Immune Responses to the Sexual Stages of Plasmodium falciparum Parasites.

abstract：:Cancer neoantigens derived from random somatic mutations in tumor tissue represent an attractive type of targets for the cancer immunotherapies including cancer vaccine. Vaccination against the tumor-specific neoantigens minimizes the potential induction of central and peripheral tolerance as well as the risk of autoi...

journal_title：Frontiers in immunology

authors： Guo Y,Lei K,Tang L

更新日期：2018-07-02 00:00:00

abstract：:Polyunsaturated fatty acids (PUFAs) are important for immune function. Limited evidence indicates that immune cell activation involves endogenous PUFA synthesis, but this has not been characterised. To address this, we measured metabolism of 18:3n-3 in quiescent and activated peripheral blood mononuclear cells (PBMCs)...

journal_title：Frontiers in immunology

authors： Sibbons CM,Irvine NA,Pérez-Mojica JE,Calder PC,Lillycrop KA,Fielding BA,Burdge GC

更新日期：2018-03-05 00:00:00

abstract：:Alterations in the composition of the gut microbiota have profound effects on human health. Consequently, there is great interest in identifying, characterizing, and understanding factors that initiate these changes. Despite their high prevalence, studies have only recently begun to investigate how viral lung infectio...

journal_title：Frontiers in immunology

authors： Groves HT,Cuthbertson L,James P,Moffatt MF,Cox MJ,Tregoning JS

更新日期：2018-02-12 00:00:00

abstract：:Controversy over the frequency of human B1 cells in normal individuals has arisen as different labs have begun to employ non-uniform techniques to study this population. The phenotypic profile and relative paucity of circulating human B1 cells place constraints on methodology to identify and isolate this population. M...

journal_title：Frontiers in immunology

authors： Griffin DO,Rothstein TL

更新日期：2012-05-25 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fimmu.2019.00917.]. ...

journal_title：Frontiers in immunology

authors： Magcwebeba T,Dorhoi A,du Plessis N

更新日期：2019-07-02 00:00:00

abstract：:The cyclic AMP/protein kinase A (cAMP/PKA) pathway is one of the most common and versatile signal pathways in eukaryotic cells. A-kinase anchoring proteins (AKAPs) target PKA to specific substrates and distinct subcellular compartments providing spatial and temporal specificity for mediation of biological effects chan...

journal_title：Frontiers in immunology

authors： Wehbi VL,Taskén K

更新日期：2016-06-08 00:00:00

abstract：:Endometriosis is an estrogen-dependent disease with symptoms of dysmenorrhea, chronic pain, and infertility that affects 6-10% of women of reproductive age. Medical or surgical therapy, such as administration of an anti-gonadotropin or ovarian cystectomy, provide effective pain relief. However, neither therapy can be ...

journal_title：Frontiers in immunology

authors： Kato T,Yasuda K,Matsushita K,Ishii KJ,Hirota S,Yoshimoto T,Shibahara H

更新日期：2019-08-22 00:00:00

abstract：:Acute pancreatitis (AP) is a common and devastating inflammatory disorder of the pancreas. However, there are still no effective treatments available for the disease. Therefore, it is important to discover new therapeutic targets and strategies for better treatment and prognosis of AP patients. Toll-like receptor 3 (T...

journal_title：Frontiers in immunology

authors： Huang C,Chen S,Zhang T,Li D,Huang Z,Huang J,Qin Y,Chen B,Cheng G,Ma F,Zhou M

更新日期：2019-05-03 00:00:00

abstract：:IL-1β and IL-18 are pro-inflammatory cytokines that are linked to inflammation. Activation of the NOD-like receptor protein 3 (NLRP3) inflammasome is involved in the maturation and secretion of IL-1β and IL-18 and, thus, plays a key role in the pathogenesis of many inflammatory conditions, including multiple sclerosis...

journal_title：Frontiers in immunology

authors： Sánchez-Fernández A,Skouras DB,Dinarello CA,López-Vales R

更新日期：2019-11-01 00:00:00

abstract：:Cell migration is indispensable for various biological processes including angiogenesis, wound healing, and immunity. In general, there are two different migration modes described, the mesenchymal migration mode and the amoeboid migration mode. Neutrophils rapidly migrate toward the sites of injury, infection, and inf...

journal_title：Frontiers in immunology

authors： Salvermoser M,Begandt D,Alon R,Walzog B

更新日期：2018-11-16 00:00:00

abstract：:Hemolysis-associated anemia is characteristic of diseases such as atherosclerosis, lupus, malaria, and leishmaniasis; the toxic effects of free hemoglobin (Hb) have been extensively described. This study was based on the premise that release of this sequestered, inflammatory molecule can result in deleterious immunolo...

