Elevated Expression of Serum Amyloid A 3 Protects Colon Epithelium Against Acute Injury Through TLR2-Dependent Induction of Neutrophil IL-22 Expression in a Mouse Model of Colitis.

abstract：:The induction of Th2 responses is thought to be multifactorial, and emerge from specific pathways distinct from those associated with antagonistic antibacterial or antiviral Th1 responses. Here, we show that the recognition of non-viable Nippostrongylus brasiliensis (Nb) in the skin induces a strong recruitment of mon...

journal_title：Frontiers in immunology

authors： Pellefigues C,Tang SC,Schmidt A,White RF,Lamiable O,Connor LM,Ruedl C,Dobrucki J,Le Gros G,Ronchese F

更新日期：2017-11-16 00:00:00

abstract：:Mast cells are immune cells of the myeloid lineage and are present in connective tissues throughout the body. The activation and degranulation of mast cells significantly modulates many aspects of physiological and pathological conditions in various settings. With respect to normal physiological functions, mast cells ...

journal_title：Frontiers in immunology

authors： Krystel-Whittemore M,Dileepan KN,Wood JG

更新日期：2016-01-06 00:00:00

abstract：:Neurological disorders caused by neuroviral infections are an obvious pathogenic manifestation. However, non-neurotropic viruses or peripheral viral infections pose a considerable challenge as their neuropathological manifestations do not emerge because of primary infection. Their secondary or bystander pathologies de...

journal_title：Frontiers in immunology

authors： Mishra R,Banerjea AC

更新日期：2020-09-10 00:00:00

abstract：:Probiotics such as Lactobacillus and Bifidobacterium have been successfully used to promote growth and prevent diseases. Previous reports have demonstrated that Bacillus subtilis (B. subtilis) was a potential probiotic for animals. In this research, 180 B. subtilis were isolated from the soil, identified, and investig...

journal_title：Frontiers in immunology

authors： Guo M,Wu F,Hao G,Qi Q,Li R,Li N,Wei L,Chai T

更新日期：2017-03-29 00:00:00

abstract：:Immunomodulation and chronic inflammation are important mechanisms utilized by cancer cells to evade the immune defense and promote tumor progression. Therefore, various efforts were focused on the development of approaches to reprogram the immune response to increase the immune detection of cancer cells and enhance p...

journal_title：Frontiers in immunology

authors： Hammoudeh SM,Venkatachalam T,Ansari AW,Bendardaf R,Hamid Q,Rahmani M,Hamoudi R

更新日期：2020-12-14 00:00:00

abstract：:Chimeric antigen receptor (CAR) therapy has been proved effective in a stream of clinical trials, especially in hematologic malignancies. However, current CAR therapy is highly personalized as cells used are derived from patients themselves, which can be costly, time-consuming, and sometimes fails to achieve optimal t...

journal_title：Frontiers in immunology

authors： Zhang Y,Li P,Fang H,Wang G,Zeng X

更新日期：2020-12-10 00:00:00

abstract：:Fighting external pathogens requires an ever-changing immune system that relies on tight regulation of gene expression. Transcriptional control is the first step to build efficient responses while preventing immunodeficiencies and autoimmunity. Post-transcriptional regulation of RNA editing, location, stability, and t...

journal_title：Frontiers in immunology

authors： Díaz-Muñoz MD,Turner M

更新日期：2018-05-23 00:00:00

abstract：:DT-13(25(R,S)-ruscogenin-1-O-[β-d-glucopyranosyl-(1→2)][β-d-xylopyranosyl-(1→3)]-β-d-fucopyranoside) has been identified as an important factor in TNF-α-induced vascular inflammation. However, the effect of DT-13 on TNF-α-induced endothelial permeability and the potential molecular mechanisms remain unclear. Hence, th...

journal_title：Frontiers in immunology

authors： Zhang Y,Han Y,Zhao Y,Lv Y,Hu Y,Tan Y,Bi X,Yu B,Kou J

更新日期：2017-08-14 00:00:00

abstract：:Heavy chain-only antibodies (HCAbs) do not associate with light chains and their VH regions are functional as single domains, forming the smallest active antibody fragment. These VH regions are ideal building blocks for a variety of antibody-based biologics because they tolerate fusion to other molecules and may also ...

journal_title：Frontiers in immunology

authors： Clarke SC,Ma B,Trinklein ND,Schellenberger U,Osborn MJ,Ouisse LH,Boudreau A,Davison LM,Harris KE,Ugamraj HS,Balasubramani A,Dang KH,Jorgensen B,Ogana HAN,Pham DT,Pratap PP,Sankaran P,Anegon I,van Schooten WC,Brüggem

更新日期：2019-01-07 00:00:00

abstract：:Construction of an optimal vaccine against tumors relies on the availability of appropriate tumor-specific antigens capable to stimulate CD4+ T helper cells (TH) and CD8+ cytolytic T cells (CTL). CTL are considered the major effectors of the anti-tumor adaptive immune response as they recognize antigens presented on M...

