Endothelial activation and repair during hantavirus infection: association with disease outcome.


BACKGROUND:Endothelial activation and dysfunction play a central role in the pathogenesis of sepsis and viral hemorrhagic fevers. Hantaviral disease is a viral hemorrhagic fever and is characterized by capillary dysfunction, although the underlying mechanisms for hantaviral disease are not fully elucidated. METHODS:The temporal course of endothelial activation and repair were analyzed during Puumala hantavirus infection and associated with disease outcome and a marker for hypoxia, insulin-like growth factor binding protein 1 (IGFBP-1). The following endothelial activation markers were studied: endothelial glycocalyx degradation (syndecan-1) and leukocyte adhesion molecules (soluble vascular cellular adhesion molecule 1, intercellular adhesion molecule 1, and endothelial selectin). Cytokines associated with vascular repair were also analyzed (vascular endothelial growth factor, erythropoietin, angiopoietin, and stromal cell-derived factor 1). RESULTS:Most of the markers we studied were highest during the earliest phase of hantaviral disease and associated with clinical and laboratory surrogate markers for disease outcome. In particular, the marker for glycocalyx degradation, syndecan-1, was significantly associated with levels of thrombocytes, albumin, IGFBP-1, decreased blood pressure, and disease severity. CONCLUSIONS:Hantaviral disease outcome was associated with endothelial dysfunction. Consequently, the endothelium warrants further investigation when designing future medical interventions.


Open Forum Infect Dis


Connolly-Andersen AM,Thunberg T,Ahlm C




Has Abstract


2014-05-29 00:00:00












  • Atherosclerotic Cardiovascular Disease Risk Profile of Tenofovir Alafenamide Versus Tenofovir Disoproxil Fumarate.

    abstract:Background:In human immunodeficiency virus (HIV) treatment, tenofovir alafenamide (TAF) is associated with greater increases in all fasting cholesterol subgroups compared with tenofovir disoproxil fumarate (TDF). Because lipid abnormalities may contribute to cardiovascular morbidity and mortality, cardiovascular risk a...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Huhn GD,Shamblaw DJ,Baril JG,Hsue PY,Mills BL,Nguyen-Cleary T,McCallister S,Das M

    更新日期:2019-11-11 00:00:00

  • National Survey of US HIV Clinicians: Knowledge and Attitudes About the Affordable Care Act and Opinions of its Impact on Quality of Care and Barriers to Care.

    abstract:Background:The Affordable Care Act's (ACA's) major reforms started in 2014. In addition to assessing HIV clinicians' ACA knowledge and attitudes, this study aims to evaluate HIV clinicians' perspectives on whether the ACA has impacted the quality of HIV care and whether it addresses the main barriers to HIV care. Meth...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: McManus KA,Ferey J,Farrell E,Dillingham R

    更新日期:2020-06-10 00:00:00

  • Pneumococcal Conjugate Vaccine Safety in Elderly Adults.

    abstract:Background:The 13-valent pneumococcal conjugate vaccine (PCV13) and the 23-valent pneumococcal polysaccharide vaccine (PPSV23) were both recommended to adults aged ≥65 years. The study examines adults ≥65 years for risk of adverse events (AEs) requiring medical attention following vaccination with PCV13 as compared wit...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Tseng HF,Sy LS,Qian L,Liu IA,Mercado C,Lewin B,Tartof SY,Nelson J,Jackson LA,Daley MF,Weintraub E,Klein NP,Belongia E,Liles EG,Jacobsen SJ

    更新日期:2018-05-02 00:00:00

  • Continuing Decline in Varicella Incidence After the 2-Dose Vaccination Recommendation-Connecticut, 2009-2014.

    abstract::Background.  Varicella is a highly contagious vaccine-preventable illness. In 1996, the Advisory Committee for Immunization Practices recommended 1 dose of vaccine for children, and in 2006 it recommended 2 doses; Connecticut required 1 dose for school entry in 2000 and 2 doses for school entry starting in 2011. Conne...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Mullins J,Kudish K,Sosa L,Hadler J

    更新日期:2015-10-09 00:00:00

  • Impact of a 24/7 Rapid Molecular Assay for Influenza Detection on the Prescription of Oseltamivir.

