Anti-Transforming Growth Factor β IgG Elicits a Dual Effect on Calcium Oxalate Crystallization and Progressive Nephrocalcinosis-Related Chronic Kidney Disease.

abstract：:Immunoglobulin (Ig) replacement therapy dramatically changed the clinical course of primary hypogammaglobulinemias, significantly reducing the incidence of infectious events. Over the last two decades its use has been extended to secondary antibody deficiencies, particularly those related to hematological disorders as...

journal_title：Frontiers in immunology

authors： Compagno N,Malipiero G,Cinetto F,Agostini C

更新日期：2014-12-08 00:00:00

abstract：:Plasminogen activation is essential for fibrinolysis-the breakdown of fibrin polymers in blood clots. Besides this important function, plasminogen activation participates in a wide variety of inflammatory conditions. One of these conditions is hereditary angioedema (HAE), a rare disease with characteristic attacks of ...

journal_title：Frontiers in immunology

authors： Maas C

更新日期：2019-08-27 00:00:00

abstract：:Exposure to traumatic or infectious insults results in a rapid activation of the complement cascade as major fluid defense system of innate immunity. The complement system acts as a master alarm system during the molecular danger response after trauma and significantly contributes to the clearance of DAMPs and PAMPs. ...

journal_title：Frontiers in immunology

authors： Karasu E,Nilsson B,Köhl J,Lambris JD,Huber-Lang M

更新日期：2019-03-21 00:00:00

abstract：:Adults exposed to childhood maltreatment have increased stress reactivity. This profile is associated with dysregulation of the immune system, including enhanced inflammatory reactions and accelerated senescence. Subjects exposed to ear stress have increased risk for several age-related diseases, including cardiovascu...

journal_title：Frontiers in immunology

authors： Trintinaglia L,Bandinelli LP,Grassi-Oliveira R,Petersen LE,Anzolin M,Correa BL,Schuch JB,Bauer ME

更新日期：2018-07-16 00:00:00

abstract：:The advent of induced pluripotent stem cells (iPSCs) has begun to revolutionize cell therapy by providing a convenient source of rare cell types not normally available from patients in sufficient numbers for therapeutic purposes. In particular, the development of protocols for the differentiation of populations of leu...

journal_title：Frontiers in immunology

authors： Sachamitr P,Leishman AJ,Davies TJ,Fairchild PJ

更新日期：2018-01-08 00:00:00

abstract：:Influenza A viruses (IAVs) continue to pose major risks of morbidity and mortality during yearly epidemics and periodic pandemics. The genomic instability of IAV allows it to evade adaptive immune responses developed during prior infection. Of particular concern are pandemics which result from wholesale incorporation ...

journal_title：Frontiers in immunology

authors： Hsieh IN,De Luna X,White MR,Hartshorn KL

更新日期：2018-06-13 00:00:00

abstract：:Red blood cells (RBCs) have a well-defined lifespan, indicating a mechanism by which senescent cells of a certain age are removed from circulation. However, the specifics by which senescent cells are recognized and removed are poorly understood. There are multiple competing hypotheses for this process, perhaps the mos...

journal_title：Frontiers in immunology

authors： Hudson KE,de Wolski K,Kapp LM,Richards AL,Schniederjan MJ,Zimring JC

更新日期：2017-10-30 00:00:00

abstract：:Pulmonary edema, a major complication of lung injury and inflammation, is defined as accumulation of extravascular fluid in the lungs leading to impaired diffusion of respiratory gases. Lung fluid balance across the alveolar epithelial barrier protects the distal airspace from excess fluid accumulation and is mainly r...

journal_title：Frontiers in immunology

authors： Weidenfeld S,Kuebler WM

更新日期：2017-04-07 00:00:00

abstract：Purpose:In the elderly population, the influenza infection and its clinical complications are important causes of hospitalization and death, particularly, in longer-lived age. The objective of this study is to analyze the impact of influenza virus circulation on mortality in the elderly and adults, in years with differ...

journal_title：Frontiers in immunology

authors： Freitas ARR,Donalisio MR

更新日期：2018-01-08 00:00:00

abstract：:Acute infection of bovine viral diarrhea virus (BVDV) is associated with immune dysfunction and can cause peripheral blood lymphopenia and lymphocyte apoptosis. Our previous study has confirmed that programmed death-1 (PD-1) blockade inhibits peripheral blood lymphocyte (PBL) apoptosis and restores proliferation and a...

