Is It Actionable? An Evaluation of the Rapid PCR-Based Blood Culture Identification Panel on the Management of Gram-Positive and Gram-Negative Blood Stream Infections.


Background:There is growing interest in the use of rapid blood culture identification (BCID) in antimicrobial stewardship programs (ASPs). Although many studies have looked at its clinical and economic utility, its comparative utility in gram-positive and gram-negative blood stream infections (BSIs) has not been as well characterized. Methods:The study was a quasi-experimental retrospective study at the Mayo Clinic in Phoenix, Arizona. All adult patients with positive blood cultures before BCID implementation (June 2015 to December 2015) and after BCID implementation (June 2016 to December 2016) were included. The outcomes of interest included time to first appropriate antibiotic escalation, time to first appropriate antibiotic de-escalation, time to organism identification, length of stay, infectious diseases consultation, discharge disposition, and in-hospital mortality. Results:In total, 203 patients were included in this study. There was a significant difference in the time to organism identification between the pre- and post-BCID cohorts (27.1 hours vs 3.3 hours, P < .0001). BCID did not significantly reduce the time to first appropriate antimicrobial escalation or de-escalation for either gram-positive BSIs (GP-BSIs) or gram-negative BSIs (GN-BSIs). Providers were more likely to escalate antimicrobial therapy in GP-BSIs after gram stain and more likely to de-escalate therapy in GN-BSIs after susceptibilities. Although there were no significant differences in changes in antimicrobial therapy for organism identification by BCID vs traditional methods, more than one-quarter of providers (28.1%) made changes after organism identification. There were no differences in hospital length of stay or in-hospital mortality comparing pre- vs post-BCID. Conclusions:Although BCID significantly reduced the time to identification for both GP-BSIs and GN-BSIs, BCID did not reduce the time to first appropriate antimicrobial escalation and de-escalation.


Open Forum Infect Dis


Tseng AS,Kasule SN,Rice F,Mi L,Chan L,Seville MT,Grys TE




Has Abstract


2018-12-11 00:00:00












  • Endothelial activation and repair during hantavirus infection: association with disease outcome.

    abstract:BACKGROUND:Endothelial activation and dysfunction play a central role in the pathogenesis of sepsis and viral hemorrhagic fevers. Hantaviral disease is a viral hemorrhagic fever and is characterized by capillary dysfunction, although the underlying mechanisms for hantaviral disease are not fully elucidated. METHODS:Th...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Connolly-Andersen AM,Thunberg T,Ahlm C

    更新日期:2014-05-29 00:00:00

  • Empiric vancomycin use in febrile neutropenic oncology patients.

    abstract::Vancomycin is commonly added as empiric therapy for febrile neutropenia. A retrospective chart review was conducted at a large community teaching institution to evaluate vancomycin use in oncology patients. The results revealed that a majority of empiric vancomycin therapy was inappropriate, raising concern for antibi...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Libuit J,Whitman A,Wolfe R,Washington CS

    更新日期:2014-04-10 00:00:00

  • Can Hepatitis C Virus Antigen Testing Replace Ribonucleic Acid Polymearse Chain Reaction Analysis for Detecting Hepatitis C Virus? A Systematic Review.

    abstract::The complexity and cost of current diagnostics for hepatitis C virus (HCV) may act as a prevention to the scale-up of treatment in the developing world. Currently, ribonucleic acid (RNA)-polymerase chain reaction tests are the gold standard. However, there is potential for the use of simpler and cheaper antigen tests ...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章,评审


    authors: Khan H,Hill A,Main J,Brown A,Cooke G

    更新日期:2017-05-26 00:00:00

  • Influence of Reported Penicillin Allergy on Mortality in MSSA Bacteremia.

    abstract:Background:Penicillin allergy frequently impacts antibiotic choice. As beta-lactams are superior to vancomycin in treating methicillin-susceptible Staphylococcus aureus (MSSA) bacteremia, we examined the effect of reported penicillin allergy on clinical outcomes in patients with MSSA bacteremia. Methods:In this retros...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Turner NA,Moehring R,Sarubbi C,Wrenn RH,Drew RH,Cunningham CK,Fowler VG,Anderson DJ