    abstract::We assessed the impact of a rapid molecular assay for influenza detection whether outsourced or performed onsite 24/7 in a University Hospital in Paris, France. Shorter median time-to-results (16.8 vs 2.3 hours, P < .05) and an increased rate of adequate prescription of oseltamivir (76.6% vs 95.3%, P < .05) were obser...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Jacquier H,Péan de Ponfilly G,Chauvin A,Amarsy R,Benmansour H,Hoang-Nguyen DT,Lecorché E,Mesnil C,Mougari F,Munier AL,Salmona M,Berçot B,Le Goff J,Cambau E

    更新日期:2020-08-25 00:00:00

  • Interferon Lambda 4 Genotype Is Associated With Jaundice and Elevated Aminotransferase Levels During Acute Hepatitis C Virus Infection: Findings From the InC3 Collaborative.

    abstract::Symptomatic acute HCV infection and interferon lambda 4 (IFNL4) genotypes are important predictors of spontaneous viral clearance. Using data from a multicohort database (Injecting Cohorts [InC3] Collaborative), we establish an independent association between host IFNL4 genotype and symptoms of acute hepatitis C virus...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Page K,Mirzazadeh A,Rice TM,Grebely J,Kim AY,Cox AL,Morris MD,Hellard M,Bruneau J,Shoukry NH,Dore GJ,Maher L,Lloyd AR,Lauer G,Prins M,McGovern BH

    更新日期:2016-02-08 00:00:00

  • Absence of HBV Reactivation in Patients With Resolved HBV Infection Following DAA Therapy for Hepatitis C: A 1-Year Follow-up Study.

    abstract:Background:Patients with chronic hepatitis C virus (HCV) infection and active or previous hepatitis B virus (HBV) are at risk of HBV reactivation (HBV-R) during direct-acting antiviral (DAA) therapy. Recent reports suggest that HBV-R may even occur several months after completion of DAA therapy. The aim of this study w...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Mücke MM,Mücke VT,Peiffer KH,Sarrazin C,Zeuzem S,Berger A,Vermehren J

    更新日期:2018-12-15 00:00:00

  • Risk Factors for Septicemia Deaths and Disparities in a Longitudinal US Cohort.

    abstract:Background:There are few longitudinal data on the risk factors and mediators of racial disparities in sepsis among community- dwelling US adults. Methods:This is a longitudinal study of adult participants in the 1999-2005 National Health Interview Survey with data linked to the 1999-2011 National Death Index. We utili...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Kempker JA,Kramer MR,Waller LA,Martin GS

    更新日期:2018-11-15 00:00:00

  • Variability of Antibiotic Prescribing in a Large Healthcare Network Despite Adjusting for Patient-Mix: Reconsidering Targets for Improved Prescribing.

    abstract:Background:In the outpatient setting, the majority of antibiotic prescriptions are for acute respiratory infections (ARIs), but most of these infections are viral and antibiotics are unnecessary. We analyzed provider-specific antibiotic prescribing in a group of outpatient clinics affiliated with an academic medical ce...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Jung S,Sexton ME,Owens S,Spell N,Fridkin S

    更新日期:2019-01-18 00:00:00

  • Herpes Zoster and Recurrent Herpes Zoster.

    abstract:BACKGROUND:The incidence of recurrent herpes zoster (HZ) and the relationship between initial and recurrent HZ are not clear. METHODS:The Miyazaki Dermatologist Society has surveyed ~5000 patients with HZ annually since 1997. A questionnaire regarding HZ and its recurrence was completed by the dermatologists. RESULTS...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Shiraki K,Toyama N,Daikoku T,Yajima M,Miyazaki Dermatologist Society.