journal_title：Frontiers in immunology

authors： Accolla RS,Ramia E,Tedeschi A,Forlani G

更新日期：2019-07-30 00:00:00

abstract：:While rodent cancer models are essential for early proof-of-concept and mechanistic studies for immune therapies, these models have limitations with regards to predicting the ultimate effectiveness of new immunotherapies in humans. As a unique spontaneous, large animal model of cancer, the value of conducting studies ...

journal_title：Frontiers in immunology

authors： Dow S

更新日期：2020-01-17 00:00:00

abstract：:Human pathogen Campylobacter jejuni is a significant risk factor for the development of long-term intestinal dysfunction although the cellular and molecular mechanisms remain scantily defined. IL-23 is an emerging therapeutic target for the treatment of inflammatory intestinal diseases, however its role in C. jejuni-d...

journal_title：Frontiers in immunology

authors： Jing X,Korchagina AA,Shein SA,Muraoka WT,Koroleva E,Tumanov AV

更新日期：2021-01-06 00:00:00

abstract：:In human brucellosis, the liver is frequently affected. Brucella abortus triggers a profibrotic response on hepatic stellate cells (HSCs) characterized by inhibition of MMP-9 with concomitant collagen deposition and TGF-β1 secretion through type 4 secretion system (T4SS). Taking into account that it has been reported ...

journal_title：Frontiers in immunology

authors： Arriola Benitez PC,Pesce Viglietti AI,Gomes MTR,Oliveira SC,Quarleri JF,Giambartolomei GH,Delpino MV

更新日期：2020-01-21 00:00:00

abstract：:Delivery of high doses of radiation to thoracic region, particularly with non-small cell lung cancer patients, becomes difficult due to subsequent complications arising in the lungs of the patient. Radiation-induced pneumonitis is an early event evident in most radiation exposed patients observed within 2-4 months of ...

journal_title：Frontiers in immunology

authors： Kainthola A,Haritwal T,Tiwari M,Gupta N,Parvez S,Tiwari M,Prakash H,Agrawala PK

更新日期：2017-05-02 00:00:00

abstract：:The VH replacement process is a RAG-mediated secondary recombination in which the variable region of a rearranged VHDJH is replaced by a different germline VH gene. In almost all human and mouse VH genes, two sequence features appear to be crucial for VH replacement. First, an embedded heptamer, which is located near ...

journal_title：Frontiers in immunology

authors： Sun Y,Liu Z,Li Z,Lian Z,Zhao Y

更新日期：2012-12-20 00:00:00

abstract：:Polyunsaturated fatty acids (PUFAs) are important for immune function. Limited evidence indicates that immune cell activation involves endogenous PUFA synthesis, but this has not been characterised. To address this, we measured metabolism of 18:3n-3 in quiescent and activated peripheral blood mononuclear cells (PBMCs)...

journal_title：Frontiers in immunology

authors： Sibbons CM,Irvine NA,Pérez-Mojica JE,Calder PC,Lillycrop KA,Fielding BA,Burdge GC

更新日期：2018-03-05 00:00:00

abstract：:Toll-like receptor 9 (TLR9) belongs to the group of endosomal receptors of the innate immune system with the ability to recognize hypomethylated CpG sequences from DNA. There is scarce information about TLR9 expression and its association with the circadian cycle (CC). Different patterns of TLR9 expression are regulat...

journal_title：Frontiers in immunology

authors： Martínez-García EA,Zavala-Cerna MG,Lujano-Benítez AV,Sánchez-Hernández PE,Martín-Márquez BT,Sandoval-García F,Vázquez-Del Mercado M

更新日期：2018-07-06 00:00:00

abstract：:Toll-like receptors (TLR) triggering of B cells are known to promote B cell expansion, differentiation of B cells into antibody-producing and memory cells, but the TLR responses of porcine B cells is poorly characterized. Therefore, this study investigated the response pattern of porcine B cell subsets to a large coll...

journal_title：Frontiers in immunology

authors： Braun RO,Python S,Summerfield A

更新日期：2017-08-25 00:00:00

abstract：:Controversy over the frequency of human B1 cells in normal individuals has arisen as different labs have begun to employ non-uniform techniques to study this population. The phenotypic profile and relative paucity of circulating human B1 cells place constraints on methodology to identify and isolate this population. M...

journal_title：Frontiers in immunology

authors： Griffin DO,Rothstein TL

更新日期：2012-05-25 00:00:00

abstract：:Monocyte differentiation to macrophages is triggered by migration across the endothelial barrier, which is constituted by both endothelial cells and their underlying basement membrane. We address here the role of the endothelial basement membrane laminins (laminins 411 and 511) in this monocyte to macrophage switch. C...

journal_title：Frontiers in immunology

authors： Li L,Song J,Chuquisana O,Hannocks MJ,Loismann S,Vogl T,Roth J,Hallmann R,Sorokin L