    更新日期:2018-02-19 00:00:00

  • Safety and Efficacy of Ombitasvir, Paritaprevir With Ritonavir ± Dasabuvir With or Without Ribavirin in Patients With Human Immunodeficiency Virus-1 and Hepatitis C Virus Genotype 1 or Genotype 4 Coinfection: TURQUOISE-I Part 2.

    abstract:BACKGROUND:Ombitasvir, paritaprevir with ritonavir, and dasabuvir (OBV/PTV/r ± DSV) ±ribavirin (RBV) are approved to treat hepatitis C virus (HCV) genotype 1 and 4 infection. Here, we investigate the safety and efficacy of OBV/PTV/r + DSV ±RBV for HCV genotype 1, and OBV/PTV/r + RBV for HCV genotype 4, in human immunod...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Rockstroh JK,Orkin C,Viani RM,Wyles D,Luetkemeyer AF,Lazzarin A,Soto-Malave R,Nelson MR,Bhagani SR,Klinker HHF,Rizzardini G,Girard PM,Tural C,Shulman NS,Mobashery N,Hu YB,Fredrick LM,Pilot-Matias T,Trinh R,Gane E

    更新日期:2017-07-22 00:00:00

  • Difficulties of Identifying the Early HIV Antibody Seroconversion Period Depending on the Confirmatory Assay.

    abstract:Background:Identification of HIV infection at the early stage is valuable for patient management, for prevention, and for research purposes. In practice, identification of a recent HIV infection at diagnosis proves challenging after HIV antibody seroconversion but can be suspected using Western blots (WBs) or immunoblo...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Stefic K,Mahjoub N,Desouche C,Néré ML,Thierry D,Delaugerre C,Barin F,Chaix ML

    更新日期:2020-04-21 00:00:00

  • Lack of Tularemia Among Health Care Providers With Close Contact With Infected Patients-A Case Series.

    abstract::Francisella tularensis has a low infectious dose and can infect laboratory staff handling clinical specimens. The risk to health care providers exposed during patient care is poorly defined. We describe 9 examples of health care providers who did not develop tularemia after significant exposures to infected patients. ...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Nelson CA,Brown J,Riley L,Dennis A,Oyer R,Brown C

    更新日期:2019-11-19 00:00:00

  • A Clinical Prediction Score Including Trial of Antibiotics and C-Reactive Protein to Improve the Diagnosis of Tuberculosis in Ambulatory People With HIV.

    abstract:Background:The use of a "trial of antibiotics" as empiric therapy for bacterial pneumonia as a diagnostic tool for tuberculosis in people with HIV (PWH) was removed from World Health Organization (WHO) recommendations in 2007, based on expert opinion. Current guidelines recommend antibiotics only after 2 Xpert MTB/RIF ...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Boyles TH,Nduna M,Pitsi T,Scott L,Fox MP,Maartens G

    更新日期:2020-01-06 00:00:00

  • The Yield and Consistency of the Detection of SARS-CoV-2 in Multiple Respiratory Specimens.

    abstract:Background:Few studies have compared the yield of reverse transcription polymerase chain reaction (RT-PCR) assays in nasopharyngeal swabs, oropharyngeal swabs, and sputum for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) detection. Methods:We conducted an observational study in Beijing Ditan Hospital, C...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Zhang H,Chen M,Zhang Y,Wen J,Wang Y,Wang L,Guo J,Liu C,Li D,Wang Y,Bai J,Gao G,Wang S,Yang D,Yu F,Yan L,Wan G,Zhang F

    更新日期:2020-08-26 00:00:00

  • Antimicrobial Stewardship Review of Automated Candidemia Alerts Using the Epic Stewardship Module Improves Bundle-of-Care Adherence.

    abstract:Background:Antimicrobial stewardship interventions utilizing real-time alerting through the electronic medical record enable timely implementation of the bundle of care (BOC) for patients with severe infections, such as candidemia. Automated alerting for candidemia using the Epic stewardship module has been in place si...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Pettit NN,Han Z,Nguyen CT,Choksi A,Charnot-Katsikas A,Beavis KG,Tesic V,Pisano J