    更新日期:2017-01-28 00:00:00

  • Lack of Awareness of Human Immunodeficiency Virus (HIV) Infection: Problems and Solutions With Self-reported HIV Serostatus of Men Who Have Sex With Men.

    abstract:BACKGROUND:Lack of human immunodeficiency virus (HIV) infection awareness may be a driver of racial disparities in HIV infection among men who have sex with men (MSM). Lack of awareness is typically measured by comparing HIV test result to self-reported HIV status. This measure may be subject to reporting bias and alte...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Sanchez TH,Kelley CF,Rosenberg E,Luisi N,O'Hara B,Lambert R,Coleman R,Frew P,Salazar LF,Tao S,Clarke W,Del Rio C,Sullivan PS

    更新日期:2014-09-13 00:00:00

  • Correlation Between Tenofovir Drug Levels and the Renal Biomarkers RBP-4 and ß2M in the ION-4 Study Cohort.

    abstract:Background:Concomitant dosing of ledipasvir (LDV) and tenofovir disoproxil fumarate (TDF) results in an increased tenofovir (TFV) area under the curve (AUC). The aim of this study was to examine whether there was a correlation between the renal biomarkers retinol binding protein-4 (RBP-4) and β2 microglobulin (β2M) and...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Chan A,Park L,Collins LF,Cooper C,Saag M,Dieterich D,Sulkowski M,Naggie S

    更新日期:2019-01-24 00:00:00

  • Respiratory Syncytial Virus Infection: Its Propensity for Bacterial Coinfection and Related Mortality in Elderly Adults.

    abstract::Respiratory syncytial virus (RSV) is an increasingly recognized cause of acute respiratory infection (ARI) in adults. We compared the crude in-hospital mortality of patients with RSV infection alone with that of patients with RSV-bacterial coinfection. Overall, 12 144 hospitalized patients with ARI were screened for R...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Godefroy R,Giraud-Gatineau A,Jimeno MT,Edouard S,Meddeb L,Zandotti C,Chaudet H,Colson P,Raoult D,Cassir N

    更新日期:2020-11-12 00:00:00

  • Comparison of Rates of Hospitalization Between Single and Dual Virus Detection in a Mexican Cohort of Children and Adults With Influenza-Like Illness.

    abstract:Background:Molecular detection methods allow for the simultaneous detection of several infectious agents. This study assesses whether co-infection with 2 viruses as compared with 1 is associated with increased hospitalization in those with acute respiratory infections. Methods:We prospectively enrolled a cohort of ped...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Noyola DE,Hunsberger S,Valdés Salgado R,Powers JH 3rd,Galindo-Fraga A,Ortiz-Hernández AA,Ramirez-Venegas A,Moreno-Espinosa S,Llamosas-Gallardo B,Guerrero ML,Beigel JH,Ruiz-Palacios G,Perez-Patrigeon S,Mexico Emerging Infectious

    更新日期:2019-10-03 00:00:00

  • Prognostic Role of Bacterial and Fungal Infections in Patients With Liver Cirrhosis With and Without Acute-on-Chronic Liver Failure: A Prospective 2-Center Study.

    abstract:Background:Bacterial and fungal infections (BFIs) are frequent in patients with cirrhosis and often trigger acute-on-chronic liver failure (ACLF). This prospective observational study aims to describe the interactions between BFI and ACLF in terms of mortality and related risk factors. Methods:We performed a 2-center ...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Bartoletti M,Baldassarre M,Domenicali M,Lewis RE,Giannella M,Antognoli A,Rinaldi M,Zaccherini G,Verucchi G,Marconi L,Tamè M,Berardi S,Napoli L,Siniscalchi A,Fabbri A,Biselli M,Tufoni M,Pavarin RM,Trevisani F,Viale P

    更新日期:2020-11-04 00:00:00

  • Physician Decisions to Defer Antiretroviral Therapy in Key Populations: Implications for Reducing Human Immunodeficiency Virus Incidence and Mortality in Malaysia.

    abstract:BACKGROUND:Antiretroviral therapy (ART) is recommended for all people living with human immunodeficiency virus (HIV), yet physician attitudes and prescribing behaviors toward members of key risk populations may limit ART access and undermine treatment as prevention strategies. METHODS:Physicians in Malaysia (N = 214) ...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Ferro EG,Culbert GJ,Wickersham JA,Marcus R,Steffen AD,Pauls HA,Westergaard RP,Lee CK,Kamarulzaman A,Altice FL

    更新日期:2017-01-25 00:00:00

  • Sustained Circulating Bacterial Deoxyribonucleic Acid Is Associated With Complicated Staphylococcus aureus Bacteremia.