journal_title：Frontiers in immunology

authors： Liu Y,Liu S,Wu C,Huang W,Xu B,Lian S,Wang L,Yue S,Chen N,Zhu Z

更新日期：2020-03-17 00:00:00

abstract：:Chlamydia trachomatis (CT) is the most prevalent bacterial sexually transmitted infection in the world, with more than 100 million cases reported annually. While there have been extensive studies into the adverse effects that CT infection has on the female genital tract, and on the subsequent ability of these women to...

journal_title：Frontiers in immunology

authors： Redgrove KA,McLaughlin EA

更新日期：2014-10-27 00:00:00

abstract：:Differentiation of Natural Killer (NK) cells is a stepwise process having its origin in the bone marrow and proceeding in the periphery, where these cells follow organ specific trajectories. Several soluble factors and cytokines regulate the distinct stages of NK cell differentiation, and ultimately, their functional ...

journal_title：Frontiers in immunology

authors： Scarno G,Pietropaolo G,Di Censo C,Gadina M,Santoni A,Sciumè G

更新日期：2019-10-17 00:00:00

abstract：:T follicular helper (Tfh) cells are a subset of CD4 T cells that provide critical signals to antigen-primed B cells in germinal centers to undergo proliferation, isotype switching, and somatic hypermutation to generate long-lived plasma cells and memory B cells during an immune response. The quantity and quality of Tf...

journal_title：Frontiers in immunology

authors： Pallikkuth S,de Armas L,Rinaldi S,Pahwa S

更新日期：2017-10-23 00:00:00

abstract：:Neddylation is a type of post-translational protein modifications, in which neural precursor cell expressed developmentally downregulated protein 8 (NEDD8) is covalently conjugated to the lysine residues of target substrates. The best characterized principal substrates of neddylation are the cullin-RING ligases (CRLs)...

journal_title：Frontiers in immunology

authors： Yu G,Liu X,Tang J,Xu C,Ouyang G,Xiao W

更新日期：2019-06-25 00:00:00

abstract：:The unique capabilities of gamma-delta (γδ) T cells to recognize cells under stressed conditions, particularly infected or transformed cells, and killing them or regulating the immune response against them, paved the way to the development of promising therapeutic strategies for cancer and infectious diseases. From a ...

journal_title：Frontiers in immunology

authors： Simões AE,Di Lorenzo B,Silva-Santos B

更新日期：2018-04-27 00:00:00

abstract：:Behçet disease (BD) is an inflammatory systemic disease with a fluctuating course, which can affect the skin, eyes, central nervous system, musculoskeletal, gastrointestinal, and vascular systems. No laboratory tests are currently available for the diagnosis of BD and monitoring disease activity. Moreover there is a l...

journal_title：Frontiers in immunology

authors： Bonacini M,Soriano A,Zerbini A,Calò E,Cimino L,Muratore F,Fontana L,Braglia L,Parmeggiani M,Salvarani C,Croci S

更新日期：2018-09-25 00:00:00

abstract：:Psoriasis is a common inflammatory skin disease characterized by the appearance of red scaly plaques that can affect any part of the body. High prevalence, chronicity, disfiguration, disability, and associated comorbidity make it a challenge for clinicians of multiple specialties. Likewise, its complex pathogenesis, c...

journal_title：Frontiers in immunology

authors： Boehncke WH

更新日期：2018-04-05 00:00:00

abstract：:Recombinant Adenovirus (Ad) based vectors have been utilized extensively as a gene transfer platform in multiple pre-clinical and clinical applications. These applications are numerous, and inclusive of both gene therapy and vaccine based approaches to human or animal diseases. The widespread utilization of these vect...

journal_title：Frontiers in immunology

authors： Aldhamen YA,Seregin SS,Amalfitano A

更新日期：2011-09-06 00:00:00

abstract：:Due to limited sepsis patient cohort size and extreme heterogeneity, only one significant locus and suggestive associations at several independent loci were implicated by three genome-wide association studies. However, genes from such suggestive loci may also provide crucial information to unravel genetic mechanisms t...

journal_title：Frontiers in immunology

authors： Le KTT,Matzaraki V,Netea MG,Wijmenga C,Moser J,Kumar V

更新日期：2019-08-14 00:00:00

abstract：:It was recently reported that acute influenza infection of the lung promoted distal melanoma growth in the dermis of mice. Melanoma-specific CD8+ T cells were shunted to the lung in the presence of the infection, where they expressed high levels of inflammation-induced cell-activation blocker PD-1, and became incapabl...

journal_title：Frontiers in immunology

authors： Nikolaev EV,Zloza A,Sontag ED

更新日期：2019-01-28 00:00:00

abstract：:Monocytes that migrate into tissues during inflammatory episodes and differentiate to macrophages were previously classified as classically (M1) or alternatively (M2) activated macrophages, based on their exposure to different fate-determining mediators. These macrophage subsets display distinct molecular markers and ...

