Is It Actionable? An Evaluation of the Rapid PCR-Based Blood Culture Identification Panel on the Management of Gram-Positive and Gram-Negative Blood Stream Infections.


Background:There is growing interest in the use of rapid blood culture identification (BCID) in antimicrobial stewardship programs (ASPs). Although many studies have looked at its clinical and economic utility, its comparative utility in gram-positive and gram-negative blood stream infections (BSIs) has not been as well characterized. Methods:The study was a quasi-experimental retrospective study at the Mayo Clinic in Phoenix, Arizona. All adult patients with positive blood cultures before BCID implementation (June 2015 to December 2015) and after BCID implementation (June 2016 to December 2016) were included. The outcomes of interest included time to first appropriate antibiotic escalation, time to first appropriate antibiotic de-escalation, time to organism identification, length of stay, infectious diseases consultation, discharge disposition, and in-hospital mortality. Results:In total, 203 patients were included in this study. There was a significant difference in the time to organism identification between the pre- and post-BCID cohorts (27.1 hours vs 3.3 hours, P < .0001). BCID did not significantly reduce the time to first appropriate antimicrobial escalation or de-escalation for either gram-positive BSIs (GP-BSIs) or gram-negative BSIs (GN-BSIs). Providers were more likely to escalate antimicrobial therapy in GP-BSIs after gram stain and more likely to de-escalate therapy in GN-BSIs after susceptibilities. Although there were no significant differences in changes in antimicrobial therapy for organism identification by BCID vs traditional methods, more than one-quarter of providers (28.1%) made changes after organism identification. There were no differences in hospital length of stay or in-hospital mortality comparing pre- vs post-BCID. Conclusions:Although BCID significantly reduced the time to identification for both GP-BSIs and GN-BSIs, BCID did not reduce the time to first appropriate antimicrobial escalation and de-escalation.


Open Forum Infect Dis


Tseng AS,Kasule SN,Rice F,Mi L,Chan L,Seville MT,Grys TE




Has Abstract


2018-12-11 00:00:00












  • Liver Fibrosis Regression Measured by Transient Elastography in Human Immunodeficiency Virus (HIV)-Hepatitis B Virus (HBV)-Coinfected Individuals on Long-Term HBV-Active Combination Antiretroviral Therapy.

    abstract::Background.  Advanced fibrosis occurs more commonly in human immunodeficiency virus (HIV)-hepatitis B virus (HBV) coinfected individuals; therefore, fibrosis monitoring is important in this population. However, transient elastography (TE) data in HIV-HBV coinfection are lacking. We aimed to assess liver fibrosis using...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Audsley J,Robson C,Aitchison S,Matthews GV,Iser D,Sasadeusz J,Lewin SR

    更新日期:2016-02-12 00:00:00

  • Trends in Kindergarten Rates of Vaccine Exemption and State-Level Policy, 2011-2016.

    abstract:Background:Kindergarten-entry vaccination requirements have played an important role in controlling vaccine-preventable diseases in the United States. Forty-eight states and the District of Colombia offer nonmedical exemptions to vaccines, ranging in stringency. Methods:We analyzed state-level exemption data from 2011...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Omer SB,Porter RM,Allen K,Salmon DA,Bednarczyk RA

    更新日期:2017-11-15 00:00:00

  • Prevalence of Cryptococcal Antigen and Outcomes in People With Human Immunodeficiency Virus in Honduras: A Cohort Study.

    abstract:Background:Cryptococcal meningitis is a major cause of death among people with human immunodeficiency virus (PWH). Cryptococcal antigen (CrAg) testing of asymptomatic patients is an important public health measure to reduce mortality in high-incidence areas. However, limited data exist on CrAg prevalence in Central Ame...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Zuniga-Moya JC,Romero-Reyes LE,Saavedra EB,Montoya S,Varela D,Borjas M,Cerna A,Bejarano S,Martinez P,Lujan K,Erazo K,Lainez I,Pineda L,Yanes D,O'Halloran JA,Spec A

    更新日期:2020-11-13 00:00:00

  • Blood Culture-Negative Cardiovascular Infection in a Patient With Multiple Sclerosis.

