MMP-9/Gelatinase B Degrades Immune Complexes in Systemic Lupus Erythematosus.

abstract：:The role of macrophages during regeneration in zebrafish has been well-documented. Nevertheless, new evidence indicates that zebrafish macrophages are a heterogeneous population of cells, and that they can play different roles during immune responses and in tissue restoration after damage and infection. In this work, ...

journal_title：Frontiers in immunology

authors： Morales RA,Allende ML

更新日期：2019-02-15 00:00:00

abstract：:Chronic hepatitis B virus (HBV) infection is a major global health burden affecting around 257 million people worldwide. The consequences of chronic HBV infection include progressive liver damage, liver cirrhosis, and hepatocellular carcinoma. Although current direct antiviral therapies successfully lead to suppressio...

journal_title：Frontiers in immunology

authors： Heim K,Neumann-Haefelin C,Thimme R,Hofmann M

更新日期：2019-09-20 00:00:00

abstract：:A major obstacle in kidney transplantation for primary focal segmental glomerulosclerosis (FSGS) is the risk of disease recurrence. Recurrent FSGS affects up to 60% of first kidney grafts and exceeds 80% in patients who have lost their first graft due to recurrent FSGS. Clinical and experimental evidence support the h...

journal_title：Frontiers in immunology

authors： Kienzl-Wagner K,Waldegger S,Schneeberger S

更新日期：2019-07-17 00:00:00

abstract：:Natural killer (NK) cells contribute to immunosurveillance and first-line defense in the control of tumor growth and metastasis diffusion. NK-cell-derived extracellular vesicles (NKEVs) are constitutively secreted and biologically active. They reflect the protein and genetic repertoire of originating cells, and exert ...

journal_title：Frontiers in immunology

authors： Federici C,Shahaj E,Cecchetti S,Camerini S,Casella M,Iessi E,Camisaschi C,Paolino G,Calvieri S,Ferro S,Cova A,Squarcina P,Bertuccini L,Iosi F,Huber V,Lugini L

更新日期：2020-03-13 00:00:00

abstract：:IL-1β plays a crucial role in the differentiation of human Th17 cells. We report here that IL-1RI expression is significantly increased in both naive and memory CD4+ T cells derived from relapsing-remitting multiple sclerosis (RR MS) patients in comparison to healthy controls. Interleukin 1 receptor (IL-1R)I expressio...

journal_title：Frontiers in immunology

authors： Sha Y,Markovic-Plese S

更新日期：2016-11-29 00:00:00

abstract：:Mucosal epithelia encounter both physicochemical and biological stress during their life and have evolved several mechanisms to deal with them, including regulation of immune cell functions. Stressed and damaged cells need to be cleared to control local inflammation and trigger tissue healing. Engagement of the activa...

journal_title：Frontiers in immunology

authors： Antonangeli F,Soriani A,Cerboni C,Sciumè G,Santoni A

更新日期：2017-11-20 00:00:00

abstract：:Re-directing T cells via chimeric antigen receptors (CARs) was first tested in HIV-infected individuals with limited success, but these pioneering studies laid the groundwork for the clinically successful CD19 CARs that were recently FDA approved. Now there is great interest in revisiting the concept of using CAR-expr...

journal_title：Frontiers in immunology

authors： Kim GB,Hege K,Riley JL

更新日期：2019-09-27 00:00:00

abstract：Purpose:Patients with juvenile idiopathic arthritis (JIA) are prone to developing chronic anterior uveitis (JIA-U+). Although several risk factors for JIA-U+ have been identified, the underlying etiology is poorly understood. Histopathological studies demonstrate B cell infiltrates in eye tissues of patients with JIA-U...

journal_title：Frontiers in immunology

authors： Wennink RAW,Pandit A,Haasnoot AJW,Hiddingh S,Kalinina Ayuso V,Wulffraat NM,Vastert BJ,Radstake TRDJ,de Boer JH,Kuiper JJW

更新日期：2020-09-17 00:00:00

abstract：:Myeloid-derived suppressor cells (MDSC) are a heterogeneous group of immune cells from the myeloid lineage. MDSCs expand in pathological situations, such as chronic infection, cancer, autoimmunity, and allograft rejection. As chronic lung allograft dysfunction (CLAD) limits long-term survival after lung transplantatio...

journal_title：Frontiers in immunology

authors： Heigl T,Singh A,Saez-Gimenez B,Kaes J,Van Herck A,Sacreas A,Beeckmans H,Vanstapel A,Verleden SE,Van Raemdonck DE,Verleden G,Vanaudenaerde BM,Hartl D,Vos R

更新日期：2019-04-26 00:00:00

abstract：:Human Campylobacter infections are progressively rising and of high socioeconomic impact. In the present preclinical intervention study we investigated anti-pathogenic, immuno-modulatory, and intestinal epithelial barrier preserving properties of vitamin D applying an acute campylobacteriosis model. Therefore, seconda...