更新日期：2020-10-30 00:00:00

abstract：:In the current quest for a complete cure for HIV/AIDS, highly sensitive HIV-1 latency detection methods are critical to verify full viral eradication. Until now, the in vitro quantitative viral outgrowth assays (qVOA) have been the gold standard for assessing latent HIV-1 viral burden. However, these assays have been ...

journal_title：Frontiers in immunology

authors： Schmitt K,Akkina R

更新日期：2018-03-05 00:00:00

abstract：:Iron is a trace element, essential to support life due to its inherent ability to exchange electrons with a variety of molecules. The use of iron as a cofactor in basic metabolic pathways is essential to both pathogenic microorganisms and their hosts. During evolution, the shared requirement of micro- and macro-organi...

journal_title：Frontiers in immunology

authors： Tarifeño-Saldivia E,Aguilar A,Contreras D,Mercado L,Morales-Lange B,Márquez K,Henríquez A,Riquelme-Vidal C,Boltana S

更新日期：2018-06-05 00:00:00

abstract：:The task of epitope discovery and vaccine design is increasingly reliant on bioinformatics analytic tools and access to depositories of curated data relevant to immune reactions and specific pathogens. The Immune Epitope Database and Analysis Resource (IEDB) was indeed created to assist biomedical researchers in the d...

journal_title：Frontiers in immunology

authors： Fleri W,Paul S,Dhanda SK,Mahajan S,Xu X,Peters B,Sette A

更新日期：2017-03-14 00:00:00

abstract：:Sepsis is one of the well-established diseases with specific patterns of neutrophil dysfunctions. Previous studies demonstrated sepsis-related neutrophil dysfunctions in comparison with subjects without infection. Since sepsis and infection are recently recognized as distinctive processes, whether these neutrophil dys...

journal_title：Frontiers in immunology

authors： Seree-Aphinan C,Vichitkunakorn P,Navakanitworakul R,Khwannimit B

更新日期：2020-12-23 00:00:00

abstract：:Vγ9Vδ2-T cells are considered as potent effector cells for tumor immunotherapy through directly killing tumor cells and indirectly regulating other innate and adaptive immune cells to establish antitumoral immunity. The antitumoral activity of Vγ9Vδ2-T cells is governed by a complicated set of activating and inhibitor...

journal_title：Frontiers in immunology

authors： Xiang Z,Tu W

更新日期：2017-08-28 00:00:00

abstract：:Cross-presentation of endocytosed antigen as peptide/class I major histocompatibility complex complexes plays a central role in the elicitation of CD8(+) T cell clones that mediate anti-viral and anti-tumor immune responses. While it has been clear that there are specific subsets of professional antigen presenting cel...

journal_title：Frontiers in immunology

authors： Compeer EB,Flinsenberg TW,van der Grein SG,Boes M

更新日期：2012-03-07 00:00:00

abstract：:M2 macrophage (Mφ) promotes pathologic angiogenesis through a release of pro-angiogenic mediators or the direct cell-cell interaction with endothelium in the micromilieu of several chronic inflammatory diseases, including rheumatoid arthritis and cancer, where interleukin (IL)-18 also contributes to excessive angiogen...

journal_title：Frontiers in immunology

authors： Kobori T,Hamasaki S,Kitaura A,Yamazaki Y,Nishinaka T,Niwa A,Nakao S,Wake H,Mori S,Yoshino T,Nishibori M,Takahashi H

更新日期：2018-03-06 00:00:00

abstract：:Intravesical instillation of bacillus Calmette-Guérin (BCG) is used to treat superficial bladder cancer, either papillary tumors (after transurethral resection) or high-grade flat carcinomas (carcinoma in situ), reducing recurrence in about 70% of patients. Initially, BCG was proposed to work through an inflammatory r...

journal_title：Frontiers in immunology

authors： García-Cuesta EM,López-Cobo S,Álvarez-Maestro M,Esteso G,Romera-Cárdenas G,Rey M,Cassady-Cain RL,Linares A,Valés-Gómez A,Reyburn HT,Martínez-Piñeiro L,Valés-Gómez M

更新日期：2015-06-08 00:00:00

abstract：:Psoriasis is a common inflammatory skin disease characterized by the appearance of red scaly plaques that can affect any part of the body. High prevalence, chronicity, disfiguration, disability, and associated comorbidity make it a challenge for clinicians of multiple specialties. Likewise, its complex pathogenesis, c...

journal_title：Frontiers in immunology

authors： Boehncke WH

更新日期：2018-04-05 00:00:00

abstract：:Mucosal-associated Invariant T (MAIT) cells recognize vitamin B-based antigens presented by the non-polymorphic MHC class I related-1 molecule (MR1). Both MAIT T cell receptors (TCR) and MR1 are highly conserved among mammals, suggesting an important, and conserved, immune function. For many years, the antigens they r...

journal_title：Frontiers in immunology

authors： Corbett AJ,Awad W,Wang H,Chen Z

更新日期：2020-08-27 00:00:00