    更新日期:2019-10-11 00:00:00

  • Risk Factors for Clinician-Diagnosed Lyme Arthritis, Facial Palsy, Carditis, and Meningitis in Patients From High-Incidence States.

    abstract:Background:Clinical features of Lyme disease (LD) range from localized skin lesions to serious disseminated disease. Information on risk factors for Lyme arthritis, facial palsy, carditis, and meningitis is limited but could facilitate disease recognition and elucidate pathophysiology. Methods:Patients from high-incid...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Kwit NA,Nelson CA,Max R,Mead PS

    更新日期:2017-11-18 00:00:00

  • Geographic Expansion of Lyme Disease in the Southeastern United States, 2000-2014.

    abstract::Background.  The majority of Lyme disease cases in the United States are acquired on the east coast between northern Virginia and New England. In recent years the geographic extent of Lyme disease has been expanding, raising the prospect of Lyme disease becoming endemic in the southeast. Methods.  We collected confirm...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Lantos PM,Nigrovic LE,Auwaerter PG,Fowler VG Jr,Ruffin F,Brinkerhoff RJ,Reber J,Williams C,Broyhill J,Pan WK,Gaines DN

    更新日期:2015-09-27 00:00:00

  • Sustained Response and Rationale of Programmed Cell Death-1-Targeting for Progressive Multifocal Leukoencephalopathy.

    abstract::In this study, we report a complete (clinical, radiological, and virological) sustained (1 year) response after nivolumab salvage therapy in a progressive multifocal leukoencephalopathy patient. Analyses of the cells infiltrate in a pretreatment brain biopsy suggest that parenchymal programmed cell death-L1+ macrophag...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Audemard-Verger A,Gasnault J,Faisant M,Besse MC,Martin-Silva N,Berra M,Fournier L,Boutemy J,Maigne G,De Boysson H,Ruet A,Vabret A,Chapon F,Martin-Blondel G,Aouba A

    更新日期:2019-09-30 00:00:00

  • Sustained Circulating Bacterial Deoxyribonucleic Acid Is Associated With Complicated Staphylococcus aureus Bacteremia.

    abstract:Background:Staphylococcus aureus (SA) bacteremia often requires a long treatment duration with antibiotics to prevent relapse due to the ability of SA to establish reservoirs of infection in sites such as heart and bone. These metastatic sites of infection cannot be serially sampled to monitor the clearance of SA infec...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Gutierrez J,Guimaraes AO,Lewin-Koh N,Berhanu A,Xu M,Cao Y,Kim J,Yan D,Chang JK,Dinoso JB,Koss CA,Clemenzi-Allen A,Chambers HF,Peck MC,Baruch A,Rosenberger CM

    更新日期:2019-02-26 00:00:00

  • Evaluation of Real-time PCR for Diagnosis of Post-Kala-azar Dermal Leishmaniasis in Endemic Foci of Bangladesh.

    abstract:Background:Post-kala-azar dermal leishmaniasis (PKDL) is a sequel to visceral leishmaniasis (VL), which is found in VL-endemic countries including Bangladesh. Because of these enigmatic cases, the success of the National Kala-azar Elimination Program is under threat. To date, diagnostic methods for PKDL cases in endemi...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Ghosh P,Hasnain MG,Hossain F,Khan MAA,Chowdhury R,Faisal K,Mural MA,Baker J,Nath R,Ghosh D,Maruf S,Shomik MS,Haque R,Matlashewski G,Hamano S,Duthie MS,Mondal D

    更新日期:2018-09-15 00:00:00

  • Emerging Aspergillus Species Almost Exclusively Associated With Primary Immunodeficiencies.

    abstract::Invasive aspergillosis (IA) is the most serious mold infection encountered in patients with iatrogenic immunosuppression. IA is also a major cause of mortality and morbidity in individuals with primary immunodeficiency (PID). Although Aspergillus fumigatus is the most common etiologic agent of IA reported in PID patie...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章,评审


    authors: Seyedmousavi S,Lionakis MS,Parta M,Peterson SW,Kwon-Chung KJ

    更新日期:2018-09-26 00:00:00

  • Risk Factors for Septicemia Deaths and Disparities in a Longitudinal US Cohort.

