor receptor-associated factor (TRAF) proteins are key signaling molecules that function in various cellular signaling events including immune response, cell death and survival, development, and thrombosis. Their roles in cellular signaling are mediated mostly by direct interactions with various rece...

journal_title：Frontiers in immunology

authors： Park HH

更新日期：2018-08-30 00:00:00

abstract：:IgA binding to FcαRI (CD89) is rapidly enhanced by cytokine induced inside-out signaling. Dephosphorylation of serine 263 in the intracellular tail of FcαRI by PP2A and PI3K activation are instrumental in this process. To further investigate these signaling pathways, we targeted downstream kinases of PI3K. Our experim...

journal_title：Frontiers in immunology

authors： Ten Broeke T,Honing H,Brandsma AM,Jacobino S,Bakema JE,Kanters D,van der Linden JAM,Bracke M,Koenderman L,Leusen JHW

更新日期：2019-01-31 00:00:00

abstract：:The 5-year survival rate of primary anorectal malignant melanoma is less than 20%. Optimal treatment of this condition remains controversial regarding locally disease, and whether any preferential survival benefit arises from either abdominoperineal resection or wide local excision remains unknown. The majority of pat...

journal_title：Frontiers in immunology

authors： Faure M,Rochigneux P,Olive D,Taix S,Brenot-Rossi I,Gilabert M

更新日期：2018-04-19 00:00:00