Abstract:
:Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by erosive polyarthritis. Beyond joint pathology, RA is associated with neuropsychiatric comorbidity including depression, anxiety, and an increased risk to develop neurodegenerative diseases in later life. Studies investigating the central nervous system (CNS) in preclinical models of RA have leveraged the understanding of the intimate crosstalk between peripheral and central immune responses. This mini review summarizes the current knowledge of CNS comorbidity in RA patients and known underlying cellular mechanisms. We focus on the differential regulation of CNS myeloid and glial cells in different mouse models of RA reflecting different patterns of peripheral immune activation. Moreover, we address CNS responses to anti-inflammatory treatment in human RA patients and mice. Finally, to illustrate the bidirectional communication between the CNS and chronic peripheral inflammation, we present the current knowledge about the impact of the CNS on arthritis. A comprehensive understanding of the crosstalk between the CNS and chronic peripheral inflammation will help to identify RA patients at risk of developing CNS comorbidity, setting the path for future therapeutic approaches in both RA and neuropsychiatric diseases.
journal_name
Front Immunoljournal_title
Frontiers in immunologyauthors
Süß P,Rothe T,Hoffmann A,Schlachetzki JCM,Winkler Jdoi
10.3389/fimmu.2020.612104subject
Has Abstractpub_date
2020-12-10 00:00:00pages
612104issn
1664-3224journal_volume
11pub_type
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journal_title:Frontiers in immunology
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.3389/fimmu.2018.02736
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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abstract::The complement system plays critical roles in development, homeostasis, and regeneration in the central nervous system (CNS) throughout life; however, complement dysregulation in the CNS can lead to damage and disease. Complement proteins, regulators, and receptors are widely expressed throughout the CNS and, in many ...
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pub_type: 杂志文章
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更新日期:2018-05-22 00:00:00
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doi:10.3389/fimmu.2018.03149
更新日期:2019-01-14 00:00:00
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
doi:10.3389/fimmu.2018.01666
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