    abstract:Background:There are few longitudinal data on the risk factors and mediators of racial disparities in sepsis among community- dwelling US adults. Methods:This is a longitudinal study of adult participants in the 1999-2005 National Health Interview Survey with data linked to the 1999-2011 National Death Index. We utili...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Kempker JA,Kramer MR,Waller LA,Martin GS

    更新日期:2018-11-15 00:00:00

  • A Longitudinal Study of S. aureus Infection in a National Cohort of Surgical Patients.

    abstract:BACKGROUND:Postoperative infections are a common and often preventable complication of surgery. S. aureus is a prevalent organism cultured in these infections and is associated with morbidity, mortality, and increased healthcare utilization. However, the long-term burden of S. aureus infection in surgical patients is n...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: O'Brien WJ,Gupta K,Itani KMF

    更新日期:2019-08-13 00:00:00

  • Liver Fibrosis Regression Measured by Transient Elastography in Human Immunodeficiency Virus (HIV)-Hepatitis B Virus (HBV)-Coinfected Individuals on Long-Term HBV-Active Combination Antiretroviral Therapy.

    abstract::Background.  Advanced fibrosis occurs more commonly in human immunodeficiency virus (HIV)-hepatitis B virus (HBV) coinfected individuals; therefore, fibrosis monitoring is important in this population. However, transient elastography (TE) data in HIV-HBV coinfection are lacking. We aimed to assess liver fibrosis using...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Audsley J,Robson C,Aitchison S,Matthews GV,Iser D,Sasadeusz J,Lewin SR

    更新日期:2016-02-12 00:00:00

  • Factor Xa Inhibition Reduces Coagulation Activity but Not Inflammation Among People With HIV: A Randomized Clinical Trial.

    abstract:Background:Coagulation activity among persons with HIV is associated with end-organ disease risk, but the pathogenesis is not well characterized. We tested a hypothesis that hypercoagulation contributes to disease risk, in part, via upregulation of inflammation. Methods:Treatment effects of edoxaban (30 mg), a direct ...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Baker JV,Wolfson J,Peterson T,Mooberry M,Gissel M,Mystakelis H,Henderson MW,Garcia-Myers K,Rhame FS,Schacker TW,Brummel-Ziedins KE,Sereti I,Key NS,Tracy RP

    更新日期:2020-02-01 00:00:00

  • Standardized electrolyte supplementation and fluid management improves survival during amphotericin therapy for cryptococcal meningitis in resource-limited settings.

    abstract:BACKGROUND:Amphotericin B is the preferred treatment for cryptococcal meningitis, but it has cumulative severe side effects, including nephrotoxicity, hypokalemia, and hypomagnesemia. Amphotericin-induced severe hypokalemia may predispose the patient to cardiac arrhythmias and death, and there is very little data avail...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Bahr NC,Rolfes MA,Musubire A,Nabeta H,Williams DA,Rhein J,Kambugu A,Meya DB,Boulware DR

    更新日期:2014-08-25 00:00:00

  • Inappropriate Management of Asymptomatic Patients With Positive Urine Cultures: A Systematic Review and Meta-analysis.

    abstract:Background:Mismanagement of asymptomatic patients with positive urine cultures (referred to as asymptomatic bacteriuria [ASB] in the literature) promotes antimicrobial resistance and results in unnecessary antimicrobial-related adverse events and increased health care costs. Methods:We conducted a systematic review an...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Flokas ME,Andreatos N,Alevizakos M,Kalbasi A,Onur P,Mylonakis E

    更新日期:2017-11-20 00:00:00

  • Learning Experiences Within Infectious Diseases Pharmacy Residency Programs in the United States: A Cross-Sectional Survey.

    abstract:Background:Pharmacists with residency training in infectious diseases (ID) optimize antimicrobial therapy outcomes in patients and support antimicrobial stewardship (AS) programs. Although most ID residencies are accredited and assessed by certain standards, the degree to which these programs are similar is not known. ...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Cho JC,Crotty MP,Kufel WD,Chahine EB,Sofjan AK,Gallagher JC,Estrada SJ