journal_title：Frontiers in immunology

authors： Jain S,Bose A,Bastia B,Sharma H,Sachdeva R,Jain AK,Pal R

更新日期：2017-06-26 00:00:00

abstract：:Most animals maintain mutually beneficial symbiotic relationships with their intestinal microbiota. Resident microbes in the gastrointestinal tract breakdown indigestible food, provide essential nutrients, and, act as a barrier against invading microbes, such as the enteric pathogen Vibrio cholerae. Over the last deca...

journal_title：Frontiers in immunology

authors： Davoodi S,Foley E

更新日期：2020-01-24 00:00:00

abstract：:Impaired immune reconstitution after allogeneic hematopoietic stem cell transplantation (HSCT) contributes to increased risk of cancer relapse and infection resulting in significant morbidity and mortality. Unfortunately, effective strategies to functionally assess the quality of immune reconstitution are still missin...

journal_title：Frontiers in immunology

authors： Pradier A,Masouridi-Levrat S,Bosshard C,Dantin C,Vu DL,Zanella MC,Boely E,Tapparel C,Kaiser L,Chalandon Y,Simonetta F,Roosnek E

更新日期：2020-05-27 00:00:00

abstract：:Dendritic cells (DCs) are central to the adoptive immune response, and their function is regulated by diverse signals in a context-specific manner. Different DCs have been described in physiologic conditions, inflammation, and cancer, prompting a series of questions on how adoptive immune responses, or tolerance, deve...

journal_title：Frontiers in immunology

authors： Palombo F,Focaccetti C,Barnaba V

更新日期：2014-01-06 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fimmu.2019.01135.]. ...

journal_title：Frontiers in immunology

authors： Ramirez GA,Rovere-Querini P,Blasi M,Sartorelli S,Di Chio MC,Baldini M,De Lorenzo R,Bozzolo EP,Leone R,Mantovani A,Manfredi AA,Tombetti E

更新日期：2019-07-24 00:00:00

abstract：:During the acute phase of Trypanosoma cruzi infection, macrophages can act as host cells for the parasites as well as effector cells in the early anti-parasitic immune response. Thus, the targeting of specific signaling pathways could modulate macrophages response to restrict parasite replication and instruct an appro...

journal_title：Frontiers in immunology

authors： Volpini X,Ambrosio LF,Fozzatti L,Insfran C,Stempin CC,Cervi L,Motran CC

更新日期：2018-04-23 00:00:00

abstract：:Dysregulation of macrophage has been demonstrated to contribute to aberrant immune responses and inflammatory diseases. CD11b, expressed on macrophages, plays a critical role in regulating pathogen recognition, phagocytosis, and cell survival. In the present study, we explored the effect of leukadherin-1 (LA1), an ago...

journal_title：Frontiers in immunology

authors： Yao X,Dong G,Zhu Y,Yan F,Zhang H,Ma Q,Fu X,Li X,Zhang Q,Zhang J,Shi H,Ning Z,Dai J,Li Z,Li C,Wang B,Ming J,Yang Y,Hong F,Meng X,Xiong H,Si C

更新日期：2019-02-12 00:00:00

abstract：:Though promoting remyelination in multiple sclerosis (MS) has emerged as a promising therapeutic strategy, it does not address inflammatory signals that continue to induce neuronal damage and inhibit effectiveness of repair mechanisms. Our lab has previously characterized the immunomodulatory tetrapeptide, tuftsin, wh...

journal_title：Frontiers in immunology

authors： Thompson KK,Nissen JC,Pretory A,Tsirka SE

更新日期：2018-11-28 00:00:00

abstract：:Obesity-induced chronic low-grade inflammation, in particular in adipose tissue, contributes to the development of insulin resistance and type 2 diabetes. However, the mechanism by which obesity induces adipose tissue inflammation has not been completely elucidated. Recent studies suggest that alteration of the nuclea...

journal_title：Frontiers in immunology

authors： Kim Y,Bayona PW,Kim M,Chang J,Hong S,Park Y,Budiman A,Kim YJ,Choi CY,Kim WS,Lee J,Cho KW

更新日期：2018-04-20 00:00:00

abstract：:Clematichinenoside AR (C-AR) is a triterpene saponin isolated from the root of Clematis manshurica Rupr., which is a herbal medicine used in traditional Chinese medicine for the treatment of arthritis. C-AR exerts anti-inflammatory and immunosuppressive properties, but little is known about its action in the suppressi...

journal_title：Frontiers in immunology

authors： Li Y,Zheng JY,Liu JQ,Yang J,Liu Y,Wang C,Ma XN,Liu BL,Xin GZ,Liu LF

更新日期：2016-12-07 00:00:00

abstract：:Phloretin (PT), isolated from the apple tree, was previously demonstrated to have antioxidative and anti-inflammatory effects in macrophages and anti-adiposity effects in adipocytes. Inflammatory immune cells generate high levels of reactive oxygen species (ROS) for stimulated severe airway hyperresponsiveness (AHR) a...