    abstract:Background:Staphylococcus aureus (SA) bacteremia often requires a long treatment duration with antibiotics to prevent relapse due to the ability of SA to establish reservoirs of infection in sites such as heart and bone. These metastatic sites of infection cannot be serially sampled to monitor the clearance of SA infec...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Gutierrez J,Guimaraes AO,Lewin-Koh N,Berhanu A,Xu M,Cao Y,Kim J,Yan D,Chang JK,Dinoso JB,Koss CA,Clemenzi-Allen A,Chambers HF,Peck MC,Baruch A,Rosenberger CM

    更新日期:2019-02-26 00:00:00

  • The Effect of Shorter Treatment Regimens for Hepatitis C on Population Health and Under Fixed Budgets.

    abstract:Background:Direct acting antiviral hepatitis C virus (HCV) therapies are highly effective but costly. Wider adoption of an 8-week ledipasvir/sofosbuvir treatment regimen could result in significant savings, but may be less efficacious compared with a 12-week regimen. We evaluated outcomes under a constrained budget and...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Morgan JR,Kim AY,Naggie S,Linas BP

    更新日期:2017-12-08 00:00:00

  • Corrigendum: Hepatitis B Virus (HBV) Infection and Re-activation During Nucleos(t)ide Reverse Transcriptase Inhibitor-Sparing Antiretroviral Therapy in a High-HBV Endemicity Setting.

    abstract::[This corrects the article DOI: 10.1093/ofid/ofy251.]. ...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章,已发布勘误


    authors: Abdullahi A,Fopoussi OM,Torimiro J,Atkins M,Kouanfack C,Geretti AM

    更新日期:2019-04-03 00:00:00

  • Errors in Diagnostic Test Use and Interpretation Contribute to the High Number of Lyme Disease Referrals in a Low-Incidence State.

    abstract::Lyme disease accounted for more than two-thirds (56 of 81, 69.1%) of all tick-borne disease referrals to a large, academic infectious diseases clinic in a low-incidence state. Deviations from diagnostic testing guidelines and errors in test interpretation were common (23 of 35, 65.7%), suggesting that frontline provid...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Boyce RM,Speight C,Lin JT,Farel CE

    更新日期:2020-01-11 00:00:00

  • Intra-abdominal Infections: The Role of Anaerobes, Enterococci, Fungi, and Multidrug-Resistant Organisms.

    abstract:BACKGROUND:Intra-abdominal infections (IAI) constitute a common reason for hospitalization. However, there is lack of standardization in empiric management of (1) anaerobes, (2) enterococci, (3) fungi, and (4) multidrug-resistant organisms (MDRO). The recommendation is to institute empiric coverage for some of these or...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Marcus G,Levy S,Salhab G,Mengesha B,Tzuman O,Shur S,Burke E,Mayeda RC,Cochavi L,Perluk I,Zaidenstein R,Lazarovitch T,Dadon M,Marchaim D

    更新日期:2016-12-20 00:00:00

  • Treatment Options for Carbapenem-Resistant Enterobacteriaceae Infections.

    abstract::This article provides a comprehensive review of currently available treatment options for infections due to carbapenem-resistant Enterobacteriaceae (CRE). Antimicrobial resistance in Gram-negative bacteria is an emerging and serious global public health threat. Carbapenems have been used as the "last-line" treatment f...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章,评审


    authors: Morrill HJ,Pogue JM,Kaye KS,LaPlante KL

    更新日期:2015-05-05 00:00:00

  • Chagas Disease in the New York City Metropolitan Area.

    abstract:Background:Chagas disease, caused by the parasite Trypanosoma cruzi, once considered a disease confined to Mexico, Central America, and South America, is now an emerging global public health problem. An estimated 300 000 immigrants in the United States are chronically infected with T. cruzi. However, awareness of Chaga...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Zheng C,Quintero O,Revere EK,Oey MB,Espinoza F,Puius YA,Ramirez-Baron D,Salama CR,Hidalgo LF,Machado FS,Saeed O,Shin J,Patel SR,Coyle CM,Tanowitz HB

    更新日期:2020-05-06 00:00:00

  • A Longitudinal Study of S. aureus Infection in a National Cohort of Surgical Patients.