    abstract::A patient with multiple sclerosis presented with seronegative C. burnetii endocarditis diagnosed using C. burnetii-specific polymerase chain reaction and fluorescence in situ hybridization on cardiovascular biopsy. This case supports the necessity of a systematic polymerase chain reaction testing of removed cardiac va...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Melenotte C,Loukil A,Rico A,Lepidi H,Raoult D

    更新日期:2019-10-04 00:00:00

  • A Clinical Prediction Score Including Trial of Antibiotics and C-Reactive Protein to Improve the Diagnosis of Tuberculosis in Ambulatory People With HIV.

    abstract:Background:The use of a "trial of antibiotics" as empiric therapy for bacterial pneumonia as a diagnostic tool for tuberculosis in people with HIV (PWH) was removed from World Health Organization (WHO) recommendations in 2007, based on expert opinion. Current guidelines recommend antibiotics only after 2 Xpert MTB/RIF ...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Boyles TH,Nduna M,Pitsi T,Scott L,Fox MP,Maartens G

    更新日期:2020-01-06 00:00:00

  • Perioperative Bacterial Contamination From Patients on Contact Precaution in Operating Room Environment.

    abstract::We investigated the microbial burden on the operating room environment when patients on contact precautions for a multidrug-resistant pathogen received surgery. Our study demonstrated that the perioperative environment was contaminated with aerobic bacteria and methicillin-resistant Staphylococcus aureus (MRSA) after ...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Kanamori H,Rutala WA,Gergen MF,Weber DJ

    更新日期:2020-10-27 00:00:00

  • A Recent Human Immunodeficiency Virus Outbreak Among People Who Inject Drugs in Munich, Germany, Is Associated With Consumption of Synthetic Cathinones.

    abstract:Background:Needle and syringe sharing among people who inject drugs (PWID) can result in a rapid regional spread of a human immunodeficiency virus (HIV) variant. Such outbreaks have been identified recently in several countries and have raised public health attention because of an association with new psychoactive subs...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Hanke K,Fiedler S,Grumann C,Ratmann O,Hauser A,Klink P,Meixenberger K,Altmann B,Zimmermann R,Marcus U,Bremer V,Auwärter V,Bannert N

    更新日期:2020-05-27 00:00:00

  • HIV Testing After a First Positive Rapid Diagnostic Test: A Role for Nucleic Acid Testing?

    abstract::We developed an open-access, Excel-based model simulating currently recommended and alternative algorithms for adult HIV testing as a preliminary investigation of trade-offs between accuracy and costs. Despite higher costs, simpler HIV testing algorithms incorporating point of care nucleic acid testing may improve out...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Neilan AM,Cohn JE,Lemaire JF,Sacks E,Alban R,Freedberg KA,Walensky RP,Ciaranello AL

    更新日期:2018-08-29 00:00:00

  • Difficulties of Identifying the Early HIV Antibody Seroconversion Period Depending on the Confirmatory Assay.

    abstract:Background:Identification of HIV infection at the early stage is valuable for patient management, for prevention, and for research purposes. In practice, identification of a recent HIV infection at diagnosis proves challenging after HIV antibody seroconversion but can be suspected using Western blots (WBs) or immunoblo...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Stefic K,Mahjoub N,Desouche C,Néré ML,Thierry D,Delaugerre C,Barin F,Chaix ML

    更新日期:2020-04-21 00:00:00

  • Advanced Human Immunodeficiency Virus Disease at Diagnosis in Mozambique and Swaziland.

    abstract:BACKGROUND:Early diagnosis of human immunodeficiency virus (HIV) is a prerequisite to maximizing individual and societal benefits of antiretroviral therapy. METHODS:Adults ≥18 years of age testing HIV positive at 10 health facilities in Mozambique and Swaziland received point-of-care CD4+ cell count testing immediatel...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Kujawski SA,Lamb MR,Lahuerta M,McNairy ML,Ahoua L,Abacassamo F,Nuwagaba-Biribonwoha H,Gachuhi A,El-Sadr WM,Elul B