journal_title：Frontiers in immunology

authors： Huang WC,Fang LW,Liou CJ

更新日期：2017-02-13 00:00:00

abstract：:Severe combined immunodeficiency (SCID) and other severe non-SCID primary immunodeficiencies (non-SCID PID) can be treated by allogeneic hematopoietic stem cell (HSC) transplantation, but when histocompatibility leukocyte antigen-matched donors are lacking, this can be a high-risk procedure. Correcting the patient's o...

journal_title：Frontiers in immunology

authors： Ott de Bruin LM,Volpi S,Musunuru K

更新日期：2015-05-21 00:00:00

abstract：:There is accumulating evidence to indicate that long non-coding RNAs (lncRNAs) are important regulators of the inflammatory response. In this report, we have employed next generation sequencing to identify 14 lncRNAs that are differentially expressed in human lung fibroblasts following the induction of inflammation us...

journal_title：Frontiers in immunology

authors： Hadjicharalambous MR,Roux BT,Feghali-Bostwick CA,Murray LA,Clarke DL,Lindsay MA

更新日期：2018-12-11 00:00:00

abstract：:In dairy herds, mastitis caused by Staphylococcus aureus is difficult to completely cure on the account that S. aureus can invade bovine mammary epithelial cells (BMECs) and result in persistent infection in the mammary gland. Recent studies have demonstrated that autophagy can participate in cell homeostasis by elimi...

journal_title：Frontiers in immunology

authors： Geng N,Wang X,Yu X,Wang R,Zhu Y,Zhang M,Liu J,Liu Y

更新日期：2020-05-05 00:00:00

abstract：:Solid organ transplant recipients (SOTRs) are at increased risk for many infections, whether viral, bacterial, or fungal, due to immunosuppressive therapy to prevent organ rejection. The same immune defects that render transplanted patients susceptible to infection dampen their immune response to vaccination. Therefor...

journal_title：Frontiers in immunology

authors： Scanlon N,Saklawi Y,Rouphael N

更新日期：2020-11-25 00:00:00

abstract：:Tumors must evade the immune system to survive and metastasize, although the mechanisms that lead to tumor immunoediting and their evasion of immune surveillance are far from clear. The first line of defense against metastatic invasion is the innate immune system that provides immediate defense through humoral immunit...

journal_title：Frontiers in immunology

authors： Benito-Martin A,Di Giannatale A,Ceder S,Peinado H

更新日期：2015-02-24 00:00:00

abstract：:Bone is a highly dynamic organ that is continuously being remodeled by the reciprocal interactions between bone and immune cells. We have originally established an advanced imaging system for visualizing the in vivo behavior of osteoclasts and their precursors in the bone marrow cavity using two-photon microscopy. Usi...

journal_title：Frontiers in immunology

authors： Hasegawa T,Kikuta J,Ishii M

更新日期：2019-03-26 00:00:00

abstract：:Plasmodium vivax is the most geographically widespread and the dominant human malaria parasite in most countries outside of sub-Saharan Africa and, although it was classically recognized to cause benign infection, severe cases and deaths caused by P. vivax have remarkably been reported. In contrast to Plasmodium falci...

journal_title：Frontiers in immunology

authors： Totino PR,Lopes SC

更新日期：2017-09-20 00:00:00

abstract：:Neutrophil extracellular traps (NETs), DNA webs released into the extracellular environment by activated neutrophils, are thought to play a key role in the entrapment and eradication of microbes. However, NETs are highly cytotoxic and a likely source of autoantigens, suggesting that NET release is tightly regulated. N...

journal_title：Frontiers in immunology

authors： Majewski P,Majchrzak-Gorecka M,Grygier B,Skrzeczynska-Moncznik J,Osiecka O,Cichy J

更新日期：2016-06-30 00:00:00

abstract：:Colony-stimulating factor 1 (CSF1) and interleukin 34 (IL34) signal via the CSF1 receptor to regulate macrophage differentiation. Studies in IL34- or CSF1-deficient mice have revealed that IL34 function is limited to the central nervous system and skin during development. However, the roles of IL34 and CSF1 at homeost...

journal_title：Frontiers in immunology

authors： Lin W,Xu D,Austin CD,Caplazi P,Senger K,Sun Y,Jeet S,Young J,Delarosa D,Suto E,Huang Z,Zhang J,Yan D,Corzo C,Barck K,Rajan S,Looney C,Gandham V,Lesch J,Liang WC,Mai E,Ngu H,Ratti N,Chen Y,Misner D,Lin T

更新日期：2019-09-04 00:00:00