journal_title：Frontiers in immunology

authors： Ariel A,Serhan CN

更新日期：2012-01-31 00:00:00

abstract：:Chikungunya virus (CHIKV), a mosquito-borne Alphavirus, is endemic in different parts of the globe. The host macrophages are identified as the major cellular reservoirs of CHIKV during infection and this virus triggers robust TNF production in the host macrophages, which might be a key mediator of virus induced inflam...

journal_title：Frontiers in immunology

authors： Nayak TK,Mamidi P,Sahoo SS,Kumar PS,Mahish C,Chatterjee S,Subudhi BB,Chattopadhyay S,Chattopadhyay S

更新日期：2019-04-12 00:00:00

abstract：:Immunodominant T cell epitopes preferentially targeted in multiple individuals are the critical element of successful vaccines and targeted immunotherapies. However, the underlying principles of this "convergence" of adaptive immunity among different individuals remain poorly understood. To quantitatively describe epi...

journal_title：Frontiers in immunology

authors： Ogishi M,Yotsuyanagi H

更新日期：2019-04-16 00:00:00

abstract：:Disease suppressive T cell regulation may depend on cognate interactions of regulatory T cells with self-antigens that are abundantly expressed in the inflamed tissues. Heat shock proteins (HSPs) are by their nature upregulated in stressed cells and therefore abundantly present as potential targets for such regulation...

journal_title：Frontiers in immunology

authors： van Eden W,Jansen MAA,de Wolf ACM,Ludwig IS,Leufkens P,Broere F

更新日期：2017-11-30 00:00:00

abstract：:Natural killer (NK) cells are large granular lymphocytes involved in our defense against certain virus-infected and malignant cells. In contrast to T cells, NK cells elicit rapid anti-tumor responses based on signals from activating and inhibitory cell surface receptors. They also lyse target cells via antibody-depend...

journal_title：Frontiers in immunology

authors： Carlsten M,Järås M

更新日期：2019-10-11 00:00:00

abstract：:Innate immunity is one of the main protection mechanisms against viral infections, but how this system works at the maternal-fetal interface, especially during HIV infection, is still poorly known. In this study, we investigated the relationship between pregnancy and innate mechanisms associated with HIV immunity by e...

journal_title：Frontiers in immunology

authors： Pereira NZ,Branco ACCC,Manfrere KCG,de Lima JF,Yoshikawa FSY,Milanez HMBPM,Pereira NV,Sotto MN,Duarte AJDS,Sato MN

更新日期：2020-08-25 00:00:00

abstract：:The induction of donor-specific transplant tolerance is one of the main goals of modern immunology. Establishment of a mixed chimerism state in the transplant recipient has proven to be a suitable strategy for the induction of long-term allograft tolerance; however, current experimental recipient preconditioning proto...

journal_title：Frontiers in immunology

authors： Ruiz P,Maldonado P,Hidalgo Y,Sauma D,Rosemblatt M,Bono MR

更新日期：2015-11-23 00:00:00

abstract：:Regulatory B (Breg) cells represent a population of suppressor B cells that participate in immunomodulatory processes and inhibition of excessive inflammation. The regulatory function of Breg cells have been demonstrated in mice and human with inflammatory diseases, cancer, after transplantation, and particularly in a...

journal_title：Frontiers in immunology

authors： Ran Z,Yue-Bei L,Qiu-Ming Z,Huan Y

更新日期：2020-08-20 00:00:00

abstract：Objective:To examine the utility of the peripheral blood neutrophil-to-lymphocyte ratio (NLR) and monocyte-to-lymphocyte ratio (MLR) as biomarkers of prognosis in seropositive autoimmune encephalitis (AE). Methods:In this multicenter study, we retrospectively analyzed 57 cases of seropositive AE with hospital admissio...

journal_title：Frontiers in immunology

authors： Broadley J,Wesselingh R,Seneviratne U,Kyndt C,Beech P,Buzzard K,Nesbitt C,D'Souza W,Brodtmann A,Kalincik T,Butzkueven H,O'Brien TJ,Monif M,Australian Autoimmune Encephalitis Consortium.

更新日期：2021-01-14 00:00:00

abstract：:The VH replacement process is a RAG-mediated secondary recombination in which the variable region of a rearranged VHDJH is replaced by a different germline VH gene. In almost all human and mouse VH genes, two sequence features appear to be crucial for VH replacement. First, an embedded heptamer, which is located near ...

journal_title：Frontiers in immunology

authors： Sun Y,Liu Z,Li Z,Lian Z,Zhao Y

更新日期：2012-12-20 00:00:00