    更新日期:2017-07-23 00:00:00

  • Human Case Infected With Babesia venatorum: A 5-Year Follow-Up Study.

    abstract:Background:Human babesiosis is a common zoonosis caused by Babesia and is attracting an increasing concern worldwide. The natural course of babesiosis infection and how the human immune system changes during the course of babesiosis infection are not clear. Methods:We followed up 1 case infected with Babesia venatorum...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Zhao L,Jiang R,Jia N,Ning N,Zheng Y,Huo Q,Sun Y,Yuan T,Jiang B,Li T,Liu H,Liu X,Chu Y,Wei R,Bian C,Wang H,Song J,Wang H,Jiang J,Cao W

    更新日期:2020-02-18 00:00:00

  • Recombinant Human Plasma Gelsolin Improves Survival and Attenuates Lung Injury in a Murine Model of Multidrug-Resistant Pseudomonas aeruginosa Pneumonia.

    abstract:Background:Plasma gelsolin (pGSN) is an abundant circulating protein quickly consumed by extensive tissue damage. Marked depletion is associated with later poor outcomes in diverse clinical circumstances. Repletion with recombinant human (rhu)-pGSN in animal models of inflammation lessens mortality and morbidity. Meth...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: DiNubile MJ,Levinson SL,Stossel TP,Lawrenz MB,Warawa JM

    更新日期:2020-06-19 00:00:00

  • Emerging Aspergillus Species Almost Exclusively Associated With Primary Immunodeficiencies.

    abstract::Invasive aspergillosis (IA) is the most serious mold infection encountered in patients with iatrogenic immunosuppression. IA is also a major cause of mortality and morbidity in individuals with primary immunodeficiency (PID). Although Aspergillus fumigatus is the most common etiologic agent of IA reported in PID patie...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章,评审


    authors: Seyedmousavi S,Lionakis MS,Parta M,Peterson SW,Kwon-Chung KJ

    更新日期:2018-09-26 00:00:00

  • Correlates of Immunity to Influenza as Determined by Challenge of Children with Live, Attenuated Influenza Vaccine.

    abstract::Background.  The efficacy of live, attenuated live attenuated influenza vaccine(LAIV) and inactivated influenza vaccine(IIV) is poorly explained by either single or composite immune responses to vaccination. Protective biomarkers were therefore studied in response to LAIV or IIV followed by LAIV challenge in children....

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Wright PF,Hoen AG,Ilyushina NA,Brown EP,Ackerman ME,Wieland-Alter W,Connor RI,Jegaskanda S,Rosenberg-Hasson Y,Haynes BC,Luke CJ,Subbarao K,Treanor JJ

    更新日期:2016-05-23 00:00:00

  • Correlation Between Tenofovir Drug Levels and the Renal Biomarkers RBP-4 and ß2M in the ION-4 Study Cohort.

    abstract:Background:Concomitant dosing of ledipasvir (LDV) and tenofovir disoproxil fumarate (TDF) results in an increased tenofovir (TFV) area under the curve (AUC). The aim of this study was to examine whether there was a correlation between the renal biomarkers retinol binding protein-4 (RBP-4) and β2 microglobulin (β2M) and...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Chan A,Park L,Collins LF,Cooper C,Saag M,Dieterich D,Sulkowski M,Naggie S

    更新日期:2019-01-24 00:00:00

  • Occurrence of 4 Dengue Virus Serotypes and Chikungunya Virus in Kilombero Valley, Tanzania, During the Dengue Outbreak in 2018.

    abstract:Background:Dengue and Chikungunya viruses can cause large-scale epidemics, with attack rates of up to 80%. In Tanzania, there have been repeated outbreaks of dengue fever, the most recent in 2018 and 2019, mostly affecting the coastal areas. Despite the importance of these viruses, there is limited knowledge on the epi...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Chipwaza B,Sumaye RD,Weisser M,Gingo W,Yeo NK,Amrun SN,Okumu FO,Ng LFP

    更新日期:2020-12-26 00:00:00

  • Treatment of Staphylococcal Device Infections: Synergistic Daptomycin With Ceftaroline Versus Rifampin-Adjunct Therapy.