    更新日期:2019-09-06 00:00:00

  • A Deeper Dive Into Antibiotic Stewardship Needs: A Multihospital Survey.

    abstract::In a 2016 survey of 46 Michigan hospitals, we identified four key needs for antibiotic stewardship: clinically-relevant antibiotic data, monitoring compliance, syndrome-specific interventions, and discharge stewardship. A stewardship initiative now addresses these needs within the Michigan Hospital Medicine Safety Con...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Vaughn VM,Petty LA,Flanders SA,Malani AN,Patel T,Bernstein SJ,Hsaiky LM,Thyagarajan R,Osterholzer D,McLaughlin E,Horowitz JK,Gandhi TN

    更新日期:2020-01-11 00:00:00

  • Addressing the Disease Burden of Vertically Acquired Hepatitis C Virus Infection Among Opioid-Exposed Infants.

    abstract:Background:This study aims to estimate the disease burden of vertically acquired hepatitis C virus (HCV) in a large Midwestern hospital and to identify factors associated with HCV diagnostic testing among high-risk infants. Methods:This is a retrospective analysis of an infant cohort (n = 58 427) born from 2014 to 201...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Protopapas S,Murrison LB,Wexelblatt SL,Blackard JT,Hall ES

    更新日期:2019-10-21 00:00:00

  • Splenic Infarction: An Under-recognized Complication of Infectious Mononucleosis?

    abstract::Splenic infarction is a rare complication of infectious mononucleosis. We describe 3 cases of splenic infarction attributed to infectious mononucleosis that we encountered within a 2-month period. We underscore the awareness of this potential complication of infectious mononucleosis and discuss the differential diagno...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Li Y,George A,Arnaout S,Wang JP,Abraham GM

    更新日期:2018-02-17 00:00:00

  • Analytical Performance of the Exacto Test HIV Self-Test: A Cross-Sectional Field Study in the Democratic Republic of the Congo.

    abstract::The Democratic Republic of the Congo (DRC) has begun implementing HIV self-testing to boost the first "95" of the UNAIDS 95-95-95 targets by 2025. This study aims to assess the performance and usability of the Exacto Test HIV (Biosynex, Strasbourg, France) self-test in the lab and in the field. The Exacto Test HIV sel...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Tonen-Wolyec S,Muwonga Masidi J,Kamanga Lukusa LF,Nsiku Dikumbwa G,Sarassoro A,Bélec L

    更新日期:2020-11-29 00:00:00

  • Diabetes Modifies the Clinic Presentation of Cutaneous Leishmaniasis.

    abstract:Background:Cutaneous leishmaniasis (CL) caused by L. braziliensis is characterized by 1 or multiple well-limited ulcerated lesions. Diabetes mellitus (DM) impairs neutrophil and monocyte function, and there is a report of vegetative lesions in a patient with both diseases in Morocco. Here we evaluate the influence of D...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Lago AS,Lima FR,Carvalho AM,Sampaio C,Lago N,Guimarães LH,Lago J,Machado PRL,Carvalho LP,Arruda S,Carvalho EM

    更新日期:2020-10-19 00:00:00

  • CFTR Heterozygotes Are at Increased Risk of Respiratory Infections: A Population-Based Study.

    abstract:Background:Patients heterozygous for mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene may be more susceptible to respiratory infections than the general population. Methods :We conducted a retrospective case-control study using health insurance claims. We identified patients as either h...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Polgreen PM,Brown GD,Hornick DB,Ahmad F,London B,Stoltz DA,Comellas AP

    更新日期:2018-11-01 00:00:00

  • Cytomegalovirus Retinitis Screening and Treatment in Human Immunodeficiency Virus Patients in Malawi: A Feasibility Study.

    abstract:Background:Cytomegalovirus retinitis is a treatable cause of blindness in people with human immunodeficiency virus (HIV) typically with CD4 counts <50 cells/mm3. Diagnosis is with indirect fundoscopy, and treatment is with intravitreal ganciclovir injections or systemic therapy. However, diagnosis and treatment are not...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Ocieczek P,Barnacle JR,Gumulira J,Phiri S,Heller T,Grabska-Liberek I

    更新日期:2019-11-06 00:00:00