journal_title：Frontiers in immunology

authors： Mousavi S,Lobo de Sá FD,Schulzke JD,Bücker R,Bereswill S,Heimesaat MM

更新日期：2019-09-03 00:00:00

abstract：:Vaccines aiming to promote T-cell-mediated immune responses have so far showed limited efficacy, and there is a need for novel strategies. Studies indicate that autophagy plays an inherent role in antigen processing and presentation for CD4(+) and CD8(+) T cells. Here, we report a novel vaccine strategy based on fusio...

journal_title：Frontiers in immunology

authors： Andersen AN,Landsverk OJ,Simonsen A,Bogen B,Corthay A,Øynebråten I

更新日期：2016-05-10 00:00:00

abstract：:The lungs, a special site that is frequently challenged by tumors, pathogens and other environmental insults, are populated by large numbers of innate immune cells. Among these, natural killer (NK) cells are gaining increasing attention. Recent studies have revealed that NK cells are heterogeneous populations consisti...

journal_title：Frontiers in immunology

authors： Cong J,Wei H

更新日期：2019-06-25 00:00:00

abstract：:Bone is a highly dynamic organ that is continuously being remodeled by the reciprocal interactions between bone and immune cells. We have originally established an advanced imaging system for visualizing the in vivo behavior of osteoclasts and their precursors in the bone marrow cavity using two-photon microscopy. Usi...

journal_title：Frontiers in immunology

authors： Hasegawa T,Kikuta J,Ishii M

更新日期：2019-03-26 00:00:00

abstract：:Inflammatory bowel disease (IBD) is a chronic and relapsing intestinal inflammatory condition with no effective treatment. Probiotics have gained wide attention because of their outstanding advantages in intestinal health issues. In previous studies, a novel soluble protein, HM0539, which is derived from Lactobacillus...

journal_title：Frontiers in immunology

authors： Li Y,Yang S,Lun J,Gao J,Gao X,Gong Z,Wan Y,He X,Cao H

更新日期：2020-10-05 00:00:00

abstract：:Ageing, like obesity, is often associated with alterations in metabolic and inflammatory processes resulting in morbidity from diseases characterised by poor metabolic control, insulin insensitivity, and inflammation. Ageing populations also exhibit a decline in immune competence referred to as immunosenescence, which...

journal_title：Frontiers in immunology

authors： Trim W,Turner JE,Thompson D

更新日期：2018-02-09 00:00:00

abstract：:For many years, disappointing results have been generated by many investigations, which have utilized a variety of immunologic strategies to enhance the ability of a patient's immune system to recognize and eliminate malignant cells. However, in recent years, immunotherapy has been used successfully for the treatment ...

journal_title：Frontiers in immunology

authors： Caratelli S,Sconocchia T,Arriga R,Coppola A,Lanzilli G,Lauro D,Venditti A,Del Principe MI,Buccisano F,Maurillo L,Ferrone S,Sconocchia G

更新日期：2017-04-27 00:00:00

abstract：:Functional cross-talk between osteoblasts and osteoclasts is a key process for bone homeostasis. Although osteoblast hypoxia-inducible factor-1α (HIF-1α) pathway activation results in impaired osteoclastogenesis via the direct regulation of osteoprotegerin (OPG), it is unclear whether there are other efficient mediato...

journal_title：Frontiers in immunology

authors： Kang H,Yang K,Xiao L,Guo L,Guo C,Yan Y,Qi J,Wang F,Ryffel B,Li C,Deng L

更新日期：2017-10-16 00:00:00

abstract：:Extracellular vesicles (EVs) are increasingly recognized as important mediators of intercellular communication. In this study, we aimed to further characterize the role of macrophage-derived EVs in immune responses against hepatitis C virus (HCV) and the potential of polyunsaturated fatty acids (PUFAs) to modulate thi...

journal_title：Frontiers in immunology

authors： Cai C,Koch B,Morikawa K,Suda G,Sakamoto N,Rueschenbaum S,Akhras S,Dietz J,Hildt E,Zeuzem S,Welsch C,Lange CM

更新日期：2018-04-12 00:00:00

abstract：:Recently, a second individual (the "London patient") with HIV-1 infection and concomitant leukemia was cured of both diseases by a conditioning myeloablative regimen followed by transplantation of stem cells bearing the homozygous CCR5 Δ32 mutation. The substantial risks and cost associated with this procedure render ...

journal_title：Frontiers in immunology

authors： Gavegnano C,Savarino A,Owanikoko T,Marconi VC

更新日期：2019-10-04 00:00:00

abstract：:Mast cells are immune cells of the myeloid lineage and are present in connective tissues throughout the body. The activation and degranulation of mast cells significantly modulates many aspects of physiological and pathological conditions in various settings. With respect to normal physiological functions, mast cells ...

