Abstract:
:Latent Epstein-Barr virus (EBV) infection can clinically reactivate in immunosuppressed individuals causing lymphoproliferative disease and rarely hepatitis. In this study, we provide in vivo and in vitro evidence that Treponema pallidum infection can cause EBV reactivation with hepatitis in an immunocompetent patient. We report the diagnostic challenges and immunological findings of coinciding syphilis and EBV-associated hepatitis. Using an in vitro EBV-reactivation assay, we demonstrate that T pallidum reactivates latent EBV in a Toll-like receptor (TLR)2/B-cell receptor signaling-dependent manner. Epstein-Barr virus-associated reactivation or lymphoproliferation should be considered in infections with pathogens that activate TLR2.
journal_name
Open Forum Infect Disjournal_title
Open forum infectious diseasesauthors
Hirsiger JR,Fuchs PS,Häusermann P,Müller-Durovic B,Daikeler T,Recher M,Hirsch HH,Terracciano L,Berger CTdoi
10.1093/ofid/ofz317subject
Has Abstractpub_date
2019-07-03 00:00:00pages
ofz317issue
9issn
2328-8957pii
ofz317journal_volume
6pub_type
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