    abstract:BACKGROUND:Postoperative infections are a common and often preventable complication of surgery. S. aureus is a prevalent organism cultured in these infections and is associated with morbidity, mortality, and increased healthcare utilization. However, the long-term burden of S. aureus infection in surgical patients is n...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: O'Brien WJ,Gupta K,Itani KMF

    更新日期:2019-08-13 00:00:00

  • Perspectives of Physician and Pharmacist Stewards on Successful Antibiotic Stewardship Program Implementation: A Qualitative Study.

    abstract:Background:Antibiotic stewardship programs (ASPs) are required at every hospital regardless of size. We conducted a qualitative study across different hospital settings to examine perspectives of physician and pharmacist stewards about the dynamics within their team and contextual factors that facilitate the success of...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Barlam TF,Childs E,Zieminski SA,Meshesha TM,Jones KE,Butler JM,Damschroder LJ,Goetz MB,Madaras-Kelly K,Reardon CM,Samore MH,Shen J,Stenehjem E,Zhang Y,Drainoni ML

    更新日期:2020-06-15 00:00:00

  • Cytomegalovirus Retinitis Screening and Treatment in Human Immunodeficiency Virus Patients in Malawi: A Feasibility Study.

    abstract:Background:Cytomegalovirus retinitis is a treatable cause of blindness in people with human immunodeficiency virus (HIV) typically with CD4 counts <50 cells/mm3. Diagnosis is with indirect fundoscopy, and treatment is with intravitreal ganciclovir injections or systemic therapy. However, diagnosis and treatment are not...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Ocieczek P,Barnacle JR,Gumulira J,Phiri S,Heller T,Grabska-Liberek I

    更新日期:2019-11-06 00:00:00

  • Seroprevalence of Strongyloides stercoralis and Evaluation of Universal Screening in Kidney Transplant Candidates: A Single-Center Experience in Houston (2012-2017).

    abstract:BACKGROUND:Disseminated strongyloidiasis in solid organ transplant recipients is a rare but devastating infection. In our center, we implemented a universal screening of all candidates for kidney transplantation. We assessed the seroprevalence and utility of universal screening for strongyloidiasis in our center. METH...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Al-Obaidi M,Hasbun R,Vigil KJ,Edwards AR,Chavez V,Hall DR,Dar WA,De Golovine A,Ostrosky-Zeichner L,Bynon JS,Nigo M

    更新日期:2019-07-01 00:00:00

  • Diagnosing diabetic foot osteomyelitis: narrative review and a suggested 2-step score-based diagnostic pathway for clinicians.

    abstract::The diabetic foot infection remains a major cause of morbidity and mortality in many patients and remains a challenging diagnosis for most clinicians. Diagnosis is largely based on clinical signs supplemented by various imaging tests. Magnetic resonance imaging (MRI) is not readily available to many clinicians, and bo...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章,评审


    authors: Markanday A

    更新日期:2014-08-07 00:00:00

  • Heterogeneity Between States in the Health and Economic Impact of Measles Immunization in the United States.

    abstract:Background:Vaccines have been used successfully for disease elimination programs in many countries. Evidence on the impact of vaccination programs can support decision-making among medical practitioners and policy makers to improve immunization rates. We estimated the health and economic impact of measles vaccination f...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Paternina-Caicedo A,Driessen J,Roberts M,van Panhuis WG

    更新日期:2018-06-16 00:00:00

  • Cost of Public Health Response and Outbreak Control With a Third Dose of Measles-Mumps-Rubella Vaccine During a University Mumps Outbreak-Iowa, 2015-2016.

    abstract:Background:The United States is experiencing mumps outbreaks in settings with high 2-dose measles-mumps-rubella (MMR) vaccine coverage, mainly universities. The economic impact of mumps outbreaks on public health systems is largely unknown. During a 2015-2016 mumps outbreak at the University of Iowa, we estimated the c...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Marin M,Kitzmann TL,James L,Quinlisk P,Aldous WK,Zhang J,Cardemil CV,Galeazzi C,Patel M,Ortega-Sanchez IR

    更新日期:2018-10-04 00:00:00