    abstract::This is a single-center retrospective observational cohort study comparing daptomycin/ceftaroline combination therapy with rifampin-adjunct therapy for the treatment of staphylococcal device infections. The results of this study support use of the daptomycin/ceftaroline as an alternative or salvage option to standard ...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Chang AT,Cosimi RA,Bochan MR

    更新日期:2020-02-28 00:00:00

  • Development and Validation of a Model to Predict Growth of Potentially Antibiotic-Resistant Gram-Negative Bacilli in Critically Ill Children With Suspected Infection.

    abstract:Background:Risk-based guidelines aid empiric antibiotic selection for critically ill adults with suspected infection with Gram-negative bacilli with high potential for antibiotic resistance (termed high-risk GNRs). Neither evidence-based guidelines for empiric antibiotic selection nor validated risk factors predicting ...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Karsies T,Moore-Clingenpeel M,Hall M

    更新日期:2018-10-24 00:00:00

  • Histoplasmosis in Patients With Cell-Mediated Immunodeficiency: Human Immunodeficiency Virus Infection, Organ Transplantation, and Tumor Necrosis Factor-α Inhibition.

    abstract::Background.  Histoplasmosis causes severe disease in patients with defects of cell-mediated immunity. It is not known whether outcomes vary related to the type of immunodeficiency or class of antifungal treatment. Methods.  We reviewed cases of active histoplasmosis that occurred at Vanderbilt University Medical Cente...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Luckett K,Dummer JS,Miller G,Hester S,Thomas L

    更新日期:2015-02-20 00:00:00

  • The Yield and Consistency of the Detection of SARS-CoV-2 in Multiple Respiratory Specimens.

    abstract:Background:Few studies have compared the yield of reverse transcription polymerase chain reaction (RT-PCR) assays in nasopharyngeal swabs, oropharyngeal swabs, and sputum for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) detection. Methods:We conducted an observational study in Beijing Ditan Hospital, C...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Zhang H,Chen M,Zhang Y,Wen J,Wang Y,Wang L,Guo J,Liu C,Li D,Wang Y,Bai J,Gao G,Wang S,Yang D,Yu F,Yan L,Wan G,Zhang F

    更新日期:2020-08-26 00:00:00

  • Clofazimine in Nontuberculous Mycobacterial Infections: A Growing Niche.

    abstract::Infection secondary to rapidly growing mycobacteria (RGM) is associated with significant morbidity and mortality, especially in individuals with underlying structural lung disease or immune compromise. Such infections, particularly those caused by the Mycobacterium abscessus group, are challenging to treat due to high...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章,评审


    authors: McGuffin SA,Pottinger PS,Harnisch JP

    更新日期:2017-07-20 00:00:00

  • Ocular Actinomycosis Mimicking Meningioma.

    abstract::Orbital actinomycosis is an unusual clinical manifestation of orbital infection caused by Actinomyces species. Herein we report a case of orbital actinomycosis in a 67-year-old woman with recurrent swelling and erythema around her left eye with an orbital mass initially thought to be a meningioma. ...

    journal_title:Open forum infectious diseases



    authors: Kobayashi T,Ford B,Fujita N,Appenheimer AB

    更新日期:2020-05-19 00:00:00

  • Impact of Procalcitonin-Guided Antibiotic Management on Antibiotic Exposure and Outcomes: Real-world Evidence.

    abstract:Background:Delayed pathogen identification and nonspecific clinical findings make definitive decisions regarding antibiotics challenging. The stimuli of bacterial toxins and inflammation make procalcitonin (PCT) unique in its ability to differentiate bacterial infection from other causes of inflammation, and thus it is...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Broyles MR

    更新日期:2017-10-03 00:00:00

  • Hepatitis E Virus Infection Among Solid Organ Transplant Recipients at a North American Transplant Center.

