Therapeutic Trial of Rifabutin After Rifampicin-Associated DRESS Syndrome in Tuberculosis-Human Immunodeficiency Virus Coinfected Patients.

Abstract:

:Elimination of a rifamycin from the treatment regimen for tuberculosis negatively impacts outcomes. Cross-reactivity between the rifamycins after drug eruptions is unclear. We report 6 consecutive human immunodeficiency virus-infected patients with rifampicin-associated drug rash with eosinophilia and systemic symptoms (DRESS) syndrome confirmed on diagnostic rechallenge. The patients subsequently tolerated rifabutin. These data inform clinical management of tuberculosis-associated drug reactions.

journal_name

Open Forum Infect Dis

authors

Lehloenya RJ,Dlamini S,Muloiwa R,Kakande B,Ngwanya MR,Todd G,Dheda K

doi

10.1093/ofid/ofw130

subject

Has Abstract

pub_date

2016-06-20 00:00:00

pages

ofw130

issue

3

issn

2328-8957

pii

ofw130

journal_volume

3

pub_type

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