journal_title：Frontiers in immunology

authors： Krystel-Whittemore M,Dileepan KN,Wood JG

更新日期：2016-01-06 00:00:00

abstract：:Influenza A virus (IAV) remains a significant global health issue causing annual epidemics, pandemics, and sporadic human infections with highly pathogenic avian or swine influenza viruses. Current inactivated and live vaccines are the mainstay of the public health response to influenza, although vaccine efficacy is l...

journal_title：Frontiers in immunology

authors： Sridhar S

更新日期：2016-05-19 00:00:00

abstract：:Experimental animal models of tuberculosis (TB) have convincingly demonstrated that inhaled dose predicts immunopathology and survival. In contrast, the importance of inhaled dose has generally not been appreciated in TB epidemiology, clinical science, or the practice of TB control. Infectiousness of TB patients has t...

journal_title：Frontiers in immunology

authors： Fennelly KP,Jones-López EC

更新日期：2015-06-29 00:00:00

abstract：:In recent years, chimeric antigen receptor (CAR) T-cell therapy has become popular in immunotherapy, particularly after its tremendous success in the treatment of lineage-restricted hematologic cancers. However, the application of CAR T-cell therapy for solid tumors has not reached its full potential because of the la...

journal_title：Frontiers in immunology

authors： Wang Y,Luo F,Yang J,Zhao C,Chu Y

更新日期：2017-12-22 00:00:00

abstract：:Many a disease associates with inflammation. Upon binding of antigen-antibody complexes to immunoglobulin-like receptors, mast cells release tumor necrosis factor-α and proteases, causing fibroblasts to release endogenous antigens that may be cross reactive with exogenous antigens. We made a predictive dynamic map of ...

journal_title：Frontiers in immunology

authors： Abudukelimu A,Barberis M,Redegeld FA,Sahin N,Westerhoff HV

更新日期：2018-08-07 00:00:00

abstract：:Functional impairment of T-cells and a concomitant augmented expression of programmed death-1 (PD-1) have been observed in visceral leishmaniasis patients, as well as in experimental models for visceral and cutaneous leishmaniasis. The PD-1/PD-1-ligand (PD-1/PD-L) interaction negatively regulates T-cell effector funct...

journal_title：Frontiers in immunology

authors： Filippis C,Arens K,Noubissi Nzeteu GA,Reichmann G,Waibler Z,Crauwels P,van Zandbergen G

更新日期：2017-12-22 00:00:00

abstract：:In addition to physical barriers, neutrophils are considered a part of the first line of immune defense. They can be found in the bloodstream, with a lifespan of 6-8 h, and in tissue, where they can last up to 7 days. The mechanisms that neutrophils utilize for host defense are phagocytosis, degranulation, cytokine pr...

journal_title：Frontiers in immunology

authors： Delgado-Rizo V,Martínez-Guzmán MA,Iñiguez-Gutierrez L,García-Orozco A,Alvarado-Navarro A,Fafutis-Morris M

更新日期：2017-02-06 00:00:00

abstract：:T follicular helper CD4 cells (Tfh) are essential for the development and maintenance of germinal center (GC) reactions, a critical process that promotes the generation of long-lived high affinity humoral immunity. It is becoming increasingly evident that GC-Tfh cells are heterogeneous in nature with some cellular cha...

journal_title：Frontiers in immunology

authors： Velu V,Mylvaganam G,Ibegbu C,Amara RR

更新日期：2018-06-06 00:00:00

abstract：:It is now clear that the outcome of an inflammatory process caused by infections depends on the balance of responses by several components of the immune system. Of particular relevance is the interplay between regulatory T cells (Tregs) and CD4+ T cells that produce IL-17 (Th17 cells) during immunoinflammatory events....

journal_title：Frontiers in immunology

authors： Sehrawat S,Rouse BT

更新日期：2017-04-03 00:00:00

abstract：:Antibodies are commonly used in organ transplant induction therapy and to treat autoimmune disorders. The effects of some biologics on the human immune system remain incompletely characterized and a deeper understanding of their mechanisms of action may provide useful insights for their clinical application. The goal ...

journal_title：Frontiers in immunology

authors： Binder C,Sellberg F,Cvetkovski F,Berglund E,Berglund D

更新日期：2020-11-11 00:00:00

abstract：:Objectives: Considering the critical role of microRNAs (miRNAs) in regulation of cell activation, we investigated their role in circulating type-2 conventional dendritic cells (cDC2s) of patients with primary Sjögren's syndrome (pSS) compared to healthy controls (HC). Methods: CD1c-expressing cDC2s were isolated from ...

journal_title：Frontiers in immunology

authors： Lopes AP,van Roon JAG,Blokland SLM,Wang M,Chouri E,Hartgring SAY,van der Wurff-Jacobs KMG,Kruize AA,Burgering BMT,Rossato M,Radstake TRDJ,Hillen MR

更新日期：2019-06-20 00:00:00