    abstract::Background.  Autochthonous hepatitis E virus (HEV) infection has been reported in over 200 solid organ transplant (SOT) recipients since 2006, yet little is known about the burden of HEV among SOT recipients in North America. We performed a retrospective, cross-sectional study to investigate the prevalence and risk fa...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Sue PK,Pisanic N,Heaney CD,Forman M,Valsamakis A,Jackson AM,Ticehurst JR,Montgomery RA,Schwarz KB,Nelson KE,Karnsakul W

    更新日期:2016-01-18 00:00:00

  • Antimicrobial Agent Shortages: The New Norm for Infectious Diseases Physicians.

    abstract:Background:In 2012, the US Food and Drug Administration (FDA) required drug manufacturers to give advance notice of impending drug shortages. A survey of infectious diseases (ID) physicians was undertaken to determine the impact of this requirement and to follow-up on prior perceptions of ID physicians on shortages of ...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Gundlapalli AV,Beekmann SE,Graham DR,Polgreen PM,Members of the Emerging Infections Network.

    更新日期:2018-04-23 00:00:00

  • Addressing the Disease Burden of Vertically Acquired Hepatitis C Virus Infection Among Opioid-Exposed Infants.

    abstract:Background:This study aims to estimate the disease burden of vertically acquired hepatitis C virus (HCV) in a large Midwestern hospital and to identify factors associated with HCV diagnostic testing among high-risk infants. Methods:This is a retrospective analysis of an infant cohort (n = 58 427) born from 2014 to 201...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Protopapas S,Murrison LB,Wexelblatt SL,Blackard JT,Hall ES

    更新日期:2019-10-21 00:00:00

  • Soluble Tumor Necrosis Factor-α Receptor 2 in Urine Is a Potential Biomarker for Noninvasive Diagnosis of Malaria During Pregnancy.

    abstract::Background.  During pregnancy, the placenta is inaccessible for diagnosis of placental malaria (PM), but soluble tumor necrosis factor-α receptors (sTNFR) are elevated in the plasma of women with PM. Methods.  In this study, sTNFR-1 and sTNFR-2 were quantified in urine of pregnant and nonpregnant Cameroonian women who...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Tassi Yunga S,Thévenon AD,Leke RG,Taylor DW

    更新日期:2016-04-26 00:00:00

  • Absence of HBV Reactivation in Patients With Resolved HBV Infection Following DAA Therapy for Hepatitis C: A 1-Year Follow-up Study.

    abstract:Background:Patients with chronic hepatitis C virus (HCV) infection and active or previous hepatitis B virus (HBV) are at risk of HBV reactivation (HBV-R) during direct-acting antiviral (DAA) therapy. Recent reports suggest that HBV-R may even occur several months after completion of DAA therapy. The aim of this study w...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Mücke MM,Mücke VT,Peiffer KH,Sarrazin C,Zeuzem S,Berger A,Vermehren J

    更新日期:2018-12-15 00:00:00

  • Human Immunodeficiency Virus-1 Sequence Changes and Drug Resistance Mutation Among Virologic Failures of Lopinavir/Ritonavir Monotherapy: AIDS Clinical Trials Group Protocol A5230.

    abstract:: Background.  The mechanism of virologic failure (VF) of lopinavir/ritonavir (LPV/r) monotherapy is not well understood. We assessed sequence changes in human immunodeficiency virus-1 reverse-transcriptase (RT) and protease (PR) regions. Methods. ...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Vardhanabhuti S,Katzenstein D,Bartlett J,Kumarasamy N,Wallis CL

    更新日期:2016-08-24 00:00:00

  • Rapid Emergence of a New Clone Impacts the Population at Risk and Increases the Incidence of Type emm89 Group A Streptococcus Invasive Disease.

    abstract:BACKGROUND:Invasive group A Streptococcus (iGAS) disease caused by type emm89 strains has been increasing worldwide, driven by the emergence of an epidemic clonal variant (clade 3 emm89). The clinical characteristics of patients with emm89 iGAS disease, and in particular with clade 3 emm89 iGAS disease, are poorly desc...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Teatero S,Coleman BL,Beres SB,Olsen RJ,Kandel C,Reynolds O,Athey TBT,Musser JM,McGeer A,Fittipaldi N

    更新日期:2017-03-04 00:00:00